Article
Clinical Neurology
Massimiliano Pau, Bruno Leban, Michela Deidda, Micaela Porta, Giancarlo Coghe, Davide Cattaneo, Eleonora Cocco
Summary: This study aimed to quantitatively assess the actual upper limb usage among people with Multiple Sclerosis (pwMS) and found that they exhibited lower overall activity levels, used their dominant limb more frequently, and had higher intensity movements in their dominant limb during bilateral activities.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Clinical Neurology
Raffaello Bonacchi, Paola Valsasina, Elisabetta Pagani, Alessandro Meani, Paolo Preziosa, Maria A. Rocca, Massimo Filippi
Summary: The study found that sex influences 9HPT performance in healthy controls mainly through differences in volume and RS FC of motor and cognitive areas, while sex-related effects on motor performance become secondary but still present in multiple sclerosis patients.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Claudio Solaro, Rachele Di Giovanni, Erica Grange, Giampaolo Brichetto, Margit Mueller, Andrea Tacchino, Rita Bertoni, Francesco Patti, Angelo Pappalardo, Luca Prosperini, Letizia Castelli, Rosalba Rosato, Davide Cattaneo, Davide Marengo
Summary: The study aims to evaluate the associations between Manual Ability Measure-36 (MAM-36) and objective measures, including the Nine Hole Peg Test (9-HPT), Box and Block Test (BBT), and Hand Grip Strength (HGS) in people with multiple sclerosis (PwMS). The study found small correlations between MAM-36 and these objective measures, with different correlations seen in different subgroups. Combining 9-HPT and HGS can enhance the assessment of upper limb function in daily activities.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Chemistry, Multidisciplinary
Sofia Straudi, Marco Tramontano, Emanuele Francesco Russo, Luca Perrero, Michela Agostini, Marialuisa Gandolfi, Irene Aprile, Matteo Paci, Emanuela Casanova, Dario Marino, Giuseppe La Rosa, Federica Bressi, Silvia Sterzi, Daniele Giansanti, Alberto Battistini, Sandra Miccinilli, Serena Filoni, Monica Sicari, Salvatore Petrozzino, Claudio Marcello Solaro, Stefano Gargano, Paolo Benanti, Paolo Boldrini, Donatella Bonaiuti, Enrico Castelli, Francesco Draicchio, Vincenzo Falabella, Silvia Galeri, Francesca Gimigliano, Mauro Grigioni, Stefano Mazzoleni, Stefano Mazzon, Franco Molteni, Maurizio Petrarca, Alessandro Picelli, Federico Posteraro, Michele Senatore, Giuseppe Turchetti, Giovanni Morone
Summary: This review systematically reports the evidence on the clinical applications and functional recovery effects of robotic-assisted arm training (RAT) in patients with Multiple Sclerosis (PwMS). The study found that RAT improved shoulder range of motion, handgrip strength, and proximal arm impairment, as well as manual dexterity, arm function, and daily life use. However, the high clinical heterogeneity of treatment programs and the variety of robot devices call for standardization of intervention types in future studies. Overall, robot-assisted treatment appears safe and useful for improving manual dexterity and movement execution quality in PwMS with moderate to severe disability. Further studies with larger sample sizes and rigorous methodologies are needed to draw definitive conclusions.
APPLIED SCIENCES-BASEL
(2022)
Article
Rehabilitation
Lewis A. Ingram, Annie A. Butler, Matthew A. Brodie, Phu Hoang, Simon C. Gandevia, Stephen R. Lord
Summary: The upper-limb Physiological Profile Assessment (PPA) is a valid and clinically suitable assessment for evaluating upper-limb function in people with multiple sclerosis (MS). Motor speed, fine motor control, and functional tasks are the most commonly and significantly impaired domains in upper-limb function among MS patients.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Clinical Neurology
Antonio Lauletta, Laura Fionda, Gioia Merlonghi, Luca Leonardi, Stefania Morino, Elisabetta Bucci, Laura Tufano, Girolamo Alfieri, Rocco Costanzo, Elena Rossini, Marco Salvetti, Giovanni Antonini, Matteo Garibaldi
Summary: We report a novel case of MG-IM association with typical distal upper limb weakness, and provide histopathological evidence of a prominent inflammatory process responsible for this weakness. The muscle biopsy showed marked inflammation in the extensor digitorum communis muscle.
NEUROLOGICAL SCIENCES
(2023)
Article
Rehabilitation
Shannon Pike, Natasha A. Lannin, Lisa Cameron, Mithu Palit, Anne Cusick
Summary: The study identified the impact of upper limb spasticity on stroke survivors, linking their experiences to the ICF categories. It found that additional eight categories were needed to fully represent the experiences of stroke survivors with upper limb spasticity.
DISABILITY AND REHABILITATION
(2022)
Article
Biophysics
Caroline Massot, Nicolas Decoufour, Mathias Blandeau, Franck Barbier, Cecile Donze, Emilie Simoneau, Sebastien Leteneur
Summary: Tandem gait is commonly used to evaluate balance in chronic diseases like MS. In this study, two indexes were proposed to measure limb and trunk movements during tandem gait in early-stage MS patients. The results showed that MS patients had higher speed and step length during tandem gait compared to healthy participants. The contribution indexes of upper limbs were decreased and the inefficiency index was higher in MS patients. These indexes can be used as physical markers to evaluate balance deterioration and rehabilitation efficiency in early-stage MS.
JOURNAL OF BIOMECHANICS
(2023)
Review
Hospitality, Leisure, Sport & Tourism
Thomas Edwards, Anne Sophie Michelsen, Afolasade O. Fakolade, Ulrik Dalgas, Lara A. Pilutti
Summary: This review examined the effects of exercise training on participation in persons with multiple sclerosis (MS). The findings indicate that exercise training has a moderate, positive effect on participation in individuals with MS.
JOURNAL OF SPORT AND HEALTH SCIENCE
(2022)
Article
Automation & Control Systems
Ran Jiao, Wenjie Liu, Ramy Rashad, Jianfeng Li, Mingjie Dong, Stefano Stramigioli
Summary: A novel end-effector bilateral rehabilitation robotic system (EBReRS) is developed for upper limb rehabilitation of patients with hemiplegia, providing simulations of multiple bimanual coordinated training modes, showing potential for application in home rehabilitation.
Article
Health Care Sciences & Services
Ka-Hoo Lam, James Twose, Birgit Lissenberg-Witte, Giovanni Licitra, Kim Meijer, Bernard Uitdehaag, Vincent De Groot, Joep Killestein
Summary: This study investigated the association between smartphone keystroke dynamics and clinical outcomes in patients with multiple sclerosis and found that keystroke dynamics were associated with arm function and cognitive function in these patients over time.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Engineering, Biomedical
Pei-Cheng Shih, Christopher J. Steele, Dennis Hoepfel, Toni Muffel, Arno Villringer, Bernhard Sehm
Summary: The study investigated how patients with left and right hemispheric stroke are differentially affected in individual-limb control and inter-limb coordination during bilateral movements. Results showed that RHS patients exhibited greater impairment in both individual- and inter-limb control during anti-phase movements, while LHS patients showed greater impairment in individual-limb control during in-phase movements alone. Additionally, LHS patients demonstrated a swap in hand dominance during in-phase movements.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2023)
Review
Biochemistry & Molecular Biology
Alexander V. Blagov, Vasily N. Sukhorukov, Alexander N. Orekhov, Margarita A. Sazonova, Alexandra A. Melnichenko
Summary: This article reviews the role of mitochondrial dysfunction in the pathogenesis of multiple sclerosis and proposes new therapeutic strategies to restore mitochondrial function in this disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Adriana P. Rebelo, Andrea Cortese, Amit Abraham, Yael Eshed-Eisenbach, Gal Shner, Anna Vainshtein, Elena Buglo, Vladimir Camarena, Gabriel Gaidosh, Ramin Shiekhattar, Lisa Abreu, Steve Courel, Dennis K. Burns, Yunhong Bai, Chelsea Bacon, Shawna M. E. Feely, Diana Castro, Elior Peles, Mary M. Reilly, Michael E. Shy, Stephan Zuchner
Summary: The CADM family of proteins mediate direct contact and interaction between axons and glia, with mutations in CADM3 potentially causing abnormal axon-glia interaction and disease manifestation in CMT patients.
Article
Multidisciplinary Sciences
Ben J. E. Raveney, Wakiro Sato, Daiki Takewaki, Chenyang Zhang, Tomomi Kanazawa, Youwei Lin, Tomoko Okamoto, Manabu Araki, Yukio Kimura, Noriko Sato, Terunori Sano, Yuko Saito, Shinji Oki, Takashi Yamamura
Summary: This study identified a subset of cytotoxic CD4(+) T cells expressing Eomes, known as Eomes(+) Th cells, that are crucially involved in the pathogenesis of secondary progressive MS (SPMS). Eomes levels could act as a biomarker to predict disease worsening in SPMS patients with over 80% accuracy. These findings have significant implications for SPMS biomarkers and potential therapeutic targets.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Clinical Neurology
Cigdem Yilmazer, Ilse Lamers, Claudio Solaro, Peter Feys
Summary: This article provides an overview of the current knowledge on pain in multiple sclerosis, including its definitions, assessments, treatments, and rehabilitation. It also highlights the lack of experimental studies focusing on pain reduction.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Environmental Sciences
Els Knippenberg, Ilse Lamers, Annick Timmermans, Annemie Spooren
Summary: The i-ACT system was developed as a low-cost client-centred task-oriented system for neurorehabilitation, showing high usability and credibility. The study found that training with i-ACT improved upper limb functional ability significantly, indicating its potential to enhance upper limb training in persons with neurological diseases.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Neurosciences
Bruno Bonnechere, Aki Rintala, Annemie Spooren, Ilse Lamers, Peter Feys
Summary: The development of mobile technology and mobile Internet presents new possibilities for rehabilitation and clinical assessment in managing multiple sclerosis. Studies have shown promising effects of mHealth in cognitive function and fatigue rehabilitation for patients with multiple sclerosis, though further research is needed to validate these solutions in other areas.
Article
Rehabilitation
Nastasia Marinus, Dominique Hansen, Peter Feys, Raf Meesen, Annick Timmermans, Joke Spildooren
Summary: This study analyzed the impact of television images on the motivation and exercise intensity of older adults in residential care during cycling exercises. The results indicated that the addition of television images may increase the exercise intensity and motivation of older adults.
DISABILITY AND REHABILITATION-ASSISTIVE TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Renee Veldkamp, Lousin Moumdjian, Kim van Dun, Joren Six, Antoine Vanbeylen, Daphne Kos, Peter Feys
Summary: Motor sequence learning in individuals with multiple sclerosis in a stepping task showed similar levels to healthy controls, regardless of learning conditions or group differences.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Multidisciplinary Sciences
Lousin Moumdjian, Joren Six, Renee Veldkamp, Jenke Geys, Channa Van der Linden, Mieke Goetschalckx, Johan Van Nieuwenhoven, Ilse Bosmans, Marc Leman, Peter Feys
Summary: This study investigated the effects of embodied learning on motor and cognitive functions in persons with multiple sclerosis (PwMS). The results showed that balance impairment and information processing speed predicted the speed of executing cognitive sequences. Furthermore, participants who learned performed the sequence faster in the melody condition and overall improved their speed over time.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Clinical Neurology
Rita Bertoni, Davide Cattaneo, Cristina Grosso, Francesca Baglio, Johanna Jonsdottir
Summary: This study examined the alterations in bilateral gross and fine manual dexterity in persons with multiple sclerosis (PwMS) and found that most patients exhibited abnormalities in their manual dexterity. The abnormalities in gross manual dexterity were more prevalent and pronounced with increasing disability levels. The prevalence of bilateral alterations in gross manual dexterity was higher than that of fine manual dexterity in all types of multiple sclerosis considered.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Review
Rehabilitation
A. Rintala, O. Kossi, B. Bonnechere, L. Evers, E. Printemps, P. Feys
Summary: This study evaluated the effectiveness of mobile health applications (mHealth apps) with a physical training component on physical function and physical activity in stroke rehabilitation. The results showed that these apps have potential in improving physical function and physical activity in stroke survivors, but the impact on quality of life was limited.
DISABILITY AND REHABILITATION
(2022)
Article
Clinical Neurology
Claudio Solaro, Rachele Di Giovanni, Erica Grange, Giampaolo Brichetto, Margit Mueller, Andrea Tacchino, Rita Bertoni, Francesco Patti, Angelo Pappalardo, Luca Prosperini, Letizia Castelli, Rosalba Rosato, Davide Cattaneo, Davide Marengo
Summary: The study aims to evaluate the associations between Manual Ability Measure-36 (MAM-36) and objective measures, including the Nine Hole Peg Test (9-HPT), Box and Block Test (BBT), and Hand Grip Strength (HGS) in people with multiple sclerosis (PwMS). The study found small correlations between MAM-36 and these objective measures, with different correlations seen in different subgroups. Combining 9-HPT and HGS can enhance the assessment of upper limb function in daily activities.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Environmental Sciences
Elisabetta Brigo, Aki Rintala, Oyene Kossi, Fabian Verwaest, Olivier Vanhoof, Peter Feys, Bruno Bonnechere
Summary: This review analyzes the feasibility and effectiveness of telehealth solutions proposed during the COVID-19 pandemic to ensure the continuity of rehabilitation. The findings suggest that telerehabilitation is a feasible and effective solution for providing continuous rehabilitation while reducing the risk of infection and burden of travel. However, further research is needed to strengthen and confirm these findings.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Clinical Neurology
Rita Bertoni, Fabiola Giovanna Mestanza Mattos, Micaela Porta, Federico Arippa, Eleonora Cocco, Massimiliano Pau, Davide Cattaneo
Summary: The study investigated the feasibility and effects of an immersive commercial virtual reality system for upper limb bilateral rehabilitation in people with multiple sclerosis. The results showed improvement in gross manual dexterity in the less affected limb but did not translate into modifications in terms of self-reported ability or other outcomes.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Chemistry, Analytical
Ilaria Carpinella, Denise Anastasi, Elisa Gervasoni, Rachele Di Giovanni, Andrea Tacchino, Giampaolo Brichetto, Paolo Confalonieri, Marco Rovaris, Claudio Solaro, Maurizio Ferrarin, Davide Cattaneo
Summary: In this study, an instrumented modified Romberg test (ImRomberg) was used to assess the balance of early-stage multiple sclerosis (MS) patients. By extracting two key parameters that are descriptive of different aspects of balance, significant correlations with clinical scales were found. The results showed that the proposed approach, when integrated with the clinical tandem gait test, could identify balance impairments in early-stage MS patients with higher sensitivity compared to traditional tests. This approach could help identify patients who could benefit from preventive rehabilitation interventions.
Review
Environmental Sciences
Zuhal Abasiyanik, Renee Veldkamp, Amber Fostier, Carolien Van Goubergen, Alon Kalron, Peter Feys
Summary: This review examines the patient perspective and assessment methods for dual-task (DT) impairment. Five patient-reported outcome measures (PROMs) were identified, and the Dual-Task-Impact on Daily-life Activities Questionnaire (DIDA-Q) showed the highest measurement quality in individuals with multiple sclerosis.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Rehabilitation
Elogni R. Amanzonwe, Lisa Tedesco Triccas, Leopold Codjo, Dominique Hansen, Peter Feys, Oyene Kossi
Summary: This study analyzed the optimal dosage and effectiveness of aerobic training (AT) and resistance training (RT) on balance, walking capacity, and quality of life (QoL) in stroke survivors. The results showed that AT was the most effective in improving walking capacity, while combining AT and RT was beneficial for improving QoL. High-dose aerobic exercise conducted in rehabilitation facilities was more effective in improving walking capacity in chronic stroke patients.
SOUTH AFRICAN JOURNAL OF PHYSIOTHERAPY
(2023)
Article
Medicine, General & Internal
Peter Feys, Marijke Duportail, Daphne Kos, Stephan Ilsbroukx, Ilse Lamers, Paul Van Asch, Werner Helsen, Lousin Moumdjian
Summary: This study investigated the effect of peripheral upper limb cooling on tremor severity and functional performance in multiple sclerosis patients with intention tremor. The results showed that cooling the forearm significantly reduced tremor severity and improved functional performance, and cooling the whole upper limb had a noticeable effect on tremor severity during the first half-hour after cooling.
JOURNAL OF CLINICAL MEDICINE
(2023)
