Article
Clinical Neurology
Anna M. Bank, Ruben Kuzniecky, Robert C. Knowlton, Gregory D. Cascino, Graeme Jackson, Heath R. Pardoe
Summary: The study aimed to determine the frequency of MRI-identified potentially epileptogenic structural abnormalities in individuals with newly diagnosed focal epilepsy. The results showed that one in five patients may have causative MRI findings and an additional one in five patients have abnormalities of unknown relationship to epilepsy. This information is crucial for patient counseling, prognostication, and treatment planning.
Article
Neurosciences
Julien Jung, Romain Bouet, Helene Catenoix, Alexandra Montavont, Jean Isnard, Sebastien Boulogne, Marc Guenot, Philippe Ryvlin, Sylvain Rheims
Summary: PIH occurrence during temporal lobe seizures may be related to the activation of a widespread network of cortical structures, with the amygdala and anterior insula playing a key role.
HUMAN BRAIN MAPPING
(2022)
Article
Neuroimaging
Qiuxing Lin, Wei Li, Yuming Li, Peiwen Liu, Yingying Zhang, Qiyong Gong, Dong Zhou, Dongmei An
Summary: This study compared the topological characteristics and rich club organization between TLE patients with only FS and those with both FS and FBTCS. The results showed that both the FS and FBTCS group had a significant reduction in whole-brain connectivity strength and global efficiency compared to healthy controls. The FBTCS group had lower connectivity strength in the rich club and feeder connections, while the FS group had lower connectivity strength in the feeder and local connections. NBS analysis revealed that the decreased connectivity strength in the FBTCS group involved a wider range of regions, mainly affecting connections between the temporal lobe and other regions. The decreased connectivity strength in the FS group was more localized, mainly affecting the temporal-subcortical lobe.
NEUROIMAGE-CLINICAL
(2023)
Article
Clinical Neurology
Elisa Micalizzi, Anna Elisabetta Vaudano, Giada Giovannini, Giulia Turchi, Leandra Giunta, Stefano Meletti
Summary: Patients with temporal lobe epilepsy may present with central apnea as the first clinical manifestation of their seizures, which could be related to alterations in mesial temporal lobe structures, including the amygdala. Monitoring respiratory changes and oxygen saturation in focal seizures is important for identifying the epileptogenic zone and understanding risk factors for seizure-related autonomic changes.
FRONTIERS IN NEUROLOGY
(2021)
Article
Behavioral Sciences
Yao Wang, Xiu Wang, Bao-tian Zhao, Lin Sang, Chao Zhang, Wen-han Hu, Xiao-qiu Shao, Jian-guo Zhang, Kai Zhang
Summary: The study confirmed that the symptomatogenic zone of facial symptoms in insulo-opercular epilepsy (IOE) is the Rolandic operculum. Compared with mesial temporal lobe epilepsy (MTLE) patients, IOE patients with facial symptoms showed stronger functional connectivity and a higher energy ratio (ER) in the high frequency sub-bands. Additionally, the analysis of electroclinical correlation revealed that the Rolandic operculum was the only brain area showing any correlations.
EPILEPSY & BEHAVIOR
(2021)
Article
Clinical Neurology
Ali A. Asadi-Pooya, Mohsen Farazdaghi
Summary: This study investigated the characteristics of patients with MRI-negative temporal lobe epilepsy (TLE) and compared them with patients with hippocampal sclerosis (HS)-TLE, non-HS structural TLE, and dual pathology. The findings suggest that MRI-negative TLE is not a homogeneous group and may not be a distinct entity from other forms of TLE. With advanced imaging technologies, the underlying pathologies of MRI-negative TLE may be revealed.
ACTA NEUROLOGICA BELGICA
(2023)
Article
Clinical Neurology
Bo Zhang, Jing Wang, Mengyang Wang, Xiongfei Wang, Yuguang Guan, Zhao Liu, Yao Zhang, Changqing Liu, Meng Zhao, Pandeng Xie, Mingwang Zhu, Tianfu Li, Guoming Luan, Jian Zhou
Summary: By analyzing ictal semiology in patients with temporal lobe epilepsy, different anatomical and semiologic subgroups can be identified. These subgroups are correlated with specific ictal signs.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Mikail Inal, Nuray Bayar Muluk, Nese Asal, Murat Alpua
Summary: The study indicates that patients with temporal and frontal epilepsy have significantly lower OB volumes compared to the control group, but no significant difference in OS depth. Positive correlations were found between OB volume, OS depth, left OB volume, and bilateral OS depth in the epilepsy groups, while there were no significant correlations between OB volume, OS depth, age, and gender of the patients.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)
Article
Clinical Neurology
Yue Niu, Pan Gong, Xianru Jiao, Haipo Yang, Zhixian Yang
Summary: The study reviewed the clinical, radiological, and pathological findings of pediatric epilepsy patients with temporal onset focal seizures induced by intermittent photic stimulation. The interictal EEG showed different types of spike and wave discharges, with all patients showing photoparoxysmal response. Follow-up revealed that most patients had controlled seizures, with only one experiencing occasional seizures.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Niravkumar Barot, Kavita Batra, Jerry Zhang, Mary Lou Klem, James Castellano, Jorge Gonzalez-Martinez, Anto Bagic
Summary: MRgLITT is an effective and safe intervention for drug-resistant epilepsy with different disease etiologies. The seizure freedom outcome is overall comparable between extratemporal and temporal lobe epilepsy; and highest with patients having hypothalamic hamartomas.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Celine Boileau, Severine Deforges, Angelique Peret, Didier Scavarda, Fabrice Bartolomei, April Giles, Nicolas Partouche, Justine Gautron, Julio Viotti, Haley Janowitz, Guillaume Penchet, Cecile Marchal, Stanislas Lagarde, Agnes Trebuchon, Nathalie Villeneuve, Julie Rumi, Thomas Marissal, Roustem Khazipov, Ilgam Khalilov, Fanny Martineau, Marine Marechal, Anne Lepine, Mathieu Milh, Dominique Figarella-Branger, Etienne Dougy, Soutsakhone Tong, Romain Appay, Stephane Baudouin, Andrew Mercer, Jared B. Smith, Olivier Danos, Richard Porter, Christophe Mulle, Valerie Crepel
Summary: This study aims to reduce chronic epileptic discharges in TLE patients by downregulating KARs in the hippocampus using gene therapy. The results demonstrate that gene silencing strategy can inhibit chronic seizures in a mouse TLE model and IEDs in cultured slices derived from TLE patients.
ANNALS OF NEUROLOGY
(2023)
Article
Immunology
Chong Liu, Xue-Min Zhao, Qiao Wang, Ting-Ting Du, Mo-Xuan Zhang, Hui-Zhi Wang, Ren-Peng Li, Kun Liang, Yuan Gao, Si-Yu Zhou, Tao Xue, Jian-Guo Zhang, Chun-Lei Han, Lin Shi, Liang-Wen Zhang, Fan-Gang Meng
Summary: Impaired activation and regulation of inflammatory cells and molecules in injured neuronal tissues play a crucial role in epilepsy development. SerpinA3N, primarily associated with acute and inflammatory response, was found to be significantly increased in the hippocampus of mice with KA-induced temporal lobe epilepsy. This molecule is mainly expressed in astrocytes and its overexpression in astrocytes promotes the release of proinflammatory factors, aggravating seizures. Mechanistically, SerpinA3N activates the NF-κB signaling pathway and interacts with RYR2, promoting RYR2 phosphorylation. This study reveals a novel SerpinA3N-mediated mechanism in seizure-induced neuroinflammation and provides a potential target for reducing seizure-induced brain injury.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Clinical Neurology
Fatme Seval Ismail, Marianna Spatola, Friedrich G. Woermann, Stoyan Popkirov, Johannes Jungilligens, Christian G. Bien, Jorg Wellmer, Uwe Schlegel
Summary: In patients with temporal lobe seizures and additional signs of limbic involvement, 17% had neuronal antibodies confirming the diagnosis of ALE. Mediotemporal MRI changes were present in all antibody-positive cases and had a positive likelihood ratio of 2.11.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Doodipala Samba Reddy, Robert H. Mbilinyi, Sreevidhya Ramakrishnan
Summary: At present, there is no drug therapy available for curing epilepsy. However, recent research has shown the potential of cannabidiol (CBD) in controlling epileptogenesis and reducing seizure burden. CBD can also be used in combination with other antiseizure medications, indicating strong potential as an adjunct therapy.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Clinical Neurology
Elena Fonseca, Manuel Quintana, Ivan Seijo-Raposo, Zurine Ortiz de Zarate, Laura Abraira, Estevo Santamarina, Jose Alvarez-Sabin, Manuel Toledo
Summary: This study evaluated the use of quantitative electroencephalography in analyzing baseline activity in patients with temporal lobe epilepsy, finding that alpha-delta and alpha-theta ratios may be reliable measures in identifying TLE patients, while a higher contralateral theta power ratio may indicate longer epilepsy duration.
ACTA NEUROLOGICA SCANDINAVICA
(2022)
