Review
Biochemistry & Molecular Biology
Teresa Magnes, Sandro Wagner, Dominik Kiem, Lukas Weiss, Gabriel Rinnerthaler, Richard Greil, Thomas Melchardt
Summary: Head and neck squamous cell carcinoma is a heterogeneous disease arising from the mucosa of the upper aerodigestive tract, with only about one third of patients responding to checkpoint inhibitors. HPV status and combined positive score are the main biomarkers used in clinical practice, while other factors like tumor mutational burden and immune microenvironment show promise but require validation in prospective trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Kamila Romanowska, Agnieszka Sobecka, Agnieszka A. Rawluszko-Wieczorek, Wiktoria M. Suchorska, Wojciech Golusinski
Summary: Head and neck squamous carcinoma (HNSCC) is the sixth most prevalent cancer worldwide, with molecular pathogenesis involving cell cycle disorders, intercellular signaling, proliferation, squamous cell differentiation, and apoptosis. In addition to genetic mutations, epigenetic alterations such as DNA methylation and histone modifications play a key role in promoting cancer formation and progression, making them potential biomarkers and therapeutic targets for HNSCC.
Article
Oncology
Chen Chen, June Ho Shin, Zhuoqing Fang, Kevin Brennan, Nina B. Horowitz, Kathleen L. Pfaff, Emma L. Welsh, Scott J. Rodig, Olivier Gevaert, Or Gozani, Ravindra Uppaluri, John B. Sunwoo
Summary: In head and neck squamous cell carcinoma (HNSCC), inactivating mutations in the histone methyltransferase NSD1 disproportionately contribute to tumor development and immune exclusion. Understanding the NSD1-mediated mechanism and targeting the histone-modifying enzyme KDM2A could enhance T-cell infiltration and suppress tumor growth in HNSCC.
Article
Oncology
Tobias Jagomast, Christian Idel, Luise Klapper, Patrick Kuppler, Anne Offermann, Eva Dreyer, Karl-Ludwig Bruchhage, Julika Ribbat-Idel, Sven Perner
Summary: This study investigated the clinical implications of CDK7 and pMED1 as potential biomarkers in head and neck squamous-cell cancer (HNSCC). The results showed that high levels of CDK7 were associated with lower survival rates and disease-free survival rates in HNSCC patients. Additionally, CDK7 expression was significantly elevated in immune cell infiltrated tumors. In vitro studies also demonstrated the potential of CDK7 inhibition as a therapeutic target.
Article
Multidisciplinary Sciences
Shuyan Sheng, Wenzhuo Su, Deshen Mao, Conghan Li, Xinyang Hu, Wanyu Deng, Yong Yao, Yongsheng Ji
Summary: Drug resistance can impair treatment effects and miR-21 may facilitate the development or maintenance of drug resistance in cancer cells. Restoring drug sensitivity by inhibiting miR-21 expression can improve therapeutic strategies.
Article
Dentistry, Oral Surgery & Medicine
Shijin Yu, Zongjun Ma, Tao Chen, Hong Wang, Qin Yao, Jin Li, Jie Cheng
Summary: The overexpression of ETV5 in head and neck squamous cell carcinoma is associated with aggressive features and reduced survival. Silencing ETV5 inhibits cell proliferation, migration, invasion, and induces apoptosis in vitro, and impairs tumor growth in vivo. ETV5 activates Slug transcription by binding its promoter region in HNSCC cells. Patients with ETV5highSlughigh have the worst survival outcomes.
Review
Immunology
K. Devaraja, Sadhna Aggarwal, Manisha Singh
Summary: Therapeutic vaccination is a promising approach for head and neck squamous cell carcinomas (HNSCC), which tend to exhibit unfavorable responses to existing treatments. Inducing antigen-specific cytotoxicity and countering the immunosuppressive tumor microenvironment have shown encouraging results in HNSCC immunotherapy.
Article
Oncology
Julia Schnoell, Alexandra Scheiflinger, Sega Al-Gboore, Lorenz Kadletz-Wanke, Lukas Kenner, Gregor Heiduschka, Bernhard J. Jank
Summary: PSMD14 is commonly expressed in HNSCC patients and associated with advanced stages. High expression of PSMD14 mRNA is associated with a worse outcome, but this may be due to the association of PSMD14 with poor prognosticators.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Cell Biology
Nargess Farhangdoost, Cynthia Horth, Bo Hu, Eric Bareke, Xiao Chen, Yinglu Li, Mariel Coradin, Benjamin A. Garcia, Chao Lu, Jacek Majewski
Summary: Chromatin dysregulation plays a key role in oncogenesis, and mutations in the histone methyltransferase gene NSD1 have been identified in head and neck squamous cell carcinomas. Loss of NSD1 leads to alterations in chromatin modifications, affecting gene expression. This study sheds light on the downstream effects of NSD1 loss and provides insights into the role of chromatin modifications in cancer.
Article
Oncology
Yue Chen, Zhi-Yong Li, Guan-Qun Zhou, Ying Sun
Summary: IRGPI is a promising biomarker for distinguishing prognosis, molecular and immune characteristics, and immune benefit from ICI therapy in HNSCC. Different IRGPI scores are associated with different molecular and immune characteristics, which affect patients' response to ICI therapy.
CLINICAL CANCER RESEARCH
(2021)
Article
Cell Biology
Nupur Nigam, Benjamin Bernard, Samantha Sevilla, Sohyoung Kim, Mohd Saleem Dar, Daniel Tsai, Yvette Robbins, Kyunghee Burkitt, Cem Sievers, Clint T. Allen, Richard L. Bennett, Theophilus T. Tettey, Benjamin Carter, Lorenzo Rinaldi, Mark W. Lingen, Houssein Sater, Elijah F. Edmondson, Arfa Moshiri, Abbas Saeed, Hui Cheng, Xiaolin Luo, Kevin Brennan, Vishal Koparde, Chen Chen, Sudipto Das, Thorkell Andresson, Abdalla Abdelmaksoud, Madhavi Murali, Seiji Sakata, Kengo Takeuchi, Raj Chari, Yusuke Nakamura, Ravindra Uppaluri, John B. Sunwoo, Carter Van Waes, Jonathan D. Licht, Gordon L. Hager, Vassiliki Saloura
Summary: We identified SMYD3 as a mediator of immune escape in HPV-negative HNSCC. SMYD3 depletion upregulates type I IFN response and antigen presentation genes in HNSCC cells. Mechanistically, SMYD3 regulates the transcription of UHRF1, which binds to H3K9me3-enriched promoters of immune-related genes and silences their expression.
Article
Biochemistry & Molecular Biology
Ioannis Zygouras, Danai Leventakou, Abraham Pouliakis, Styliana Panagiotou, Dimitris Tsakogiannis, Georgios Konstantopoulos, Eirini Logotheti, Menelaos Samaras, Zaharoula Kyriakopoulou, Apostolos Beloukas, Ioannis S. Pateras, Alexandros Delides, Amanda Psyrri, Ioannis G. Panayiotides, Minas Yiangou, Christine Kottaridi
Summary: This study investigates the epigenetic landscape and DNA physical status of HPV16 in Greek HNSCC patients. The findings reveal significant methylation in the HPV16 L1 gene and UTR, with methylation at specific sites showing associations with tumor histological grade.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Qiuxu Wang, Weiwei Yang, Wei Peng, Xuemei Qian, Minghui Zhang, Tianzhen Wang
Summary: This study identified a DNA methylation-dysregulated four-lncRNA signature in Head and Neck Squamous Cell Carcinoma (HNSCC), which could be used as an independent prognostic factor and was associated with chemotherapy response. These lncRNAs were found to be related to cell differentiation, tissue development, and immune-related pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jingyu He, Simin Ouyang, Yilong Zhao, Yuqi Liu, Yaolong Liu, Bing Zhou, Qiwen Man, Bing Liu, Tianfu Wu
Summary: Through bioinformatic analysis and human tissue verification, it was found that CAV1 and CAV2 are significantly upregulated in head and neck squamous cell carcinoma (HNSCC) and are closely associated with tumor development. High expression of CAV1 and CAV2 is associated with poor survival rates and may play a role in tumor growth and cell adhesion, as well as protein degradation processes and immune cell infiltration.
Article
Immunology
Ling-ling Fu, Ming Yan, Min-Xian Ma, Yi Luo, Min Shao, Martin Gosau, Reinhard E. Friedrich, Tobias Vollkommer, Hong-chao Feng, Ralf Smeets
Summary: DCBLD1 is highly expressed in head and neck squamous cell carcinoma and is associated with poor patient prognosis. Further research is needed to investigate the underlying mechanism.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Chahrazade Kantari-Mimoun, Magali Castells, Ralph Klose, Anna-Katharina Meinecke, Ursula J. Lemberger, Pierre-Emmanuel Rautou, Helene Pinot-Roussel, Cecile Badoual, Katrin Schroedter, Christoph H. Oesterreicher, Joachim Fandrey, Christian Stockmann
Article
Immunology
Thibault Voron, Orianne Colussi, Elie Marcheteau, Simon Pernot, Mevyn Nizard, Anne-Laure Pointet, Sabrina Latreche, Sonia Bergaya, Nadine Benhamouda, Corinne Tanchot, Christian Stockmann, Pierre Combe, Anne Berger, Franck Zinzindohoue, Hideo Yagita, Eric Tartour, Julien Taieb, Magali Terme
JOURNAL OF EXPERIMENTAL MEDICINE
(2015)
Article
Cardiac & Cardiovascular Systems
Kiave-Yune Howangyin, Ivana Zlatanova, Cristina Pinto, Anta Ngkelo, Clement Cochain, Marie Rouanet, Jose Vilar, Mathilde Lemitre, Christian Stockmann, Bernd K. Fleischmann, Ziad Mallat, Jean-Sebastien Silvestre
Article
Multidisciplinary Sciences
Ralph Klose, Ewelina Krzywinska, Magali Castells, Dagmar Gotthardt, Eva Maria Putz, Chahrazade Kantari-Mimoun, Naima Chikdene, Anna-Katharina Meinecke, Katrin Schroedter, Iris Helfrich, Joachim Fandrey, Veronika Sexl, Christian Stockmann
NATURE COMMUNICATIONS
(2016)
Article
Oncology
Dagmar Gotthardt, Eva M. Putz, Eva Grundschober, Michaela Prchal-Murphy, Elisabeth Straka, Petra Kudweis, Gerwin Heller, Zsuzsanna Bago-Horvath, Agnieszka Witalisz-Siepracka, Abbarna A. Cumaraswamy, Patrick T. Gunning, Birgit Strobl, Mathias Mueller, Richard Moriggl, Christian Stockmann, Veronika Sexl
Article
Multidisciplinary Sciences
Ewelina Krzywinska, Chahrazade Kantari-Mimoun, Yann Kerdiles, Michal Sobecki, Takayuki Isagawa, Dagmar Gotthardt, Magali Castells, Johannes Haubold, Corinne Millien, Thomas Viel, Bertrand Tavitian, Norihiko Takeda, Joachim Fandrey, Eric Vivier, Veronika Sexl, Christian Stockmann
NATURE COMMUNICATIONS
(2017)
Article
Oncology
Chahrazade Kantari-Mimoun, Ewelina Krzywinska, Magali Castells, Corinne Milien, Ralph Klose, Anna-Katharina Meinecke, Ursula Lemberger, Thomas Mathivet, Milos Gojkovic, Katrin Schroedter, Christoph Oesterreicher, Joachim Fandrey, Helene Rundqvist, Christian Stockmann
Article
Hematology
Anna-Katharina Meinecke, Nadine Nagy, Gabriela D'Amico Lago, Santina Kirmse, Ralph Klose, Katrin Schroedter, Annika Zimmermann, Iris Helfrich, Helene Rundqvist, Dirk Theegarten, Olaf Anhenn, Veronique Orian-Rousseau, Randall S. Johnson, Kari Alitalo, Jens W. Fischer, Joachim Fandrey, Christian Stockmann
Article
Oncology
Jung-whan Kim, Colin Evans, Alexander Weidemann, Norihiko Takeda, Yun Sok Lee, Christian Stockmann, Cristina Branco-Price, Filip Brandberg, Gustavo Leone, Michael C. Ostrowski, Randall S. Johnson
Article
Immunology
Wiebke Hansen, Marina Hutzler, Simone Abel, Christina Alter, Christian Stockmann, Stefanie Kliche, Juliane Albert, Tim Sparwasser, Shimon Sakaguchi, Astrid M. Westendorf, Dirk Schadendorf, Jan Buer, Iris Helfrich
JOURNAL OF EXPERIMENTAL MEDICINE
(2012)
Article
Immunology
Nina Scheerer, Nathalie Dehne, Christian Stockmann, Sandra Swoboda, Hideo A. Baba, Agnes Neugebauer, Randall S. Johnson, Joachim Fandrey
JOURNAL OF IMMUNOLOGY
(2013)
Letter
Dermatology
Christian Stockmann, Santina Kirmse, Iris Helfrich, Alexander Weidemann, Norihiko Takeda, Andrew Doedens, Randall S. Johnson
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2011)
Review
Oncology
Christian Stockmann, Dirk Schadendorr, Ralph Klose, Iris Helfrich
FRONTIERS IN ONCOLOGY
(2014)
Article
Medicine, Research & Experimental
Thomas Mathivet, Claire Bouleti, Matthias Van Woensel, Fabio Stanchi, Tina Verschuere, Li-Kun Phng, Joost Dejaegher, Marly Balcer, Ken Matsumoto, Petya B. Georgieva, Jochen Belmans, Raf Sciot, Christian Stockmann, Massimiliano Mazzone, Steven De Vleeschouwer, Holger Gerhardt
EMBO MOLECULAR MEDICINE
(2017)