Journal
FOOD & FUNCTION
Volume 9, Issue 9, Pages 4673-4682Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8fo00993g
Keywords
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Funding
- China Agriculture Research System [CARS-08-D2-01]
- Scientific and Technological Research Program of the Chongqing Municipal Education Commission [KJ1601010, KJ1401021]
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As a dimer of proanthocyanidin, proanthocyanidin B-2 (PB2) was found to effectively attenuate postprandial blood glucose in mice after sucrose loading. Further studies showed that PB2 revealed strong inhibitory activity against -glucosidase with an IC50 value of (0.23 +/- 0.01) g mL(-1), and this process was reversible with a mixed-type inhibitory manner. PB2 quenched the intrinsic fluorescence of -glucosidase through a static quenching mechanism and changed the micro-environments and conformations of -glucosidase that led to an aggregation phenomenon. A further molecular docking study provided more information about the interactions of PB2 with the amino acid residues of -glucosidase. Our results suggest that PB2 is useful for protection against hyperglycemia through inhibiting the activity of -glucosidase.
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