Article
Dermatology
Giulia Briatico, Pamela Mancuso, Giuseppe Argenziano, Caterina Longo, Lucia Mangone, Elvira Moscarella, Gabriella Brancaccio, Riccardo Pampena
Summary: The mortality rate for cutaneous melanoma in Italy has been steadily increasing from 1982 to 2016, especially among elderly men. This may be attributed to differences in sun exposure habits and prevention campaigns.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Article
Immunology
Anita K. Kambhampati, Laura Calderwood, Mary E. Wikswo, Leslie Barclay, Claire P. Mattison, Neha Balachandran, Jan Vinje, Aron J. Hall, Sara A. Mirza
Summary: This analysis of 10 years of norovirus outbreak data suggests a west-to-east pattern in the strength of the norovirus seasonality in the United States.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Obstetrics & Gynecology
Ann M. Bruno, Amanda A. Allshouse, Torri D. Metz, Lauren H. Theilen
Summary: The prevalence of hypertensive disorders of pregnancy has been increasing over the past 30 years, with an increase in chronic hypertension and a decrease in eclampsia.
OBSTETRICS AND GYNECOLOGY
(2022)
Article
Oncology
Manette A. W. Dinnessen, Marjolein W. M. van der Poel, Sanne H. Tonino, Otto Visser, Nicole M. A. Blijlevens, Daphne de Jong, King H. Lam, Marie Jose Kersten, Pieternella J. Lugtenburg, Avinash G. Dinmohamed
Summary: The study assessed stage-specific trends in primary therapy and survival among adult follicular lymphoma patients in the Netherlands between 1989-2016. The use of radiotherapy in stage I FL remained stable, while the start of chemotherapy within 12 months post-diagnosis decreased over time in stage II-IV FL. Relative survival improved considerably over time, particularly since the introduction of rituximab in 2003, especially for stage III-IV FL patients and older age groups.
Article
Oncology
Stephanie G. Lashway, Robin B. Harris, Leslie Farland, Mary Kay O'Rourke, Leslie K. Dennis
Summary: The incidence of malignant melanoma in the United States is increasing over time, possibly due to changes in ultraviolet radiation exposure, lifestyle factors, or increased awareness and diagnosis. Recent birth cohorts may experience higher rates of melanoma as they age. The increase in thin melanomas is a significant factor driving the overall rise in malignant melanoma cases.
Article
Dermatology
Catherine M. Olsen, Nirmala Pandeya, Bruna S. Ragaini, Rachel E. Neale, David C. Whiteman
Summary: We compared the incidence trends of cutaneous SCC (cSCC) and melanoma in populations residing at mid-to-high latitudes and found that the ratio of cSCC-to-melanoma incidence increased with proximity to the equator and over time, especially in women.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Medicine, General & Internal
Orly Termeie, Lawrence Fiedler, Lisa Martinez, Jennifer Foster, Parvathi Perumareddi, Robert S. Levine, Charles H. Hennekens
Summary: This study compared the trends in mortality from alcoholic cirrhosis in the United States between 1999 and 2019 using data from the CDC. The results showed a significant increase in the mortality rate of alcoholic cirrhosis, which may be attributed to heavy alcohol consumption and the obesity epidemic. Further research and intervention are needed to address these alarming trends.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Immunology
Emily E. Ricotta, Yi Ling Lai, Ahmed Babiker, Jeffrey R. Strich, Sameer S. Kadri, Michail S. Lionakis, D. Rebecca Prevots, Jennifer Adjemian
Summary: The study found that the incidence of invasive candidiasis (IC) in the United States is relatively stable, primarily caused by Candida albicans, while nonbloodstream IC is on the rise.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Maeve E. Wallace
Summary: The rate of pregnancy-associated homicides in 2020 increased significantly, particularly among adolescents and non-Hispanic Black women. Most incidents involved firearms. Pregnant and postpartum women had a 35% higher risk of homicide compared to their nonpregnant counterparts.
AMERICAN JOURNAL OF PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Lauren D. Nephew, Shannon M. Knapp, Kawthar A. Mohamed, Marwan Ghabril, Eric Orman, Kavish R. Patidar, Naga Chalasani, Archita P. Desai
Summary: This cross-sectional study found that in 2018, there were no racial disparities in the receipt of upper endoscopy for variceal hemorrhage, but Black patients were less likely to receive transjugular portosystemic shunt for variceal hemorrhage and ascites compared to White patients. Both Black and Hispanic patients were less likely to receive liver transplant, and Black patients had higher odds of death. These findings suggest persistent racial and ethnic disparities in the receipt of complex life-saving procedures and mortality in the US.
Article
Dermatology
M. Kiuru, Q. Li, G. Zhu, J. R. Terrell, K. Beroukhim, E. Maverakis, T. H. M. Keegan
Summary: Pregnancy-associated melanoma is more frequent in Hispanic women and post-partum melanoma is associated with greater tumor thickness. However, pregnancy status does not affect survival. Race/ethnicity, socio-economic status, and health insurance impact survival, highlighting the importance of reducing health disparities.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Nutrition & Dietetics
Mary Brauchla, Mark J. Dekker, Colin D. Rehm
Summary: The study found that the decline in vitamin C intake is mainly due to a decrease in fruit juice consumption and a slight increase in whole fruit intake. While vitamin C intake increased in children/adolescents, it did not increase in adults, and the contribution from vegetables remained generally unchanged. The proportion of the population consuming vitamin C below the Estimated Average Requirement has increased.
Article
Dermatology
Catharina C. van Niekerk, J. Hans D. M. Otten, Michelle M. van Rossum, Juul M. P. A. van den Reek, Erik Brummelkamp, Martijn Mol, J. Hans M. M. Groenewoud, Andre L. M. Verbeek
Summary: Time trend analysis of cutaneous melanoma (CM) mortality in fair skin populations shows both a gradual decrease and/or an increase. To explain these differences, the study analyzed long-term time trends in the incidence of the most common histological subtypes of CM: superficial spreading melanoma (SSM), lentigo maligna melanoma (LMM), and nodular melanoma (NM). The study found a significant increase in the incidence of CM in the light-skinned Dutch population, which is likely due to younger generations having higher rates of SSM and LMM diagnosis than older generations.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Surgery
Adrian Diaz, Anna Schoenbrunner, Timothy M. Pawlik
Summary: Despite a decrease in the number of rural hospitals over the past decade, there has been an increase in the number of large, academic medical centers. This has resulted in a significant increase in the number of people living outside a 60-minute driving range to a hospital capable of performing surgery.
Article
Ergonomics
Ibraheem M. Karaye, Kameron Farhadi, Grace Sengstock, Shihab Shahidullah, Rachel Taravella, Rida Nasir
Summary: This study aimed to examine the trends in fatal unintentional drowning rates among persons aged < 29 years by various factors. The results showed that unintentional fatal drowning rates have improved in recent years, highlighting the need for continued research efforts and improved policies for sustained reduction in trends.
JOURNAL OF SAFETY RESEARCH
(2023)
Review
Dermatology
Mary D. Sun, Allan C. Halpern
Summary: Seborrheic keratoses (SKs) are common benign skin tumors with high clinical variability. While age is a known risk factor, the roles of UV exposure and immune abnormalities are unclear. The underlying mechanisms are paradoxically driven by oncogenic mutations, with potential therapeutic implications in inhibiting Akt and APP.
Article
Dermatology
Gabriele Campanella, Cristian Navarrete-Dechent, Konstantinos Liopyris, Jilliana Monnier, Saud Aleissa, Brahmteg Minhas, Alon Scope, Caterina Longo, Pascale Guitera, Giovanni Pellacani, Kivanc Kose, Allan C. Halpern, Thomas J. Fuchs, Manu Jain
Summary: Basal cell carcinoma (BCC), the most common skin cancer, has traditionally been diagnosed using limited methods. Recent advances in reflectance confocal microscopy have shown improved diagnostic capabilities, with a deep learning-based model demonstrating comparable performance to experts in detecting BCC.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Dermatology
Ofer Reiter, Shenara Musthaq, Nicholas R. Kurtansky, Dulce M. Barrios, Allan C. Halpern, Michael A. Marchetti, Ashfaq A. Marghoob, Japbani K. Nanda, Joseph Stoll, Veronica Rotemberg
Summary: In melanoma screening, comparing nevi between two different time points is more consistent, while manual and automated measurements of nevus diameter can serve as a time-saving reproducible substitute for manual measurements.
SKIN RESEARCH AND TECHNOLOGY
(2022)
Letter
Dermatology
M. D. Sun, J. Kentley, P. Mehta, S. Dusza, A. C. Halpern, V. Rotemberg
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
Nicholas R. Kurtansky, Stephen W. Dusza, Allan C. Halpern, Rebecca I. Hartman, Alan C. Geller, Ashfaq A. Marghoob, Veronica M. Rotemberg, Michael A. Marchetti
Summary: The primary cause of the increase in melanoma incidence in the United States has been suggested to be overdiagnosis. This study investigates epidemiologic trends of melanoma incidence and mortality in white Americans using surveillance data from 1975 to 2017. The findings suggest that overdiagnosis is more significant in American females and for melanoma in situ, with mixed changes observed in other population subgroups.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Aditi Sahu, Jose Cordero, Xiancheng Wu, Susanne Kossatz, Ucalene Harris, Paula Demetrio Desouza Franca, Nicholas R. Kurtansky, Niasia Everett, Stephen Dusza, Jilliana Monnier, Piyush Kumar, Christi Fox, Christian Brand, Sheryl Roberts, Kivanc Kose, William Phillips, Erica Lee, Chih-Shan Jason Chen, Anthony Rossi, Kishwer Nehal, Melissa Pulitzer, Caterina Longo, Allan Halpern, Thomas Reiner, Milind Rajadhyaksha, Manu Jain
Summary: This study investigated the use of combined fluorescence and reflectance contrast in confocal microscopy to improve the diagnosis of basal cell carcinoma (BCC). The results showed that the PARPi-FL contrast agent had higher binding affinity in BCC tissues compared to normal skin structures, leading to improved contrast and diagnostic accuracy. The study also determined the optimal parameters for the permeation of PARPi-FL through intact skin.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Letter
Dermatology
Manu Jain, Isidora Autuori, Niasia Everett, Ucalene Harris, Miko Yamada, Tarl Prow, Klaus Busam, Michael A. Marchetti, Allan C. Halpern, Irene Orlow
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Letter
Dermatology
Paras P. Mehta, Yuna Oh, Miguel Cordova, Chih-Shan Chen, Allan Halpern, Ucalene Harris, Jonathan Kentley, Nicholas R. Kurtansky, Kivanc Kose, Erica H. Lee, Michael A. Marchetti, Ashfaq Marghoob, Alina Markova, Cristian Navarrete-Dechent, Kishwer Nehal, Milind Rajadhyaksha, Anthony Rossi, Aditi Sahu, Mary Sun, Manu Jain, Veronica Rotemberg
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Editorial Material
Computer Science, Artificial Intelligence
M. Emre Celebi, Catarina Barata, Allan Halpern, Philipp Tschandl, Marc Combalia, Yuan Liu
MEDICAL IMAGE ANALYSIS
(2022)
Article
Dermatology
Jennifer L. Hay, Erica H. Lee, Stephanie N. Christian, Elizabeth Schofield, Jada G. Hamilton, Ciyu Yang, Bobak Hedayati, Keimya Sadeghi, Mark E. Robson, Allan Halpern, Liying Zhang, Irene Orlow
Summary: This study investigated the interest and uptake of genetic testing in dermatology patients, specifically for melanocortin receptor gene (MC1R) variants. The results showed a high level of interest in MC1R genetic testing and promising outcomes, including increased family and physician communication.
JOURNAL OF SKIN CANCER
(2022)
Letter
Dermatology
Emily A. Cowen, Mary Daotung Sun, Lilly Gu, Christian Acevedo, Veronica Rotemberg, Allan C. Halpern
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
M. A. Marchetti, Z. H. Nazir, J. K. Nanda, S. W. Dusza, B. M. D'Alessandro, J. DeFazio, A. C. Halpern, V. M. Rotemberg, A. A. Marghoob
Summary: This study demonstrated that automated analysis of whole-body 3D-images using simple image processing techniques can accurately discriminate melanoma from other skin lesions.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Medical Informatics
Jonathan Kentley, Jochen Weber, Konstantinos Liopyris, Ralph P. Braun, Ashfaq A. Marghoob, Elizabeth A. Quigley, Kelly Nelson, Kira Prentice, Erik Duhaime, Allan C. Halpern, Veronica Rotemberg
Summary: This study aims to demonstrate that crowdsourcing can label basic dermoscopic structures from images of pigmented lesions with similar reliability to a group of experts. The results showed good agreement and reliability between the crowd and the expert group in annotating dermoscopic images.
JMIR MEDICAL INFORMATICS
(2023)
Article
Dermatology
Paras P. Mehta, Mary Sun, Brigid Betz-Stablein, Allan Halpern, Jochen Weber, Kivanc Kose, H. Peter Soyer, Veronica Rotemberg
Summary: The objective of this study was to compare the performance of an artificial intelligence model trained on a standard adult-predominant dermoscopic dataset before and after the addition of additional pediatric training images. Two models were trained: one on an adult-predominant dataset and the other on additional pediatric images. The performance of the models was compared using adult and pediatric test images. Adding pediatric training images improved algorithm performance on pediatric images without diminishing performance on adult images, demonstrating the importance of diverse data for improving the generalizability of AI models for dermatology.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Medical Informatics
Marc Combalia, Noel Codella, Veronica Rotemberg, Cristina Carrera, Stephen Dusza, David Gutman, Brian Helba, Harald Kittler, Nicholas R. Kurtansky, Konstantinos Liopyris, Michael A. Marchetti, Sebastian Podlipnik, Susana Puig, Christoph Rinner, Philipp Tschandl, Jochen Weber, Allan Halpern, Josep Malvehy
Summary: This study aimed to evaluate the performance of artificial intelligence (AI) technology in skin cancer classification and investigate the impact of image source, diagnoses outside of the training set, and image artifacts on classification accuracy. The results showed that AI algorithms outperformed dermatologists in most categories, but performed poorly in certain specific scenarios, posing safety concerns.
LANCET DIGITAL HEALTH
(2022)