Article
Medicine, General & Internal
Nicholas A. Turner, Rebekah Wrenn, Christina Sarubbi, Renee Kleris, Patricia L. Lugar, Christine Radojicic, Rebekah W. Moehring, Deverick J. Anderson
Summary: A pharmacist-led allergy assessment program was associated with decreased use of nonpenicillin alternative antibiotics and high-CDI-risk antibiotics at the hospital level. Individual patients who underwent comprehensive allergy assessment were less likely to receive high-CDI-risk antibiotics at discharge, indicating potential benefits of allergy delabeling. However, reductions in mortality and hospital-acquired CDI risk did not reach statistical significance, suggesting longer-term benefits may require further study.
Article
Pharmacology & Pharmacy
Jinhui Xu, Jian Huang, YanXia Yu, Dayong Zhou, Ying Wang, Sudong Xue, Erning Shang, Jiantong Sun, Xinyuan Ding, Lu Shi, Lufen Duan, Lian Tang, Qin Zhou, Xin Li
Summary: This study provides evidence that implementation of AMS interventions was associated with a marked reduction of antibiotic use, cost of antibiotics, and irrationality of antibiotic prescribing in China.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Ying Wang, Chongchong Zhou, Chengying Liu, Shuanghai Liu, Xiaoliang Liu, Xin Li
Summary: The study evaluates the impact of antimicrobial stewardship programs driven by pharmacists on antibiotic consumption, costs, and appropriateness of use. The results reveal that the implementation of these programs can reduce hospital stay, decrease antibiotics use and costs, and improve appropriateness of antimicrobial use.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Infectious Diseases
Oana Joean, Daniel Tahedl, Madita Flintrop, Thorben Winkler, Ruxandra Sabau, Tobias Welte, Markus A. Kuczyk, Ralf-Peter Vonberg, Jessica Rademacher
Summary: Antimicrobial stewardship programs can effectively reduce antibiotic use and resistance rates without increasing infection-related complications in urologic settings, highlighting their importance in this field.
Article
Infectious Diseases
Bushra Salman, Amna Al-Hashar, Athar Al-Khirbash, Ibrahim Al-Zakwani
Summary: In 2018, clinical pharmacists' interventions on antimicrobial use at Sultan Qaboos University Hospital in Oman had a positive impact on both clinical and financial outcomes. The most common intervention types were adjusting dosing regimens and deletion of antimicrobial orders.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Infectious Diseases
Jan J. De Waele, Jerina Boelens, Dirk Van De Putte, Diana Huis In't Veld, Tom Coenye
Summary: Intra-abdominal infections are common in hospitalized patients and require antimicrobial therapy and source control. The use of abdominal drains is increasing for treating these infections, but biofilm formation in the drains makes using abdominal fluid for diagnosis unreliable.
Article
Infectious Diseases
Bindiya Bagga, Jeremy S. Stultz, Sandra Arnold, Kelley R. Lee
Summary: This study demonstrates that a pediatric ASP based on guideline development and prospective audit with feedback can improve antibiotic utilization and institutional bacterial susceptibilities without negatively affecting patient outcomes.
Article
Immunology
Rebecca O'Toole, Kathryn A. Martinez, Michael B. Rothberg, Gillian Diiorio, Edward A. Stenehjem, Kristina E. Ward, Kerry L. LaPlante
Summary: The rapid growth of telehealth services has led to the emergence of direct-to-consumer telemedicine platforms, where patients can acquire antibiotic prescriptions online without a consultation. This trend raises concerns about appropriate antibiotic use and patient safety. Recent experiences with two such platforms revealed the need for stronger antimicrobial stewardship efforts and safety measures.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Pharmacology & Pharmacy
Jie Cheng, Chuandong Dang, Xiao Li, Jianjun Wang, Xin Huang, Yan Li, Xueyan Cui
Summary: This study evaluated the impact of clinical pharmacists on the anti-infective treatment of patients with central nervous system infections (CNSI) in neurosurgery. The results showed that pharmacist-led antimicrobial stewardship programs significantly improved the rational use of antibiotics and decreased antibiotic use density.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jing Yu, Yan Liu, Ruochen Qu, Ziyang Wang, Yan Zhao, Yuanyuan Zhao, Chunhua Zhou
Summary: The study successfully reduced the use of antibacterial agents among patients in neurosurgical ICU through the implementation of a comprehensive Antimicrobial Stewardship program, leading to a significant decrease in the rate of drug-resistant bacterial infections.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Infectious Diseases
Oana Sandulescu, Anca Streinu-Cercel, Maria Magdalena Motoi, Adrian Streinu-Cercel, Liliana Lucia Preotescu
Summary: The implementation of multiplex polymerase chain reaction for syndromic testing in clinical practice has allowed for early diagnosis and targeted treatment. However, diagnostic stewardship is necessary to prevent the risks of misdiagnosis. We present two cases illustrating the importance of proper diagnostic stewardship for patient management and antimicrobial usage.
Article
Critical Care Medicine
Prateek Sehgal, Marion Elligsen, Jennifer Lo, Philip W. Lam, Jerome A. Leis, Rob Fowler, Ruxandra Pinto, Nick Daneman
Summary: The study evaluated the long-term uptake of an antimicrobial stewardship program in a diverse ICU population and identified factors associated with stewardship suggestions and acceptance rates. The findings showed sustained suggestion and acceptance rates over a decade and highlighted the importance of persistent presence of audit-and-feedback, especially for potentially nephrotoxic agents and specialized care units.
CRITICAL CARE MEDICINE
(2021)
Article
Infectious Diseases
Savera Arain, Fahad Khalawi, Sainul Abideen Parakkal, Hassan S. S. AlHamad, Shabeer Ali Thorakkattil, Faisal Fahad J. Alghashmari, Bader AlHarbi, Nujud Bakhashwain, Weaam Mustafa Alzawad, Ali AlHomoud
Summary: This study aimed to evaluate the utilization practice of piperacillin/tazobactam in a hospital setting and assess the impact of pharmacist intervention. The results showed that inappropriate usage of piperacillin/tazobactam was improved with pharmacist intervention, including dose optimization, timely bacterial culture orders, prompt de-escalation, and adherence to extended infusion guidelines. The study highlighted the important role of pharmacists in improving the quality and safety of medication use in healthcare organizations globally.
Article
Surgery
Shannon L. Cramm, Nicole M. Chandler, Dionne A. Graham, Shaun M. Kunisaki, Robert T. Russell, Martin L. Blakely, Aaron M. Lipskar, Myron Allukian, Danielle I. Aronowitz, Brendan T. Campbell, Devon T. Collins, Sarah J. Commander, Robert A. Cowles, Jennifer R. Defazio, Joseph R. Esparaz, Christina Feng, Cornelia L. Griggs, Richard A. Guyer, David N. Hanna, Anastasia M. Kahan, Olivia A. Keane, Abdulraouf Lamoshi, Carla M. Lopez, Elizabeth Pace, Maia D. Regan, Matthew T. Santore, Stefan Scholz, Elisabeth T. Tracy, Sacha A. Williams, Lucy Zhang, Shawn J. Rangel
Summary: Redosing antibiotics within an hour of incision was not associated with a reduction in the risk of incisional site infection in children with appendicitis, unless cefoxitin was used as the initial antibiotic.
Article
Infectious Diseases
Roberta Manente, Biagio Santella, Pasquale Pagliano, Emanuela Santoro, Vincenzo Casolaro, Anna Borrelli, Mario Capunzo, Massimiliano Galdiero, Gianluigi Franci, Giovanni Boccia
Summary: This study analyzed the bacterial species involved in ocular infections and their antimicrobial susceptibility patterns. It found that coagulase-negative staphylococci (CoNS) were the most commonly isolated Gram-positive bacteria, while Pseudomonas spp. and Escherichia coli were the main species isolated among Gram-negative bacteria. Resistance rates for certain antibiotics increased over time. The findings provide valuable information for improving treatments and antibiotic choices for ocular infections.
Letter
Public, Environmental & Occupational Health
Rodrigo Pires dos Santos, Lucas Magedanz, Erci Maria Onzi Siliprandi
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2009)
Article
Public, Environmental & Occupational Health
T. S. Jacoby, R. S. Kuchenbecker, R. P. dos Santos, L. Magedanz, P. Guzatto, L. B. Moreira
JOURNAL OF HOSPITAL INFECTION
(2010)
Article
Public, Environmental & Occupational Health
Lucas Magedanz, Jessica Vick de Oliveira Leal, Brenda Leandro dos Santos, Evelin Soares de Brito, Pamela Alejandra Escalante Saavedra, Leticia Santana da Silva Soares, Leticia da Costa Lima D'Oliveira, Dayani Galato
Summary: This article describes the distribution of Transplant Centers and hematopoietic stem-cell transplants in Brazil. The study found that the majority of transplant centers are located in the southeastern region of the country, with none in the northern region. The procedures performed were mainly concentrated in the southeastern and southern regions, with allogeneic transplants being the most prevalent. The distribution and number of transplants were concentrated in more developed regions, leading to potential inequities in access to treatment.
CIENCIA & SAUDE COLETIVA
(2022)
Article
Public, Environmental & Occupational Health
Leticia Santana da Silva Soares, Evelin Soares de Brito, Lucas Magedanz, Fernanda Alves Franca, Wildo Navegantes de Araujo, Dayani Galato
EPIDEMIOLOGIA E SERVICOS DE SAUDE
(2020)