Article
Immunology
Banndith Cheat, Coralie Torrens, Asmaa Foda, Brigitte Baroukh, Jeremy Sadoine, Lotfi Slimani, Veronique Witko-Sarsat, Olivier Huck, Marjolaine Gosset, Jerome Bouchet
Summary: Our study investigates the role of NLRP3 in periodontitis, demonstrating its ambiguous role in neutrophils and its interaction with Porphyromonas gingivalis. The study reveals that NLRP3 is involved in regulatory pathways that limit periodontitis in mouse models, but its protective effect is diminished in the presence of P. gingivalis. Overexpression of NLRP3 in connective tissue leads to increased production of mature IL-1 beta and mobilization of neutrophils, while NLRP3 deficiency results in lower IL-1 beta expression and almost no neutrophil mobilization.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Ting Gong, Qi Chen, Hongchen Mao, Yao Zhang, Huan Ren, Mengmeng Xu, Hong Chen, Deqin Yang
Summary: This study found that the outer membrane vesicles of Porphyromonas gingivalis (Pg OMVs) can cause memory and learning impairments in elderly mice, damage the blood-brain barrier, activate neuroinflammatory responses, promote phosphorylation of Tau protein, and trigger NLRP3 inflammasome. These findings suggest that Pg OMVs play an important role in the development of Alzheimer's disease-like pathology induced by Porphyromonas gingivalis, and the activation of NLRP3 inflammasome may be one possible mechanism.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jacopo Pizzicannella, Luigia Fonticoli, Simone Guarnieri, Guya D. Marconi, Thangavelu Soundara Rajan, Oriana Trubiani, Francesca Diomede
Summary: This study found that ascorbic acid can alleviate the inflammation and reactive oxygen species generation induced by lipopolysaccharide in human gingival mesenchymal stem cells and endothelial committed hGMSCs. Through suppression of specific pathways, it shows anti-inflammatory effects in vitro.
Article
Microbiology
Lulu Wang, Wenchen Pu, Chun Wang, Lang Lei, Houxuan Li
Summary: This study found that MARK4 promotes the activation of NLRP3 inflammasome and pyroptosis in P. gingivalis-infected macrophages by affecting microtubule dynamics. Inhibition of MARK4 may be a potential therapeutic target for regulating NLRP3 inflammasome during the progress of periodontitis.
JOURNAL OF ORAL MICROBIOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Shuyu Guo, Jiawen Gu, Yue Jiang, Wenxiao Cui, Jialu Chen, Lu Li, Kai Zheng, Yan Xu
Summary: In this study, a new drug delivery strategy was developed to target Porphyromonas gingivalis (Pg)-accelerated atherosclerosis (AS). The biomimetic nanoparticles coated with Pg-treated macrophage membranes effectively eliminated Pg and resolved inflammation in Pg-infected regions, leading to a reduction in atheromatous plaque formation and alveolar bone loss.
MATERIALS & DESIGN
(2022)
Review
Immunology
Jie Lin, Dingming Huang, Hongwei Xu, Fenghuang Zhan, XueLian Tan
Summary: This review focuses on the interaction between P. gingivalis and macrophages in the development and progression of various diseases. P. gingivalis induces macrophage polarization and inflammasome activation, and promotes the development of inflammatory diseases, autoimmune diseases, and tumors through immune response evasion.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Na Lu, Weijia Cheng, Dongling Liu, Gang Liu, Can Cui, Chaoli Feng, Xianwei Wang
Summary: NLRP3 inflammasome is a crucial part of the body's immune system, and its overactivation has been linked to inflammatory responses and atherosclerosis. Therefore, finding specific inhibitors for NLRP3 inflammasome has become a potential target for clinical treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Sowon Park, Inyoung Kim, Soo Jung Han, Soyeon Kwon, Eun-Ji Min, Wonkyoung Cho, Hong Koh, Bon-Nyeo Koo, Jung Seok Lee, Jae-Sung Kwon, Kyoung Yul Seo, Jong-Won Ha, Young Mi Park
Summary: This study investigated the link between periodontitis and intestinal dysbiosis in relation to atherosclerosis. The findings suggest that oral infection with Porphyromonas gingivalis (PG) can promote atherosclerosis and induce metabolic changes, as well as alter the intestinal microbiota.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Xuelian Li, Xianjie Zhu, Yumiao Wei
Summary: Atherosclerosis is a lipid-driven disease characterized by the imbalance between inflammatory and regressive processes. Recent studies have suggested a link between autophagy and vascular inflammation. This review summarizes the underlying mechanisms associated with different autophagic pathways and NLRP3 inflammasomes in vascular inflammation, aiming to provide additional evidence for atherosclerosis research.
Article
Dentistry, Oral Surgery & Medicine
Sowon Park, Inyoung Kim, Soo Jung Han, Soyeon Kwon, Eun-Ji Min, Wonkyoung Cho, Hong Koh, Bon-Nyeo Koo, Jung Seok Lee, Jae-Sung Kwon, Kyoung Yul Seo, Jong-Won Ha, Young Mi Park
Summary: Oral infection with Porphyromonas gingivalis (PG), the major pathogen for periodontitis, promotes atherosclerosis and induces significant metabolic changes, including reduced serum HDL and reduced hepatic SR-B1 and ABCA1 expression, as well as changes in intestinal microbiota.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Review
Medicine, Research & Experimental
Sibo Liu, Hongfeng Bi, Meiling Jiang, Yuanli Chen, Meixiu Jiang
Summary: This review summarizes the relationship between atherosclerosis and NLRP3 inflammasome, and explores the regulatory role of the TRIM family in mediating inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Immunology
Yanan Wang, Dan Fang, Qinzhi Yang, Jingcan You, Liqun Wang, Jianbo Wu, Min Zeng, Mao Luo
Summary: Atherosclerosis is an early pathological basis of cardiovascular events resulting in death or disability. Recent studies have identified PCSK9 as a target for atherosclerosis treatment, as it degrades LDLR and acts as an inflammatory modulator. The NLRP3 inflammasome plays a key role in atherosclerotic disease, and interactions between PCSK9 and NLRP3 inflammasome contribute to inflammation-driven development and progression of atherosclerosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuri Song, Jin Chung, Grzegorz Wegrzyn
Summary: This study found that the relative abundance of Porphyromonas gingivalis (P. gingivalis) was significantly higher in periodontitis patients, especially in the elderly. The inflammatory response to P. gingivalis infection was greater in older individuals, and they also experienced more severe bone loss. These findings enhance understanding of the relationship between periodontal immunosenescence and inflammatory response in the elderly.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Review
Immunology
Qijun Ruan, Peng Guan, Weijuan Qi, Jiatong Li, Mengying Xi, Limin Xiao, Sulan Zhong, Dandan Ma, Jia Ni
Summary: Atherosclerosis is a chronic inflammatory disease that involves endothelial dysfunction, lipid deposition, plaque rupture, and arterial occlusion. Periodontitis, which is associated with Porphyromonas gingivalis, has been shown to increase the risk of atherosclerosis. P. gingivalis promotes the progression of atherosclerosis through immune pathways, including the induction of local inflammation in blood vessels, production of systemic inflammatory mediators, disruption of serum lipid profile, and colonization of arterial walls.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Jiaqi Zhang, Mengru Xie, Xiaofei Huang, Guangjin Chen, Ying Yin, Xiaofeng Lu, Guangxia Feng, Ran Yu, Lili Chen
Summary: Atherosclerosis (AS) is increasingly recognized as a chronic inflammatory disease, related to infectious diseases such as periodontitis. Porphyromonas gingivalis (P. gingivalis) is commonly found in atherosclerotic plaque in AS patients and can influence the function of various cells, ultimately promoting the occurrence and development of atherosclerosis. Elucidating the underlying mechanisms of P. gingivalis in AS provides new insights for preventing or slowing down the progression of AS by inhibiting periodontal pathogens.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yohei Nakayama, Ryoki Kobayashi, Sari Matsui, Hiroyoshi Matsumura, Yasunobu Iwai, Keisuke Noda, Mizuho Yamazaki, Tomoko Kurita-Ochiai, Atsutoshi Yoshimura, Tamayuki Shinomura, Bernhard Ganss, Yorimasa Ogata
Article
Microbiology
Etsuko Sugawara, Hiroshi Nikaido
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2014)
Article
Dentistry, Oral Surgery & Medicine
M. Hagiwara, T. Kurita-Ochiai, R. Kobayashi, T. Hashizume-Takizawa, K. Yamazaki, M. Yamamoto
JOURNAL OF DENTAL RESEARCH
(2014)
Article
Multidisciplinary Sciences
R. Kobayashi, T. Kobayashi, F. Sakai, T. Hosoya, M. Yamamoto, T. Kurita-Ochiai
SCIENTIFIC REPORTS
(2017)
Article
Biochemistry & Molecular Biology
Yohei Nakayama, Ryoki Kobayashi, Yasunobu Iwai, Keisuke Noda, Mizuho Yamazaki, Tomoko Kurita-Ochiai, Atsutoshi Yoshimura, Bernhard Ganss, Yorimasa Ogata
Article
Immunology
Tomomi Hashizume-Takizawa, Ryoki Kobayashi, Osamu Tsuzukibashi, Masanori Saito, Tomoko Kurita-Ochiai
PATHOGENS AND DISEASE
(2019)
Article
Immunology
Eiji Kobatake, Ryoki Kobayashi, Toshihide Kabuki, Tomoko Kurita-Ochiai
MICROBIOLOGY AND IMMUNOLOGY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Ryoki Kobayashi, Tomomi Hashizume-Takizawa, Tomoko Kurita-Ochiai
Summary: The study suggests that oral intake of Lactobacillus gasseri helps prevent periodontitis and atherosclerosis by improving intestinal flora changes induced by periodontopathic bacteria and reducing inflammatory cytokine production, resulting in a decrease in atherosclerotic plaque lesion size.
JOURNAL OF PERIODONTAL RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Emily Chang, Ryoki Kobayashi, Mio Hagiwara-Hamano, Tomoko Kurita-Ochiai, Masamichi Komiya
Summary: The study indicates that sublingual immunization with the GroEL vaccine can significantly suppress bone resorption induced by Porphyromonas gingivalis, and induce sustained immune responses in saliva and serum for about 1 year.
MOLECULAR ORAL MICROBIOLOGY
(2022)
Article
Nutrition & Dietetics
Yohei Nakayama, Shinichi Tabe, Arisa Yamaguchi, Yuto Tsuruya, Ryoki Kobayashi, Katsunori Oyama, Daisuke Kitano, Keisuke Kojima, Rikitake Kogawa, Yasuo Okumura, Jun Ogihara, Hidenobu Senpuku, Yorimasa Ogata
Summary: This study examines the associations between nutritional factors, blood biochemical items, and clinical parameters in patients with systemic diseases. Weak negative correlations were found between clinical parameters and nutritional factors, and the frequency of vegetable intake may be used to evaluate periodontal stabilization in these patients.
Article
Cell Biology
Emily Chang, Ryoki Kobayashi, Kohtaro Fujihashi, Masamichi Komiya, Tomoko Kurita-Ochiai
Summary: The study revealed significant differences in oral bacterial composition, metabolites, and periodontitis development between IgA-deficient mice and wild-type mice, highlighting the important role of SIgA in regulating oral microbiota to prevent periodontal diseases.
INFLAMMATION RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Emily Chang, Ryoki Kobayashi, Mio Hagiwara, Masamichi Komiya, Tomoko Kurita-Ochiai
ORAL SCIENCE INTERNATIONAL
(2019)
Article
Dentistry, Oral Surgery & Medicine
Takashi Takeuchi, Tomomi Hashizume-Takizawa, Ryoki Kobayashi
JOURNAL OF ORAL BIOSCIENCES
(2017)
Article
Dentistry, Oral Surgery & Medicine
Tomoko Kurita-Ochiai, Tomomi Hashizume-Takizawa, Ryoki Kobayashi, Ujjal K. Bhawal, Akira Hosono, Noriko Kinukawa, Sumito Oguchi
JOURNAL OF ORAL BIOSCIENCES
(2017)