Article
Endocrinology & Metabolism
Maria Savvateeva, Anna Kudryavtseva, Elena Lukyanova, Anastasiya Kobelyatskaya, Vladislav Pavlov, Maria Fedorova, Elena Pudova, Zulfiya Guvatova, Dmitry Kalinin, Alexander Golovyuk, Elizaveta Bulavkina, Irina Katunina, George Krasnov, Anastasiya Snezhkina
Summary: This study analyzed somatic mutation profiles in HNPGLs and found that most patients had germline and somatic variants in paraganglioma susceptibility genes or related genes. The study also identified six significantly mutated genes and four mutational signatures associated with HNPGLs. These findings provide important insights into the molecular mechanisms involved in the development of HNPGLs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Oncology
Aini Hyytiainen, Wafa Wahbi, Otto Vayrynen, Kauko Saarilahti, Peeter Karihtala, Tuula Salo, Ahmed Al-Samadi
Summary: Most studies did not demonstrate the benefits of angiogenesis inhibitors in the treatment of HNSCC, and these inhibitors were associated with significant toxicity. However, some results showed promising effects, indicating a need for further investigation of angiogenesis inhibitors, particularly in combination therapies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
David Myssiorek, Stephen C. Scharf
Summary: Nuclear medical imaging is commonly used for suspected paragangliomas in the head and neck, but it is not suitable for all patients. Advances in technology and the use of somatostatin receptor analogs have increased the specificity and sensitivity of this imaging technique.
Review
Dentistry, Oral Surgery & Medicine
Cristina Valero, Ian Ganly
Summary: Paragangliomas are rare neuroendocrine tumors that can be found from the skull base to the pelvis. The management of head and neck paragangliomas has changed in recent years, with a trend toward a more conservative approach. Surgical resection is recommended for carotid body tumors, while non-surgical treatments such as observation and radiation therapy are usually preferred for non-carotid body tumors. Factors such as comorbidities, tumor type, and tumor growth rate should be considered when deciding the most appropriate treatment.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2022)
Article
Otorhinolaryngology
Akina Tamaki, Sarah Nyirjesy, Claudia Cabrera, Peter Lancione, Angel Hatef, Robin Rice, Songzhu Zhao, Stephen Y. Kang, Enver Ozer, Amit Agrawal, Matthew O. Old, Nolan B. Seim
Summary: Head and neck paragangliomas have slow growth rates, if they grow at all. Patients in the surgical cohort present with more clinical symptoms and experience significant postoperative symptom worsening.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2022)
Review
Clinical Neurology
John P. Leonetti
Summary: This paper outlines the clinical neurologic presentation and diagnostic evaluation of patients with paragangliomas of the head and neck, and summarizes contemporary management options. Recent research focuses on traditional and robotic image-guided radiosurgery. Paragangliomas are rare, slow-growing tumors of the head and neck that typically present with silent cranial nerve deficits or mild speech and swallowing symptoms. Radiologic surveillance is the optimal treatment choice, but subtotal resection with case-specific radiosurgery is commonly used for large tumors.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Anasuya Guha, Ales Vicha, Tomas Zelinka, Zdenek Musil, Martin Chovanec
Summary: Multiple head and neck paragangliomas (HNPGLs) are mostly benign neuroendocrine tumors associated with germline mutations, with SDHB mutations predisposing to malignant tumors. Patients with multiple HNPGLs are often incidentally found, with some having germline mutations. Preventative measures like genetic counseling and tumor surveillance are key in controlling the disease, as new therapeutic measures have shown limited contribution. Managing patients with multiple HNPGLs, especially those with sporadic or malignant forms, remains challenging due to lack of standardized protocols.
Article
Otorhinolaryngology
Yiming Ding, Lifeng Li, Demin Han, Shaozhong Wang, Xiaohong Chen
Summary: This study retrospectively reviewed 6 patients with head and neck malignant paragangliomas, analyzing their clinicopathological characteristics and genetic mutations. The results showed that after comprehensive treatment, patients can achieve a favorable prognosis, with genetic mutations commonly detected in these patients. Additionally, mutations in ATR and MAP3K13 were identified in this study.
ENT-EAR NOSE & THROAT JOURNAL
(2021)
Review
Oncology
Patryk Gugnacki, Ewa Sierko
Summary: Human microbiome research is rapidly expanding in various medical and public health disciplines, showing potential in oncology for investigating the impact of oral microbiome on oncogenesis and treatment side effects. Studies indicate that the human microbiome can have oncogenic effects through various mechanisms, and that the oral microbiome plays a role in the development of head and neck cancer and radiation-induced oral mucositis. Further research is needed to better understand the structure and dynamics of the oral microbiome to develop personalized preventive measures and treatments.
Article
Oncology
Alessa Fischer, Umberto Maccio, Katharina Wang, Juliane Friemel, Martina A. Broglie Daeppen, Diana Vetter, Kuno Lehmann, Astrid Reul, Mercedes Robledo, Constanze Hantel, Nicole Bechmann, Karel Pacak, Kathrin Zitzmann, Christoph J. Auernhammer, Ashley B. Grossman, Felix Beuschlein, Svenja Noelting
Summary: In pheochromocytomas and paragangliomas, hypoxia upregulates the expression of PD-L1 and HIF-2 alpha, promoting tumor progression and immune microenvironment alterations. Head and neck paragangliomas undergoing embolization show significantly higher expression levels of PD-L1 and HIF-2 alpha, suggesting that targeted treatment using HIF-2 alpha and checkpoint inhibitors may be beneficial.
Article
Oncology
Jia-Qi Wang, Rong-Xin Deng, Hui Liu, Yuan Luo, Meng-Meng Lu, Zhi-Cheng Yang
Summary: This study based on the SEER database demonstrated that HNMM patients often have a favorable prognosis, with distant metastasis, pathological grade, and the use of surgery contributing to their survival. Furthermore, a prognostic nomogram was developed to predict OS and DSS for HNMM patients, aiding physicians in the clinical management of this rare disease.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Leslie Chang, Sherif G. Shaaban, Emile Gogineni, Brandi Page, Harry Quon, Heng Li, Rachel Ger
Summary: This retrospective study aimed to evaluate the absolute fractional deviation for dose and volume treatment metrics using 3 mm vs. 5 mm setup robustness in patients treated with head and neck proton therapy. The results showed that deviations from planning clinical target volumes were greater using 3 mm setup robustness, and the variation was greater for patients with primary and secondary clinical targets. However, the average fractional deviation was less than 1% in primary targets and up to 2% in secondary targets using 3 mm setup uncertainty. Robust optimization using 3 mm setup uncertainty with daily CBCT is recommended for patients being treated with proton head and neck therapy.
Article
Medicine, General & Internal
Anasuya Guha, Martin Chovanec
Summary: Head and neck paragangliomas are rare tumors that require early diagnosis and surgical treatment for tumor control and minimal cranial nerve morbidity. Surgery is curative in most cases, especially for young patients, hereditary and secretory tumors.
Review
Oncology
Hoda Mahdavi
Summary: Locally advanced stages of squamous cancers of the head and neck (LAHNCs) have a high risk of local and systemic relapse. The addition of induction therapy to the standard concurrent chemoradiotherapy (CCRT) has been widely used but did not improve survival rates in unselected populations. The TPF induction regimen showed superiority but did not demonstrate a survival advantage over CCRT alone. Newer systemic therapy combinations are currently being tested to find more effective treatments for LAHNCs.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Oncology
Yong Gan, Johannes A. Langendijk, Arjen van der Schaaf, Lisa van den Bosch, Edwin Oldehinkel, Zhixiong Lin, Stefan Both, Charlotte L. Brouwer
Summary: This study aimed to develop an efficient strategy to select candidates for adaptive radiotherapy (ART) in the first two weeks of head and neck cancer (HNC) radiotherapy. By retrospectively analyzing data from 110 HNC patients, it was found that using the difference between planning and actual dose and clinical relevance as cut-off points could identify potential candidates for ART. The proposed strategy showed improved sensitivity, specificity, and predictive values.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Eric C. Yang, Richard A. Schwarz, Alexander K. Lang, Nancy Bass, Hawraa Badaoui, Katelin D. Cherry, Michelle D. Williams, Ann M. Gillenwater, Nadarajah Vigneswaran, Rebecca R. Richards-Kortum
CANCER PREVENTION RESEARCH
(2018)
Article
Clinical Neurology
Jack Phan, Courtney Pollard, Paul D. Brown, Nandita Guha-Thakurta, Adam S. Garden, David I. Rosenthal, Clifton D. Fuller, Steven J. Frank, G. Brandon Gunn, William H. Morrison, Jennifer C. Ho, Jing Li, Amol J. Ghia, James N. Yang, Dershan Luo, He C. Wang, Shirley Y. Su, Shaan M. Raza, Paul W. Gidley, Ehab Y. Hanna, Franco DeMonte
JOURNAL OF NEUROSURGERY
(2019)
Article
Oncology
Tracy Spinks, Alexis Guzman, Beth M. Beadle, Seohyun Lee, Delrose Jones, Ron Walters, Jim Incalcaterra, Ehab Hanna, Amy Hessel, Randal Weber, Sandra Denney, Lee Newcomer, Thomas W. Feeley
JOURNAL OF ONCOLOGY PRACTICE
(2018)
Editorial Material
Oncology
Moran Amit, Ehab Y. Hanna
ANNALS OF SURGICAL ONCOLOGY
(2018)
Review
Otorhinolaryngology
K. Thomas Robbins, Asterios Triantafyllou, Carlos Suarez, Fernando Lopez, Jennifer L. Hunt, PrimoI Strojan, Michelle D. Williams, Boudewijn J. M. Braakhuis, Remco de Bree, Michael L. Hinni, Luiz P. Kowalski, Alessandra Rinaldo, Juan P. Rodrigo, Vincent Vander Poorten, Lain J. Nixon, Robert P. Takes, Carl E. Silver, Alfio Ferlito
AURIS NASUS LARYNX
(2019)
Review
Otorhinolaryngology
Fernando Lopez, Carlos Suarez, Vincent Vander Poorten, Antti Makitie, Iain J. Nixon, Primoz Strojan, Ehab Y. Hanna, Juan Pablo Rodrigo, Remco de Bree, Miquel Quer, Robert P. Takes, Carol R. Bradford, Ashok R. Shaha, Alvaro Sanabria, Alessandra Rinaldo, Alfio Ferlito
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2019)
Article
Oncology
Moran Amit, Ahmed S. Abdelmeguid, Teemaranawich Watcherporn, Hideaki Takahashi, Samantha Tam, Diana Bell, Renata Ferrarotto, Bonnie Glisson, Michael E. Kupferman, Dianna B. Roberts, Shirley Y. Sue, Shaan M. Raza, Franco DeMonte, Ehab Y. Hanna
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Article
Oncology
Nikhil S. Chari, Cristina Ivan, Xiandong Le, Jinzhong Li, Ainiwaer Mijiti, Ameeta A. Patel, Abdullah A. Osman, Christine B. Peterson, Michelle D. Williams, Curtis R. Pickering, Carlos Caulin, Jeffrey N. Myers, George A. Calin, Stephen Y. Lai
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2020)
Review
Otorhinolaryngology
Mohsin Shah, Mona K. Jomaa, Renata Ferrarotto, Sai-Ching J. Yeung, Ehab Y. Hanna, Cielito C. Reyes-Gibby
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2019)
Article
Oncology
Dario Pasalic, Ethan B. Ludmir, Pamela K. Allen, Nikhil G. Thaker, Bhavana V. Chapman, Ehab Y. Hanna, Shirley Y. Su, Renata Ferrarotto, Bonnie S. Glisson, Jay P. Reddy, G. Brandon Gunn, C. David Fuller, Jack Phan, David I. Rosenthal, William H. Morrison, Adam S. Garden, Steven J. Frank
RADIOTHERAPY AND ONCOLOGY
(2020)
Article
Pathology
Michelle D. Williams, Ron A. DeLellis, Lori A. Erickson, Ruta Gupta, Sarah J. Johnson, Kaori Kameyama, Sonali Natu, Tony Ng, Aurel Perren, Nancy D. Perrier, Raja R. Seethala, Anthony J. Gill
Summary: Standardized pathologic reporting improves patient care and prognosis determination for cancers. The International Collaboration on Cancer Reporting (ICCR) aims to develop and disseminate standardized data sets globally, providing essential resources for documenting rare tumors.
Article
Immunology
Xerxes Pundole, Amy Little Jones, Michael T. Tetzlaff, Michelle D. Williams, William A. Murphy, Adegbenga Otun, Ryan P. Goepfert, Michael A. Davies
Article
Oncology
Rozita Bagheri-Yarmand, Ramona Dadu, Lei Ye, Yaashmin Shiny Jebaraj, Jade A. Martinez, Junsheng Ma, Rohinton S. Tarapore, Joshua E. Allen, Steven Sherman, Michelle D. Williams, Robert F. Gagel
Summary: Gain-of-function mutations in the receptor tyrosine kinase RET drive medullary thyroid carcinoma (MTC) by preventing apoptosis through ATF4 inhibition. Depletion of RET decreases IGFBP2 and VEGFR2 expression in MTC cells, affecting cell survival and migration. Treatment with ONC201 decreases tumor growth and cell proliferation by regulating RET, VEGFR2, and IGFBP2 expression.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anton S. Becker, Rocio Perez-Johnston, Sona A. Chikarmane, Melissa M. Chen, Maria El Homsi, Kimberly N. Feigin, Katherine M. Gallagher, Ehab Y. Hanna, Marshall Hicks, Ahmet T. Ilica, Erica L. Mayer, Atul B. Shinagare, Randy Yeh, Marius E. Mayerhoefer, Hedvig Hricak, H. Alberto Vargas
Summary: Vaccination-associated adenopathy is a common imaging finding after COVID-19 vaccination, which may be mistaken for malignant nodal involvement in patients with cancer. Routine imaging should be scheduled at least 6 weeks after vaccination, while clinically indicated imaging should not be delayed.
Letter
Medicine, General & Internal
Ewe-Seng Ch'ng
NEW ENGLAND JOURNAL OF MEDICINE
(2020)