Review
Cardiac & Cardiovascular Systems
Alexander G. Truesdell, Mirvat A. Alasnag, Prashant Kaul, Syed Tanveer Rab, Robert F. Riley, Michael N. Young, Wayne B. Batchelor, Akiko Maehara, Frederick G. Welt, Ajay J. Kirtane, ACC Interventional Counci
Summary: Coronary angiography has been the standard for diagnosing coronary artery disease and guiding percutaneous coronary intervention (PCI). Intravascular imaging (IVI) technologies are used in conjunction with angiography to better assess plaque morphology and optimize PCI. IVI has utility in preintervention assessment, procedural guidance, and postintervention evaluation. IVI's role in reducing major adverse cardiac events in complex lesions is emerging, and further studies are underway. This paper provides an overview of available IVI technologies, reviews evidence supporting their use in PCI, and advocates for broader utilization.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Vincenzo Tufaro, Patrick Washington Serruys, Lorenz Raber, Martin Richard Bennett, Ryo Torii, Sophie Zhaotao Gu, Yoshinobu Onuma, Anthony Mathur, Andreas Baumbach, Christos Vasileios Bourantas
Summary: Intravascular imaging plays an important role in assessing the effectiveness of drug therapies targeting atherosclerosis. Serial intravascular ultrasound, optical coherence tomography, or near-infrared spectroscopy-intravascular ultrasound studies allow for evaluation of the impact of different treatments on plaque burden and morphology. However, established intravascular imaging surrogate endpoints have limited efficacy in predicting the prognostic value of these therapies, necessitating the development of alternative imaging endpoints based on multimodality/hybrid intravascular imaging.
CARDIOVASCULAR RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Emrah Erdogan, Retesh Bajaj, Alexandra Lansky, Anthony Mathur, Andreas Baumbach, Christos Bourantas
Summary: Advancements in stent technology and endovascular devices have improved the safety and effectiveness of second-generation drug-eluting stents. However, in-stent restenosis and stent thrombosis still pose challenges in percutaneous coronary intervention. Recent studies have highlighted the value of intravascular imaging in identifying causes of stent failure and guiding therapy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Reza Fazel, Robert W. Yeh, David J. Cohen, Sunil Rao, Siling Li, Yang Song, Eric A. Secemsky
Summary: The use of intravascular imaging (IVI)-guided percutaneous coronary intervention (PCI) has been increasing among Medicare beneficiaries in the USA. IVI-guided PCI is associated with lower rates of major adverse cardiovascular events and target lesion revascularization compared with standard angiographic guidance.
EUROPEAN HEART JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Gary S. Mintz, Mitsuaki Matsumura, Ziad Ali, Akiko Maehara
Summary: Coronary angiography, although widely used, has limitations in assessing coronary artery disease. Intravascular imaging technologies provide more accurate information about the coronary arteries and have been shown to improve patient outcomes.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Olle Holmberg, Tobias Lenz, Valentin Koch, Aseel Alyagoob, Lea Utsch, Andreas Rank, Emina Sabic, Masaru Seguchi, Erion Xhepa, Sebastian Kufner, Salvatore Cassese, Adnan Kastrati, Carsten Marr, Michael Joner, Philipp Nicol
Summary: The study demonstrated the use of a deep-learning algorithm, DeepAD, to automatically predict atherosclerotic lesions in optical coherence tomography (OCT) with good performance. Training the algorithm with histopathology-based annotations improved the accuracy of atherosclerotic lesion detection.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Jiayue Huang, Shengxian Tu, Shinichiro Masuda, Kai Ninomiya, Jouke Dijkstra, Miao Chu, Daixin Ding, Sean O. O. Hynes, Neil O'Leary, Yoshinobu Onuma, Patrick W. W. Serruys, William Wijns
Summary: Deep learning algorithm provides a feasible and reliable method to estimate plaque burden from OCT images, showing good concordance with IVUS and not affected by media visibility. OCT DL has a high diagnostic accuracy in identifying high plaque burden.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Review
Medicine, General & Internal
Piotr Barus, Jakub Modrzewski, Karolina Gumiezna, Piotr Dunaj, Marcin Glod, Adrian Bednarek, Wojciech Wanha, Tomasz Roleder, Janusz Kochman, Mariusz Tomaniak
Summary: Although coronary angiography is the standard method for guiding percutaneous coronary intervention, recent advancements in intravascular imaging techniques, such as intravascular ultrasound and optical coherence tomography, have provided more detailed visualization of coronary lesions. These intravascular imaging modalities have the potential to improve the efficacy and long-term outcomes of percutaneous coronary intervention.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemical Research Methods
Cai Li, Julien Bec, Xiangnan Zhou, Laura Marcu
Summary: This study designs and characterizes a robust multimodal imaging system that combines optical coherence tomography and multispectral fluorescence lifetime imaging. By adopting key features, the system addresses existing shortcomings and achieves excellent experimental results.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Article
Biochemical Research Methods
Guangqian Yang, Emile Mehanna, Chao Li, Hongyi Zhu, Chong He, Fang Lu, Ke Zhao, Yubin Gong, Zhao Wang
Summary: This study developed a deep learning method to automatically analyze stents with different thicknesses and vessels implanted with multiple stents, providing effective assistance for the evaluation of stent implantation and post-stent tissue coverage.
BIOMEDICAL OPTICS EXPRESS
(2021)
Review
Cardiac & Cardiovascular Systems
Amr Abouelnour, Tommaso Gori
Summary: Intravascular imaging plays an important role in the treatment of in-stent restenosis, helping optimize stenting procedures, guide treatment, and evaluate re-intervention results.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Tariq Jamal Siddiqi, Muhammad Shahzeb Khan, Keyvan Karimi Galougahi, Evan Shlofmitz, Jeffrey W. Moses, Sunil Rao, Nick E. J. West, Eric Wolff, Jason Hochler, Karen Chau, Omar Khalique, Richard A. Shlofmitz, Allen Jeremias, Ziad A. Ali
Summary: This study conducted a systematic review and meta-analysis comparing the clinical outcomes of optical coherence tomography (OCT)-guided versus angiography-guided and intravascular ultrasound (IVUS)-guided coronary stent implantation. The results showed that OCT-guided PCI was associated with increased minimal stent area compared to angiography and reduced all-cause and cardiovascular mortality compared to angiography-guided PCI. However, OCT-guided and IVUS-guided PCI had similar post-PCI outcomes.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Weili Teng, Qi Li, Yuliang Ma, Chengfu Cao, Jian Liu, Hong Zhao, Mingyu Lu, Chang Hou, Weimin Wang
Summary: The study compared the effectiveness and outcomes of optical coherence tomography (OCT)-guided rotational atherectomy (RA) with intravascular ultrasound (IVUS)-guided RA in treating calcified coronary lesions. Results showed that OCT-guided RA led to better stent expansion and potentially improved prognosis compared to IVUS-guided RA.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Florian Blachutzik, Sophie Meier, Melissa Weissner, Sophia Schlattner, Tommaso Gori, Helen Ullrich-Daub, Luise Gaede, Stephan Achenbach, Helge Moellmann, Bogdan Chitic, Adem Aksoy, Georg Nickenig, Maren Weferling, Oliver Doerr, Niklas Boeder, Matthias Bayer, Albrecht Elsaesser, Christian Hamm, Holger Nef
Summary: This study aimed to compare the effects of coronary intravascular lithotripsy (IVL) and rotational atherectomy (RA) on severely calcified lesions. Based on OCT analysis, it was found that IVL induced more and longer fractures of the calcified plaque, while RA achieved a greater acute lumen gain.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Kenji Kawai, Yu Sato, Jason Y. Hokama, Rika Kawakami, Takao Konishi, Saikat Kumar B. Ghosh, Renu Virmani, Aloke Finn
Summary: In this study, the histologic effects of intravascular lithotripsy (IVL) on coronary calcified lesions were examined. IVL demonstrated a superior fracturing effect on coronary calcified lesions compared with plain old balloon angioplasty (POBA). Optical coherence tomography (OCT) failed to identify the presence of some calcium fractures and underestimated the depth of fracture when compared with micro-computed tomography (CT).
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Review
Cardiac & Cardiovascular Systems
Vincenzo Tufaro, Patrick Washington Serruys, Lorenz Raber, Martin Richard Bennett, Ryo Torii, Sophie Zhaotao Gu, Yoshinobu Onuma, Anthony Mathur, Andreas Baumbach, Christos Vasileios Bourantas
Summary: Intravascular imaging plays an important role in assessing the effectiveness of drug therapies targeting atherosclerosis. Serial intravascular ultrasound, optical coherence tomography, or near-infrared spectroscopy-intravascular ultrasound studies allow for evaluation of the impact of different treatments on plaque burden and morphology. However, established intravascular imaging surrogate endpoints have limited efficacy in predicting the prognostic value of these therapies, necessitating the development of alternative imaging endpoints based on multimodality/hybrid intravascular imaging.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Sukhdeep Bhogal, Ron Waksman, Paul Gordon, Afshin Ehsan, Sean R. Wilson, Robert Levitt, Puja Parikh, Thomas Bilfinger, Nicholas Hanna, Maurice Buchbinder, Federico M. Asch, Gaby Weissman, Itsik Ben-Dor, Christian C. Shults, Syed Ali, Corey Shea, Cheng Zhang, Hector M. Garcia-Garcia, Lowell F. Satler, Toby Rogers
Summary: This study evaluated the impact of antithrombotic regimens on subclinical leaflet thrombosis (SLT) in low-risk patients who underwent transcatheter aortic valve implantation (TAVI). The results showed that oral anticoagulation was associated with significantly lower rates of SLT at 30 days compared to dual antiplatelet therapy (DAPT) or single antiplatelet therapy (SAPT), and there was no apparent benefit of DAPT over SAPT. Additionally, short-term oral anticoagulation did not increase bleeding risk compared to SAPT or DAPT.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Masafumi Ono, Shigetaka Kageyama, Neil O'Leary, Mohammed S. El-Kurdi, Jochen Reinoehl, Eric Solien, Richard W. Bianco, Mirko Doss, Bart Meuris, Renu Virmani, Martijn Cox, Yoshinobu Onuma, Patrick W. Serruys
Summary: This study demonstrates the feasibility and effectiveness of a novel biorestorative graft in an ovine coronary artery bypass graft model, suggesting its potential as an alternative to saphenous vein grafts. These findings could pave the way for the first-in-man trial of using this new material for coronary artery bypass graft patients who struggle with harvesting SVGs.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Kai Ninomiya, Patrick W. Serruys, Scot Garg, Shinichiro Masuda, Shigetaka Kageyama, Nozomi Kotoku, Marie Angele Morel, Charles Taylor, John D. Puskas, Jagat Narula, Ulrich Schneider, Torsten Doenst, Kaoru Tanaka, Johan De Mey, Mark La Meir, Saima Mushtaq, Antonio L. Bartorelli, Giulio Pompilio, Daniele Andreini, Yoshinobu Onuma
Summary: The feasibility of using CCTA and FFRCT as guidance in the FASTTRACK CABG trial is determined by the need for invasive coronary angiography. According to the SS-2020, the first 57 patients enrolled in the trial received the appropriate revascularization modality, and the DSMB allowed the investigators to continue the study.
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Sneha S. Jain, Ditian Li, Ovidiu Dressler, Lak Kotinkaduwa, Patrick W. Serruys, A. Pieter Kappetein, Joseph F. Sabik, Marie-Claude Morice, John Puskas, David E. Kandzari, Dimitri Karmpaliotis, Nicholas J. Lembo, W. Morris Brown, Adrian P. Banning, Gregg W. Stone
Summary: This study assessed the association between periprocedural major adverse events (MAE) and subsequent mortality after percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) for left main coronary artery revascularization. The study found that nonfatal periprocedural MAE strongly predicted both early and late mortality after both PCI and CABG.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Tsung-Ying Tsai, Shigetaka Kageyama, Fabio Ramponi, Jagat Narula, Charles Taylor, Adam Updegrove, Scot Garg, Yoshinobu Onuma, Patrick W. Serruys, John Puskas
Article
Cardiac & Cardiovascular Systems
Cesar E. Soria Jimenez, Jorge Sanz Sanchez, Molly Brooke Levine, Fatima Hayat, Jerway Chang, Hector M. Garcia-Garcia
Summary: This meta-analysis found that adding colchicine to standard medical therapy in patients undergoing PCI did not reduce overall mortality, cardiovascular mortality, or the risk of urgent revascularization. However, it showed a trend towards a lower risk of myocardial infarction and a significantly lower risk of stroke.
REC-INTERVENTIONAL CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Hesham Elzomor, Timotheus J. Neumann, Linus Boas, Philipp Ruile, Mahmoud Abdelshafy, Ahmed Elkoumy, Pruthvi C. Revaiah, Tsung-Ying Tsai, Klaus Kaier, Osama Soliman, Miroslaw Ferenc, Dirk Westermann, Franz-Josef Neumann, Patrick Serruys, Simon Schoechlin
Summary: Background estimation of regurgitant fraction using videodensitometry (VD-AR) is a new objective grading tool for paravalvular regurgitation (PVR) after transcatheter aortic valve implantation (TAVI). This study found that VD-AR > 17% was independently associated with 3-year mortality. Compared to subjective visual evaluation, VD-AR resulted in a smaller proportion of patients classified as prognostically relevant for PVR.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Patrick W. Serruys, Pruthvi C. Revaiah, Yoshinobu Onuma
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Hesham El Zomor, Hendrik Wienemann, Matti Adam, Tanja Rudolph, Ahmed Elkoumy, Mahmoud Abdelshafy, Pruthvi Chenniganahosahalli Revaiah, Patrick W. Serruys, Osama Soliman
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Shinichiro Masuda, Patrick W. Serruys, Shigetaka Kageyama, Nozomi Kotoku, Kai Ninomiya, Scot Garg, Alan Soo, Marie-Angele Morel, John D. Puskas, Jagat Narula, Ulrich Schneider, Torsten Doenst, Kaoru Tanaka, Johan de Mey, Mark La Meir, Antonio L. Bartorelli, Saima Mushtaq, Giulio Pompilio, Daniele Andreini, Yoshinobu Onuma
Summary: This study compared treatment recommendations based on the SYNTAX score 2020 derived from coronary computed tomography angiography (CCTA) and invasive coronary angiography (ICA). The results showed moderate to substantial agreement between the anatomical SYNTAX scores derived from CCTA and ICA, suggesting that CCTA could be used as an alternative to ICA when making decisions regarding the modality of revascularization.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Nozomi Kotoku, Patrick W. Serruys, Kai Ninomiya, Alan Soo, Shinichiro Masuda, Shigetaka Kageyama, Pruthvi C. Revaiah, Michael J. Mack, David R. Holmes, Marie -Claude Morice, Piroze M. Davierwala, Friedrich W. Mohr, Milan Milojevic, Arie Pieter Kappetein, Scot Garg, Yoshinobu Onuma
Summary: This study aimed to evaluate the impact of non-fatal periprocedural major adverse events (PMAE) on 10-year mortality and investigate whether PMAE affect mortality predicted by SYNTAX score II 2020 (SSII-2020) and whether optimal medical therapy (OMT) has a positive effect on the prognosis of patients with non-fatal PMAE. The results show that non-fatal PMAE are more common following CABG than PCI, but their prognostic impact is similar, being significant in the first year and then diminishing out to 10 years. Therefore, patients with non-fatal PMAE may require more careful follow-up and additional preventive treatment in the first year post-procedure.
Meeting Abstract
Cardiac & Cardiovascular Systems
Yoshinobu Onuma, Shinichiro Masuda, Takashi Muramatsu, Yuki Ishibashi, Ken Kozuma, Hideyuki Kawashima, Gaku Nakazawa, Kuniaki Takahashi, Kengo Tanabe, Norihiro Kogame, Masato Nakamura, Taku Asano, Takayuki Okamura, Yosuke Miyazaki, Hiroki Tateishi, Yukio Ozaki, Shimpei Nakatani, Yuki Katagiri, Yoshihiro Morino, Kai Ninomiya, Shigetaka Kageyama, Nozomi Kotoku, Patricia O. Guimaraes, Pedro A. Lemos, Patrick W. Serruys
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Pruthvi Chenniganahosahalli Revaiah, Gregg W. Stone, Shinichiro Masuda, Kai Ninomiya, Nozomi Kotoku, Shigetaka Kageyama, Yoshinobu Onuma, Patrick W. Serruys
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Patrick Serruys, Kai Ninomiya, Jinying Zhou, Nozomi Kotoku, Shigetaka Kageyama, Shinichiro Masuda, Yoshinobu Onuma
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
