Journal
EUROINTERVENTION
Volume 9, Issue 5, Pages 582-593Publisher
EUROPA EDITION
DOI: 10.4244/EIJV9I5A94
Keywords
3-dimensional coronary reconstruction; coronary angiography; endothelial shear stress; intravascular ultrasound
Categories
Funding
- Hellenic Heart Foundation
- George D. Behrakis Fellowship
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Aims: To develop and validate a new methodology that allows accurate 3-dimensional (3-D) coronary artery reconstruction using standard, simple angiographic and intravascular ultrasound (IVUS) data acquired during routine catheterisation enabling reliable assessment of the endothelial shear stress (ESS) distribution. Methods and results: Twenty-two patients (22 arteries: 7 LAD; 7 LCx; 8 RCA) who underwent angiography and IVUS examination were included. The acquired data were used for 3-D reconstruction using a conventional method and a new methodology that utilised the luminal 3-D centreline to place the detected IVUS borders and anatomical landmarks to estimate their orientation. The local ESS distribution was assessed by computational fluid dynamics. In corresponding consecutive 3 mm segments, lumen, plaque and ESS measurements in the 3-D models derived by the centreline approach were highly correlated to those derived from the conventional method (r>0.98 for all). The centreline methodology had a 99.5% diagnostic accuracy for identifying segments exposed to low ESS and provided similar estimations to the conventional method for the association between the change in plaque burden and ESS (centreline method: slope=-1.65%/Pa, p=0.078; conventional method: slope= -1.64%/Pa, p=0.084; p=0.69 for difference between the two methodologies). Conclusions: The centreline methodology provides geometrically correct models and permits reliable ESS computation. The ability to utilise data acquired during routine coronary angiography and IVUS examination will facilitate clinical investigation of the role of local ESS patterns in the natural history of coronary atherosclerosis.
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