Article
Multidisciplinary Sciences
Victoria Vargas, Weston Blakeslee, Colin Banas, Christian Teter, Katherine Dupuis-Dobson, Carol Aboud
Summary: This study established a rating scale for reporting medication errors corrected by pharmacy staff during admission medication reconciliation and quantifying the value of investment in transitions-of-care pharmacy staff.
Article
Health Care Sciences & Services
Maria Jesus Rojas-Ocana, Cristina Teresa-Morales, Juan Diego Ramos-Pichardo, Miriam Araujo-Hernandez
Summary: This study aimed to describe barriers to and facilitators of effective communication during the medication reconciliation process at hospital discharge in people over 65 years old, from the perspective of primary healthcare professionals. In-depth interviews were conducted with 21 individuals, including 13 nurses and 8 physicians. The barriers mainly related to the adequacy and use of technological tools, time available, workload, and the level of collaboration of patients/caregivers. Facilitating elements included technologies such as computerized medical history, protocolization of clinical sessions, the presence of case management nurse, and interdisciplinary teamwork.
Article
Health Care Sciences & Services
Pi-Lien Hung, Pei-Chin Lin, Jung-Yi Chen, Miao-Ting Chen, Ming-Yueh Chou, Wei-Chun Huang, Wang-Chuan Juang, Yu-Te Lin, Alex C. Lin
Summary: The study aimed to develop an integrated electronic medication reconciliation (ieMR) platform to prevent potential duplicated medications and reduce the rate of 30-day medication-related hospital revisits for patients. The findings demonstrated that the ieMR platform significantly decreased the number of potential duplicated medications and lowered the rate of hospital revisits within 30 days for the geriatric unit.
JOURNAL OF MEDICAL SYSTEMS
(2021)
Article
Chemistry, Multidisciplinary
Maria del Carmen Gonzalez-Lopez, Carlos Ruiz-Gonzalez, Bruno Jose Nievas-Soriano, Sonia Garcia-Duarte, Tesifon Parron-Carreno
Summary: The study found that after hospital discharge, most patients in primary health care showed medication discrepancies in their records, with medication errors being the most common type of discrepancy, especially medication omission. Women aged 65 and older were more likely to have medication errors.
APPLIED SCIENCES-BASEL
(2021)
Article
Pharmacology & Pharmacy
V. S. Meda, K. L. P. Babu, V. Prasanna Reddy, M. Mounika, S. Sekhar Reddy, Y. Manasa Reddy
Summary: This study aimed to monitor discrepancies in admission and treatment, with a focus on medication errors and drug-drug interactions in a South Indian Tertiary Care Hospital. The lack of medication reconciliation was found to lead to medication errors, but successful implementation of medication reconciliation can enhance patient safety.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Health Care Sciences & Services
C. C. M. Stuijt, B. J. F. van den Bemt, V. E. Boerlage, M. J. A. Janssen, K. Taxis, F. Karapinar-Carkit
Summary: This study compared the number and type of medication reconciliation (MedRec) interventions between hospitals upon admission and discharge. The findings showed significant differences in the interventions performed, which were influenced by factors such as patient demographics, healthcare professionals involved, and the extent of medication optimization. The study provides valuable insights for hospitals seeking to optimize their MedRec processes.
BMC HEALTH SERVICES RESEARCH
(2022)
Review
Multidisciplinary Sciences
Lisbeth Damlien Nymoen, Trude Eline Flatebo, Tron Anders Moger, Erik Oie, Espen Molden, Kirsten Kilvik Viktil
Summary: The objective of this study was to investigate the impact of medication review conducted by clinical pharmacists on clinical outcomes and post-discharge outcomes for patients admitted to the emergency department. The results showed that pharmacist-led medication review did not significantly influence patients' contact with the hospital within 12 months after discharge. However, the study provided important practical implementations for tailored pharmacist-led interventions in the emergency department setting.
Article
Medicine, General & Internal
Frederique Bouchand, Celine Leplay, Ricardo Guimaraes, Sarah Fontenay, Lesly Fellous, Aurelien Dinh, Laurene Deconinck, Olivia Senard, Morgan Matt, Hugues Michelon, Christian Perronne, Jerome Salomon, Maryvonne Villart, Fatima Izedaren, Sandra Pottier, Frederic Barbot, David Orlikowski, Isabelle Vaugier, Benjamin Davido
Summary: This study compared the impact of a care bundle including medication reconciliation at discharge by a pharmacist versus standard of care on continuity of therapeutic changes and patient outcomes within 1 month post-discharge. The care bundle resulted in a reduction of treatment changes between hospital discharge and primary care, with fewer patients experiencing hospital readmissions or adverse drug reactions in the intervention group.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Pharmacology & Pharmacy
Alessandra de Sa Soares, Daisson Jose Trevisol, Fabiana Schuelter-Trevisol
Summary: The study found a high prevalence of medication discrepancies in a hospital in southern Brazil, with factors such as chronic diseases, number of medications taken at home, and incomplete documentation in medical records associated with these discrepancies. Medication reconciliation is crucial in reducing medication-related errors and risks, where pharmacists play a key role in helping to mitigate these issues.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Medicine, General & Internal
Shawn Varghese, Shoshana Hahn-Goldberg, ZhiDi Deng, Glyneva Bradley-Ridout, Sara J. T. Guilcher, Lianne Jeffs, Craig Madho, Karen Okrainec, Zahava R. S. Rosenberg-Yunger, Lisa M. McCarthy
Summary: This study reviewed patient or caregiver-centered medication support processes or tools that have been studied within 3 months following transitions in care (TiC) between hospitals and other care settings. It found that most studies were randomized controlled trials involving verbal and written education as medication support. Few studies included electronic components or considered high-risk patients.
PATIENT PREFERENCE AND ADHERENCE
(2022)
Review
Health Care Sciences & Services
Jacinta Sheehan, Kate Laver, Anoo Bhopti, Miia Rahja, Tim Usherwood, Lindy Clemson, Natasha A. Lannin
Summary: There is currently a lack of in-depth research on the methods and effectiveness of communication between hospital allied health and primary care practitioners. Four enablers to effective communication have been identified in the studies.
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2021)
Article
Medicine, General & Internal
Jerry H. Gurwitz, Alok Kapoor, Lawrence Garber, Kathleen M. Mazor, Joann Wagner, Sarah L. Cutrona, Sonal Singh, Abir O. Kanaan, Jennifer L. Donovan, Sybil Crawford, Kathryn Anzuoni, Timothy J. Konola, Yanhua Zhou, Terry S. Field
Summary: This study aimed to improve medication safety for discharged patients prescribed high-risk medications through a clinical pharmacist intervention. The results showed that the intervention did not significantly reduce the rate of adverse drug-related incidents or clinically important medication errors.
JAMA INTERNAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Melinda Gusmeroli, Stephen Perks, Nicole Bates
Summary: This study aimed to assess the quality of effective discharge communication to primary practice from a hospital that uses integrated electronic Medical Record (ieMR). The findings showed that the completeness of discharge summaries varied, with 22.0% being incomplete at 30 days post discharge. Furthermore, the proper use of electronic programs and completion of all crucial steps of reconciliation significantly increased the likelihood of having medications listed in the discharge summary. The study highlights the importance of targeted interventions to improve discharge communication.
AUSTRALIAN JOURNAL OF PRIMARY HEALTH
(2023)
Article
Public, Environmental & Occupational Health
C. C. M. Stuijt, C. L. Bekker, B. J. F. van den Bemt, F. Karapinar
Summary: Although medication reconciliation is effective in reducing medication discrepancies, its impact on Adverse Events (AEs) is limited. This study found that while the proportion of patients with AEs after discharge was similar between the control and intervention groups, there was a significant reduction in the median number of potential AEs in the intervention group. The intervention was more effective in reducing potential AEs among women compared to men, and previous hospital admissions were associated with a higher number of potential AEs.
RESEARCH IN SOCIAL & ADMINISTRATIVE PHARMACY
(2021)
Article
Pharmacology & Pharmacy
Fatema A. Alqenae, Douglas Steinke, Andrew Carson-Stevens, Richard N. Keers
Summary: Medication-related incidents during transition of care from secondary to primary care are common and associated with patient harm. The most common contributory factors are organization factors and staff factors.
THERAPEUTIC ADVANCES IN DRUG SAFETY
(2023)
Article
Nursing
Janique Gabrielle Jessurun, Nicole Geertruida Maria Hunfeld, Michelle de Roo, Hein Antonius Walterus van Onzenoort, Joost van Rosmalen, Monique van Dijk, Patricia Maria Lucia Adriana van den Bemt
Summary: This study identified a high prevalence of medication administration errors (MAEs). The findings suggest that focusing interventions on complex pharmaceutical forms and error-prone administration times may contribute to reducing MAEs.
JOURNAL OF CLINICAL NURSING
(2023)
Article
Pharmacology & Pharmacy
Fatema Hashemi, Thomas G. van Gelder, Casper W. Bollen, Yves T. B. Liem, Toine C. G. Egberts
Summary: The study assessed the impact of a specific dosing CDSS on reducing prescription errors in a paediatric intensive care unit, and found that it significantly reduced unintentional prescription dose deviations.
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2022)
Article
Oncology
Eward J. Melis, Jeannette E. F. Zwart-van Rijkom, Toine C. G. Egberts, Bart J. F. van den Bemt, Petronella O. Witteveen, Helga Gardarsdottir
Summary: This study assesses the association between patient satisfaction with information about oral anticancer agents and adherence. The results showed no significant relationship between patient satisfaction with information and adherence, despite the high level of satisfaction with the information. However, 35.5% of patients were found to be non-adherent based on refill data.
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
(2023)
Article
Public, Environmental & Occupational Health
E. M. Smale, T. C. G. Egberts, E. R. Heerdink, B. J. F. van den Bemt, C. L. Bekker
Summary: The study aims to identify key factors underlying the willingness of cancer patients to participate in the redispensing of unused oral anticancer drugs. Semi-structured interviews were conducted with adult cancer patients from two Dutch hospitals, using the COM-B model as a framework to understand patients' capability, opportunity and motivation to participate in medication redispensing. Thematic analysis revealed factors such as positive societal impact, trust in product quality, adequate information provision, and a convenient process to be important for patient participation in medication redispensing.
RESEARCH IN SOCIAL & ADMINISTRATIVE PHARMACY
(2022)
Article
Health Care Sciences & Services
Janique G. Jessurun, Nicole G. M. Hunfeld, Joost van Rosmalen, Monique van Dijk, Patricia M. L. A. van den Bemt
Summary: The centralized intravenous admixture service showed significant improvement in reducing intravenous admixture preparation errors and noncompliance to hygiene procedures compared to clinical wards. Nurses were satisfied with the CIVAS.
JOURNAL OF PATIENT SAFETY
(2022)
Article
Public, Environmental & Occupational Health
Janique Gabrielle Jessurun, Nicole Geertruida Maria Hunfeld, Monique van Dijk, Patricia Maria Lucia Adriana van den Bemt, Suzanne Polinder
Summary: This study evaluated the cost-effectiveness of cADD with BCMA compared to usual care and found that this intervention can reduce the rate of medication errors, including harmful ones, at higher overall costs. The costs per avoided error are relatively low, suggesting that this intervention could be an important strategy to improve patient safety in hospitals.
RESEARCH IN SOCIAL & ADMINISTRATIVE PHARMACY
(2022)
Review
Computer Science, Information Systems
Britt W. M. van de Burgt, Arthur T. M. Wasylewicz, Bjorn Dullemond, Rene J. E. Grouls, Toine C. G. Egberts, Arthur Bouwman, Erik M. M. Korsten
Summary: This review examines the use of text mining and clinical decision support in clinical practice, discussing their potential benefits, implementation challenges, and barriers. The findings suggest that combining text mining and clinical decision support can improve diagnostic and therapeutic processes, leading to increased patient safety. However, there are still barriers to implementation that need to be addressed through further research.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2023)
Article
Genetics & Heredity
Corine de Jong, Gerarda J. M. Herder, Simone W. A. van Haarlem, Femke S. van der Meer, Anne S. R. van Lindert, Alexandra ten Heuvel, Jan Brouwer, Toine C. G. Egberts, Vera H. M. Deneer
Summary: This study investigated the genetic risk factors for chemotherapy-induced peripheral neuropathy (CIPN) in non-small cell lung cancer (NSCLC) patients. It revealed that the GG genotype of TRPV1 gene (rs879207) is associated with an increased risk of severe neuropathy. Additionally, concomitant use of paclitaxel and GG genotype also showed a significant association with severe CIPN.
Article
Biophysics
T. (Tim) Bognar, J. S. (Jurjen) Kingma, E. H. (Erin) Smeijsters, K. C. M. (Kim) van der Elst, C. T. M. (Klaartje) de Kanter, C. A. (Caroline) Lindemans, A. C. G. (Toine) Egberts, I. H. (Imke) Bartelink, A. (Arief) Lalmohamed
Summary: This observational study assessed the impact of therapeutic drug monitoring on busulfan exposure in pediatric patients undergoing hematopoietic cell transplantation. The results showed no significant difference in achieving therapeutic busulfan exposure between the two monitoring regimens, suggesting that day 1-guided dosing may be sufficient with subsequent monitoring if needed.
BONE MARROW TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Darko Mitrovic, Margriet van Elp, Loes Visser, Nienke van Rein, Patricia van den Bemt, Marinus van Hulst, Albert Dreijer, Heleen Lameijer, Nic Veeger, Karina Meijer, Eric van Roon
Summary: This study aimed to evaluate the adherence to protocols for the use of reversal agents in Dutch hospitals. The results showed that overall adherence to the protocol for bleeding under DOAC was moderate, but it was low for patients needing an urgent procedure.
CURRENT MEDICAL RESEARCH AND OPINION
(2023)
Article
Immunology
Marjon V. Verschueren, Talitha Dijs, Judith L. Gulikers, Ard van Veelen, Sander Croes, Lizza E. L. Hendriks, Adrianus A. J. Smit, Lourens T. Bloem, Antoine C. G. Egberts, Ewoudt M. W. van de Garde, Bas J. M. Peters
Summary: Real-world stage III NSCLC patients who received durvalumab after CRT had better outcomes than those who received CRT alone. Longer PFS in real-world versus trial may be due to follow-up differences.
Article
Health Care Sciences & Services
Laura Mortelmans, Eva Goossens, Anne-Marie De Cock, Mirko Petrovic, Patricia van den Bemt, Tinne Dilles
Summary: This study aimed to develop recommendations for healthcare providers to support patients with medication self-management problems. Through three phases of research, 20 medication self-management problems were identified, and 67 relevant recommendations were established. These recommendations can serve as a resource for healthcare providers to support patients with medication self-management problems.
Article
Hematology
Anouk A. M. T. Donners, Konrad van der Zwet, Carin M. A. Rademaker, Toine C. G. Egberts, Roger E. G. Schutgens, Kathelijn Fischer
Summary: This study evaluated the efficacy of entire-vial dosing of emicizumab in a real-world setting. The results demonstrated that this dosing method can achieve therapeutic plasma concentrations, effectively control bleeding, and reduce drug waste.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Pharmacology & Pharmacy
Renate C. A. E. van Uden, Marit A. Bakker, Stephan G. L. Joosten, Karina Meijer, Patricia M. L. A. van den Bemt, Matthijs L. Becker, Marcia Vervloet
Summary: This study investigated the implementation of an antithrombotic questionnaire tool in community pharmacy practice and identified potential barriers and facilitators. The questionnaire tool was found to be easily adaptable and easy to use, with a relatively short duration for completion, which facilitated implementation. However, a possible barrier was a lower priority for using the questionnaire when workload was high.
Article
Pharmacology & Pharmacy
Celine Koot, Marion Rook, Patricia A. M. Pols, Patricia M. L. A. van den Bemt, Matthijs L. Becker
Summary: Medication discrepancies can lead to adverse drug events, and lack of communication between hospitals and community pharmacies is a major cause. This study aimed to reduce unintentional medication discrepancies after discharge by electronically transmitting basic discharge medication reports. The intervention significantly reduced the proportion of drugs with discrepancies, but not the proportion of patients with discrepancies.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2023)