The pyruvate carboxylase-pyruvate dehydrogenase axis in islet pyruvate metabolism: Going round in circles?

Differences between Human and Rodent Pancreatic Islets

(2011) Michael J. MacDonald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Cell-specific pyruvate dehydrogenase deficiency impairs glucose-stimulated insulin secretion

(2010) Malathi Srinivasan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Supplement of TCA cycle intermediates protects against high glucose/palmitate-induced INS-1 beta cell death

(2010) Sung-E Choi et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal β-cells

(2010) Ulrika Krus et al.   BIOCHEMICAL JOURNAL

The dicarboxylate carrier plays a role in mitochondrial malate transport and in the regulation of glucose-stimulated insulin secretion from rat pancreatic beta cells

(2010) P. Huypens et al.   DIABETOLOGIA

Regulation of insulin secretion: role of mitochondrial signalling

(2010) S. Jitrapakdee et al.   DIABETOLOGIA

The Mitochondrial 2-Oxoglutarate Carrier Is Part of a Metabolic Pathway That Mediates Glucose- and Glutamine-stimulated Insulin Secretion

(2010) Matthew L. Odegaard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling

(2010) Eric Verdin et al.   TRENDS IN BIOCHEMICAL SCIENCES

Identification of genes selectively disallowed in the pancreatic islet

(2010) Timothy J. Pullen et al.   Islets

Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion

(2009) Emma Heart et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Silencing of the mitochondrial NADH shuttle component aspartate–glutamate carrier AGC1/Aralar1 in INS-1E cells and rat islets

(2009) Marina Casimir et al.   BIOCHEMICAL JOURNAL

Overexpression of the malate–aspartate NADH shuttle member Aralar1 in the clonal β-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism

(2009) Katrin Bender et al.   CLINICAL SCIENCE

Overexpression of Kinase-Negative Protein Kinase C  in Pancreatic  -Cells Protects Mice From Diet-Induced Glucose Intolerance and  -Cell Dysfunction

(2009) A. M. Hennige et al.   DIABETES

Decreased levels of metabolic enzymes in pancreatic islets of patients with type 2 diabetes

(2009) M. J. MacDonald et al.   DIABETOLOGIA

Phosphoenolpyruvate Cycling via Mitochondrial Phosphoenolpyruvate Carboxykinase Links Anaplerosis and Mitochondrial GTP with Insulin Secretion

(2009) Romana Stark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Glutamate Carrier GC1 as a Newly Identified Player in the Control of Glucose-stimulated Insulin Secretion

(2009) Marina Casimir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diabetic β-Cells Can Achieve Self-Protection against Oxidative Stress through an Adaptive Up-Regulation of Their Antioxidant Defenses

(2009) Grégory Lacraz et al.   PLoS One

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Metabolic cycling in control of glucose-stimulated insulin secretion

(2008) Mette V. Jensen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Oxidative stress: the vulnerable β-cell

(2008) Sigurd Lenzen   BIOCHEMICAL SOCIETY TRANSACTIONS

Malic enzyme is present in mouse islets and modulates insulin secretion

(2008) J. Xu et al.   DIABETOLOGIA

A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis

(2008) M. Fex et al.   DIABETOLOGIA

The role of pyruvate carboxylase in insulin secretion and proliferation in rat pancreatic beta cells

(2008) J. Xu et al.   DIABETOLOGIA

The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus

(2008) Décio L. Eizirik et al.   ENDOCRINE REVIEWS

Deletion of Glutamate Dehydrogenase in ß-Cells Abolishes Part of the Insulin Secretory Response Not Required for Glucose Homeostasis

(2008) Stefania Carobbio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Silencing of Cytosolic or Mitochondrial Isoforms of Malic Enzyme Has No Effect on Glucose-stimulated Insulin Secretion from Rodent Islets

(2008) Sarah M. Ronnebaum et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired Anaplerosis and Insulin Secretion in Insulinoma Cells Caused by Small Interfering RNA-mediated Suppression of Pyruvate Carboxylase

(2008) Noaman M. Hasan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70

(2008) N. R. Sundaresan et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

(2008) Deborah M. Muoio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY