Article
Dentistry, Oral Surgery & Medicine
Ming Ying, Bin Zhang
Summary: This study investigated the effect of daidzein on the proliferation and osteogenic differentiation of human periodontal ligament stem cells. It was found that daidzein promotes these processes by activating the Wnt/β-catenin signaling pathway.
Article
Biochemistry & Molecular Biology
Maria Abancens, Brian J. Harvey, Jean McBryan
Summary: Women have lower incidence and mortality rates for colorectal cancer compared to men. Estrogen may protect against colorectal cancer progression through GPER-mediated modulation of the Wnt/beta-catenin pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mohd Farhan, Mohamed El Oirdi, Mohammad Aatif, Insha Nahvi, Ghazala Muteeb, Mir Waqas Alam
Summary: Cancer incidence varies globally, suggesting a correlation between food and cancer risk. Plant polyphenols, specifically isoflavones like genistein and daidzein found in soybeans, have been identified as potential anticancer agents. Epidemiological studies have shown that soy consumption is associated with a decreased risk of certain cancers. Our research demonstrates that isoflavones inhibit prostate cancer cell growth by increasing endogenous copper levels, highlighting the significance of copper dynamics and providing new insights into the potential use of isoflavones as cancer-fighting nutraceuticals.
Article
Multidisciplinary Sciences
Line Mygland, Shoshy Alam Brinch, Martin Frank Strand, Petter Angell Olsen, Aleksandra Aizenshtadt, Kaja Lund, Nina Therese Solberg, Max Lycke, Tor Espen Thorvaldsen, Sandra Espada, Dorna Misaghian, Christian M. Page, Oleg Agafonov, Stale Nygard, Nai-Wen Chi, Eva Lin, Jenille Tan, Yihong Yu, Mike Costa, Stefan Krauss, Jo Waaler
Summary: Small-molecule tankyrase 1 and tankyrase 2 (TNKS1/2) inhibitors have shown to be effective antitumor agents in specific tumor cell lines, with the ability to inhibit key signaling pathways and reduce expression of crucial oncogenes, ultimately impairing cell growth. Additionally, these inhibitors induce the accumulation of beta-catenin degradasomes containing TNKS1/2, which interact with YAP and angiomotin proteins, leading to attenuation of YAP signaling. Further research is needed to fully evaluate the potential of TNKS inhibitors in cancer treatment.
Article
Genetics & Heredity
Winston R. Becker, Stephanie A. Nevins, Derek C. Chen, Roxanne Chiu, Aaron M. Horning, Tuhin K. Guha, Rozelle Laquindanum, Meredith Mills, Hassan Chaib, Uri Ladabaum, Teri Longacre, Jeanne Shen, Edward D. Esplin, Anshul Kundaje, James M. Ford, Christina Curtis, Michael P. Snyder, William J. Greenleaf
Summary: Single-cell ATAC-seq and RNA-seq profiling were used to study the transformation process from healthy colon to precancerous adenomas to colorectal cancer. Most of the polyp and CRC cells exhibited a stem-like phenotype. The study identified a continuum of epigenetic and transcriptional changes that occur in stem-like cells as they progress from homeostasis to CRC. The results also revealed the presence of T cell exhaustion and specific fibroblast subtypes in advanced polyps and cancerous states. Additionally, DNA methylation changes were found to be negatively correlated with accessibility changes, providing potential regulatory markers for polyp staging.
Article
Cell Biology
Xiaoxuan Duan, Yihuan Chen, Kai Zhang, Wei Chen, Jun Zhao, Xiaoshuo Dai, Wenbo Cao, Ziming Dong, Saijun Mo, Jing Lu
Summary: This study found that phosphoglycerate dehydrogenase (PHGDH) was highly expressed in esophageal squamous carcinoma (ESCC), and high expression was associated with poor prognosis. In vitro and in vivo experiments demonstrated that PHGDH knockdown inhibited ESCC progression by suppressing Wnt/beta-catenin signaling pathway. These results indicate that PHGDH may be a potential therapeutic target for ESCC.
CELLULAR SIGNALLING
(2023)
Article
Oncology
Kathleen A. O'Leary, Debra E. Rugowski, Michael P. Shea, Ruth Sullivan, Amy R. Moser, Linda A. Schuler
Summary: Prolactin (PRL) collaborates with Apc(Min/+) to increase tumor incidence and modulate cancer stem cell activity through Notch-driven signals, shedding light on mechanisms whereby PRL elevates risk of breast cancer.
Article
Agriculture, Multidisciplinary
Duoduo Zhang, Xingtao Zhou, Linyuan Liu, Mi Guo, Tongwen Huang, Wengan Zhou, Fang Geng, Steve W. Cui, Shaoping Nie
Summary: The study revealed that glucomannan from Aloe vera gel promoted proliferation and differentiation of intestinal stem cells through the Wnt/β-catenin signaling pathway, facilitating epithelial cell regeneration and alleviating colitis in mice.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Hematology
Yue Sheng, Rui Ma, Chunjie Yu, Qiong Wu, Steven Zhang, Kimberly Paulsen, Jiwang Zhang, Hongyu Ni, Yong Huang, Yi Zheng, Zhijian Qian
Summary: This study investigated the dosage effect of c-Myc on hematopoiesis and its role in the Wnt/beta-catenin pathway in HSC and bone marrow niche cells. The results demonstrated the critical role of Nr4a1, Nr4a2, and Jmjd3 as downstream targets of c-Myc in HSCs. Additionally, the study provided evidence of c-Myc-mediated Apc loss inducing IL6 secretion in endothelial cells and its impact on erythroid cell differentiation.
Article
Pharmacology & Pharmacy
Hyeon Ji Kim, Tae-Jun Kim, Yu Gyung Kim, Chaeeun Seong, Jin-Hwa Cho, Wanil Kim, Kyung-Ha Lee, Do-Yeon Kim
Summary: Finasteride, known for treating benign prostate hyperplasia and androgenic alopecia, shows potential as an anti-glioblastoma drug by inhibiting glioma stem-like cells maintenance and glioblastoma proliferation, possibly through lowering intracellular ROS levels and reducing beta-catenin accumulation.
Article
Biotechnology & Applied Microbiology
Zhi Fang, Min Zhong, Ling Zhou, Yi Le, Heng Wang, Ziling Fang
Summary: LRP8 is markedly overexpressed in NSCLC tissues and cell lines, correlating with poor clinicopathological characteristics and prognosis. Depletion of LRP8 suppresses proliferation, migration, invasion, and epithelial-mesenchymal transition of NSCLC cells, partly by inhibiting the Wnt/beta-catenin pathway.
Article
Biotechnology & Applied Microbiology
Yuanzhe Zhu, Huala Wu, Xi Yang, Zhijuan Xiong, Tiantian Zhao, Xin Gan
Summary: This study revealed that LINC00514 is upregulated in NSCLC and plays a role in the proliferation, migration, and invasion of NSCLC cells through activation of the Wnt/β-catenin pathway and EMT. Silencing LINC00514 restored the biological phenotypes of NSCLC cells by inhibiting the Wnt/β-catenin pathway. Additionally, silencing LINC00514 attenuated the growth of xenograft tumors in vivo.
Article
Oncology
Wei Zhang, Yanwei Zhang, Wensheng Zhou, Fangfei Qian, Minjuan Hu, Ya Chen, Jun Lu, Yuqing Lou, Baohui Han
Summary: PlGF plays a role in promoting cell proliferation and glycolysis in LUAD cells through activating the Wnt/β-catenin pathway. Knockdown of PlGF significantly inhibits these processes.
CANCER CELL INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Pratyusha Bala, Jonathan P. Rennhack, Daulet Aitymbayev, Clare Morris, Sydney M. Moyer, Gina N. Duronio, Paul Doan, Zhixin Li, Xiaoyan Liang, Jason L. Hornick, Matthew B. Yurgelun, William C. Hahn, Nilay S. Sethi
Summary: Cell state plasticity is regulated in adult epithelia to prevent cancer, but its expansion in neoplasia is poorly understood. Mouse models and patient samples revealed that impaired differentiation precedes cancer development, with aberrant transcriptional state marked by Ly6a and reactivation of fetal genes. Genetic inactivation of Sox9 prevents adenoma formation and restores multilineage differentiation. These findings indicate that unabated regenerative activity and developmental reprogramming contribute to the aberrant cell state plasticity preceding cancer development.
Review
Biochemistry & Molecular Biology
Qiyun Xiao, Johannes Werner, Nachiyappan Venkatachalam, Kim E. Boonekamp, Matthias P. Ebert, Tianzuo Zhan
Summary: Targeting cancer hallmarks is crucial for improving anti-cancer treatment, but cross-talk between signaling pathways often leads to resistance. This article provides an overview of the molecular interactions between the p53 and Wnt pathways in cancer, including complex feedback loops and reciprocal transactivation, as well as the mutational landscape of genes associated with these pathways.
Article
Oncology
Raquely M. Lenzi, Luciano H. Campestrini, Simone C. Semprebon, Jonas A. R. Paschoal, Monique A. G. Silva, Selma F. Zawadzki-Baggio, Mario S. Mantovani, Carmen L. O. Petkowicz, Juliana B. B. Maurer
Summary: Consumption of GL-rich foods like Brassica vegetables and maca is linked to reduced cancer risk. Maca has significantly higher GL content and shows growth-inhibitory effects against cancer cell lines, supporting its categorization as a superfood.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Rafael Claudino dos Santos, Raquel Oliveira Nascimento de Freitas, Mary Ann Foglio, Joao Ernesto de Carvalho, Ana Lucia Tasca Goes Ruiz, Lucas Roberto Pessatto, Rodrigo Juliano Oliveira, Adrivanio Baranoski, Bruna Isabela Biazi, Mario Sergio Mantovani, Candida Aparecida Leite Kassuya, Pedro Cruz de Oliveira Junior, Anelise Samara Nazari Formagio
Summary: This study synthesized and evaluated a series of galloyl-substituted compounds for their antiproliferative activity. The results showed that some of these compounds exhibited moderate to high inhibition activity against various human cancer cells, and galloyl hydrazide also demonstrated cytotoxicity in hepatocarcinoma cells.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2022)
Article
Toxicology
Andressa Megumi Niwa, Simone Cristine Semprebon, Glaucia Fernanda Rocha D'Epiro, Lilian Areal Marques, Thalita Alves Zanetti, Mario Sergio Mantovani
Summary: The study demonstrates that salinomycin has antitumor potential against human hepatocellular carcinoma cells through inducing cell cycle arrest, upregulating certain genes related to apoptosis, and modulating hepatic cytochrome P450 expression. These findings suggest that salinomycin may interfere with chemotherapy treatment by affecting metabolizing enzymes and should be considered in conjunction with other treatments.
TOXICOLOGY MECHANISMS AND METHODS
(2022)
Article
Environmental Sciences
Luan Vitor Alves de Lima, Matheus Felipe da Silva, Virginia Marcia Concato, Debora Berbel Lirio Rondina, Thalita Alves Zanetti, Ingrid Felicidade, Lilian Areal Marques, Sandra Regina Lepri, Ane Stefano Simionato, Galdino Andrade Filho, Giuliana Castello Coatti, Mario Sergio Mantovani
Summary: Fluopsin C, an antibiotic compound derived from microorganisms, has exhibited antitumor, antibacterial, and antifungal activities. This study investigated the mechanisms of fluopsin C's antiproliferative effects, including cytotoxicity, genotoxicity, cell cycle arrest, apoptosis induction, mitochondrial membrane potential change, and modulation of mRNA expression of genes involved in stress response and cell death. The results demonstrated that fluopsin C interferes with tumor spheroid growth and regulates essential molecular processes associated with stress and cell death.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2022)
Article
Biotechnology & Applied Microbiology
Matheus Felipe da Silva, Luan Vitor Alves de Lima, Thalita Alves Zanetti, Ingrid Felicidade, Phelipe Oliveira Favaron, Sandra Regina Lepri, Debora Berbel Lirio Rondina, Mario Sergio Mantovani
Summary: This study aimed to evaluate the mechanisms of action of diosgenin in human hepatocellular carcinoma cells. The results showed that diosgenin induced cell cycle arrest and apoptosis through DNA damage, leading to reduced cell viability and inhibited growth of spheroids.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2022)
Article
Endocrinology & Metabolism
Marilia Rizzon Zaparolli Ramos, Ingrid Felicidade, Ligia de Oliveira Carlos, Nathalia Ramori Farinha Wagner, Mario Sergio Mantovani, Luan Vitor Alves de Lima, Lucia Regina Ribeiro, Thiago Inacio Barros Lopes, Fernanda Carla Henrique-Bana, Joao Vitor Zimmerman, Fernando Cesar Macedo Junior, Magda Rosa Ramos da Cruz, Antonio Carlos Ligocki Campos
Summary: This study investigated the effects of probiotic supplementation on the plasma metabolite profile after Roux-Y gastric bypass (RYGB). The results showed that probiotics were associated with significant differences in plasma metabolites, contributing to improved metabolic health.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Mycology
Cassia Milena de Souza, Alane Tatiana Pereira Moralez, Murilo Moreira dos Santos, Mario Sergio Mantovani, Luciana Furlaneto-Maia, Marcia Cristina Furlaneto
Summary: The structure and genetic factors of switched morphotypes colonies in Candida tropicalis were investigated. The switched colonies had distinct arrangements of ECM, higher amounts of total carbohydrates and proteins in ECM, and higher percentage of hyphae. The expression levels of EFG1, WOR1, and BCR1 were significantly higher in the switched colonies.
Article
Pharmacology & Pharmacy
Lilian Areal Marques, Simone Cristine Semprebon, Bruna Isabela Biazi, Ingrid Felicidade, Thalita Alves Zanetti, Adrivanio Baranoski, Virginia Marcia Concato, Wander Rogerio Pavanelli, Mario Sergio Mantovani
Summary: This study demonstrates the synergistic cytotoxic and antiproliferative effects of Salinomycin and 1,25D on MCF-7 breast carcinoma cells. The combination of these two drugs activates multiple cell death pathways and inhibits cell proliferation, suggesting a potential novel therapy strategy for breast cancer.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Toxicology
Camila Lehnhardt Pires, Thalita Alves Zanetti, Mario Sergio Mantovani, Isabel O'Neill de Mascarenhas Gaivao, Fabio Ferreira Perazzo, Paulo Cesar Pires Rosa, Edson Luis Maistro
Summary: This study investigated the effects of Pracaxi oil on HepG2/C3A cells and found that the oil did not have significant cytotoxic, cell cycle, or apoptosis effects. Additionally, the oil up-regulated genes related to metabolism, cell proliferation, and oxidative stress.
TOXICOLOGY IN VITRO
(2022)
Article
Toxicology
Ana Paula Oliveira De Quadros, Bruna Oshiiwa, Marcel Petreanu, Rivaldo Niero, Paulo Cesar Pires Rosa, Alexandra Christine Helena Frankland Sawaya, Mario Sergio Mantovani, Isabel O'Neill De Mascarenhas Gaivao, Edson Luis Maistro
Summary: Rubus rosifolius, a common medicinal plant in southern Brazil, has been found to have genotoxic and apoptotic effects in in vitro studies, indicating potential risks in human use.
TOXICOLOGY IN VITRO
(2023)
Article
Toxicology
Debora Berbel Lirio Rondina, Luan Vitor Alves de Lima, Matheus Felipe da Silva, Thalita Alves Zanetti, Ingrid Felicidade, Lilian Areal Marques, Giuliana Castello Coatti, Mario Sergio Mantovani
Summary: This study evaluated the cytotoxicity of ZER combined with chemotherapeutic agents and its effect on the expression of mRNA genes related to cell cycle, cell death, xenobiotic metabolism, DNA damage, and endoplasmic reticulum stress. The results showed that ZER had cytotoxic and antiproliferative effects, and could modulate the expression of genes involved in various cellular processes. However, its efficacy might be influenced when combined with other chemotherapeutic agents.
TOXICOLOGY IN VITRO
(2022)
Article
Environmental Sciences
Ana Paula Oliveira de Quadros, Isabel Braganca Baraldi, Marcel Petreanu, Rivaldo Niero, Mario Sergio Mantovani, Isabel O'Neill De Mascarenhas Gaivao, Edson Luis Maistro
Summary: Extracts from the leaves and stems of Rubus rosifolius may have adverse effects on humans, causing genotoxic and mutagenic effects on DNA in cells.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2023)
Article
Environmental Sciences
Liana Martins de Oliveira, Luan Vitor Alves de Lima, Matheus Felipe da Silva, Ingrid Felicidade, Sandra Regina Lepri, Mario Sergio Mantovani
Summary: Curcumin, extracted from Curcuma longa L, has been studied for its antiproliferative activity using different cell culture systems. This study investigated the effects of curcumin on cytotoxicity, genotoxicity, and spheroid growth, and found that curcumin exhibited potential for drug development with antiproliferative activity in cancer.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2023)
Article
Pharmacology & Pharmacy
Nayane de Oliveira Silva, Luan Vitor Alves de Lima, Liana Martins de Oliveira, Matheus Felipe da Silva, Amanda Passuello de Aguiar, Simone Cristine Semprebon, Phelipe Oliveira Favaron, Sandra Regina Lepri, Ingrid Felicidade, Mario Sergio Mantovani
Summary: This study evaluated the antiproliferative effects of ZER on HT-29 cells, and found that ZER could inhibit cell migration, induce apoptosis and cell cycle arrest, and affect key signaling pathways.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Gerontology
Liliya Martynova
Summary: Since the 1960s, the goal of active longevity has been repeatedly mentioned in Russian policy documents. Two interpretations of the term exist, with one considering it synonymous with active aging and the other viewing it as a policy goal alongside other aspects of healthy aging, employment, and social participation. Current observations on active longevity policy implementations show progress in health-care development and social participation, but pose challenges in terms of employment and life expectancy data.
JOURNAL OF AGING & SOCIAL POLICY
(2023)