Article
Oncology
Kosei Takagi, Tomokazu Fuji, Motohiko Yamada, Jiro Kimura, Kazuya Yasui, Yuzo Umeda, Toshiyoshi Fujiwara
Summary: This study presents a unique surgical technique using the hanging maneuver with ICG fluorescence imaging for type III PAP. Surgeons should determine the surgical strategy based on the fusion and ductal anatomy of the pancreas.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Kazuyuki Nagai, Toshihiko Masui, Takayuki Anazawa, Etsuro Hatano
Summary: Portal annular pancreas is a congenital pancreatic anomaly. Laparoscopic pancreatoduodenectomy can be successfully performed in patients with this condition, with uncomplicated postoperative recovery.
SURGICAL ONCOLOGY-OXFORD
(2022)
Review
Medicine, General & Internal
Dasong Wang, Qihui Zeng, Xiaoya Niu, Xinghan Chen, Hui Ye
Summary: Pancreatic head carcinoma arising from the dorsal or ventral pancreas exhibit distinct clinicopathological features and prognosis, with better survival outcomes observed in cases originating from the ventral pancreas.
Review
Medicine, General & Internal
Abhirup Chatterjee, Surinder Singh Rana
Summary: Embryological development of the pancreas can have multiple aberrations, but most ductal anomalies are asymptomatic. Accurate pre-operative diagnosis is important to prevent inadvertent duct injury during surgery. MRCP and EUS are effective tools for diagnosing ductal anomalies.
Review
Gastroenterology & Hepatology
Munenori Tahara, Takuya Harada, Yosuke Wakui, Shoichiro Mizukami, Kengo Kita, Tohru Funakoshi, Kenji Wakayama, Hiroyuki Ishizu
Summary: Portal annular pancreas is a rare congenital pancreatic anomaly that requires careful preoperative consideration to avoid postoperative complications.
Article
Cell Biology
Diletta Overi, Guido Carpino, Marta Moretti, Antonio Franchitto, Lorenzo Nevi, Paolo Onori, Enrico De Smaele, Luca Federici, Daniele Santorelli, Marella Maroder, Lola M. Reid, Vincenzo Cardinale, Domenico Alvaro, Eugenio Gaudio
Summary: There is contrasting evidence on the contribution of stem/progenitor cell populations to pancreatic regeneration in diabetes, however, the PDG compartment may play a role in this process. T2DM patients show signs of pancreatic islet regeneration and involvement of the PDG niche, and PDX1 administration could support increased endocrine pancreatic regeneration in experimental diabetes. These findings contribute to defining the role and participation of stem/progenitor cell compartments within the pancreas.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Ji Young Bang, C. Mel Wilcox, Juan Pablo Arnoletti, Shyam Varadarajulu
Summary: In patients with disconnected pancreatic duct syndrome (DPDS), replacing lumen-apposing metal stents (LAMS) with indwelling plastic stents after resolving pancreatic fluid collection (PFC) can significantly reduce the risk of PFC recurrence and morbidity.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Saneya Pandrowala, Aamir Parray, Vikram Chaudhari, Shailesh V. Shrikhande, Manish S. Bhandare
Summary: This article presents a case report and systematic review of literature on patients undergoing major pancreatic surgery with portal annular pancreas. The study found a high incidence of postoperative pancreatic fistula and suggested that extended pancreatic resection may reduce the occurrence of clinically relevant postoperative pancreatic fistula.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Gastroenterology & Hepatology
Peter Herbert Kann, Adrian Scheunemann, Peter Dorzweiler, Jan Adelmeyer, Simona Bergmann, Joachim Nils Goebel, Verena Mann, Detlef K. Bartsch, Katharina Holzer, Max B. Albers, Jerena Manoharan, Lisann M. Scheunemann
Summary: The majority of pNENs in MEN1 patients are located in the dorsal anlage of the pancreas, while the ventral anlage appears to be less affected by pNENs. This finding may have implications for new surgical strategies.
Article
Gastroenterology & Hepatology
Braulio A. Marfil-Garza, Ryekjang Kim, A. M. James Shapiro, Tatsuya Kin
Summary: Islet isolation is a critical step in islet transplantation, where anomalies in the pancreatic duct system can affect the process. Duct obliteration is found in a proportion of deceased donor pancreata, with a higher frequency of patent dorsal duct in black race individuals. Pancreas divisum is more common in chronic pancreatitis cases.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Medicine, General & Internal
V. Sharath Kumar, Prashanth Sangu, C. Kolandasamy, R. Prabhakaran, Sugumar Chidambaranathan, Naganath Babu Obla Lakshmanamoorthy
Summary: Congenital anomalies of the pancreas can result in various clinical manifestations, and their management strategies and outcomes are similar to patients with normal pancreatic development.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Gastroenterology & Hepatology
Richard Dumbill, James Goetz, Sanjay Sinha, Martin Drage, Christopher J. E. Watson, Shruti Mittal
Summary: The study found that there was no protective benefit of ReY drainage over duodenojejunostomy in terms of early graft loss, but there was an increased risk of return to theater.
Article
Oncology
Amir M. Parray, Shravan Nadkarni, Vikram Chaudhari, Shailesh V. Shrikhande, Manish S. Bhandare
Summary: This article discusses a case of Portal Annular Pancreas (PAP) and the surgical strategy. Pancreaticoduodenectomy in cases with PAP is challenging and associated with higher rates of postoperative complications. Therefore, it is crucial to have knowledge of the various types of PAP for intraoperative management.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Masahiro Iseki, Hiroshi Noda, Fumiaki Watanabe, Takaharu Kato, Yuhei Endo, Hidetoshi Aizawa, Taro Fukui, Kosuke Ichida, Nao Kakizawa, Toshiki Rikiyama
Summary: The study found that deep pancreas may be an important parameter associated with significant risk factors for clinically relevant postoperative pancreatic fistula after pancreaticoduodenectomy in patients with a nondilated main pancreatic duct.
Article
Surgery
Seung Soo Hong, Jae Uk Chong, Ho Kyoung Hwang, Woo Jung Lee, Chang Moo Kang
Summary: This study demonstrated the safety and feasibility of laparoscopic duct-to-mucosa pancreaticojejunostomy and compared perioperative outcomes of laparoscopic pancreaticoduodenectomy (LPD) and open pancreaticoduodenectomy (OPD) in patients with soft pancreas and small pancreatic duct. LPD group showed significantly reduced clinically relevant postoperative pancreatic fistula (CR-POPF) rates compared to the OPD group, especially in high-risk patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Editorial Material
Clinical Neurology
Satoshi Kiyofuji, Masahiro Shin, Kenji Kondo, Taichi Kin, Tatsuya Uchida, Nobuhito Saito
Summary: Trigeminal schwannoma is a rare skull base tumor that can be managed in various ways, with endoscopic transnasal surgery being particularly effective in certain cases. This case report details the successful treatment of a 74-year-old male patient with satisfactory results.
JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE
(2022)
Article
Clinical Neurology
Yasuhiro Takeda, Hirotaka Hasegawa, Taichi Kin, Yuki Shinya, Mariko Kawashima, Yasuyuki Furuta, Yuichi Suzuki, Tetsuro Sekine, Nobuhito Saito
Summary: This retrospective study aimed to assess changes in AVM hemodynamics after SRS using 3D flow MRI. Patients were divided into two groups based on AVM obliteration time, with group A showing faster blood flow decrease after SRS compared to group B.
NEUROSURGICAL FOCUS
(2022)
News Item
Clinical Neurology
Motoyuki Umekawa, Hirotaka Hasegawa, Yasuhiro Takeda, Yuki Shinya, Taichi Kin, Satoshi Koizumi, Nobuhito Saito
WORLD NEUROSURGERY
(2022)
Article
Multidisciplinary Sciences
Ryota Inoue, Takahiro Tsuno, Yu Togashi, Tomoko Okuyama, Aoi Sato, Kuniyuki Nishiyama, Mayu Kyohara, Jinghe Li, Setsuko Fukushima, Tatsuya Kin, Daisuke Miyashita, Yusuke Shiba, Yoshitoshi Atobe, Hiroshi Kiyonari, Kana Bando, A. M. James Shapiro, Kengo Funakoshi, Rohit N. Kulkarni, Yasuo Terauchi, Jun Shirakawa
Summary: This study highlights the molecular link between the increase in UCP2 expression in beta-cells and beta-cell failure, and suggests that targeting the UCP2/AldB axis may be a promising approach for the recovery of beta-cell function.
Article
Immunology
Kevin Verhoeff, Nerea Cuesta-Gomez, Patrick Albers, Rena Pawlick, Braulio A. Marfil-Garza, Ila Jasra, Nidheesh Dadheech, Doug O'Gorman, Tatsuya Kin, Anne Halpin, Lori J. West, A. M. James Shapiro
Summary: This study evaluated the expression of ABH glycans in human pancreas, isolated islets, and hESC-derived islets. The study found that endocrine and ductal cells in the pancreas do not express ABH antigens, while acinar tissues strongly express them. Clinical pancreatic islet transplantation should remain ABO-matched due to the presence of acinar tissue expressing ABH glycans in islet preparations.
Article
Immunology
Kevin Verhoeff, Braulio A. Marfil-Garza, Khaled Dajani, David L. Bigam, Blaire Anderson, Tatsuya Kin, Anna Lam, Doug O'Gorman, Peter A. Senior, A. M. James Shapiro
Summary: This study analyzed patients undergoing islet transplantation and found that C-peptide levels are correlated with blood glucose control and insulin independence. The study determined threshold values for insulin independence and hypoglycemic freedom based on C-peptide levels, as well as BETA-2 scores, providing reference values for evaluating pancreatic or stem cell therapies.
Article
Multidisciplinary Sciences
Alexander U. Ernst, Long-Hai Wang, Scott C. Worland, Braulio A. Marfil-Garza, Xi Wang, Wanjun Liu, Alan Chiu, Tatsuya Kin, Doug O'Gorman, Scott Steinschneider, Ashim K. Datta, Klearchos K. Papas, A. M. James Shapiro, Minglin Ma
Summary: This study presents a computational platform for investigating the therapeutic capacity of bioartificial pancreas devices. The platform takes into account stochastic properties like cell size distribution and random localization, and optimizes device structures and estimates cell doses. It also proposes a new islet equivalence conversion table and develops a machine learning model for generating coefficients for user-defined devices.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Jun Shirakawa, Yu Togashi, Giorgio Basile, Tomoko Okuyama, Ryota Inoue, Megan Fernandez, Mayu Kyohara, Dario F. De Jesus, Nozomi Goto, Wei Zhang, Takahiro Tsuno, Tatsuya Kin, Hui Pan, Jonathan M. Dreyfuss, A. M. James Shapiro, Peng Yi, Yasuo Terauchi, Rohit N. Kulkarni
Summary: This study investigates the replication pathways of β cells under acute insulin resistance and identifies the involvement of insulin-independent factors CENP-A and transcription factor E2F1 in the multiplication of β cells induced by S961. Inhibition of E2F1 blocks β-cell proliferation in S961-injected mice. Furthermore, adipocytes activate E2F1 to promote β-cell replication.
Article
Surgery
Braulio A. Marfil-Garza, Joshua Hefler, Kevin Verhoeff, Anna Lam, Khaled Dajani, Blaire Anderson, Doug O'Gorman, Tatsuya Kin, Omar Yaxmehen Bello-Chavolla, Donald Grynoch, Anne Halpin, Patricia M. Campbell, Peter A. Senior, David Bigam, A. M. James Shapiro
Summary: This study provides the largest single-center analysis of islet (ITx) and pancreas (PTx) transplantation. It shows that PTx has higher mortality, procedure-related complications, and readmissions compared to ITx. However, PTx has better insulin independence, graft survival, and glycemic control. This study provides data to improve shared decision-making on the risks and benefits of ITx and PTx.
Article
Clinical Neurology
Satoshi Kiyofuji, Taichi Kin, Toki Saito, Tsukasa Koike, Yasuhiro Takeda, Tatsuya Uchida, Katsuya Sato, Naoyuki Shono, Ryoko Niwa, Yasuyuki Furuta, Nobuhito Saito
Summary: An online interactive neurosurgical simulator was developed to enhance portability and validate a unique psychometric method for providing tactile information. Neurosurgical residents evaluated the simulator along with lectures, slide reviews, and dissection of a 3D printed temporal bone model. Questionnaires were used to gather feedback from the residents.
OPERATIVE NEUROSURGERY
(2023)
Article
Computer Science, Interdisciplinary Applications
Tatsuya Uchida, Taichi Kin, Toki Saito, Naoyuki Shono, Satoshi Kiyofuji, Tsukasa Koike, Katsuya Sato, Ryoko Niwa, Ikumi Takashima, Hiroshi Oyama, Nobuhito Saito
Summary: A new de-identification technique for head CT images was developed to prevent face identification while maintaining the accuracy of deep-learning models.
Article
Oncology
Yoshiaki Goto, Ai Kawaguchi, Yuki Inoue, Yuki Nakamura, Yuta Oyama, Arisa Tomioka, Fumi Higuchi, Takeshi Uno, Masaaki Shojima, Taichi Kin, Masahiro Shin
Summary: In endoscopic transsphenoidal skull base surgery, a precise three-dimensional computer graphic model was created from preoperative radiographic data and superimposed on a visual image of the actual surgical field, allowing immediate three-dimensional understanding of the lesion and surrounding structures. The efficacy of this augmented reality (AR) navigation system was evaluated in 15 patients with sellar and parasellar tumors, with an average score of 4.7 indicating its usefulness. In two cases, AR navigation was deemed less useful due to difficulties perceiving the depth of the lesion.
Article
Immunology
Kevin Verhoeff, Braulio A. Marfil-Garza, Gurpal Sandha, David Cooper, Khaled Dajani, David L. Bigam, Blaire Anderson, Tatsuya Kin, Anna Lam, Doug O'Gorman, Peter A. Senior, Camillo Ricordi, A. M. James Shapiro
Summary: This study evaluated patients receiving extrahepatic or intraportal islet transplantation. The results indicate that intraportal islet infusion remains the gold standard for clinical transplantation, with superior engraftment, graft function, and glycemic outcomes compared to extrahepatic transplantation.
Proceedings Paper
Imaging Science & Photographic Technology
Ding Xia, Xi Yang, Oliver van Kaick, Taichi Kin, Takeo Igarashi
Summary: This paper introduces a learning-based method that provides good initialization for partial image registration. By learning the mapping from small patches of the image to positions in the template space and computing a rigid transformation matrix, accurate registration can be achieved. Experimental results show that MSE registration with this method outperforms other baseline methods.
MEDICAL IMAGE COMPUTING AND COMPUTER ASSISTED INTERVENTION, MICCAI 2022, PT VI
(2022)
Article
Engineering, Biomedical
Naoyuki Shono, Takeo Igarashi, Taichi Kin, Toki Saito, Nobuhito Saito
Summary: The study tested a segmentation workflow called threshold field painting for segmenting morbid minute arteries, and found that it significantly reduced segmentation time and improved usability scores. The method was more efficient in segmenting normally nonexistent minute arteries, such as MMA feeders, compared to the conventional method.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2022)
