Journal
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
Volume 11, Issue 4, Pages 244-253Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1534734612463935
Keywords
mesenchymal stem cells/multipotent mesenchymal stromal cells; chronic wounds; cell therapy; mechanism
Categories
Funding
- National Basic Science and Development Program (973 Program) [2012CB518105]
- Postdoctoral Science Foundation [20080440225, 21003777]
- National Natural Science Foundation of China [81121004, 81171812, 81000843, 81272105]
- National Nature and Science Foundation of P R China [30973127]
- World Diabetes Foundation [WDF 09-467]
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Chronic wounds remain a major challenge in modern medicine and represent a significant health care burden. Several treatments have been suggested, but without a full understanding of the exact mechanism by which chronic wound occurs. Numerous studies have shown that mesenchymal stem cells/multipotent mesenchymal stromal cells (MSCs) may have therapeutic potential in healing cutaneous chronic wounds through various mechanisms. So far, a series of hypotheses have been proposed, but a holistic image of them is lacking. This review provides a systematic analysis of recent research in animal models and preclinical or clinic trails to evaluate the potential role of MSCs in chronic cutaneous wound healing. Most important, we highlight how mesenchymal stem cells could potentially revolutionize our approach to treating cutaneous chronic wounds. Special attention should be focused on ongoing research regarding the challenges in using and prospects of MSCs in clinical settings.
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