Review
Cardiac & Cardiovascular Systems
Yoon Kyung Choi, Young-Myeong Kim
Summary: The interaction between CO and NO plays a crucial role in maintaining vascular homeostasis and regeneration by improving endothelial function and promoting cell-cell communication, thus sustaining the health of cardiovascular and neurovascular systems.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Plant Sciences
Ting-Ting Chang, Yi-An Chen, Szu-Yuan Li, Jaw-Wen Chen
Summary: The study showed that Ginkgo biloba extract (GbE) prevented diabetic nephropathy (DN) by activating heme oxygenase (HO)-1, improving renal function, decreasing glomerular hypertrophy, proteinuria, and kidney/body weight ratio, reducing inflammatory factors in the glomeruli, and protecting podocytes against the effects of high glucose.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Xueqi Chen, Leijuan Xiao, Shiyue Yu, Zhiyun Ren, Weiwan Wang, Yutao Jia, Mingda Liu, Ping Wang, Daxi Ji, Yanting Yu, Xiaoyan Wang
Summary: Diabetic nephropathy (DN) is a common complication of diabetes mellitus and is associated with oxidative stress. Hydrogen sulfide (H2S) has potential as a treatment for DN, but its antioxidant effects are not well studied. In a mouse model of DN, treatment with the H2S donor GYY4137 improved albuminuria and decreased serum creatinine, but had no effect on hyperglycemia. GYY4137 also reduced oxidative damage markers and affected the levels of enzymes involved in reactive oxygen species (ROS) production and cleavage in the kidney. This study suggests that H2S donors may be a therapeutic option for DN by reducing oxidative damage.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Endocrinology & Metabolism
Xiaomeng Feng, Shuo Wang, Zhencheng Sun, Hengbei Dong, Haitian Yu, Mengxiu Huang, Xia Gao
Summary: The study found that ferroptosis aggravated diabetic nephropathy and damaged renal tubules in db/db mice through the HIF-1 alpha/HO-1 pathway.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Chemistry, Inorganic & Nuclear
Ana C. Pena, Ana Pamplona
Summary: Transition metals, especially iron, play important roles in the chemistry of life. Hemoproteins, including hemoglobin, are common targets for binding with biologically active gases such as NO and CO. Heme oxygenases, particularly HO-1, are crucial enzymes involved in heme metabolism and have documented antioxidant and anti-inflammatory properties. However, their role in infection, such as malaria, can be dual, either limiting pathogen burden or promoting pathogen growth. CO-releasing molecules have been considered as a potential alternative to CO gas inhalation for therapeutic purposes.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Plant Sciences
Nana Su, Ze Liu, Lu Wang, Yuanyuan Liu, Mengyang Niu, Xin Chen, Jin Cui
Summary: This study reveals that hemin treatment increases anthocyanin accumulation in radish sprouts through HO-1 and NO signaling network.
Review
Endocrinology & Metabolism
Ying Wang, Tongtong Liu, Yuzi Cai, Weijing Liu, Jing Guo
Summary: This article discusses the important role of SIRT6 in glucose and lipid metabolism and its potential as a therapeutic target to improve glucose and lipid metabolism and alleviate DN occurrence and progression.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ulises Novoa, Karen Soto, Cristian Valdes, Jorge Villasenor, Adriana Treuer, Daniel R. Gonzalez
Summary: This study found that treatment with BH4 can prevent the development of diabetic cardiomyopathy and nephropathy. BH4 treatment reduced cardiac hypertrophy and fibrosis, as well as glomerular hypertrophy and fibrosis. These results suggest that BH4-based treatment may ameliorate the cardiorenal effects of diabetes by restoring the nitroso-redox balance.
Review
Biochemistry & Molecular Biology
Subir Kumar Juin, Rosemary Ouseph, Dibson Dibe Gondim, Venkatakrishna Rao Jala, Utpal Sen
Summary: Diabetic nephropathy (DN) is still the main cause of morbidity and mortality in diabetes patients. Gasotransmitters, including nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S), play a vital role in the development and progression of DN. Aberrant levels of gasotransmitters have been observed in patients with diabetes, and gasotransmitter donors show potential in ameliorating diabetic renal dysfunction. This review provides an overview of the physiological relevance of gasotransmitters and their interaction with other factors in the severity modulation of DN, highlighting the possible therapeutic interventions.
Article
Chemistry, Multidisciplinary
Xiaodi Rong, Yiyuan Peng, Caiyun Liu, Mingzhu Li, Jiafan Shi, Miaohui Yu, Shuaikang Ba, Wenlong Sheng, Baocun Zhu
Summary: In this study, the issues of sensitivity, selectivity, and water solubility of CO fluorescent probes were investigated. A probe named HS-CO was designed to greatly increase the rigid plane of the probe through intramolecular cyclization, resulting in high sensitivity for CO detection. The probe was successfully used to detect CO in HeLa cells and zebrafish, demonstrating its great potential as a tool for functional analysis of CO in organisms.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Michal Majewski, Leszek Gromadzinski, Ewelina Cholewinska, Katarzyna Ognik, Bartosz Fotschki, Jerzy Juskiewicz
Summary: This study aimed to investigate the effects of dietary fiber supplementation with different types of nanoparticles on the cardiovascular system in rats. The results showed that compared to pectin, inulin and psyllium supplementation with a standard dose of copper nanoparticles improved antioxidant capacity and reduced heart malondialdehyde levels. Furthermore, with an enhanced dose of copper nanoparticles, inulin and psyllium enhanced vasodilation through up-regulation of COX-2-derived vasodilator prostanoids.
Article
Chemistry, Applied
Na Yeon Kim, Sooji Kim, Hwa Jin Lee, Jae-Ha Ryu
Summary: Four sesquiterpenoids were isolated from A. princeps ethanolic extract, and they showed anti-inflammatory activity by up-regulating the Nrf2/HO-1 pathway.
NATURAL PRODUCT RESEARCH
(2023)
Article
Cell Biology
Yanjuan Hou, Qian Wang, Baosheng Han, Yiliang Chen, Xi Qiao, Lihua Wang
Summary: In diabetic nephropathy, CD36 mediates ROS production that enhances NLRP3 inflammasome activation, leading to IL-1 beta secretion and cell apoptosis. Inhibition of CD36 protects mice from tubulointerstitial inflammation and tubular epithelial cell apoptosis.
CELL DEATH & DISEASE
(2021)
Article
Medicine, General & Internal
Gehan H. Heeba, Marwa A. M. Ali, Azza A. K. El-Sheikh
Summary: This study found that rosuvastatin has a hemin-like nephroprotective effect in streptozotocin-induced diabetic rats. By increasing the expression and activity of renal heme oxygenase-1, rosuvastatin can improve kidney function and reduce oxidative stress, inflammation, and apoptosis.
MEDICINA-LITHUANIA
(2022)
Review
Physiology
Katharine L. Bunch, Ammar A. Abdelrahman, Ruth B. Caldwell, R. William Caldwell
Summary: Diabetic retinopathy (DR) and diabetic macular edema (DME) are complications of diabetes that can cause vision loss and reduced quality of life. Current treatments for advanced DR and DME are invasive, expensive, and can have adverse side-effects. Therefore, there is a need for more effective, affordable, and accessible therapies that can target early stage disease. Novel therapies under investigation include erythropoietin-derived peptides, inducers of antioxidant gene expression, activators of nitric oxide/cyclic GMP signaling pathways, and manipulation of arginase activity.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Ariadne Stavare Leal Araujo, Carina Verna, Osvaldo Pereira Araujo Junior, Jose Maria Soares Junior, Ricardo Santos Simoes, Edmund Chada Baracat, Manuel de Jesus Simoes, Regina Celia Teixeira Gomes
Summary: Metoclopramide-induced hyperprolactinemia can lead to increased cell death and proliferation in the harderian gland of female mice.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2021)
Article
Multidisciplinary Sciences
Yuanji Tang, Tamires D. A. Serdan, Amanda L. Alecrim, Diego R. Souza, Bruno R. M. Nacano, Flaviano L. R. Silva, Eliane B. Silva, Sarah O. Poma, Matheus Gennari-Felipe, Patricia N. Iser-Bem, Laureane N. Masi, Sherry Tang, Adriana C. Levada-Pires, Elaine Hatanaka, Maria F. Cury-Boaventura, Fernanda T. Borges, Tania C. Pithon-Curi, Marli C. Curpertino, Jarlei Fiamoncini, Carol Gois Leandro, Renata Gorjao, Rui Curi, Sandro Massao Hirabara
Summary: A mathematical model was proposed to predict the evolution of COVID-19 in different Brazilian states and cities, showing the significant impact of governmental decisions on the pandemic curve growth. The predicted number of new cases was found to be closely related to the total number of hospitalizations and deaths, indicating the effectiveness of intervention and preventive measures.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Pedro L. R. Guedes, Carolina P. F. Carvalho, Adriana A. F. Carbonel, Manuel J. Simoes, Marcelo Y. Icimoto, Jair A. K. Aguiar, Maria Kouyoumdjian, Marcos L. Gazarini, Marcia R. Nagaoka
Summary: Chondroitin sulfate (CS) has been found to have therapeutic effects in an experimental model of bile duct ligation. CS reduces collagen content and increases liver parenchyma content, and can alter the hepatic collagen III/I ratio. Additionally, CS reduces cell death indicators and promotes regeneration. Therefore, CS has potential hepatoprotective action in fibrogenesis induced by bile duct ligation.
Article
Medicine, Research & Experimental
Danilo B. M. Lucchi, Gisela R. S. Sasso, Leticia S. Sena, Diego D. Santos, Paulo C. Franco, Izabella Lice, Fernanda T. Borges, Sonia M. Oliani, Cristiane D. Gil
Summary: In this study, the pharmacological treatment with AnxA1-derived peptide Ac2-26 was evaluated in an experimental model of cisplatin-induced toxicity. The results showed that Ac2-26 treatment could alleviate the inflammatory response induced by cisplatin and protect the liver and kidneys from cisplatin-induced damage. However, the peptide treatment had no significant effect on kidney morphology injury.
Article
Nutrition & Dietetics
Adriana Aparecida Ferraz Carbonel, Rafael Andre da Silva, Luiz Philipe de Souza Ferreira, Renata Ramos Vieira, Ricardo dos Santos Simoes, Gisela Rodrigues da Silva Sasso, Manuel de Jesus Simoes, Jose Maria Soares Junior, Patricia Daniele Azevedo Lima, Fernanda Teixeira Borges
Summary: This study investigated the protective effect of isoflavone on diabetic kidney disease in postmenopausal rats. Isoflavone was found to inhibit renal injury, regulate blood glucose levels, and may be associated with PPARγ overexpression.
Editorial Material
Medicine, General & Internal
Adriana Aparecida Ferraz Carbonel, Ricardo Santos Simoes, Gisela da Silva Sasso, Renata Ramos Vieira, Patricia Azevedo Lima, Manuel de Jesus Simoes, Jose Maria Soares Jr
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2022)
Review
Microbiology
Alef Aragao Carneiro dos Santos, Luiz Eduardo Rodrigues, Amanda Lins Alecrim-Zeza, Liliane de Araujo Ferreira, Caio dos Santos Trettel, Gabriela Mandu Gimenes, Adelson Fernandes da Silva, Celso Pereira Batista Sousa-Filho, Tamires Duarte Afonso Serdan, Adriana Cristina Levada-Pires, Elaine Hatanaka, Fernanda Teixeira Borges, Marcelo Paes de Barros, Maria Fernanda Cury-Boaventura, Gisele Lopes Bertolini, Priscila Cassolla, Gabriel Nasri Marzuca-Nassr, Kaio Fernando Vitzel, Tania Cristina Pithon-Curi, Laureane Nunes Masi, Rui Curi, Renata Gorjao, Sandro Massao Hirabara
Summary: COVID-19-induced tissue dysfunction is associated with cell damage in multiple organs and involves metabolic disturbances and mechanisms such as the production of proinflammatory cytokines, oxidative stress, and deregulation of the renin-angiotensin-aldosterone system.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Glaucia Mara MenezesdaSilva, Eduardo Carvalho de Arruda Veiga, Manuel Jesus Simoes, Ricardo Santos Simoes, Marcos Eiji Shiroma, Maria Candida Pinheiro Baracat, Givanna Santos Cavalcanti, Jose Maria Soares Junior, Edmund Chada Baracat
Summary: This study aimed to evaluate the effects of estrogen and raloxifene on the synaptic density profile in the CA1 region of the hippocampus in ovariectomized rats. The results showed a significant increase in the synaptic density profile in the estrogen and raloxifene treatment groups compared to the control groups, suggesting their important role in hippocampal learning and memory.
Article
Dentistry, Oral Surgery & Medicine
Gisela Rodrigues Da Silva Sasso, Paulo Sergio Cerri, Estela Sasso-Cerri, Manuel Jesus Simoes, Cristiane Damas Gil, Rinaldo Florencio-Silva
Summary: This study investigated the expression profiles of ANXA1 and NLRP3 in bone cells under diabetes mellitus and estrogen-deficient conditions. The results suggest a possible role for the ANXA1/FPR2 pathway as a fine-tuning/anti-inflammatory regulator to counterbalance exacerbated COX2/NLRP3/IL-1 beta activation in bone cells during bone remodeling under estrogen deficiency and DM.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Cell Biology
Gisela Rodrigues da Silva Sasso, Rinaldo Florencio-Silva, Jose Paulo de Pizzol-Junior, Cristiane Damas Gil, Manuel de Jesus Simoes, Estela Sasso-Cerri, Paulo Sergio Cerri
Summary: This study revealed the presence of osteocalcin in osteoblast precursors and its involvement in osteoblast differentiation and regulation of calcium/phosphate precipitation during early mineralization of the alveolar process.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2023)
Article
Toxicology
Rafael da Silva Luiz, Rodolfo Rosseto Rampaso, Alef Aragao Carneiro dos Santos, Marcia Bastos Convento, Dulce Aparecida Barbosa, Cassiane Dezoti da Fonseca, Andreia Silva de Oliveira, Agnaldo Caires, Andrei Furlan, Nestor Schor, Fernanda Teixeira Borges
Summary: The study demonstrated that sEV secreted by BM-MSC from trained rats showed increased nephroprotective potential compared to untrained ones, carrying pro-angiogenic miR-296 and promoting angiogenesis in the kidney tissue.
JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES
(2021)
Article
Medicine, General & Internal
Cassiane Dezoti da Fonseca, Mirian Watanabe, Sheila Marques Fernandes Couto, Alef Aragao Carneiro Dos Santos, Fernanda Teixeira Borges, Maria de Fatima Fernandes Vattimo
Summary: The study demonstrated the renoprotective effects of HO-1 in CI-AKI and preclinical diabetic models, showing improved kidney function, reduced oxidative stress, and prevention of cell necrosis.
Article
Biology
M. Watanabe, F. T. Borges, E. A. Pessoa, C. D. Fonseca, S. M. Fernandes, R. C. Drew, R. A. Volpini, M. F. F. Vattimo
Summary: The study investigated the protective effect of N-acetylcysteine (NAC) in short-term and long-term ischemic acute kidney injury, showing antioxidant effects of NAC in short-term ischemia but not in long-term ischemia, suggesting the existence of a therapeutic window for its renoprotective effect.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Leonardo Augusto Lombardi, Leandro Sabara Mattos, Ricardo Santos Simoes, Rinaldo Florencio-Silva, Manuel de Jesus Simoes, Paulo Celso Franco, Adriana Aparecida Ferraz Carbonell, Gisela Rodrigues da Silva Sasso, Edmund Chada Baracat, Jose Maria Soares-Jr
Summary: Histomorphometric and immunohistochemical changes in rats treated with clomiphene citrate showed a decrease in ovarian cysts, an increase in ovarian follicles, and a decrease in the area occupied by interstitial cells.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)