Article
Pharmacology & Pharmacy
Jun Peng, Sheng Xiao, Juan Xie, Wan Fu
Summary: Appropriate fracture pain management not only improves the patient's subjective perception, but also increases compliance with rehabilitation training. Bulleyaconitine A (BLA), a non-addictive analgesic medicine, has the potential to be used as a promising treatment for fracture pain. BLA can alleviate fracture-induced mechanical and thermal hyperalgesia, promote bone mineralization, and therefore enhance fracture healing.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biology
Dominik Saul, David G. Monroe, Jennifer L. Rowsey, Robyn Laura Kosinsky, Stephanie J. Vos, Madison L. Doolittle, Joshua N. Farr, Sundeep Khosla
Summary: Senescent cells and senescence-related secretory phenotype markers increase during fracture healing. Intermittent treatment with senolytics reduces senescence markers in the fracture callus and accelerates the time course of fracture healing.
Article
Materials Science, Multidisciplinary
Yan Peng, Huaizhi Liu, Hao Peng, Jiuyang Zhang
Summary: Self-healing materials have long struggled to achieve both high mechanical strength and self-healing ability. This work successfully achieves self-repair in mechanically robust materials, inspired by biological self-healing. The mechanical performance and self-healing behavior of these materials can be precisely controlled through temperature and composition. An artificial bone-tissue system is created with bionic structure, effective self-healing, and high modulus.
Article
Anesthesiology
Chen Zhong, Gang Min, Xun-Wei Liu, Zhen Yang, Shuai Li, Min Li
Summary: The study found that using rotary cutter-PVP (RCPVP) to treat patients with KOmmell's disease and IVC can lead to better clinical outcomes and fewer complications compared to conventional PVP.
Article
Materials Science, Multidisciplinary
Shahbaz Mahmood Khan, Zhifei Deng, Ting Yang, Ling Li
Summary: A method for preparing bio-inspired ceramic-metal composites using stereolithographic additive manufacturing and centrifugal infiltration has been proposed to address the strength-toughness dilemma. This method allows for flexibility in designing the individual phases of the composites architecturally and offers scalability and dimensional control. By fabricating silica-aluminum composites inspired by mineralized layers in bivalve mollusk shells, including both 2D prismatic and 3D interpenetrating composites, the versatility of this approach has been demonstrated.
ADVANCED ENGINEERING MATERIALS
(2022)
Review
Endocrinology & Metabolism
Dominik Saul, Sundeep Khosla
Summary: More than 2.1 million age-related fractures occur in the United States annually, resulting in a significant socioeconomic burden. Age-related deterioration of bone structure is associated with impaired bone healing, which occurs in four stages: inflammation, angiogenesis and cartilage formation, soft callus development, and remodeling. Impaired fracture healing due to aging is related to detrimental changes at the cellular level, and recent studies show that clearing senescent cells enhances fracture repair.
Article
Biochemistry & Molecular Biology
Silvia Concetta Colucci, Cinzia Buccoliero, Lorenzo Sanesi, Mariella Errede, Graziana Colaianni, Tiziana Annese, Mohd Parvez Khan, Roberta Zerlotin, Manuela Dicarlo, Ernestina Schipani, Kenneth M. Kozloff, Maria Grano
Summary: The study found that irisin promotes bone formation and accelerates the fracture healing process, suggesting its potential use as a novel pharmacologic modulator.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Chul-Ho Kim, Dong Hwan Kim, Han-Vit Kang, Won Jun Kim, Minkyu Shin, Ji Wan Kim
Summary: Percutaneous intramedullary nailing is an effective technique for metacarpal fractures, but the fracture site and number of K-wires used can affect the time to achieve bone union.
Review
Cardiac & Cardiovascular Systems
William Clark, Terrence Diamond
Summary: Vertebroplasty is a common treatment for painful osteoporotic vertebral fractures, but the timing of the procedure varies between centres and regions. Studies have shown mixed results, with some indicating more benefit from early vertebroplasty and others showing no additional benefit compared to placebo. This review examines data from both blinded and open label randomised studies to specifically evaluate the use of early vertebroplasty for patients with severely painful acute osteoporotic fractures.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yu-Ru V. Shih, David Kingsley, Hunter Newman, Jiaul Hoque, Ankita Gupta, B. Duncan X. Lascelles, Shyni Varghese
Summary: This study demonstrates the feasibility of using adenosine and its material-assisted local delivery as a therapeutic approach to treat bone trauma and associated pain. Adenosine provides pain relief and promotes bone healing simultaneously, offering an improved method compared to current therapeutics.
Article
Biology
Kai Sun, Chun Wang, Jianqiu Xiao, Michael D. Brodt, Luorongxin Yuan, Tong Yang, Yael Alippe, Huimin Hu, Dingjun Hao, Yousef Abu-Amer, Matthew J. Silva, Jie Shen, Gabriel Mbalaviele
Summary: Amino-terminal fragments of proteolytically cleaved GSDMs form plasma membrane pores, leading to pyroptosis. GSDMD and GSDME play roles in bone microenvironment and contribute to fracture healing. Both GSDMD and GSDME regulate inflammatory responses through the GSDM-IL-1 axis, promoting bone healing after fracture.
Article
Biotechnology & Applied Microbiology
Haowen Dai, Yang Liu, Qing Han, Aobo Zhang, Hao Chen, Yang Qu, Jincheng Wang, Jianwu Zhao
Summary: This study compared the biomechanical differences between unilateral percutaneous vertebroplasty (UPVP) and bilateral percutaneous vertebroplasty (BPVP) using finite element analysis. The results showed that BPVP could balance vertebral body stress, reduce intervertebral disc stress, and offer stability advantages compared to UPVP. Therefore, BPVP has the potential to reduce postoperative complications and provide promising clinical effects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Bo Yuan, Mintao Xue, Yin Zhao, Qunfeng Guo, Gang Zheng, Zheng Xu, Fengning Li, Xiongsheng Chen, Zhixin Chen, Jianlin Shi, Han Lin, Xiang Guo
Summary: Bionic functional coating is important for promoting bone fracture healing, but the post-traumatic microenvironment weakens the established coatings. In this study, a H-Si@HA composite coating was developed by anchoring two-dimensional H-silicene nanosheet (H-Si) onto hydroxyapatite (HA) coated metal implant. The coating exhibits pH-responsive characteristics, maintains stability in acidic conditions, simulates enzyme activities, reduces oxidative stress, and reverses the acidic microenvironment. The coating also induces cellular autophagy and promotes fracture healing through the release of Si4+ in a neutral environment.
Article
Endocrinology & Metabolism
Kenon Chua, Victor K. Lee, Cheri Chan, Andy Yew, Eric Yeo, David M. Virshup
Summary: The study found that Wnts produced by hematopoietic cells, while not essential, modulate osteoclast numbers during fracture healing, affecting the healing process. This demonstrates the importance of diverse Wnt sources in bone repair.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Emerito Carlos Rodriguez-Merchan
Summary: This article reviews recent findings on the molecular mechanisms of bone healing and presents various biological alternatives for treating recalcitrant nonunions, such as using morin, BMP9, and leptin. It also discusses factors that impact bone regeneration, including inhibition of estrogen receptor signaling, smoking-induced inflammatory responses, and delayed fracture healing in diabetic animals due to BMP6 deficiency. The combination of bioceramics and expanded autologous human mesenchymal stem cells from bone marrow is highlighted as a promising alternative for treating nonunions that do not respond well to traditional treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)