Article
Cardiac & Cardiovascular Systems
Zhiqing Wang, Junqing Yang, Chunming Li, Jiayue Huang, Simone Fezzi, En Chen, Wei Cai, Goran Stankovic, William Wijns, Lianglong Chen, Shengxian Tu
Summary: This study found that two-stent techniques for left main bifurcation lesions are associated with an increased risk of in-stent restenosis at the ostium of the left circumflex artery. The study suggests that the cyclic change of the left main-left circumflex bending angle may be associated with the risk of ostial left circumflex in-stent restenosis.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
David Hildick-Smith, Mohaned Egred, Adrian Banning, Philippe Brunel, Miroslaw Ferenc, Thomas Hovasse, Adrian Wlodarczak, Manuel Pan, Thomas Schmitz, Marc Silvestri, Andreis Erglis, Evgeny Kretov, Jens Flensted Lassen, Alaide Chieffo, Thierry Lefevre, Francesco Burzotta, James Cockburn, Olivier Darremont, Goran Stankovic, Marie-Claude Morice, Yves Louvard
Summary: A study on patients with true left main stem bifurcation lesions showed that a stepwise provisional approach was associated with fewer major adverse cardiac events compared to planned dual stenting, supporting its use as the default strategy for distal left main stem bifurcation intervention.
EUROPEAN HEART JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Zlatko Mehmedbegovie, Dario Jelie, Dorde Mladenovie, Goran Stankovie
Summary: Coronary bifurcation lesions are challenging and have poor outcomes compared to simple lesions. Drug eluting stents (DES) are the standard treatment, but their design and mechanical properties vary, requiring understanding of their characteristics and limitations to ensure procedural safety and success.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Jung-Joon Cha, Soon Jun Hong, Hyung Joon Joo, Jae Hyoung Park, Cheol Woong Yu, Tae Hoon Ahn, Hyo-Soo Kim, Woo Jung Chun, Seung-Ho Hur, Seung Hwan Han, Seung-Woon Rha, In-Ho Chae, Jin-Ok Jeong, Jung Ho Heo, Junghan Yoon, Ki Hong Choi, Young Bin Song, Hyeon-Cheol Gwon, Jong-Seon Park, Myeong-Ki Hong, Joon-Hyung Doh, Kwang Soo Cha, Doo-Il Kim, Sang Yeub Lee, Kiyuk Chang, Byung-Hee Hwang, So-Yeon Choi, Myung Ho Jeong, Chang-Wook Nam, Bon-Kwon Koo, Do-Sun Lim
Summary: Patients with left main bifurcation stenting had a higher risk of target lesion failure compared to non-left main bifurcation stenting. Different clinical and angiographic factors were found to predict outcomes in these two groups, suggesting individualized treatment strategies for better clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Stefan Dan Cezar Mot, Adela Mihaela Serban, Alexandra Dadarlat-Pop, Raluca Tomoaia, Dana Pop
Summary: Stent enhancement techniques help visualize stent deformations and measure stent enhancement side branch length (SESBL), which is associated with procedural success and long-term outcomes. In a study of 162 patients undergoing left main provisional one-stent technique, a longer SESBL was correlated with better outcomes and less side branch compromise. These findings suggest that SESBL may be a useful tool for evaluating stent expansion without intracoronary imaging.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
David Hildick-Smith, Mohaned Egred, Adrian Banning, Philippe Brunel, Miroslaw Ferenc, Thomas Hovasse, Adrian Wlodarczak, Manuel Pan, Thomas Schmitz, Marc Silvestri, Andreis Erglis, Evgeny Kretov, Jens Flensted Lassen, Alaide Chieffo, Thierry Lefevre, Francesco Burzotta, James Cockburn, Olivier Darremont, Goran Stankovic, Marie-Claude Morice, Yves Louvard
Summary: Among patients with true left main stem bifurcation lesions requiring intervention, fewer major adverse cardiac events occurred with a stepwise layered provisional approach than with planned dual stenting, although the difference was not statistically significant. The stepwise provisional strategy should remain the default for distal left main stem bifurcation intervention. Procedure time, X-ray dose and consumables favored the stepwise provisional approach.
EUROPEAN HEART JOURNAL
(2021)
Article
Medicine, General & Internal
Yongwhan Lim, Min Chul Kim, Youngkeun Ahn, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Myung Ho Jeong, Hyeon-Cheol Gwon, Hyo-Soo Kim, Seung Woon Rha, Jung Han Yoon, Yangsoo Jang, Seung-Jea Tahk, Ki Bae Seung
Summary: This study compares the outcomes of different percutaneous coronary intervention (PCI) strategies and lesion locations in non-left main (LM) bifurcation lesions. The results show that for non-LAD bifurcation lesions, the two-stent strategy has a higher risk of target lesion failure (TLF), target lesion revascularization (TLR), and target vessel revascularization (TVR) compared to the one-stent strategy. However, there is no significant difference in outcome among LAD bifurcation lesions treated with different PCI strategies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Lucian Predescu, Marin Postu, Lucian Zarma, Adrian Bucsa, Pavel Platon, Marian Croitoru, Adrian Mereuta, Leonard Licheardopol, Alexandra Predescu, Dan Dorobantu, Dan Deleanu
Summary: This study compared the choice between a one-stent and a two-stent approach in patients with unprotected distal left main coronary artery disease presenting as acute coronary syndrome. The findings showed that the two-stent approach had lower early and midterm mortality rates compared to the one-stent approach.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Gianluca Rigatelli, Marco Zuin, Filippo Gianese, Dario Adami, Mauro Carraro, Loris Roncon
Summary: In patients with non-ST-segment elevation myocardial infarction (NSTEMI), both single and double stent strategies for left main (LM) disease showed favorable long-term outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Sandeep Arunothayaraj, Jens Flensted Lassen, Gerald J. Clesham, Mark S. Spence, Rene Koning, Adrian P. Banning, Mitchell Lindsay, Evald H. Christiansen, Mohaned Egred, James Cockburn, Darren Mylotte, Philippe Brunel, Miroslaw Ferenc, Thomas Hovasse, Adrian Wlodarczak, Manuel Pan, Marc Silvestri, Andrejs Erglis, Evgeny Kretov, Alaide Chieffo, Thierry Lefevre, Francesco Burzotta, Olivier Darremont, Goran Stankovic, Marie-Claude Morice, Yves Louvard, David Hildick-Smith
Summary: This study aimed to analyze the impact of technical variables on procedural outcomes and periprocedural myocardial infarction following left main bifurcation intervention. The results showed that the use of jailed wires was associated with successful rewiring of jailed vessels, and the use of jailed wires was not associated with increased risk of periprocedural myocardial infarction. Side vessel preparation in provisional cases was linked to increased side vessel dissection requiring stenting. The use of noncompliant balloons for proximal optimization technique was associated with a reduction in the need for additional side vessel intervention and periprocedural myocardial infarction.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Koya Okabe, Masanobu Ohya, Akihiro Ikuta, Makoto Takamatsu, Kohei Osakada, Takenobu Shimada, Katsuya Miura, Shunsuke Kubo, Takeshi Tada, Hiroyuki Tanaka, Yasushi Fuku, Harumi Katoh, Kazushige Kadota
Summary: The study evaluated the 1-year clinical and angiographic outcomes of non-left main trunk bifurcation lesions treated with the 2-stent strategy using newer-generation EES, finding an acceptable ISR rate and identifying long side branch lesions and 3-link EES as independent predictors of 1-year post-procedural ISR. Target lesion revascularization rate at 1 year was 3.5%.
CIRCULATION JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Shuai Meng, Xiangyun Kong, Jing Nan, Xingsheng Yang, Jianan Li, Shenghua Yang, Lihan Zhao, Zening Jin
Summary: The optimal percutaneous coronary intervention (PCI) strategy for coronary left main (LM) bifurcation lesions remains controversial. This meta-analysis compared the medium and long-term follow-up clinical outcomes of single vs. systematic dual stenting strategies of LM bifurcation lesions. The results showed that the systematic dual stenting strategy was associated with a lower ST risk and cardiac death risk compared to the single stenting strategy, and for patients with true LM bifurcation, the risk of all-cause death, ST, and CV mortality following the systematic dual stenting strategy was significantly lower than the single stenting strategy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Health Care Sciences & Services
Marta Kaluzna-Oleksy, Wojciech Jan Skorupski, Marek Grygier, Aleksander Araszkiewicz, Wlodzimierz Skorupski, Stefan Grajek, Przemyslaw Mitkowski, Malgorzata Pyda, Maciej Lesiak
Summary: This study found gender-based differences in real-life LM PCI patients, with women being older and having higher rates of diabetes, hypertension, and chronic kidney disease compared to men. However, both genders showed similar rates of periprocedural complications and long-term all-cause mortality in LM PCI, suggesting that being female is not a predictor of adverse outcomes in this procedure. Further studies are needed to determine the optimal revascularization strategy for women.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Seong Ho Moon, Jong Woo Kim, Jun Ho Yang, Dong Hoon Kang, Sung Hwan Kim, Jae Jun Jung, Jong Hwa Ahn, Sung Eun Park, Kyung Nyeo Jeon, Joung Hun Byun
Summary: This study aimed to evaluate proximal left anterior descending coronary artery (LAD) disease using two factors: coronary artery tortuosity and bifurcation angle. The results showed that as the tortuosity and LM-LAD angle increased, the chances of proximal LAD lesions formation also increased. Therefore, d20*cos0 might be a useful predictor of proximal LAD stenosis.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Multidisciplinary Sciences
Lieyou Li, Zhihai Feng, Lin Zhang, Huang Chen, Hong Zheng, Huizhong Lin, Qiong Jiang, Yunlin Lin, Lianglong Chen, Lin Fan
Summary: This study aimed to evaluate the impact of new Murray law-based QFR of jailed LCx on long-term clinical outcomes after LM simple crossover stenting. The results showed that low QFR (<0.80) in LCx was significantly associated with higher 5-year TLF rate (27.6% vs. 6.7%), indicating QFR as a predictor of postoperative prognosis.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Brian C. Case, Rebecca Torguson, Gary S. Mintz, Carlo Di Mario, Giorgio A. Medranda, Cheng Zhang, Corey Shea, Hector M. Garcia-Garcia, Ron Waksman
Summary: The study found an association between a high volume of lipid content in the coronary arteries and subsequent adverse cardiac events. The presence of multiple lipid-rich plaques in the coronary tree was found to be associated with a higher risk of cardiac events.
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Athanasios Rempakos, Spyridon Kostantinis, Bahadir Simsek, Judit Karacsonyi, Salman Allana, Mohaned Egred, Hani Jneid, Kambis Mashayekhi, Carlo Di Mario, Oleg Krestyaninov, Dmitrii Khelimski, Anastasios Milkas, Yader Sandoval, M. Nicholas Burke, Emmanouil S. S. Brilakis
Summary: Balloon undilatable lesions are lesions that cannot be expanded despite successful cross by a guidewire and a balloon. These lesions can be either de novo or in-stent. A systematic approach using various techniques such as high-pressure balloon inflation, plaque modification balloons, intravascular lithotripsy, very high-pressure balloon inflation, coronary atherectomy, laser coronary angioplasty, and extraplaque lesion crossing can effectively treat these lesions, increasing procedure efficiency, success, and safety.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Niccolo Ciardetti, Giulia Nardi, Carlo Di Mario
EUROPEAN HEART JOURNAL
(2023)
Article
Psychology, Multidisciplinary
Martina Smorti, Lucia Ponti, Francesco Soffio, Alessia Argiro, Federico Perfetto, Mattia Zampieri, Carlotta Mazzoni, Alessia Tomberli, Marco Allinovi, Carlo Di Mario, Iacopo Olivotto, Francesco Cappelli
Summary: Patients with ATTR cardiac amyloidosis (ATTR-CA) often experience high levels of anxiety and depression. Older patients, especially females, with more advanced disease are at a higher risk of developing an anxious or depressive disorder. It is important for physicians to take into consideration the psychological well-being of ATTR-CA patients and provide them with appropriate support to reduce disease burden and improve quality of life.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Silvia Menale, Valentina Scheggi, Francesco Vanni, Carlo Di Mario
Summary: This case report describes a 41-year-old male patient with a transthyretin gene mutation and a diagnosis of cardiac sarcoidosis. The patient showed improvement after treatment with steroids and ICD implantation, but still experienced occasional ventricular arrhythmias and one appropriate ICD shock.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Lucia Ponti, Martina Smorti, Francesca Pozza, Alessia Argiro, Mattia Zampieri, Carlotta Mazzoni, Martina Gabriele, Carlo Di Mario, Iacopo Olivotto, Federico Perfetto, Francesco Cappelli
Summary: Subjective perception of symptom severity in patients with transthyretin-related cardiac amyloidosis (CA) is an important treatment target, as opposed to objective prognostic markers such as N-terminal pro b-type natriuretic peptide (NT-proBNP). However, anxiety and depression in CA patients may affect their perceptions of the disease, creating a potential gap between objective and subjective parameters. This study assesses the impact of such bias in consecutive CA patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Carlo Di Mario, Giulia Nardi
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Alexandre Avran, Andrea Zuffi, Cecilia Gobbi, Alessio Gasperetti, Marco Schiavone, Gerald S. Werner, Mashayekhi Kambis, Nicolas Boudou, Alfredo R. Galassi, George Sianos, Moussa Idali, Roberto Garbo, Andrea Gagnor, Gabriele Gasparini, Alexander Bufe, Leszek Bryniarski, Artis Kalnins, Daniel Weilenmann, Jaroslaw Wojcik, Pierfrancesco Agostoni, Nenad Z. Bozinovic, Mauro Carlino, Sergey Furkalo, David Hildick-Smith, Laurent Drogoul, Julien Lemoine, Antonio Serra, Stefano Carugo, Imre Ungi, Joseph Dens, Nicolaus Reifart, Joseph Cosma, Vincenzo Mallia, Giuseppe Vadala, Giuseppe Biondi-Zoccai, Carlo Di Mario
Summary: This study analyzed the in-hospital clinical outcomes of female patients undergoing percutaneous coronary intervention (PCI) for chronic total occlusion (CTO). The results showed that female patients had a higher procedural success rate but a higher risk of procedural complications.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Emanuele Barbato, Emanuele Gallinoro, Mohamed Abdel-Wahab, Daniele Andreini, Didier Carrie, Carlo Di Mario, Dariusz Dudek, Javier Escaned, Jean Fajadet, Giulio Guagliumi, Jonathan Hill, Margaret McEntegart, Kambis Mashayekhi, Nikolasos Mezilis, Yoshinobu Onuma, Krzyszstof Reczuch, Richard Shlofmitz, Giulio Stefanini, Giuseppe Tarantini, Gabor G. Toth, Beatriz Vaquerizo, William Wijns, Flavio L. Ribichini
Summary: Since the publication of the 2015 EAPCI consensus, there has been a significant increase in PCI performed in cases of severely calcified coronary artery disease. This has been driven by the growing need for interventions in elderly patients and the availability of new technologies. The current EAPCI clinical consensus statement provides comprehensive guidance on the management of heavily calcified coronary stenoses, including imaging assessment, tool and technique selection, and considerations for complications and training.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Domenico D'Amario, David Meerkin, Attilio Restivo, Hueseyin Ince, Horst Sievert, Andrea Wiese, Ulrich Schaefer, Carlo Trani, Antoni Bayes-Genis, Francisco I. Leyva, Zachary Whinnett, Carlo Di Mario, Michael Jonas, Habib J. Manhal, Ignacio Amat-Santos, Maria Del Trigo, Tuvia Ben Gal, Binyamin Ben Avraham, Tal Hasin, Sebastian Feickert, Giuseppe D'Ancona, Omar Abdul-Jawad Altisent, Oran Koren, Oren T. Caspi, William Abraham, Filippo D. Crea, Stefan Anker, Ran Kornowski, Leor Perl
Summary: The study evaluated a novel left atrial pressure (LAP) monitoring system in heart failure patients and found that it was safe and provided a good correlation with invasive pulmonary capillary wedge pressure (PCWP). Initial evidence also suggests possible improvement in heart failure clinical symptoms.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Margarita Brida, Salvatore De Rosa, Antoine Legendre, Magalie Ladouceur, Laura Dos Subira, Giancarlo Scognamiglio, Carlo Di Mario, Jolien Roos-Hesselink, Eva Goossens, Gerhard Diller, Michael A. Gatzoulis
Summary: The rates of successful surgical repair and life expectancy for patients with congenital heart disease have significantly increased in recent decades. However, exposure to cardiovascular risk factors has led to a shift in the clinical trajectory of adult congenital heart disease, with an increasing burden of acquired cardiovascular disease, primarily atherosclerotic cardiovascular disease (ASCVD). Currently, comprehensive guidance for the prevention and management of acquired heart disease in adult congenital heart disease patients is lacking. This document provides an overview of acquired heart disease and offers guidance on ASCVD prevention for both specialists and non-specialists in adult congenital heart disease, aiming to reduce the cardiovascular burden in this growing population.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Valentina Andrei, Nicoletta D'Ettore, Valentina Scheggi, Carlo di Mario
Summary: This article reports two cases of myopericarditis caused by hypersensitivity to 5-ASA, with cardiac magnetic resonance confirming the diagnosis. This rare but potentially life-threatening side effect is associated with mesalazine, a key therapeutic agent in IBD. Discussion highlights the difficulty of distinguishing between mesalazine-induced cardiac injury and acute IBD-induced cardiac inflammation.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)
Review
Cardiac & Cardiovascular Systems
Derk Frank, Simon Kennon, Nikolaos Bonaros, Mauro Romano, Carlo Di Mario, Dirk-Jan van Ginkel, Wilbert Bor, Markus Kasel, Ole De Backer, Violetta Hachaturyan, Claudia M. Lueske, Jana Kurucova, Peter Bramlage, Rima Styra
Summary: The objective of this study was to provide an overview of the available quality of life (QoL) instruments in aortic stenosis (AS) research and assess their strengths and weaknesses. It was found that many of the questionnaires used in AS research are not specifically developed for patients with AS, highlighting the need for AS-specific QoL research.
Article
Geriatrics & Gerontology
Carlo Fumagalli, Martina Smorti, Lucia Ponti, Francesca Pozza, Alessia Argiro, Giacomo Credi, Carlo Di Mario, Raffaele Marfella, Niccolo Marchionni, Iacopo Olivotto, Federico Perfetto, Andrea Ungar, Francesco Cappelli
Summary: The aim of this study was to investigate frailty and the quality of the caregiver relationship in older patients with transthyretin cardiac amyloidosis (ATTR-CA). The study found that 10% of patients were frail and 46% had depressive symptoms. Regression analyses showed that frailty and depression were associated with poorer perception of social support, and frailty and disease severity were associated with higher levels of conflict in the caregiver relationship. Overall, frailty was associated with worse perceived social support and caregiver relationship quality. Tertiary care heart failure clinics should actively support the patient-caregiver relationship to improve quality of life.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
M. Berteotti, A. M. Gori, B. Giusti, A. Fortini, G. Grossi, N. Ciardetti, A. Migliorini, E. Lotti, R. Valenti, C. Di Mario, N. Marchionni, R. Marcucci
Summary: High platelet reactivity (HPR) is a known thrombotic risk factor after percutaneous coronary intervention (PCI). More potent antiplatelet drugs have partially addressed this issue, but clopidogrel remains the most prescribed P2Y(12) inhibitor in patients with concomitant atrial fibrillation (AF) and PCI.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2023)