Article
Oncology
Bo Bin Lee, Dongho Kim, Yujin Kim, Joungho Han, Young Mog Shim, Duk-Hwan Kim
Summary: This study found that metformin inhibits the expression of DNMTs in non-small cell lung cancer cells by upregulating miR-148/-152 family members.
CLINICAL EPIGENETICS
(2023)
Review
Medicine, General & Internal
Long Cheng, Qinyun Li, Bangxian Tan, Daiyuan Ma, Guobo Du
Summary: The study evaluated the diagnostic value of the blood miR-148/152 family in NSCLC through meta-analysis, indicating its potential as novel non-invasive diagnostic biomarkers with good sensitivity and specificity. Further research with high quality, large sample sizes, and multiple centers is needed for validation.
Article
Cell Biology
Yu-kun Zheng, Zhong-shi Zhou, Guang-zhong Wang, Ji-yuan Tu, Huan-bo Cheng, Shang-zhi Ma, Chang Ke, Yan Wang, Qi-pan Jian, Yu-hang Shu, Xiao-wei Wu
Summary: This study found that inhibiting miR-122-5p can activate p53 and hinder the progression of the MVA pathway in non-small cell lung cancer (NSCLC). This leads to a decrease in cell proliferation and migration, and an increase in apoptosis. miR-122-5p interacts with p53 and is negatively correlated with its expression. Thus, miR-122-5p regulates NSCLC by targeting p53, offering potential molecular targets for targeted drug development.
CELL DEATH & DISEASE
(2023)
Article
Medicine, Research & Experimental
Fengyue Ding, Hongchun Wu, Xinglong Han, Xue Jiang, Yang Xiao, Yuanyuan Tu, Miao Yu, Wei Lei, Shijun Hu
Summary: Human pluripotent stem cell-derived endothelial cells (hPSC-ECs) are important for cardiovascular disease research, cell therapy, and drug screening. This study explores the function and regulation of the miR-148/152 family in hPSC-ECs to identify new targets for improving EC function. The miR-148/152 family knockout reduced endothelial differentiation efficiency and impaired the abilities of proliferation, migration, and capillary formation of hESC-ECs. Overexpression of miR-152 partially restored angiogenic capacity. Additionally, the direct target of miR-148/152 family was identified as mesenchyme homeobox 2 (MEOX2). Knockdown of MEOX2 partially restored angiogenesis ability. The study highlights the importance of miR-148/152 family in maintaining angiogenesis ability and suggests it as a potential target for enhancing EC therapy and promoting endogenous revascularization.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Biochemistry & Molecular Biology
Jinjin Duan, Li Wang, Liqun Shang, Shumei Yang, Hua Wu, Yongcheng Huang, Yi Miao
Summary: The study found that TNS1 is upregulated in NSCLC cells and tissues, and is associated with the prognosis of NSCLC patients. Additionally, TNS1 promotes the growth and metastasis of NSCLC cells via the Akt/mTOR/RhoA pathway. miR-152 targets TNS1 to influence the progression of NSCLC.
BIOSCIENCE REPORTS
(2021)
Article
Medicine, Research & Experimental
Xiaoying Li, Lin Li, Jiangying Wu
Summary: This study identified a role of the miR-148/152 family in gastric cancer and demonstrated its functional effects on gastric cancer stem cells. ITGA5 was found to be elevated in gastric cancer tissues and confirmed as a target gene of the miR-148/152 family. Upregulation of miR-148/152 family members led to reduced tumor properties in vitro and in vivo.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Jing Gao, Tinghong Pan, Hui Wang, Shuai Wang, Jin Chai, Chengyan Jin
Summary: This study explores the role of FAM138B in non-small cell lung cancer (NSCLC) and its potential as a prognostic biomarker. The study found that FAM138B is down-regulated in NSCLC cells and tissues, and its overexpression can inhibit the proliferative, migratory, and invasive abilities of NSCLC cells. Additionally, FAM138B targets miR-105-5p, and there is a negative correlation between FAM138B and miR-105-5p. Thus, FAM138B may inhibit the progression of NSCLC by targeting miR-105-5p and could be a potential prognostic biomarker for NSCLC.
Article
Oncology
Kekoolani S. Visan, Richard J. Lobb, Shu Wen Wen, Justin Bedo, Luize G. Lima, Sophie Krumeich, Carlos Palma, Kaltin Ferguson, Ben Green, Colleen Niland, Nicole Cloonan, Peter T. Simpson, Amy E. McCart Reed, Sarah J. Everitt, Michael P. MacManus, Gunter Hartel, Carlos Salomon, Sunil R. Lakhani, David Fielding, Andreas Moeller
Summary: Lung cancer is a leading cause of cancer-related death worldwide and has low survival rates due to lack of early detection. A study on a lung cancer biomarker based on a simple blood test shows promising advantages for diagnostic assessment. The study identifies a specific micro-RNA, miR-3182, as a potential biomarker for lung cancer diagnosis that can be detected in the blood.
Article
Genetics & Heredity
Chen Huang, Chuqi Lei, Boyu Pan, Senbiao Fang, Yubao Chen, Wenfeng Cao, Liren Liu
Summary: MCM2/4/10 were significantly highly expressed in both LUAD and LUSC, and MCM2/4/6/7/8 expression levels were associated with advanced tumor stages. High expression levels of MCM1/2/3/4/5/6/7/8/10 were linked to worse OS, while high expression of MCM9 was associated with better OS in NSCLC patients. These results suggest that MCM2 and MCM4 may serve as potential prospective biomarkers for high-risk subgroups of NSCLC patients.
FRONTIERS IN GENETICS
(2021)
Article
Cell Biology
Changhui Li, Jiaqi Zhang, Xiaohua Yang, Cheng Hu, Tianqing Chu, Runbo Zhong, Yinchen Shen, Fang Hu, Feng Pan, Jianlin Xu, Jun Lu, Xiaoxuan Zheng, Hai Zhang, Wei Nie, Baohui Han, Xueyan Zhang
Summary: The study has demonstrated the significant role of hsa_circ_0003222 in NSCLC progression and resistance, with its high expression associated with disease stage, metastasis, and patient survival rate. Silencing hsa_circ_0003222 led to reduced stemness-like properties and chemoresistance in tumor cells.
CELL DEATH & DISEASE
(2021)
Review
Medicine, Research & Experimental
Peiyu Tang, Dejuan Sun, Wei Xu, Hua Li, Lixia Chen
Summary: Non-small cell lung cancer (NSCLC) is a common malignancy with high morbidity and mortality rates. Long non-coding RNAs (lncRNAs) have closely associated with the development of NSCLC, including drug resistance and radiation sensitivity. Due to their functional characterization, tissue specificity and sex specificity, lncRNAs have the potential to be used as biomarkers and therapeutic targets for NSCLC. This review provides a perspective on the roles of lncRNAs in NSCLC, including proliferation, invasion, and drug resistance.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Health Care Sciences & Services
Beatriz C. Lopes, Cristine Z. Braga, Fabricio V. Ventura, Jessica G. de Oliveira, Edson M. Kato-Junior, Newton A. Bordin-Junior, Debora A. P. C. Zuccari
Summary: The research identified and validated miR-210 and miR-152 as potential non-invasive circulating biomarkers for the diagnosis and staging of breast cancer patients. The study showed that miR-210 and miR-152 have different expression patterns in tumor tissues and plasma samples, indicating their potential as diagnostic biomarkers for breast cancer. Additionally, the study found that miR-152 may also be a promising biomarker for disease staging.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Multidisciplinary Sciences
Chengyao Wan, Jing Wen, Xiaolin Liang, Qiongni Xie, Wenqi Wu, Meiqing Wu, Zhenfang Liu
Summary: The study found that the expression of the miR-320 family is up-regulated in MDS, serving as candidate diagnostic biomarkers for MDS. Additionally, high expression of miR-320d is an independent prognostic factor for overall survival in MDS.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Martina Mandarano, Elena Orecchini, Guido Bellezza, Jacopo Vannucci, Vienna Ludovini, Sara Baglivo, Francesca Romana Tofanetti, Rita Chiari, Elisabetta Loreti, Francesco Puma, Angelo Sidoni, Maria Laura Belladonna
Summary: The study found that the serum Kyn/Trp ratio may serve as a serum biomarker for risk stratification and therapy optimization in non-small-cell lung cancer patients, with high Kyn/Trp ratio associated with clinical and histopathological parameters.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Mototsugu Nagao, Izumi Fukuda, Akira Asai, Jonathan L. S. Esguerra, Naomi Hizuka, Lena Eliasson, Hitoshi Sugihara
Summary: Elevated serum levels of miR-483-5p and -3p are associated with the presence of big IGF-II in NICTH, indicating the diagnostic potential of these miRNAs.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
