Article
Multidisciplinary Sciences
Bianca R. Villa, Dhyey Bhatt, Marshal D. Wolff, Kwaku Addo-Osafo, Jonathan R. Epp, G. Campbell Teskey
Summary: Comorbidities during the period between seizures present a significant challenge for individuals with epilepsy. The pathophysiology of the interictal symptomatology is largely unknown, but postictal severe hypoxia (PIH) has been identified as a potential underlying mechanism. Using a rat model, the study found that repeated seizures led to increasingly severe episodes of PIH and decreased oxygen levels in the hippocampus during the interictal period. These reductions were prevented when PIH was blocked, and the cognitive deficits caused by seizures were alleviated. The study suggests that seizure-induced hypoxia may play a crucial role in epilepsy and targeting and preventing PIH could offer significant benefits.
SCIENTIFIC REPORTS
(2023)
Review
Behavioral Sciences
Mina Shahisavandi, Zahra Zeraatpisheh, Marzieh Rostaminejad, Ali A. Asadi-Pooya
Summary: Postictal headache is common among patients with epilepsy, with a prevalence of 43%. Current treatment options are limited, and more high-quality research is needed to advance the field. Flunarizine and sumatriptan may be promising candidates for future clinical trials in treating postictal headache.
EPILEPSY & BEHAVIOR
(2021)
Article
Health Care Sciences & Services
Anne C. Brochner, Peter Lindholm, Margrethe J. Jensen, Palle Toft, Finn L. Henriksen, Jens F. Lassen, Soren Mikkelsen
Summary: This study challenges the traditional belief that myoclonic status is a sign of poor prognosis after out-of-hospital cardiac arrest. The results show that myoclonic status may not necessarily indicate poor outcome when not associated with EEG-verified status epilepticus.
Article
Clinical Neurology
Lara Jehi, Kees Braun
Summary: Various factors, including etiology and histopathology, play crucial roles in determining the outcomes of epilepsy surgery. This review aims to investigate the relationship between etiology and surgical outcomes, while exploring possible explanatory mechanisms.
Article
Clinical Neurology
David Satzer, Yasar T. Esengul, Peter C. Warnke, Naoum P. Issa, Douglas R. Nordli
Summary: This study aimed to assess the validity of ictal SEEG source localization, and the results showed that SEEG source localization accurately mapped the onset of seizures compared to conventional interpretation. Additionally, the proximity of dipoles to the surgical treatment volume predicted the outcome of seizures when near-field recordings were analyzed.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Behavioral Sciences
Alexis Tarrada, Coraline Hingray, Olivier Aron, Sophie Dupont, Louis Maillard, Bertrand de Toffol
Summary: The study aimed to provide a precise description of psychiatric signs occurring during Postictal psychosis (PIP) and improve recognition of PIP. The study found that PIP resembles more an affective psychosis than a purely psychotic disorder. The characteristics of PIP include persecutory and religious delusions, hallucinations, mood disturbances (especially euphoria), sudden/rapid onset, duration of one to 14 days, and good response to antipsychotic medication. Recurrence of PIP is also common.
EPILEPSY & BEHAVIOR
(2022)
Article
Psychiatry
Antoine Pennou, Tania Lecomte, Yasser Khazaal, Stephane Potvin, Camille Vezina, Marianne Bouchard
Summary: Social functioning is crucial in the treatment of individuals with psychosis, as it is linked to a better overall quality of life and fewer future complications. This study suggests that theory of mind may be a more important predictor than cognitive functioning in specific domains of social functioning among individuals who have recently experienced a first episode of psychosis.
PSYCHIATRY RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Youwon Shin, Yoonho Nam, Taehoon Shin, Jin Wook Choi, Jang Hoon Lee, Da Eun Jung, Jiseon Lim, Hyun Gi Kim
Summary: A radiomics approach using MRI images can predict poor psychomotor development in preterm neonates, with white matter analysis playing a key role in the prediction model.
EUROPEAN RADIOLOGY
(2021)
Article
Clinical Neurology
Janani Kassiri, Cameron Elliott, Natarie Liu, Janette Mailo, Thilinie Rajapakse, Laura Schmitt, Matthew Wheatley, D. Barry Sinclair
Summary: Temporal lobe epilepsy in children presents differences compared to adults. Assessing structural lesions in pediatric patients with TLE and their relationship with seizure outcomes is crucial. Preoperative MRI accuracy and identification of specific pathologies, such as tumors and MTS, were associated with better long-term seizure outcomes after surgery, highlighting the importance of accurate preoperative imaging in epilepsy surgery management.
Review
Psychiatry
Bernd Hinney, Anna Walter, Soheila Aghlmandi, Christina Andreou, Stefan Borgwardt
Summary: A meta-analysis compared the baseline hippocampal volume of CHR patients who developed psychosis with those who did not, finding no statistically significant effect of hippocampal volume on the risk of transitioning to psychosis.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Chiara Pepi, Mattia Mercier, Giusy Carfi Pavia, Alessandro de Benedictis, Federico Vigevano, Maria Camilla Rossi-Espagnet, Giovanni Falcicchio, Carlo Efisio Marras, Nicola Specchio, Luca de Palma
Summary: This study used a brain machine learning approach to evaluate the role of inter-hemispheric EEG connectivity in predicting seizure outcome after hemispherotomy. The results showed that pre-surgical EEG features may have the potential to predict epilepsy outcome after hemispherotomy.
Article
Clinical Neurology
Jie Shen, Jianbo Yu, Sicong Huang, Rajneesh Mungur, Kaiyuan Huang, Xinfa Pan, Guofeng Yu, Zhikai Xie, Lihui Zhou, Zongchi Liu, Dexin Cheng, Jianwei Pan, Renya Zhan
Summary: This study successfully predicted the outcomes of poor-grade aSAH patients by developing a new scoring model, categorizing patients into low, intermediate, and high-risk groups with corresponding predicted risks of poor prognosis. The model was validated in two separate cohorts, demonstrating its clinical utility.
FRONTIERS IN NEUROLOGY
(2021)
Article
Psychology, Applied
Steven J. Lamontagne, Diego A. Pizzagalli, Mary C. Olmstead
Summary: COVID-19 not only affects patients with poor lung conditions, but also has a severe impact on patients with diseases such as hypertension, obesity, and diabetes, which may be related to inflammatory responses. It is predicted that chronic stress may interact with the inflammation caused by COVID-19, leading to a potentially fatal cytokine storm syndrome.
Article
Mathematical & Computational Biology
Xiaojin Li, Yan Huang, Samden D. D. Lhatoo, Shiqiang Tao, Laura Vilella Bertran, Guo-Qiang Zhang, Licong Cui
Summary: Sudden unexpected death of epilepsy (SUDEP) is a catastrophic complication of epilepsy, and its mechanisms are not fully understood. Postictal generalized electroencephalogram (EEG) suppression (PGES) has been identified as a potential risk marker for SUDEP, making accurate PGES detection crucial. This study presents a hybrid approach combining unsupervised and supervised learning for PGES detection using multi-channel EEG recordings. The results demonstrate that our approach outperforms existing methods in terms of detection accuracy.
FRONTIERS IN NEUROINFORMATICS
(2022)
Review
Clinical Neurology
Graham W. Johnson, Derek J. Doss, Dario J. Englot
Summary: This review examines the use of advanced network analyses to better understand network dysfunction in patients with focal drug-resistant epilepsy (DRE). Recent findings suggest that patient-specific differences in network dysfunction can be used to predict surgical outcomes, and various modalities such as functional MRI and electrophysiology have been used to gather relevant data. These studies have the potential to improve clinical decision-making and enhance surgical success rates.
CURRENT OPINION IN NEUROLOGY
(2022)
