Review
Biochemistry & Molecular Biology
Silvia Moreira, Ricardo Silva, David F. Carrageta, Marco G. Alves, Vicente Seco-Rovira, Pedro F. Oliveira, Maria de Lourdes Pereira
Summary: Carbamates, widely used as pesticides, have both medical applications and adverse effects on the male reproductive system. Their inhibitory effect on acetylcholine hydrolyzation can lead to male fertility problems and disrupt the male endocrine system. The molecular mechanisms behind these effects are not fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fang-Hao Yang, Xiao-Lei Dong, Guo-Xiang Liu, Lei Teng, Lin Wang, Feng Zhu, Feng-Hua Xu, Yi-Fan Yang, Can Cao, Guang Chen, Bing Li
Summary: This study demonstrates that C-phycocyanin can protect GC-1 spg cells and the reproductive system of male mice from injury, and it has antioxidant and inhibitory effects on the necroptotic signaling pathway. Therefore, C-phycocyanin could serve as a promising reproductive system protective agent.
Review
Biology
Vittoria Rago, Anna Perri
Summary: Many studies have shown that SARS-CoV-2 can affect the male reproductive system, particularly the testes and male fertility. Autoptic studies have revealed morphological alterations in the testes, including congestion, thrombosis, reduction of various cells, immune cell infiltration, and atrophic tubules. Men with severe infection also exhibit sperm parameter alterations and abnormalities in the hypothalamic-pituitary-testis axis, indicating a potential risk of male infertility. However, the presence of the virus in the testis and semen is still unclear. Multicentric and longitudinal studies are needed to fully understand the impact of SARS-CoV-2 on male reproduction.
Review
Endocrinology & Metabolism
Xu Zhang, Tongtong Zhang, Xiaohan Ren, Xinglin Chen, ShangQian Wang, Chao Qin
Summary: This study conducted a systematic review and meta-analysis on the effects of pyrethroid exposure on the male reproductive system, finding that exposure could reduce sperm quality and affect the reproductive system of F1 offspring. Pyrethroid exposure may lead to oxidative stress, damaging the male reproductive system.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Dana Kimelman, Andrea Torrens, Carla Bonelli, Rossana Sapiro
Summary: The study aims to evaluate the reproductive outcomes of male cancer survivors who underwent sperm freezing and assess the oncofertility counseling they received. The results show that a significant number of survivors attempted to conceive and achieved natural pregnancy, while others used their cryopreserved samples. Most survivors believed that the timing of oncofertility referrals was appropriate and considered fertility preservation important.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Bruno Garcia Montagnini, Simone Forcato, Karine Vandressa Pernoncine, Mariana Cunha Monteiro, Marina Rangel Ferro Pereira, Nathalia Orlandini Costa, Estefania Gastadello Moreira, Janete Aparecida Anselmo-Franci, Daniela Cristina Ceccatto Gerardin
Summary: The study found that TCS may act as an endocrine disruptor for the reproductive system. Exposure to TCS was shown to decrease sperm viability and motility, potentially related to the programming of reproductive cells during fetal/neonatal development.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Obstetrics & Gynecology
R. John Aitken
Summary: In modern post-transition societies, delayed reproduction and increased lifespan are observed. The impact of age on female reproduction has been extensively studied, however, the relationship between age and male reproduction is less known. It is now understood that male fertility declines with advancing age, accompanied by reduced testosterone levels, age-dependent reproductive pathologies, and increased sperm DNA damage. Age-related effects in males also result in an elevated disease burden in offspring, including genetic diseases and neuropsychiatric conditions. The underlying genetic mechanisms involve positive selection of stem cells containing mutations and increased oxidative stress which impairs reproductive function. Antioxidants may play a role in managing age-related effects on male reproduction, although clinical trials are needed.
HUMAN REPRODUCTION
(2023)
Article
Multidisciplinary Sciences
Cankiz Mina Ardic, Sinem Ilgin, Merve Baysal, A. Burak Karaduman, Volkan Kilic, Gozde Aydogan-Kilic, Seyda Ucarcan, Ozlem Atli-Eklioglu
Summary: The research revealed that olanzapine had toxic effects on the reproductive system of rats, causing abnormalities in testicular structure, decreased normal sperm morphology, alterations in hormone levels, and oxidative stress in the testis.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, General & Internal
Agnieszka Markiewicz-Gospodarek, Paulina Wdowiak, Marcin Czeczelewski, Alicja Forma, Jolanta Flieger, Jacek Januszewski, Elzbieta Radzikowska-Buchner, Jacek Baj
Summary: The SARS-CoV-2 infection can potentially impact the reproductive systems of both females and males, potentially leading to disruptions in human fertility.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Gabriela Caetano, Ines Bozinovic, Charlotte Dupont, Damien Leger, Rachel Levy, Nathalie Sermondade
Summary: Results of the study suggest that sleep parameters may affect female and male reproductive functions, with short sleep duration, evening chronotype, or shift/night work schedules potentially impacting fertility and IVF outcomes. However, due to heterogeneous study methodologies, the results were difficult to compare.
FERTILITY AND STERILITY
(2021)
Review
Andrology
Aliasghar Ghafarizadeh, Mahdi Malmir, Samira Naderi Noreini, Tayebeh Faraji
Summary: N-acetyl cysteine, a powerful antioxidant compound, has been proven to improve and normalize spermatogenesis in the male reproductive system.
Article
Multidisciplinary Sciences
Erin L. McCullough, Emma Whittington, Akanksha Singh, Scott Pitnick, Mariana F. Wolfner, Steve Dorus
Summary: This study investigates the life history of Drosophila melanogaster sperm proteome and reveals substantial compositional changes after sperm are transferred to the female reproductive tract (FRT). Multiple seminal fluid proteins initially associate with sperm, but become undetectable after sperm storage. Female-derived proteins also associate with sperm immediately after mating, and contribute nearly 20% to the postmating sperm proteome after storage in the FRT. These female-derived proteins are enriched in processes associated with energy metabolism, suggesting their role in supporting sperm viability during the period between copulation and fertilization.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Andrology
Sonali Bhattacharya, Sudipta Majumdar Nee Paul
Summary: The application of nanotechnology has had a significant impact on various fields, but concerns about the potential harmful effects of nanomaterials on biological systems and the environment remain. Research on the effects of engineered nanomaterials on the reproductive system of mammals and fertility is still in its early stages. Modifications of metal and metal oxide nanoparticles offer a way to create a safe therapeutic system for the male reproductive system.
SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE
(2023)
Article
Environmental Sciences
Samah S. Oda, El-Sayed M. El-Manakhly, Mohamed A. Abou-Srag, Hossam G. Tohamy
Summary: The study revealed that carbofuran and copper sulfate have a negative impact on the reproductive function of male Nile tilapia, with their combination showing a stronger harmful effect. Exposure to these chemicals led to testicular damage, reduced sperm quality and quantity in male Nile tilapia.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Reproductive Biology
Hamid Raei, Mohammad Amir Karimi Torshizi, Mohsen Shara, Hamed Ahmadi
Summary: This study found that 50 mg camphor/kg of feed had a positive impact on semen quality and reproductive performance in roosters, while higher doses of camphor also affected sperm motility characteristics and antioxidant capacity. Further research is needed to explore the effects of higher levels of camphor and the underlying mechanisms on male reproductive function.