Review
Biochemistry & Molecular Biology
Luke Juckett, Tiam Mana Saffari, Benjamin Ormseth, Jenna-Lynn Senger, Amy M. M. Moore
Summary: Peripheral nerve injuries (PNI) often result in lifelong disability with rare complete functional recovery. Intraoperative electrical stimulation (ES) is a promising surgical adjunct that can augment the intrinsic molecular pathways of nerve regeneration. Clinical trials have shown that ES can be an efficacious therapy to improve patient outcomes following PNIs.
Article
Cell Biology
Su-Long Wang, Xi-Lin Liu, Zhi-Chen Kang, Yue-Shu Wang
Summary: The effect of platelet-rich plasma on nerve regeneration in a rabbit model of sciatic nerve small-gap defects with preserved epineurium was investigated. Results showed that platelet-rich plasma with specific concentrations of whole blood platelets promoted repair of sciatic nerve injury. Proteomics analysis revealed that platelet-rich plasma affects angiogenesis and intracellular ubiquitin levels in the regeneration process.
NEURAL REGENERATION RESEARCH
(2023)
Review
Cell Biology
Jingxin Zhang, Binjing Zhang, Jinglan Zhang, Weimin Lin, Shiwen Zhang
Summary: Magnesium as a suitable material for promoting peripheral nerve regeneration has both challenges and potentials, but there is currently limited research on this topic, requiring further exploration to address the shortcomings and challenges identified.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Xiaolan Li, Xiang Zhang, Ming Hao, Dongxu Wang, Ziping Jiang, Liqun Sun, Yongjian Gao, Ye Jin, Peng Lei, Yue Zhuo
Summary: This review summarizes the importance of collagen in peripheral nerve regeneration, focusing on its characteristics, role, and optimization methods. Collagen, as a biomaterial, plays a crucial role in peripheral nerve repair and can be further optimized by adjusting its structure and physical properties, as well as combining it with bioactive components.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yangnan Hu, Zhuoyue Chen, Hongyang Wang, Jiahui Guo, Jiaying Cai, Xiaoyan Chen, Hao Wei, Jieyu Qi, Qiuju Wang, Huisheng Liu, Yuanjin Zhao, Renjie Chai
Summary: Inspired by the structures of peripheral nerves, researchers have developed a conductive topological scaffold for nerve repair using modified butterfly wings. The scaffold showed increased neurite length and guided cellular orientation, and successfully repaired nerve defects in rats.
Article
Neurosciences
Chang-Feng Lu, Bo Wang, Pei-Xun Zhang, Shuai Han, Wei Pi, Yu-Hui Kou, Bao-Guo Jiang
Summary: Nerve grafts constructed from chitin biological conduits combined with small autogenous nerves (SANs) and platelet-rich plasma (PRP) significantly improved the repair of 10-mm sciatic nerve defects in rats, showing potential for future therapeutic applications in repairing peripheral nerve defects.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Engineering, Biomedical
Binghui Jin, Yunru Yu, Xiangxiang Chen, Yanhong Yang, Yushan Xiong, Young Jun Im, Yuanjin Zhao, Jian Xiao
Summary: The study proposes a novel microtube for sciatic nerve regeneration using gradient decellularized porcine sciatic nerve extracellular matrix hydrogel (pDScNM-gel). The pDScNM is shown to enhance cell proliferation and migration, improve axon growth, and these effects can also be achieved through coculture in a gradient pDScNM microtube. In vivo sciatic nerve regeneration and functional recovery are demonstrated by assembling the gradient pDScNM microtubes with a medical silicon tube.
BIOACTIVE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Yongxin Zhan, Zekun Zhou, Miao Chen, Xu Gong
Summary: This study developed a photothermal material PDA NPs@HAMA and evaluated its efficacy for preventing peripheral nerve adhesion in a rat sciatic nerve adhesion model. The results showed that PDA NPs@HAMA reduced the occurrence of adhesion and preserved nerve function.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Cell Biology
Cameron L. Ghergherehchi, Jaimie T. Shores, Joseph Alderete, Erik K. Weitzel, George D. Bittner
Summary: Complete transection of peripheral mixed nerves immediately leads to loss of sensory perception, muscle contractions, and voluntary behavior, which can be restored within minutes by PEG-fusion. The inclusion of 0.5% MB in the PEG-fusion protocol significantly improves the rate and extent of behavioral recovery compared to PEG alone, making it a promising addition to future human clinical trials for peripheral nerve injuries.
NEURAL REGENERATION RESEARCH
(2021)
Article
Integrative & Complementary Medicine
Lu Yin, Yun An, Xiao Chen, Hui-xin Yan, Tao Zhang, Xin-gang Lu, Jun-tao Yan
Summary: This study investigated the effect of local vibration therapy with different amplitudes on the recovery of nerve function in rats with sciatic nerve injury. The results showed that medium amplitude vibration therapy could promote nerve function recovery and was associated with the proliferation of Schwann cells and the activation of the ERK1/2 and Akt signaling pathways.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2022)
Article
Neurosciences
Meijian Wang, Min Xie, Shuyan Yu, Pan Shang, Cong Zhang, Xiaolin Han, Cuiqin Fan, Li Chen, Xianghua Zhuang, Shihong Chen
Summary: Studies have shown that Lipin1 is involved in the pathogenesis of DPN, playing a role in regulating autophagy and maintaining normal peripheral nerve conduction function. Upregulation of Lipin1 can ameliorate autophagic disorders and pathological changes in nerves, leading to an increase in nerve conduction velocity in DPN rats.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Neurosciences
Emily A. Hibbard, Dale R. Sengelaub
Summary: Peripheral nerve injuries are the most common type of nerve trauma. A new repair technique using PEG to fuse the membranes of severed axons has shown promising results in terms of immediate reinervation and improved behavioral recovery. This study investigates the topographical organization of axons contributing to the sciatic nerve, finding consistent locations of specific axon populations. The knowledge of this organization can aid in the accurate realignment of axons during repair, enhancing recovery outcomes.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Simon C. Kellaway, Victoria Roberton, Joshua N. Jones, Rabea Loczenski, James B. Phillips, Lisa J. White
Summary: Incorporating dECMh derived from bone, liver, and small intestinal tissues can promote neurite extension and axonal regeneration, providing an alternative to current collagen I hydrogel.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Jun Yan, Yunjing Wan, Zhe Ji, Chenxi Li, Chengcheng Tao, Yunjiao Tang, Yuze Zhang, Yaobo Liu, Jian Liu
Summary: This study reports a new concept of using near infrared (NIR) laser-triggered optogenetics to promote the functional recovery and regeneration of transected peripheral nerves. The approach involves the use of acetylcholine-modified upconversion nanoparticles (UCNP) to activate channelrhodopsin 2 (ChR2) protein on the acetylcholinergic motor neurons. This leads to a cascade of events that promote axonal regeneration, remyelination of Schwann cells, enhanced expression of brain-derived neurotrophic factor, and remodeling of neuromuscular junctions (NMJ).
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Merav Antman-Passig, Jonathan Giron, Moshe Karni, Menachem Motiei, Hadas Schori, Orit Shefi
Summary: Nerve growth conduits play a crucial role in supporting and promoting axon regeneration following nerve injuries. A biomimetic regenerative gel enriched with magnetic nanoparticles coated with nerve growth factor has been developed, showing promising effects on enhancing nerve regeneration in in vivo rat models. The magnet-based therapeutic conduits demonstrate oriented and directed axonal growth, providing a novel therapeutic approach to overcoming current medical obstacles for nerve injuries.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Critical Care Medicine
Behrooz Ilkhanizadeh, Leila Zarei, Negin Farhad, Mehran Bahrami-Bukani, Rahim Mohammadi
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2017)
Article
Pediatrics
Tahereh Behroozi-Lak, Leila Zarei, Mones Moloody-Tapeh, Negin Farhad, Rahim Mohammadi
JOURNAL OF PEDIATRIC SURGERY
(2017)
Correction
Critical Care Medicine
Behrooz Ilkhanizadeh, Leila Zarei, Negin Farhad, Mehran Bahrami-Bukani, Rahim Mohammadi
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2019)
Article
Chemistry, Physical
Rahim Mohammadi, Leila Naderi, Saeed Shahrokhian
JOURNAL OF ALLOYS AND COMPOUNDS
(2019)
Article
Clinical Neurology
Salar Dolkhani, Alireza Najafpour, Rahim Mohammadi
NEUROLOGICAL RESEARCH
(2020)
Article
Clinical Neurology
Pouria Ebrahimi-Zadehlou, Alireza Najafpour, Rahim Mohammadi
Summary: The study assessed the regenerative potential of silymarin nanoparticles loaded into chitosan conduit on peripheral nerve regeneration in a transected sciatic nerve model in rats. The use of silymarin nanoparticles significantly promoted the recovery of regenerated fibers, increasing the number and diameter of myelinated fibers.
NEUROLOGICAL RESEARCH
(2021)
Article
Integrative & Complementary Medicine
Pouria Honardoust, Alireza Najafpour, Rahim Mohammadi
Summary: The study found that administration of NCOQ10 in a rat ovary ischemia-reperfusion injury model significantly improved tissue damage and had a significant impact on biochemical indices. Administering NCOQ10 intraperitoneally may have clinical benefits in reducing ischemia-reperfusion injury in ovarian tissue.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Ramezani Ali, Najafpour Alireza, Farahpour Mohammad Reza, Mohammadi Rahim
Summary: The study aimed to investigate the effect of cinnamon nanoparticles on healing of wounds infected with methicillin-resistant Staphylococcus aureus in diabetic rats. Results showed that the local application of cinnamon nanoparticles along with HAMLET sensitization could accelerate the healing of diabetic wounds infected with MRSA, indicating potential for future treatment strategies.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Amir Amniattalab, Rahim Mohammadi
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2018)
Article
Dermatology
Negin Sanaei, Rahim Mohammadi, Abbas Raisi, Leila Zarei
WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
(2018)
Article
Cell Biology
Ali Karimi, Rasoul Shahrooz, Rahim Hobbenaghi, Rahim Mohammadi, Esmaeil Mortaz
Article
Medicine, Research & Experimental
Zahra Cheraghali, Rahim Mohammadi, Ghader Jalilzadeh-Amin
MALAYSIAN JOURNAL OF MEDICAL SCIENCES
(2017)
Article
Clinical Neurology
Rahim Mohammadi, Keyvan Amini
JOURNAL OF NEUROSURGICAL SCIENCES
(2017)
