Inositol-C2-PAF acts as a biological response modifier and antagonizes cancer-relevant processes in mammary carcinoma cells

Organ-specific metastasis of breast cancer: molecular and cellular mechanisms underlying lung metastasis

(2018) Meysam Yousefi et al.   CELLULAR ONCOLOGY

d -3-Deoxy-dioctanoylphosphatidylinositol induces cytotoxicity in human MCF-7 breast cancer cells via a mechanism that involves downregulation of the D-type cyclin-retinoblastoma pathway

(2016) Cheryl S. Gradziel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Capillary Isoelectric Focusing of Akt Isoforms Identifies Highly Dynamic Phosphorylation in Neuronal Cells and Brain Tissue

(2016) Sandra Schrötter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alkyl ether lipids, ion channels and lipid raft reorganization in cancer therapy

(2016) Paul-Alain Jaffrès et al.   PHARMACOLOGY & THERAPEUTICS

Lipid raft-mediated Fas/CD95 apoptotic signaling in leukemic cells and normal leukocytes and therapeutic implications

(2015) C. Gajate et al.   JOURNAL OF LEUKOCYTE BIOLOGY

ERK1/2 acts as a switch between necrotic and apoptotic cell death in ether phospholipid edelfosine-treated glioblastoma cells

(2015) Sara Melo-Lima et al.   PHARMACOLOGICAL RESEARCH

Combining Anti-tumor Alkyl-Phospholipid Analogs and Radiotherapy: Rationale and Clinical Outlook

(2014) Marcel Verheij et al.   Anti-Cancer Agents in Medicinal Chemistry

Lipid Rafts, Endoplasmic Reticulum and Mitochondria in the Antitumor Action of the Alkylphospholipid Analog Edelfosine

(2014) Consuelo Gajate et al.   Anti-Cancer Agents in Medicinal Chemistry

Inositoylated Platelet-Activating Factor (Ino-C2-PAF) Modulates Dynamic Lymphocyte–Endothelial Cell Interactions and Alleviates Psoriasis-Like Skin Inflammation in Two Complementary Mouse Models

(2014) Susann Forkel et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

IGF-1 Regulates Cyr61 Induced Breast Cancer Cell Proliferation and Invasion

(2014) Suren Sarkissyan et al.   PLoS One

Inositol-C2-PAF down-regulates components of the antigen presentation machinery in a 2D-model of epidermal inflammation

(2013) Geo Semini et al.   BIOCHEMICAL PHARMACOLOGY

Pivotal Role of the Lipid Raft SK3-Orai1 Complex in Human Cancer Cell Migration and Bone Metastases

(2013) A. Chantome et al.   CANCER RESEARCH

Efficacy of edelfosine lipid nanoparticles in breast cancer cells

(2013) María Ángela Aznar et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Restoration of wild-type p53 in drug-resistant mouse breast cancer cells leads to differential gene expression, but is not sufficient to overcome the malignant phenotype

(2013) Benjamin Gottschalk et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Anticancer mechanisms and clinical application of alkylphospholipids

(2012) Wim J. van Blitterswijk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mesenchymal–epithelial transition (MET) as a mechanism for metastatic colonisation in breast cancer

(2012) N. P. A. Devika Gunasinghe et al.   CANCER AND METASTASIS REVIEWS

Synthetic glycosidated phospholipids induce apoptosis through activation of FADD, caspase-8 and the mitochondrial death pathway

(2011) Clarissa von Haefen et al.   APOPTOSIS

The novel synthetic ether lipid inositol-C2-PAF inhibits phosphorylation of the tyrosine kinases Src and FAK independent of integrin activation in transformed skin cells

(2011) Geo Semini et al.   BIOCHEMICAL PHARMACOLOGY

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Erufosine, an alkylphosphocholine, with differential toxicity to human cancer cells and bone marrow cells

(2011) Rebecca G. Bagley et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

IGF-1 increases invasive potential of MCF 7 breast cancer cells and induces activation of latent TGF-β1 resulting in epithelial to mesenchymal transition

(2011) Logan A Walsh et al.   Cell Communication and Signaling

New Alkyl-Lipid Blockers of SK3 Channels Reduce Cancer Cell Migration and Occurrence of Metastasis

(2011) A. Girault et al.   CURRENT CANCER DRUG TARGETS

Novel Inhibitors of AKT: Assessment of a Different Approach Targeting the Pleckstrin Homology Domain

(2011) E. J. Meuillet   CURRENT MEDICINAL CHEMISTRY

Synthesis and biological evaluation of cyclopentane-linked alkyl phosphocholines as potential anticancer agents that act by inhibiting Akt phosphorylation

(2011) Md. Maqusood Alam et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

In vitro and in vivo efficacy of edelfosine-loaded lipid nanoparticles against glioma

(2011) Ander Estella-Hermoso de Mendoza et al.   JOURNAL OF CONTROLLED RELEASE

Impact of alkylphospholipids on the gene expression profile of HaCaT cells

(2011) Geo Semini et al.   Pharmacogenetics and Genomics

The SK3/KCa2.3 potassium channel is a new cellular target for edelfosine

(2010) M Potier et al.   BRITISH JOURNAL OF PHARMACOLOGY

Glycosidated phospholipids: uncoupling of signalling pathways at the plasma membrane

(2010) Kerstin Danker et al.   BRITISH JOURNAL OF PHARMACOLOGY

Advances in Targeting Src in the Treatment of Breast Cancer and Other Solid Malignancies

(2010) E. L. Mayer et al.   CLINICAL CANCER RESEARCH

Lipid raft-targeted therapy in multiple myeloma

(2010) F Mollinedo et al.   ONCOGENE

The PTEN/PI3K/AKT Signalling Pathway in Cancer, Therapeutic Implications

(2008) Amancio Carnero et al.   CURRENT CANCER DRUG TARGETS