Review
Pharmacology & Pharmacy
Aernout van Haarst, Stephen Smith, Clare Garvin, Natacha Benrimoh, Sabina Paglialunga
Summary: This article discusses the discovery of nitrosamine impurities in rifampin formulations and the impact of this discovery on drug-drug interaction studies. Alternative options for conducting drug-drug interaction studies are also proposed.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Economics
Raviro Mercy Mhuru, Toby Daglish, Heng Geng
Summary: This paper investigates the impact of major oil discoveries on innovation. The findings indicate that innovation activity slows down after oil discovery, particularly in common law countries. This could be due to the resource windfall leading to a decline in innovative activities.
Article
Pharmacology & Pharmacy
Christine S. Kim, Lena K. Tran, Melanie Z. Goodberlet, Paul M. Szumita, Kaylee K. Marino
Summary: This retrospective analysis found that most patients achieved the goal phenytoin level after the initial loading dose. Weight-based dosing was identified as a significant predictor of achieving the goal level.
ANNALS OF PHARMACOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Layla M. S. Al Shagri, Hisham S. M. Abd-Rabboh, Majed A. Bajaber, Ayman H. Kamel
Summary: A micro-sized imprinted polymer/multiwalled carbon nanotube-based sensor is developed for potentiometric sensing of barbital. The sensor exhibits high selectivity and sensitivity for the detection of barbital in real samples.
Article
Multidisciplinary Sciences
Di Wu, Fan Fei, Qi Zhang, Xia Wang, Yiwei Gong, Xiaojie Chen, Yuyi Zheng, Bei Tan, Cenglin Xu, Hujun Xie, Wenjun Fang, Zhong Chen, Yi Wang
Summary: This study reports a nanoengineered drug delivery system for improved delivery efficiency and on-demand drug release of antiepileptic drugs (AEDs). The system utilizes receptor-mediated transcytosis and blood-brain barrier disruption induced by photothermal conversion to achieve brain-targeted delivery. The system has been shown to effectively inhibit seizures upon epileptiform abnormalities, using only one-fifth of the conventional dosage, and holds promise for clinical applications.
Article
Materials Science, Multidisciplinary
Maria E. Davila, Guy Le Lay
Summary: This concise review describes the birth and properties of silicene, a two-dimensional material that has emerged as a strong contender to graphene. It discusses the in situ synthesis of silicene under ultra-high vacuum, its exciting features, and its potential applications in various fields. The review also mentions the variants of silicene and their implications for quantum computing and other novel materials.
MATERIALS TODAY ADVANCES
(2022)
Article
Genetics & Heredity
Hafsa Maqbool, Tayyaba Saleem, Nadeem Sheikh, Aqsa Ashfaq
Summary: Epilepsy is a major global issue and drug resistance may be attributed to genetic polymorphism. This study found that none of the well-known reported SNPs of CYP2C9 was found in the Pakistani population, but a novel missense variant was identified in drug-resistant patients. Further analysis suggested that this variant may be pathogenic. The results indicated that rs1799853 and rs1057910 may be involved in drug resistance in the Pakistani population, but other CYP2C9 variants need to be explored.
Article
Plant Sciences
Ritesh Kumar, Renu Arora, Sudhir Chandra Sarangi, Shankar N. Ganeshan, Amit Agarwal, Thomas Kaleekal, Yogendra Kumar Gupta
Summary: The study found that co-administration of HECA could enhance the therapeutic efficacy of VPA and PHT in treating epilepsy, but changes in pharmacokinetic parameters require strict medical supervision to prevent toxic reactions.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Leopold Flohe, Stefano Toppo, Laura Orian
Summary: This article reviews the discoveries leading to our understanding of glutathione peroxidases (GPxs), emphasizing their role as antioxidant enzymes and their involvement in various regulatory and synthetic functions. GPx1, the first selenoenzyme in vertebrates, depends on selenium and exhibits a unique kinetic mechanism. Recent studies have further investigated the reaction mechanism using model compounds, identifying postulated intermediates.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Green & Sustainable Science & Technology
Carolyn Chisadza, Matthew Clance, Rangan Gupta, Mark E. E. Wohar
Summary: This study examines the impact of oil discoveries on conflict, distinguishing between interstate and intrastate conflicts. Using data from 1970 to 2012 for countries worldwide, the study finds a positive relationship between oil discoveries and both types of conflict, after controlling for other determinants and unobserved factors. Moreover, the effects on intrastate conflicts are immediate, while the effects on interstate conflicts take around five years to manifest. The study highlights the role of ethnic conflicts in driving the relationship between oil discoveries and intrastate conflicts. It suggests that different mechanisms may be at play for different conflict types, involving factors such as resource-induced inequality and the feasibility of engaging in conflict with neighboring resource-rich countries.
ENVIRONMENT DEVELOPMENT AND SUSTAINABILITY
(2023)
Review
Chemistry, Multidisciplinary
Daniel A. McNaughton, William G. Ryder, Alexander M. Gilchrist, Patrick Wang, Mohamed Fares, Xin Wu, Philip A. Gale
Summary: This review provides a comprehensive overview of the recent advancements in anion receptor chemistry in 2021 and 2022, including notable research in fundamental recognition, sensing and detection, catalysis, self-assembly, extraction, and transmembrane transport.
Article
Psychology, Social
Jiabi Wang, Shereen J. Chaudhry, Alex Koch
Summary: Reminders can interfere with the perceived genuineness of prosocial behavior, making reminded thankers seem less genuine and less likable than spontaneous thankers. This phenomenon has material consequences, as receivers of gratitude expressions allocate more bonus money to spontaneous thankers. Reminded thankers must engage in costly signaling to overcome the decrement in their perceived genuineness.
JOURNAL OF PERSONALITY AND SOCIAL PSYCHOLOGY
(2023)
Article
Pharmacology & Pharmacy
Malavika Deodhar, Stephanie A. Matthews, Brittany Thomas, Leena Adamian, Sarah Mattes, Tabitha Wells, Brianna Zieba, Kristina A. Simeone, Timothy A. Simeone
Summary: Drug resistant epilepsy affects around 30% of epilepsy patients. Kcna1-null mice exhibit characteristics of drug resistant epilepsy and may serve as a useful model for studying mechanisms of pharmacoresistance and testing novel therapeutic strategies.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhen Wang, Xiaoyu Wang, Zhe Wang, Xin Lv, Hang Yin, Wei Li, Wenli Li, Lili Jiang, Yong Liu
Summary: Thymoquinone, a bioactive compound of Nigella sativa L., has been shown to have neuroprotective and antiepileptic effects. This study investigated the potential drug interaction between thymoquinone and phenytoin, a commonly used drug for seizures. The results suggest that thymoquinone may inhibit the metabolism of phenytoin and caution should be taken when co-administering these two substances.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Immunology
Mia Levite, Hadassa Goldberg
Summary: Autoimmune Epilepsy is a complex disorder involving autoimmune antibodies targeting glutamate receptors and inhibitory neurotransmitter receptors, leading to neuronal damage and behavioral issues. The findings suggest a potential link between autoimmune mechanisms and epilepsy pathogenesis, highlighting the importance of understanding the role of autoimmunity in neurological disorders.
FRONTIERS IN IMMUNOLOGY
(2022)