Article
Medicine, General & Internal
Veronica Romano, Donato Di Gennaro, Anna Maria Sacco, Enrico Festa, Emanuela Roscetto, Morena Anna Basso, Tiziana Ascione, Giovanni Balato
Summary: This study evaluated the cytotoxicity of solutions containing povidone-iodine (PI) and hydrogen peroxide (H2O2), alone or in combination. The results showed that the toxicity of all tested solutions increased as exposure time increased, except for 0.3% PI solution, which exhibited the lowest toxicity. The combined solutions had lower cellular killing at 3 and 5 min compared to equal concentrations of H2O2, similar to PI solutions.
Article
Orthopedics
Nathanael D. Heckmann, Brian C. Chung, Hyunwoo P. Kang, Myles W. Chang, Jennifer C. Wang, Alexander E. Weber, Reza Omid, Denis Evseenko
Summary: This study evaluates the stability of tranexamic acid (TXA) in common orthopedic antiseptic solutions. The results show that chlorhexidine (CHX), povidone-iodine (BTD), and hydrogen peroxide (H2O2) do not degrade TXA, while 0.5% sodium hypochlorite (Dakin's) significantly diminishes its efficacy. It is important to avoid using Dakin's solution as an intraoperative irrigation solution.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Review
Endocrinology & Metabolism
Claire Saliba Thorne, Alfred Gatt, Clifford DeRaffaele, Abduarahman Bazena, Cynthia Formosa
Summary: The systematic review aimed to analyze the correlation between pressure and skin temperature in diabetic foot ulceration, focusing on technologies for in-shoe pressure and temperature measurements. The studies included showed good validity in detecting changes in in-shoe skin temperature and pressure, but further improvement and reliability testing of the systems are required.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Agriculture, Dairy & Animal Science
Delia Lacasta, Marina Rios, Marta Ruiz de Arcaute, Aurora Ortin, Juan Jose Ramos, Sergio Villanueva-Saz, Maria Teresa Tejedor, Hector Ruiz, Marta Borobia, Ramses Reina, Alex Gomez, Teresa Navarro, Peter Andrew Windsor
Summary: Contagious ecthyma, caused by the orf virus, is a highly contagious skin infection affecting sheep and goats worldwide. Current treatment with antiseptics and antibiotics may lead to antimicrobial resistance. A study investigated the use of Tri-Solfen (R), a topical gel containing local anesthetics, adrenaline, and an antiseptic, which has previously shown efficacy in treating foot-and-mouth disease in ruminants. However, the results of the study in lambs infected with orf were not as encouraging, possibly due to milder clinical signs and the location of the lesions.
Article
Orthopedics
J. A. O'Donnell, M. Wu, N. H. Cochrane, E. Belay, M. F. Myntti, G. A. James, S. P. Ryan, T. M. Seyler
Summary: The study aimed to test the efficacy of different antiseptic solutions against clinically relevant microorganisms in biofilm, with results showing significant reductions in biofilm burden with Povidone-iodine and Bactisure. Further clinical outcome data is needed to determine the impact of these solutions on PJI outcomes in vivo.
BONE & JOINT JOURNAL
(2021)
Article
Multidisciplinary Sciences
Elzbieta Piatkowska, Justyna Paleczny, Karolina Dydak, Krzysztof Letachowicz
Summary: Proper protection of vascular access after hemodialysis is essential to prevent catheter-related infections. In this study, the antimicrobial activity of solutions used for tunnelled catheter locking was compared, with polyhexanide-betaine showing high efficacy in inhibiting microbial growth, even at significantly diluted concentrations.
Article
Medicine, General & Internal
Yu-Yao Huang, Ching-Wen Lin, Nai-Chen Cheng, Shawn M. Cazzell, Hsin-Han Chen, Kuo-Feng Huang, Kwang-Yi Tung, Hsuan-Li Huang, Pao-Yuan Lin, Cherng-Kang Perng, Bimin Shi, Chang Liu, Yujin Ma, Yemin Cao, Yanbing Li, Yaoming Xue, Li Yan, Qiu Li, Guang Ning, Shun-Cheng Chang
Summary: The study compared the topical application of ON101 cream with use of an absorbent dressing in treating DFUs. Results showed that ON101 exhibited better healing efficacy than absorbent dressing alone in the treatment of DFUs and showed consistent efficacy among all patients.
Review
Endocrinology & Metabolism
Xing-xi Hu, Zheng-zhong Xiu, Gui-chun Li, Ji-yuan Zhang, Long-jun Shu, Zhong Chen, Han Li, Qing-feng Zou, Quan Zhou
Summary: This study evaluated the effectiveness and safety of transverse tibial bone transport (TTT) in treating diabetic foot ulcerations (DFUs). The findings showed that TTT operation had high healing rate and limb salvage rate, and significantly improved ankle-brachial index, skin temperature, and visual analogue scale. However, caution should be exercised regarding the risk of fracture, pin-site infection, and skin necrosis after TTT operation in DFU patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Tyler L. Coye, Mehmet A. Suludere, Gu Eon Kang, P. Andrew Crisologo, Matthew Malone, Lee C. Rogers, Lawrence A. Lavery
Summary: The objective of this study was to evaluate the effectiveness of various biomarkers, including C-reactive protein, erythrocyte sedimentation rate, and albumin, and their ratios in differentiating bone and soft tissue infection in individuals with diabetes. The results showed that the ESR/albumin and CRP/albumin ratios provided comparable diagnostic accuracy to using ESR and CRP alone.
WOUND REPAIR AND REGENERATION
(2023)
Article
Multidisciplinary Sciences
Marie Bouly, Francois-Xavier Laborne, Caroline Tourte, Elodie Henry, Alfred Penfornis, Dured Dardari
Summary: This study aims to investigate the correlation between post-healing follow-up and recurrence rates of diabetic foot ulcer patients, and evaluate the impact of multidisciplinary follow-up on foot wound recurrence.
Review
Dermatology
Daniel Ardian Soeselo, Rennie Yolanda, Maria Zita, Sandy Theresia, Yunisa Astiarani, Bryany Titi Santi
Summary: This study compared the effectiveness of antiseptic solutions with non-antiseptic solutions in reducing wound infection rate, bacterial load, and improving wound healing. It found that antiseptic solutions significantly reduced wound infection rate, while non-antiseptic solutions increased bacterial load. However, the quality of evidence was very low, and no conclusions could be made for clinical practice.
JOURNAL OF WOUND CARE
(2022)
Article
Biochemistry & Molecular Biology
Koko Barrigah-Benissan, Jerome Ory, Catherine Dunyach-Remy, Cassandra Pouget, Jean-Philippe Lavigne, Albert Sotto
Summary: This study evaluated the antibiofilm activity of four antiseptics against Pseudomonas aeruginosa strains, and found that sodium hypochlorite demonstrated the best activity against biofilms. This provides an alternative method for the management of diabetic foot ulcers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Sarah Perren, Cynthia Formosa, Liberato Camilleri, Nachiappan Chockalingam, Alfred Gatt
Summary: This study combined foot pressure and temperature measurements to establish a thermo-pressure model for more reliable risk assessment in diabetic patients. It found a positive correlation between pressure and temperature, especially in diabetic groups, suggesting potential for early identification and care initiation for diabetic foot ulceration risk.
APPLIED SCIENCES-BASEL
(2021)
Article
Endocrinology & Metabolism
A. Ghosh, S. Ray, M. K. Garg, S. Chowdhury, S. Mukhopadhyay
Summary: This study found that the average temperature and ulcer temperature in diabetic foot ulcers were significantly higher than in unaffected feet, with changing temperature gradient during the healing process. The temperature gradient can be used to predict healing outcomes of ulcers and the risk of recurrence.
Review
Endocrinology & Metabolism
Scott McNeil, Kate Waller, Yves S. Poy Lorenzo, Olimpia C. Mateevici, Stacey Telianidis, Sara Qi, Irina Churilov, Richard J. MacIsaac, Anna Galligan
Summary: Diabetes-related foot disease (DFD) is a feared complication among diabetes patients, leading to increased rates of disability, cardiovascular disease, amputation, and mortality. This review analyzes the common processes of neuropathy, arterial disease, and infection to understand and prevent these outcomes. Through an interdisciplinary approach and following guidelines, a practical and evidence-based care approach for DFD patients is provided.
WORLD JOURNAL OF DIABETES
(2023)
Article
Endocrinology & Metabolism
Monia Garofolo, Vinicio Napoli, Daniela Lucchesi, Sandra Accogli, Maria Letizia Mazzeo, Piercarlo Rossi, Emanuele Neri, Stefano Del Prato, Giuseppe Penno
Summary: The study explores the role of kidney ultrasonography in differentiating diabetic kidney disease (DKD) phenotypes in type 2 diabetes patients, showing that there are differences in morphological and vascular properties among different DKD phenotypes. The findings suggest the potential of imaging techniques in better characterizing DKD phenotypes in clinical practice.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Immunology
Manjunath P. Pai, Pier Giorgio Cojutti, Valentina Gerussi, Paola Della Siega, Carlo Tascini, Federico Pea
Summary: Linezolid-induced myelosuppression is likely to occur in cardiosurgical patients due to reduced kidney function and potential drug interactions. Population modeling and simulation demonstrate that lower doses coupled with therapeutic drug monitoring are necessary in this vulnerable population. Thus, reducing the empiric linezolid doses in cardiosurgical patients may help avoid toxicities, and further studies are needed to verify potential drug interactions.
CLINICAL INFECTIOUS DISEASES
(2023)
Letter
Endocrinology & Metabolism
Chantal Mathieu, Stefano Del Prato
Editorial Material
Endocrinology & Metabolism
Chantal Mathieu, Jeannette Soderberg, Stefano Del Prato, Anne-Marie Felton, Xavier Cos, Carine de Beaufort, Jean-Francois Gautier, Bastian Hauck, Angus Forbes, Robert Heine, Peter Schwarz, Bart Torbeyns
Article
Cardiac & Cardiovascular Systems
Hertzel C. Gerstein, Zhuoru Li, Chinthanie Ramasundarahettige, Seungjae Baek, Kelley R. H. Branch, Stefano Del Prato, Carolyn S. P. Lam, Renato D. Lopes, Richard Pratley, Julio Rosenstock, Naveed Sattar
Summary: In the AMPLITUDE-O trial, adding either 4 mg or 6 mg weekly of efpeglenatide reduced major adverse cardiovascular events in people with type 2 diabetes. The benefits of efpeglenatide appear to be dose-related.
Article
Endocrinology & Metabolism
Cristina Bianchi, Alex Brocchi, Walter Baronti, Francesca Nicoli, Fabrizia Citro, Michele Aragona, Vito Cela, Stefano Del Prato, Alessandra Bertolotto
Summary: This study aimed to evaluate the impact of assisted reproductive technology (ART) on the risk of gestational diabetes mellitus (GDM) in single pregnancies. The study found that ART women had a significantly higher prevalence of GDM compared to women with spontaneous conception, and ART women above the age of 40 were more likely to develop GDM. Additionally, ART treatment appeared to be associated with an increased rate of preterm delivery, lower neonatal birth weight, and Apgar score, especially in women with GDM.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Letter
Oncology
Francesco Marchesi, Jon Salmanton-Garcia, Caterina Buquicchio, Federico Itri, Caroline Besson, Julio Davila-Valls, Sonia Martin-Perez, Luana Fianchi, Laman Rahimli, Giuseppe Tarantini, Federica Irene Grifoni, Mariarita Sciume, Jorge Labrador, Raul Cordoba, Alberto Lopez-Garcia, Nicola S. Fracchiolla, Francesca Farina, Emanuele Ammatuna, Antonella Cingolani, Daniel Garcia-Bordallo, Stefanie K. Graefe, Yavuz M. Bilgin, Michelina Dargenio, Tomas Jose Gonzalez-Lopez, Anna Guidetti, Tobias Lahmer, Esperanza Lavilla-Rubira, Gustavo-Adolfo Mendez, Lucia Prezioso, Martin Schoenlein, Jaap Van Doesum, Dominik Wolf, Ditte Stampe Hersby, Ferenc Magyari, Jens Van Praet, Verena Petzer, Carlo Tascini, Iker Falces-Romero, Andreas Glenthoj, Oliver A. Cornely, Livio Pagano
Summary: This study reports breakthrough COVID-19 infections in hematologic malignancies patients who received prophylactic tixagevimab/cilgavimab. Most patients had lymphoproliferative disorders and were infected with the omicron variant. The use of tixagevimab/cilgavimab appears to reduce the severity of COVID-19 in these patients, but further studies are needed to determine the optimal drug administration strategies for immunocompromised patients.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Article
Immunology
Umberto Pizzano, Gabriele Facchin, Chiara Marcon, Martina Fabris, Marta Lisa Battista, Michela Cerno, Antonella Geromin, Martina Pucillo, Giuseppe Petruzzellis, Giampaolo Vianello, Giulia Battaglia, Roberto Peressutti, Lucrezia Grillone, Carlo Tascini, Francesco Curcio, Renato Fanin, Francesca Patriarca
Summary: We compared humoral responses and infection onset in patients undergoing allogeneic stem-cell transplantation (allo-SCT) after receiving anti-SARS-CoV-2 mRNA vaccine. We found that an interval shorter than 12 months between allo-SCT and first vaccine dose, as well as ongoing immunosuppression, were associated with deficiency in humoral and cellular response after two doses. The third dose induced a sustained and increased humoral response in the majority of patients, but those within 1 year after allo-SCT remained at a higher infection risk.
TRANSPLANT INFECTIOUS DISEASE
(2023)
Article
Medicine, General & Internal
Luigi Vetrugno, Cristian Deana, Nadia Castaldo, Alberto Fantin, Alessandro Belletti, Emanuela Sozio, Maria De Martino, Miriam Isola, Diego Palumbo, Federico Longhini, Gianmaria Cammarota, Savino Spadaro, Salvatore Maurizio Maggiore, Flavio Bassi, Carlo Tascini, Vincenzo Patruno
Summary: NIRS in COVID-19 patients outside the ICU carries a low risk of barotrauma, which is more common in older patients with more severe systemic disease. The type of NIRS does not seem to increase the risk. Escalation of respiratory support is associated with higher in-hospital mortality.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Infectious Diseases
Tommaso Cai, Umberto Anceschi, Francesco Prata, Lucia Collini, Anna Brugnolli, Serena Migno, Michele Rizzo, Giovanni Liguori, Luca Gallelli, Florian M. E. Wagenlehner, Truls E. Bjerklund Johansen, Luca Montanari, Alessandro Palmieri, Carlo Tascini
Summary: By using an Artificial Neural Network (ANN), we can predict the clinical efficacy of empiric antimicrobial treatment for women with recurrent urinary tract infections (rUTIs). This study trained the ANN on data from 1043 women and found that it had a high sensitivity (87.8%) and specificity (97.3%) in predicting the clinical efficacy of empirical therapy.
Article
Infectious Diseases
Simone Giuliano, Jacopo Angelini, Denise D'Elia, Monica Geminiani, Roberto Daniele Barison, Alessandro Giacinta, Assunta Sartor, Floriana Campanile, Francesco Curcio, Menino Osbert Cotta, Jason A. Roberts, Massimo Baraldo, Carlo Tascini
Summary: This study retrospectively analyzed the medical records of patients with E. faecalis infections in a university hospital. The combination of ampicillin and ceftobiprole achieved high clinical success and microbiological cure rates. Therapeutic drug monitoring helped optimize treatment efficacy with fewer side effects.
Article
Infectious Diseases
Carlo Tascini, Simone Giuliano, Vittorio Attanasio, Luca Segreti, Andrea Ripoli, Francesco Sbrana, Sergio Severino, Chiara Sordelli, Sara Hana Weisz, Agnese Zanus-Fortes, Gabriele Maria Leanza, Novella Carannante, Andrea Di Cori, Maria Grazia Bongiorni, Giulio Zucchelli, Stefano De Vivo
Summary: This study compares the outcome and safety of a single-procedure device extraction and contralateral implantation with the standard two-stage replacement for infected cardiovascular implantable electronic devices. There were no significant differences in mortality rates between the single-procedure group and the standard-of-care group. Therefore, single-procedure reimplantation with active antibiofilm therapy may be a feasible and effective therapeutic option.
Review
Endocrinology & Metabolism
Anna Solini, Domenico Trico, Stefano Del Prato
Summary: Major cardiovascular outcome trials and real-life observations have shown that GLP-1 receptor agonists (GLP-1RAs) provide clinically relevant cardiovascular protection regardless of GLP-1 homology. GLP-1RAs offer cardioprotective benefits through various mechanisms, including improved insulin secretion and action, weight loss, reduced blood pressure, improved lipid profile, as well as direct effects on the heart and vasculature. The available evidence has led professional and medical societies to recommend GLP-1RAs for reducing cardiovascular risk in people with type 2 diabetes.
Article
Infectious Diseases
Ivan Gentile, Antonio Riccardo Buonomo, Silvia Corcione, Laurenza Paradiso, Daniele Roberto Giacobbe, Davide Fiore Bavaro, Giusy Tiseo, Francesca Sordella, Michele Bartoletti, Giulia Palmiero, Antonietta Vozza, Antonio Vena, Francesca Canta, Nicola Schiano Moriello, Paola Congera, Arta Karruli, Carlo Tascini, Pierluigi Viale, Valerio Del Bono, Marco Falcone, Sergio Carbonara, Malgorzata Karolina Mikulskan, Matteo Bassettie, Emanuele Durante-Mangonid, Francesco Giuseppe De Rosa, Alberto Enrico Maraolo
Summary: This study evaluated the use of Ceftobiprole in a real-world setting and found it to be a safe and effective therapeutic choice, particularly for pneumonia and hospital-acquired pneumonia. The study also identified factors associated with treatment success or fatal outcomes.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Endocrinology & Metabolism
Pierpaolo Falcetta, Francesca Nicoli, Fabrizia Citro, Annamaria Ciccarone, Monia Garofolo, Stefano Del Prato, Cristina Bianchi
Summary: The study aimed to evaluate the impact of adding a GLP-1 RA in individuals with T2D on a BB insulin regimen. The results showed that HbA1c and body weight significantly decreased at 6 months after starting GLP-1 RA therapy and remained stable up to 24 months. In addition, at 24 months, a large percentage of subjects discontinued prandial and basal insulin. The findings suggest that replacing prandial insulin with GLP-1 RA is a valuable strategy to simplify the BB insulin regimen, improve glycemic control, and promote weight loss in people with T2D.
ACTA DIABETOLOGICA
(2023)