Review
Medicine, General & Internal
Pauline Brice, Eric de Kerviler, Jonathan W. Friedberg
Summary: Classical Hodgkin lymphoma is a relatively common lymphoma that is generally considered highly curable with standard first-line chemotherapy and radiotherapy, although some patients may not be cured or may experience late toxic effects leading to premature death. Recent changes in the gold standard of chemotherapy, now often including immunotherapy in relapse settings, have further impacted treatment outcomes.
Article
Medicine, General & Internal
Christina Poh, John D. McPherson, Joseph Tuscano, Qian Li, Arti Parikh-Patel, Christoph F. A. Vogel, Myles Cockburn, Theresa Keegan
Summary: Evidence suggests that pesticide exposure may be a risk factor for non-Hodgkin lymphoma (NHL) development, but the association between pesticide exposure and patient survival is not well-established. Using data from the California Cancer Registry and CalEnviroScreen 3.0, the study did not find consistent associations between agricultural pesticide exposure at the neighborhood level and worse survival outcomes for NHL patients.
Article
Oncology
Caron A. Jacobson, Julio C. Chavez, Alison R. Sehgal, Basem M. William, Javier Munoz, Gilles Salles, Pashna N. Munshi, Carla Casulo, David G. Maloney, Sven de Vos, Ran Reshef, Lori A. Leslie, Ibrahim Yakoub-Agha, Olalekan O. Oluwole, Henry Chi Hang Fung, Joseph Rosenblatt, John M. Rossi, Lovely Goyal, Vicki Plaks, Yin Yang, Remus Vezan, Mauro P. Avanzi, Sattva S. Neelapu
Summary: This study assessed the use of axicabtagene ciloleucel in relapsed or refractory indolent non-Hodgkin lymphoma and found that it showed high rates of durable responses and had a manageable safety profile.
Article
Oncology
Wei Zhang, Qun Zhang, Hui Liang, SuLi Wang, Jing Pan, ShaoYing Pan, Bin Zhu, ZhiYong Ding, WenLi Zhao, Ying Ni
Summary: This study investigated the impact of MDR1 C1236T single nucleotide polymorphisms (SNPs) on the susceptibility and treatment-related toxicities of B-cell non-Hodgkin lymphoma (B-NHL). The results showed that MDR1 C1236T polymorphisms were not significantly related to the risk and treatment-related toxicities of B-NHL. However, a significant association between extranodal sites and the C1236T allele was observed.
Article
Oncology
Shuyan Yao, Zhili Jin, Lingbo He, Ruoxi Zhang, Menghan Liu, Zhengjie Hua, Zhao Wang, Yini Wang
Summary: The study showed significant differences in pathological types, clinical characteristics, and prognosis between lymphoma patients with or without LAHS. Age, platelet count, IPI, history of lymphoma, and lack of HLH remission were identified as independent risk factors for the prognosis of NHL-LAHS patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Frank Cichocki, Bin Bin Zhang, Cheng-Ying Wu, Emily Chiu, Abderrahman Day, Roddy S. O'Connor, Dima Yackoubov, Ronit Simantov, David H. McKenna, Qing Cao, Todd E. Defor, Murali Janakiram, Rose Wangen, Zuzan Cayci, Nathaniel Snyder, Akhilesh Kumar, Bartosz Grzywacz, Justin Hwang, Yona Geffen, Jeffrey S. Miller, Joseph Maakaron, Veronika Bachanova
Summary: Allogeneic natural killer (NK) cell adoptive transfer, enhanced by ex vivo culture with interleukin-15 (IL-15) and nicotinamide (NAM), leads to stable induction of l-selectin (CD62L), and metabolic changes associated with elevated glucose flux. This approach improves NK cell survival, function, and persistence, and shows promising results in a clinical trial for patients with relapsed or refractory non-Hodgkin lymphoma (NHL) and multiple myeloma (MM). The therapy, named GDA-201, demonstrates high tolerability, favorable metabolic profile, and an overall response rate of 74% in advanced NHL patients.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Hematology
Dennis A. Eichenauer, Horst Muller, Leonard Elger, Helen Goergen, Michael Fuchs, Stefanie Kreissl, Boris Boll, Volker Diehl, Bastian von Tresckow, Peter Borchmann, Andreas Engert
Summary: NHL after cHL is a rare event that primarily affects older individuals, with a five-year event-free survival and overall survival estimates of 36.9% and 44.2% respectively.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Oncology
Xiaoqin Zhu, Wei Li, Jia Zhu, Huimou Chen, Jinqiu Guan, Dalei Zhou, Zijun Zhen, Feifei Sun, Junting Huang, Juan Wang, Xiaofei Sun, Suying Lu, Yizhuo Zhang
Summary: The study evaluated the impact of MTHFR C677T/A1298C polymorphisms on survival in Chinese pediatric NHL patients, showing potential significance for survival prediction and risk stratification, especially in Burkitt lymphoma and diffuse large B cell lymphoma cases.
LEUKEMIA & LYMPHOMA
(2021)
Article
Oncology
Allini Mafra, Mathieu Laversanne, Mary Gospodarowicz, Paulo Klinger, Neimar De Paula Silva, Marion Pineros, Eva Steliarova-Foucher, Freddie Bray, Ariana Znaor
Summary: Global patterns of non-Hodgkin lymphoma (NHL) in 2020 were evaluated using the GLOBOCAN 2020 database. The study found that Eastern Asia, Northern America, and South-Central Asia had the highest number of NHL cases. Incidence rates were higher in men than in women, with the highest rates in Australia, New Zealand, Northern America, Northern Europe, and Western Europe. The highest mortality rates were found in regions in Africa, Western Asia, and Oceania.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
P. Connor Johnson, Alisha Yi, Nora Horick, Hermioni L. Amonoo, Richard A. Newcomb, Mitchell W. Lavoie, Julia Rice, Matthew J. Reynolds, Christine S. Ritchie, Ryan D. Nipp, Areej El-Jawahri
Summary: The majority of older adults with aggressive non-Hodgkin lymphoma survive beyond 5 years with upfront therapy, but nearly half experience significant treatment toxicities and unplanned hospitalizations, highlighting the need for supportive care interventions in this population. In this study, hypoalbuminemia and patient comorbidity score were identified as factors associated with grade 3+ nonhematologic toxicity and unplanned hospitalization in older adults with aggressive NHL, suggesting the importance of targeted supportive care interventions in high-risk patients.
Article
Environmental Sciences
Joseph Boyle, Mary H. Ward, James R. Cerhan, Nathaniel Rothman, David C. Wheeler
Summary: Many studies have found associations between neighborhood deprivation and disease, emphasizing the importance of social determinants of health. However, when studying diseases with long latency periods such as cancers, considering the timing of exposures for deprivation becomes more important.
ENVIRONMENTAL RESEARCH
(2023)
Article
Medicine, General & Internal
H. Dean Hosgood, Meghan Davitt, Richard Cawthon, Stephanie J. Weinstein, Batel Blechter, Jason Y. Y. Wong, Mohammad L. Rahman, Wei Hu, Satu Mannisto, Demetrius Albanes, Nathaniel Rothman, Qing Lan
Summary: This study suggests that a higher fraction of mitochondrial DNA with breaks is associated with an increased risk of non-Hodgkin lymphoma (NHL).
Article
Parasitology
Iara Barreto Neves Oliveira, Clayton Luiz Borges, Rodrigo Saar Gomes, Fatima Ribeiro-Dias
Summary: This article reviews studies on SNPs in immune genes associated with susceptibility or resistance to tegumentary leishmaniasis (TL). The authors highlight the difficulties of these studies and emphasize the importance of future analyses to enhance our understanding of host genetic factors in TL. Understanding the genetic characteristics of the host can contribute to the development of immunotherapy schedules for this disease, which currently lacks effective treatment methods and a human vaccine.
Article
Health Care Sciences & Services
Sonia Guadalupe Barreno-Rocha, Sandra Guzman-Silahua, Ernesto German Cardona-Munoz, Maria Guadalupe Zavala-Cerna, David Eduardo Munoz Gaytan, Carlos Riebeling-Navarro, Benjamin Rubio-Jurado, Arnulfo Hernan Nava-Zavala
Summary: A retrospective cohort study was performed on patients diagnosed with Non-Hodgkin Lymphoma. The presence of autoantibodies was observed in 30 out of 39 patients, while 9 patients did not have autoantibodies. However, there were no statistically significant differences between the two groups in terms of clinical, demographic, staging, and prognosis characteristics. Further research on a broader panel of autoantibodies is needed to explore the relationship between their presence and the clinical outcome of patients.
Review
Veterinary Sciences
Joana N. R. Dias, Ana S. Andre, Sandra I. I. Aguiar, Solange Gil, Luis Tavares, Frederico Aires-da-Silva
Summary: The new era of immune-oncology presents challenges and opportunities, with the use of a canine model in cancer immunotherapy drug development being widely recognized. Comparative research between human and canine NHL can provide valuable insights into treatment strategies. Additionally, the canine model may help bridge the gap between preclinical studies and clinical trials.
FRONTIERS IN VETERINARY SCIENCE
(2021)