Journal
GREEN CHEMISTRY LETTERS AND REVIEWS
Volume 5, Issue 1, Pages 55-64Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/17518253.2011.578590
Keywords
pervaporation; solvent recovery; pharmaceutical synthesis; tetrahydrofuran
Funding
- U.S. Environmental Protection Agency [NP 97257006-0]
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The use of pervaporation technology as a green drying process for the recovery and reuse of the solvent, tetrahyrdofuran, in a pharmaceutical synthesis has been evaluated. A case study has been performed on a step in the synthesis of a new oncology drug. Pervaporation has been integrated with a constant volume distillation process to produce a hybrid system that allows for the recovery and reuse of tetrahydrofuran. An economic and environmental analysis shows that this is an effective technology for this application.
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