Review
Endocrinology & Metabolism
Alessandra Kobayati, Ahmad Haidar, Michael A. Tsoukas
Summary: Exogenous insulin remains the main treatment for type 1 diabetes (T1D), but adjunctive pharmacotherapies, such as GLP-1RAs, show potential in improving glycemic control and offering additional benefits for T1D patients. However, conflicting trial findings and underestimation of GLP-1 agonism's potential in T1D treatment have been observed. This narrative review aims to summarize the current evidence-based literature and explore uncharted opportunities with GLP-1 agonism in T1D populations.
DIABETES OBESITY & METABOLISM
(2022)
Review
Chemistry, Multidisciplinary
Alezandra Torres-Castano, Amado Rivero-Santana, Lilisbeth Perestelo-Perez, Andrea Duarte-Diaz, Analia Abt-Sacks, Vanesa Ramos-Garcia, Yolanda Alvarez-Perez, Ana M. Waagner, Mercedes Rigla, Pedro Serrano-Aguilar
Summary: The artificial pancreas (AP) is an effective device for helping patients with type-1 Diabetes Mellitus (T1DM) control their glucose levels. The addition of pramlintide in a dual-hormone AP could improve postprandial glycemic control. However, current research shows that controlling postprandial hyperglycemia remains a challenge.
APPLIED SCIENCES-BASEL
(2022)
Review
Multidisciplinary Sciences
Bruce A. Perkins, Jennifer L. Sherr, Chantal Mathieu
Summary: Despite innovations in insulin therapy, most type 1 diabetes patients still struggle to achieve sufficient glycemic control. The future may lie in combining pharmacological solutions with automated insulin delivery methods, utilizing machine learning and other technologies to enhance effectiveness.
Review
Endocrinology & Metabolism
Andressa Karoline Pinto de Lima Ribeiro, Josilayne Patricia Ramos Carvalho, Natali Valim Oliver Bento-Torres
Summary: This study conducted a systematic review to analyze the relationship between physical training variables and glycemic control in individuals with T2DM. The results showed that aerobic, resistance, and combined training interventions were associated with reductions in HbA1c and fasting glucose. However, the diversity of the physical exercise intervention protocols investigated in the studies limited the generalizability of the evidence.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mark Agostino, Jennifer Rooney, Lakshini Herat, Jennifer Matthews, Allyson Simonds, Susan E. Northfield, Denham Hopper, Markus P. Schlaich, Vance B. Matthews
Summary: The study found that TNFSF14-derived molecules positively regulate glucose homeostasis and lipid metabolism, potentially opening a completely novel therapeutic pathway for treating obesity and T2D.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Klara R. Klein, Jennifer L. R. Freeman, Imogene Dunn, Chris Dvergsten, M. Sue Kirkman, John B. Buse, Carmen Valcarce
Summary: TTP399 lowers HbA(1c) levels and reduces the incidence of hypoglycemia without increasing the risk of ketosis. It should be further evaluated as an adjunctive therapy for type 1 diabetes.
Article
Medical Informatics
Michael A. Tsoukas, Dorsa Majdpour, Jean-Francois Yale, Anas El Fathi, Natasha Garfield, Joanna Rutkowski, Jennifer Rene, Laurent Legault, Ahmad Haidar
Summary: The study evaluated the efficacy of a novel faster-acting insulin aspart and pramlintide full closed-loop system, which did not show non-inferiority to a hybrid closed-loop system in terms of time spent within the glucose target range. However, the fully closed-loop system still demonstrated good glucose control results.
LANCET DIGITAL HEALTH
(2021)
Review
Endocrinology & Metabolism
Kyrstin Lane, Matthew Freeby
Summary: Insulin is essential for type 1 diabetes management, but adjunctive therapies can positively impact glycemic control, reduce insulin requirements, and lead to weight loss. However, these therapies may also increase the risk of hypoglycemia and other side effects.
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
(2021)
Review
Pharmacology & Pharmacy
Sorina Mihaela Solomon, Celina Silvia Stafie, Irina-Georgeta Sufaru, Silvia Teslaru, Cristina Mihaela Ghiciuc, Florin Dumitru Petrariu, Oana Tanculescu
Summary: This review aims to present the effects, various forms of application, and aspects related to biotolerance of turmeric extract as an additional therapeutic means in the treatment of periodontal disease.
Article
Immunology
Qin Zeng, Jianfeng Song, Dandan Wang, Xiaoxiao Sun, Yalun Xiao, Haowei Zhang, Yang Xiao, Zhiguang Zhou, Tuo Deng
Summary: In this study, we identified sorafenib as a potential inhibitor of Th1 cell differentiation through screening an FDA-approved tyrosine kinase inhibitor drug library. Treatment with sorafenib inhibited Th1 cell population and impeded the development of type 1 diabetes in NOD mice. Mechanistically, sorafenib indirectly inhibited JAK2 activity.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Ehtasham Ahmad, Soo Lim, Roberta Lamptey, David R. Webb, Melanie J. Davies
Summary: Type 2 diabetes accounts for nearly 90% of global diabetes cases, with an increasing number of affected individuals, particularly among young people. Early detection and proactive management are crucial for preventing complications and reducing mortality. Technology and precision medicine offer potential improvements to treatment outcomes but face significant barriers.
Review
Medicine, General & Internal
Ildiko Lingvay, Priya Sumithran, Ricardo Cohen, Carel W. le Roux
Summary: Obesity is recognized as a disease associated with serious morbidity and increased mortality. Weight loss has been shown to improve glucose control in patients with type 2 diabetes, as well as reduce risk factors for cardiometabolic disease and improve quality of life.
Review
Nutrition & Dietetics
Daniel Herz, Sandra Haupt, Rebecca Tanja Zimmer, Nadine Bianca Wachsmuth, Janis Schierbauer, Paul Zimmermann, Thomas Voit, Ulrike Thurm, Kayvan Khoramipour, Sian Rilstone, Othmar Moser
Summary: Studies suggest that dietary behavior modification, including fasting, can improve metabolic and cardiovascular markers as well as body composition. Fasting has demonstrated beneficial effects for both healthy individuals and those with metabolic diseases, leading to increased research interest in its impact on glycemia and associated complications. This review aimed to investigate the safety and effectiveness of fasting in addition to medications for T1DM and T2DM therapy.
Article
Pharmacology & Pharmacy
Ake Sjoholm
Summary: This article surveys adjuvant treatments against type 1 diabetes, with a focus on the role of SGLT inhibitors.
EXPERT OPINION ON PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Yajun Wu, Yao Wang, Dongmin Liu
Summary: The prevalence of type 2 diabetes (T2D) is increasing worldwide. Genipin, a natural compound, can stimulate the secretion of glucagon-like peptide-1 (GLP-1) from intestinal L-cells. In mice, genipin administration can increase GLP-1 secretion and reverse hyperglycemia and insulin resistance caused by a high-fat diet (HFD). Genipin also improves lipid metabolism and reduces liver lipid accumulation in obese mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
