Article
Oncology
Rita Pinto, Tobias Hauge, Marine Jeanmougin, Heidi D. Pharo, Stine H. Kresse, Hilde Honne, Sara B. Winge, May-Britt Five, Theresa Kumar, Tom Mala, Truls Hauge, Egil Johnson, Guro E. Lind
Summary: This study investigates the distribution of genetic and epigenetic modifications in esophageal adenocarcinoma (EAC) and its precursor lesion Barrett's esophagus (BE). The study confirms the frequent occurrence of TP53 mutations in EAC, while no mutations were found in BE. MSI and MLH1 promoter hypermethylation were rare events in both EAC and BE. APC, CDKN2A, MGMT, and TIMP3 promoter hypermethylation were frequently observed in both lesions.
CLINICAL EPIGENETICS
(2022)
Review
Biochemistry & Molecular Biology
Pelin Ergun, Sezgi Kipcak, Serhat Bor
Summary: Barrett's esophagus (BE) is a condition resulting from chronic gastroesophageal reflux disease, which may progress to esophageal adenocarcinoma (EAC). The histological dysplasia grade is commonly used as a biomarker, but its effectiveness is limited due to cost and lack of progression in many BE patients. Clinicians require multiple or more quantitative biomarkers for early diagnosis of EAC, which has high mortality. Epigenetic factors in the early stages of neoplastic transformation show promise as predictive biomarkers. This review summarizes current research on DNA methylations, histone modifications, and noncoding RNAs (miRNAs) during the progression from BE dysplasia to EAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Wei-Yi Lei, Taher Omari, Tso-Tsai Liu, Ming-Wun Wong, Jui-Sheng Hung, Chih-Hsun Yi, Shu-Wei Liang, Charles Cock, Chien-Lin Chen
Summary: This study measured the effect of esophageal outflow obstruction induced by a leg-lift protocol on intrabolus pressures. The results showed an increase in relaxation pressure and distal contractile integral at the esophagogastric junction, as well as increased pressures in all bolus categories. Measuring pressures within the intrabolus domain can aid in confirming a diagnosis of EGJ outflow obstruction.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Review
Biochemistry & Molecular Biology
Ksenia Maslenkina, Liudmila Mikhaleva, Maxim Naumenko, Rositsa Vandysheva, Michail Gushchin, Dmitri Atiakshin, Igor Buchwalow, Markus Tiemann
Summary: Barrett's esophagus (BE) is a premalignant lesion that can develop into esophageal adenocarcinoma (EAC). The development of BE is caused by biliary reflux and involves various stem cell origins. The concept of healing has been replaced by the cytokine storm and inflammatory microenvironment, leading to intestinal metaplasia. This review discusses the roles of molecular pathways in the pathogenesis of BE and EAC, including NOTCH, hedgehog, NF-?B, and IL6/STAT3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Karol Nowicki-Osuch, Lizhe Zhuang, Sriganesh Jammula, Christopher W. Bleaney, Krishnaa T. Mahbubani, Ginny Devonshire, Annalise Katz-Summercorn, Nils Eling, Anna Wilbrey-Clark, Elo Madissoon, John Gamble, Massimiliano Di Pietro, Maria O'Donovan, Kerstin B. Meyer, Kourosh Saeb-Parsy, Andrew D. Sharrocks, Sarah A. Teichmann, John C. Marioni, Rebecca C. Fitzgerald
Summary: This study revealed that Barrett's esophagus originates from the gastric cardia through specific transcriptional programs. Esophageal adenocarcinoma likely arises from undifferentiated Barrett's esophagus cell types, even in the absence of a clearly identifiable metaplastic precursor. This finding has important implications for early cancer detection strategies.
Article
Nutrition & Dietetics
Alice Zaramella, Diletta Arcidiacono, Daniele Nucci, Federico Fabris, Clara Benna, Salvatore Pucciarelli, Matteo Fassan, Alberto Fantin, Valli De Re, Renato Cannizzaro, Stefano Realdon
Summary: Esophageal adenocarcinoma (EAC) is a consequence of long-term gastroesophageal reflux, which leads to inflammation and could cause Barrett's esophagus (BE), the main risk factor for EAC development. The study aims to explore the esophageal microbial profile in patients with different stages of BE and EAC, and develop a score to predict cancer risk.
Article
Biochemistry & Molecular Biology
Eszter Becskehazi, Marietta Margareta Korsos, Eleonora Gal, Laszlo Tiszlavicz, Zsofia Hoyk, Maria A. Deli, Zoltan Marton Kohler, Aniko Keller-Pinter, Attila Horvath, Kata Cseko, Zsuzsanna Helyes, Peter Hegyi, Viktoria Venglovecz
Summary: The study suggests that smoking affects the function of ion transporters, playing a role in the development of smoking-induced esophageal diseases. In metaplastic cells, CSE treatment increased the activity and protein expression of NHE-1, reducing proliferation in a NHE-1-dependent manner. Contrarily, in normal cells, the expression and activity of NHE-1 decreased due to smoke exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Maddalena Angela Di Lellis
Summary: This study examined the association between Barrett's esophagus (BE) and esophageal adenocarcinoma. BE was found to be a potential precursor to esophageal cancer. However, the effectiveness of BE screening remains uncertain due to the fact that over 90% of esophageal cancer patients do not have a history of BE.
ZEITSCHRIFT FUR GASTROENTEROLOGIE
(2022)
Review
Microbiology
Caitlin Guccione, Rena Yadlapati, Shailja Shah, Rob Knight, Kit Curtius
Summary: Esophageal adenocarcinoma (EAC) is a deadly disease with a high mortality rate, and its precursor Barrett's esophagus (BE) has been rapidly increasing since the 1970s. Changes in the esophageal microbiome in modern populations may help explain the rise in EAC cases, and non-invasive procedures to detect microbial communities in saliva, oral swabs, and brushings may offer an alternative means of BE detection. Further studies are needed to understand the dynamic changes in microbial communities within BE and their potential causal role in cancer formation.
Article
Gastroenterology & Hepatology
Tarek Sawas, Saam Dilmaghani, Lovekirat Dhaliwal, Kenneth K. Wang, Prasad G. Iyer, David A. Katzka
Summary: The study found that compared to BE patients, EAC patients had significantly lower rates of heartburn, diabetes, hyperlipidemia, hypertension, nonalcoholic steatohepatitis, and metabolic syndrome. Therefore, optimal strategies for screening for prevalent EAC may need to be adjusted.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Oncology
Franz Ludwig Dumoulin, Fabian Dario Rodriguez-Monaco, Alanna Ebigbo, Ingo Steinbruck
Summary: Esophageal adenocarcinoma is the most common subtype of esophageal cancer in Western societies and its incidence is increasing. The development and validation of artificial intelligence systems in the field of gastroenterology may help address unresolved issues in the prevention and surveillance of this cancer.
Article
Multidisciplinary Sciences
Nan Yi, Hailiang Zhao, Juan He, Xike Xie, Liexin Liang, Guowen Zuo, Mingyue Xiong, Yunxiao Liang, Tingzhuang Yi
Summary: Almost 50% of esophageal adenocarcinoma (EAC) patients are progressed from Barrett's esophagus (BE). However, effective stratification and therapy methods for BE and EAC are still lacking. Differentially expressed genes (DEGs) between BE and EAC were identified through the analysis of two public datasets (GSE26886 and GSE37200), followed by bioinformatics analyses to explore potential biomarkers associated with BE-EAC. The results revealed a number of up- and down-regulated genes, which were highly involved in tumorigenesis according to the GO and KEGG enrichment analysis. In addition, the study identified several potential diagnostic and prognostic biomarkers in BE-EAC.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Smita Sihag, Samuel C. Nussenzweig, Henry S. Walch, Meier Hsu, Kay See Tan, Francisco Sanchez-Vega, Walid K. Chatila, Sergio A. De la Torre, Assem Patel, Yelena Y. Janjigian, Steven Maron, Geoffrey Y. Ku, Laura H. Tang, Jaclyn Hechtman, Pari M. Shah, Abraham J. Wu, David R. Jones, Daniela Molena, David B. Solit, Nikolaus Schultz, Michael F. Berger
Summary: This study reveals that higher levels of genomic instability are associated with advanced disease in esophageal adenocarcinoma, and alterations in CDKN2A, KRAS, and SMAD4 are strongly associated with poor survival.
CLINICAL CANCER RESEARCH
(2021)
Article
Biology
Kailin Lin, Ke Hu, Qiwen Chen, Jiangchun Wu
Summary: In this study, we identified two hub genes, CENPE and SHCBP1, associated with cuproptosis in Barrett's esophagus and esophageal adenocarcinoma. Their overexpression was associated with poor prognosis and may contribute to the progression of BE to EAC.
Article
Gastroenterology & Hepatology
Rishabh Khatri, Jay Patel, Jun Song, Zubair Malik, Michael S. S. Smith, Henry P. P. Parkman
Summary: This study compared the prevalence, symptoms, demographic factors, and esophageal testing in patients with esophageal inlet patch (IP) and Barrett's esophagus (BE). The study found that 1.3% of patients had IP, with 17.1% having concomitant BE; 4.9% had BE, with 4.6% also having IP. Both IP and BE patients primarily presented with heartburn and/or regurgitation symptoms. Patients with IP and/or BE were older, had higher BMI, lower lower esophageal sphincter pressures, and higher acid exposure time.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Leonard Depotte, Juliette Palle, Cosimo Rasola, Chloe Broudin, Vlad-Adrian Afrasanie, Antoine Mariani, Aziz Zaanan
Summary: Advanced gastric adenocarcinoma is a disease with poor prognosis. In recent years, new drugs, such as trastuzumab for HER2-positive tumors, ramucirumab alone or in combination with paclitaxel, and trifluridine-tipiracil, have improved patient survival. Other drugs, including monoclonal antibodies and targeted therapies, are also being evaluated.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2024)