Letter
Immunology
Chen Huang, Jieshi Yu, Ben M. Hause, Jie Yeun Park, Chithra Sreenivasan, Tirth Uprety, Zizhang Sheng, Dan Wang, Feng Li
Summary: A novel group of IDV with broad antigenicity has been identified in U.S. bovine herds, showing genetic differences from previously known lineages of IDV.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Immunology
Kadir Yesilbag, Eda Baldan Toker, Ozer Ates
Summary: This study investigated the presence of IDV in nasal swab samples collected from cattle with BRD between 2012 and 2021, and identified the circulation of D/Yama2019 and D/Bursa2013 (a new lineage) in Turkey. The study also highlighted the differences in nucleotide and amino acid substitutions among different lineages of IDV.
MICROBIAL PATHOGENESIS
(2022)
Article
Biochemistry & Molecular Biology
Xu Zhang, Tim Abel, Shuo Su, Andreas Herrmann, Kai Ludwig, Michael Veit
Summary: The assembly and budding of influenza C virus is mediated by three membrane proteins. The hexagonal arrangement of the HEF protein is crucial for virus budding, and its interaction with CM1 stabilizes the clusters. CM2 and CM1 also play important roles in this process.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Eva Garcia-Moro, Jie Zhang, Lesley J. Calder, Nick R. Brown, Steven J. Gamblin, John J. Skehel, Peter B. Rosenthal
Summary: The subunits of influenza hemagglutinin (HA) trill-ter are synthesized as single-chain precursors (HA0s) that are proteolytically cleaved into the disulfide-linked polypeptides HA1 and HA2. Cleavage is required for activation of membrane fusion at low pH. Cryo-EM was used to directly image HA0 at neutral and low pH, revealing extensive structural changes and reversible conformational changes at low pH. These findings have important implications for understanding the mechanism of membrane fusion mediated by cleaved HA and for the development of antiviral drugs and antibodies against influenza.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Virology
Makoto Ujike, Yuka Etoh, Naoya Urushiyama, Fumihiro Taguchi, Hideki Asanuma, Luis Enjuanes, Wataru Kamitani
Summary: Historically part of the coronavirus (CoV) family, torovirus (ToV) was recently classified in the new family Tobaniviridae. Researchers developed a reverse genetics system using an infectious full-length cDNA clone of bovine ToV (BToV) in a bacterial artificial chromosome (BAC). Recombinant BToV with genetic markers exhibited the same phenotype as wild-type BToV. The study generated recombinant BToVs with a full-length HE gene and discovered that mutations in nonstructural proteins (NSPs) may be involved in HE gene retention. The findings provide new insights into BToV and contribute to the understanding of this neglected pathogen.
JOURNAL OF VIROLOGY
(2022)
Editorial Material
Biophysics
Milad Zandi, Mona Fani
Summary: In this review, the authors discussed the current methods for diagnosing COVID-19 and analyzed the genome structure of SARS-CoV-2. They pointed out the absence of the hemagglutinin esterase gene in SARS-CoV-2 but the presence of other accessory protein ORFs.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Virology
Jasmine Rae Frost, Saba Shaikh, Alberto Severini
Summary: Several studies have examined amino acid variations between circulating wild-type mumps strains and vaccine strains, focusing on the HN and F mumps surface glycoproteins. These variations may have potential effects on viral infection and immune responses.
Article
Biochemistry & Molecular Biology
Xiaolan Zhang, Yue Wang, Hui Zhu, Zhaohua Zhong
Summary: This study focuses on the role of an esterase (Sse) secreted by Streptococcus pyogenes in pathogenesis. By generating a gene knockout strain and conducting transcriptome analysis, the study reveals that Sse plays a crucial role in GAS virulence and metabolic pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
David E. Scheim, Paola Vottero, Alessandro D. Santin, Allen G. Hirsh
Summary: According to biochemical properties, sialylated glycan attachments between SARS-CoV-2 spike protein and host cells play a key role in the virus's pathology. The virus can attach to and damage red blood cells, platelets, and endothelial cells. Risk factors for severe COVID-19, such as age, diabetes, and obesity, are associated with increased RBC clumping. Furthermore, differences in glycan attachment release between common cold strains and deadly coronaviruses have been identified.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Ariel Isaacs, Yu Shang Low, Kyle L. L. Macauslane, Joy Seitanidou, Cassandra L. L. Pegg, Stacey T. M. Cheung, Benjamin Liang, Connor A. P. Scott, Michael J. J. Landsberg, Benjamin L. L. Schulz, Keith J. J. Chappell, Naphak Modhiran, Daniel Watterson
Summary: In 2022, a novel henipavirus called Langya virus (LayV) was discovered in China, which is closely related to Mojiang virus (MojV) and different from bat-borne henipaviruses, such as Nipah (NiV) and Hendra (HeV) viruses. This is the first documented case of human infection with a HNV other than NiV and HeV, highlighting the potential danger of this virus genus to human health.
NATURE COMMUNICATIONS
(2023)
Letter
Biochemistry & Molecular Biology
Milad Zandi, Saber Soltani
Summary: The authors of the article identified potential inhibitors of coronavirus hemagglutinin-esterase using computational approaches, but it was found that the SARS-CoV-2 genome lacks hemagglutinin-esterase gene, meaning it does not exist in SARS-CoV-2 particles.
MOLECULAR DIVERSITY
(2021)
Article
Virology
Dan David, Nick Storm, Waksman Ilan, Asaf Sol
Summary: This study isolated and characterized local BCoV strains in Israel, finding that they belong to different genetic variants and cluster together with other BCoV circulating in the area. These local strains are genetically close to other BCoV strains in the region but distant from the reference enteric strain Mebus.
Article
Biochemistry & Molecular Biology
Ahmed A. Ishola, Kayode E. Adewole, Habibu Tijjani, Suliat Abdulai, Nnaemeka T. Asogwa
Summary: The research suggests that COVID-19 likely originated from bats and identifies lopinavir, levofloxacin, and hydroxychloroquine as potential anti-COVID-19 drugs that could be further optimized and developed for treatment.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Multidisciplinary Sciences
Yutaka Sasaki, Naoto Yoshino, Takako Okuwa, Takashi Odagiri, Takashi Satoh, Yasushi Muraki
Summary: The study showed that the S16 autoantibody has a mitigating effect on acetaminophen-induced liver toxicity by cross-reacting with acetyl-CoA acyltransferase 2, suggesting it as a potential candidate for the treatment of liver injury.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Evelien Vanderlinden, Nathalie Van Winkel, Lieve Naesens, Els J. M. Van Damme, Leentje Persoons, Dominique Schols
Summary: The mannose-binding agents HHA, GNA, and UDA showed strong inhibitory activity against various influenza viruses in vitro, with a high degree of selectivity. These CBAs likely interfere with virus entry processes by interacting with HA, leading to inhibition of virus replication and release. The mechanism of action involves reducing membrane mobility and crosslinking of membrane glycoproteins with HA, providing a barrier for viral resistance.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Fisheries
Knut Wiik Vollset, Randi Ingebjorg Krontveit, Peder A. Jansen, Bengt Finstad, Bjorn Torgeir Barlaup, Ove Tommy Skilbrei, Martin Krkosek, Pal Romunstad, Arnfinn Aunsmo, Arne J. Jensen, Ian Dohoo
FISH AND FISHERIES
(2016)
Article
Veterinary Sciences
S. L. Marin, R. Ibarra, M. H. Medina, P. A. Jansen
PREVENTIVE VETERINARY MEDICINE
(2015)
Article
Multidisciplinary Sciences
Kiranpreet Kaur, Peder Andreas Jansen, Vidar Teis Aspehaug, Tor Einar Horsberg
Article
Fisheries
Randi N. Grontvedt, Anja B. Kristoffersen, Peder A. Jansen
Article
Infectious Diseases
Anja Brathen Kristoffersen, Lars Qviller, Kari Olli Helgesen, Knut Wiik Vollset, Hildegunn Viljugrein, Peder Andreas Jansen
Article
Multidisciplinary Sciences
Peder A. Jansen, Randi N. Grontvedt, Attila Tarpai, Kari O. Helgesen, Tor Einar Horsberg
Article
Infectious Diseases
M. Aldrin, P. A. Jansen, H. Stryhn
Article
Fisheries
Kari Olli Helgesen, Kristoffer Royset, Vidar Aspehaug, Peder A. Jansen
Article
Agricultural Engineering
J. B. Ulvund, S. Engebretsen, J. A. Alfredsen, T. Kristensen, H. A. Urke, P. A. Jansen
Summary: This study investigated behavioral patterns of Atlantic salmon exposed to artificial underwater lights using acoustic telemetry data and wavelet analysis. The results demonstrated the utility of wavelet analysis as a timely surveillance tool when investigating behavioral patterns in fish, particularly the individual response of farmed salmon to artificial lighting in an industrial setting. The swimming depth patterns of Atlantic salmon changed after the introduction of underwater lights, showing the potential impact of artificial lighting on fish behavior.
AQUACULTURAL ENGINEERING
(2021)
Editorial Material
Fisheries
Peder A. Jansen, Bjarne Gjerde
Summary: Researchers have developed a model to predict lice-induced mortality of virtual post-smolt Atlantic salmon from 401 Norwegian rivers, with lice sourced from farmed salmon. However, the model's predictions of mortality rates were found to be systematically overestimated compared to mortality estimates based on observed lice numbers on caught post-smolts.
ICES JOURNAL OF MARINE SCIENCE
(2021)
Article
Oceanography
H. A. Urke, K. Daae, H. Viljugrein, I Kandal, A. Staalstrom, P. A. Jansen
Summary: Aquaculture is a significant export industry in Norway managed by the Norwegian Food Safety Authority. Fish diseases and parasites pose major threats to the industry. A three-dimensional hydrodynamic model system has been developed to understand the risk of fish disease agent transmission between fish farms in Norwegian fjords.
OCEAN & COASTAL MANAGEMENT
(2021)
Article
Infectious Diseases
Katharine R. Dean, Magne Aldrin, Lars Qviller, Kari Olli Helgesen, Peder A. Jansen, Britt Bang Jensen
Summary: Norway produces over one million tonnes of salmonids annually, mainly in open-water net pens. Increasing salmonid production can lead to negative impacts on the marine environment, particularly the rise of sea lice infestations. The study shows that increasing production leads to higher sea lice abundance, but controlling the growth through lower sea lice levels and weekly treatments can result in increased costs and mortality among farmed salmonids.
Article
Fisheries
Solveig Engebretsen, Magne Aldrin, Lars Qviller, Leif Christian Stige, Trond Rafoss, Ole Roald Danielsen, Andreas Lindhom, Peder A. Jansen
Summary: This paper analyzed the stomach contents of over 20,000 lumpfish from 80 different Norwegian farms to investigate the salmon lice grazing efficacy. Factors such as lumpfish weight, weight of salmonids, salmon lice abundance in the cage, cloud cover, and sea temperature were considered. The results showed that 3.1% of the lumpfish had salmon lice in their stomach contents, with most having few lice and a few having many lice. The study found that lumpfish weight, salmon lice abundance, salmonid weight, and weather conditions influenced salmon lice grazing, while sea temperature did not. The findings contribute to understanding the factors affecting salmon lice grazing by lumpfish and can guide the best practices for using lumpfish as a control measure.
Article
Ecology
M. Aldrin, R. B. Huseby, A. Stien, R. N. Grontvedt, H. Viljugrein, P. A. Jansen
ECOLOGICAL MODELLING
(2017)
Article
Fisheries
S. S. Mikkelsen, L. Bigarre, B. Bang Jensen, A. B. Kristoffersen, P. A. Jansen, V. Panzarin, S. C. Bayliss, J. C. Avarre, N. J. Olesen
BULLETIN OF THE EUROPEAN ASSOCIATION OF FISH PATHOLOGISTS
(2016)