Article
Biochemistry & Molecular Biology
Roberta Piovesana, Annalinda Pisano, Simona Loreti, Ruggero Ricordy, Claudio Talora, Ada Maria Tata
Summary: The communication between axon and glial cells is mediated by neurotransmitters and their receptors. Specifically, the M2 muscarinic receptor subtype plays a crucial role in regulating Schwann cell development and function. In this study, the modulation of the Neuregulin-1/erbB pathway by M2 receptor activation was analyzed. The results showed that M2 agonist treatment downregulated NRG1 and erbB receptors expression and caused internalization of the erbB2 receptor. Additionally, the M2 receptor subtype was found to inhibit erbB2 receptors through the Notch-1/NICD downregulation. This study provides further insights into the cross-interaction between the M2 receptor and NRG1/erbB pathway in Schwann cell biology.
Article
Biochemistry & Molecular Biology
Qianqian Chen, Yang Miao, Zhipeng Xu, Ruirui Zhang, Sheng Yi
Summary: Schwann cells play a crucial role in nerve regeneration and are commonly used in tissue engineering. Identifying Schwann cells with enhanced migration ability is important for improving recovery effects. This study compared Schwann cells from different anatomical locations and found that dorsal root ganglia (DRG) Schwann cells have faster migration speed than sciatic nerve (SN) Schwann cells.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Oncology
Mi Shen, Yuhan Chen, Wei Tang, Mengru Ming, Yingchao Tian, Fei Ding, Han Wu, Yuhua Ji
Summary: Schwann cells (SCs) are crucial for peripheral nerve (PN) regeneration. This study reveals that Sema3E promotes the proliferation and migration of SCs, involving the receptors PlexinD1, Neuropilin 1 (Nrp1), and Vascular Endothelial Growth Factor Receptor 2 (VEGFR2).
EXPERIMENTAL CELL RESEARCH
(2022)
Review
Neurosciences
Fang Cheng Wong, Linhan Ye, Ihsan Ekin Demir, Christoph Kahlert
Summary: This review discusses the role of Schwann cell-derived exosomes in the regenerative potential and pathological processes of the peripheral nervous system, highlighting their potential applications as delivery vehicles for therapeutics and biomarkers. The research emphasizes the crucial role of SC-derived exosomes in the functional integration of the PNS, pointing to an emerging area with much to explore and re-explore.
Article
Neurosciences
Cristian Saquel, Romina J. Catalan, Rodrigo Lopez-Leal, Ramon A. Ramirez, David Necunir, Ursula Wyneken, Christophe Lamaze, Felipe A. Court
Summary: Functional recovery after peripheral nerve injuries relies on axonal regeneration, which is regulated by both autonomous and non-cell autonomous processes. This study demonstrates that neuronal activity enhances the release of repair Schwann cell-derived extracellular vesicles (EVs) and their transfer to neurons. This effect is mediated by the ATP-P2Y signaling pathway and leads to increased content of miRNA-21 in the EVs. These findings highlight the importance of neuron to glia communication in regulating axonal elongation through the transfer of EVs.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Shizuka Takaku, Kazunori Sango
Summary: Zonisamide may provide neuroprotection against OHP-induced peripheral sensory neuropathy by activating the MEK/ERK and PI3K/AKT signaling pathways and suppressing the p38 MAPK pathway in DRG neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Wencui Zhang, Yujuan Li, Tianning Sun, Zhixiao Li, Anne Manyande, Weiguo Xu, Maohui Feng, Hongbing Xiang
Summary: This study reveals the interaction between the superior cervical sympathetic ganglion and gut microbiota, suggesting the crucial role of the sympathetic nervous system in regulating the microbiome-brain axis.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Senmiao Zhu, Lili Chen, Min Wang, Jing Zhang, Gang Chen, Yinghao Yao, Shihan Song, Tong Li, Shenglan Xu, Zhonghao Yu, Bingyan Shen, Duogang Xu, Zai Long Chi, Wencan Wu
Summary: This study demonstrates the neuroprotective and regenerative effects of Schwann cell-derived extracellular vesicles (SC-EVs) on optic nerve injury. SC-EVs promote the survival and axonal growth of retinal ganglion cells (RGCs) and mitigate RGC degeneration. The underlying mechanism involves the activation of the cAMP-response element binding protein (CREB) signaling pathway and the regulation of reactive gliosis. These findings suggest the potential of SC-EVs as a cell-free therapeutic strategy and natural biomaterials for neurodegenerative diseases.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Cong Yao, Zhennan Qiu, Xiao Li, Hui Zhu, Dichen Li, Jiankang He
Summary: Electrohydrodynamic (EHD) printing is used to fabricate microfibrous architectures for cellular orientation, but orderly deposition of microfibers with cell-scale spacing is challenging. A finite element method is established to analyze the electrostatic forces induced on the EHD-printed microfibers, and it is found that uniform fiber arrangement can be achieved when the fiber spacing is five times larger than the fiber diameter. Decreasing the fiber spacing improves neurite outgrowth length and Schwann cell migration.
Article
Biochemistry & Molecular Biology
Shizuka Takaku, Masami Tsukamoto, Naoko Niimi, Hideji Yako, Kazunori Sango
Summary: This study found that Ex-4 significantly enhanced survival, proliferation, and migration of IFRS1 cells in co-culture with DRG neurons, promoting myelination. This effect may be mediated through activation of the PI3K/AKT signaling pathway, suggesting the potential efficacy of Ex-4 towards diabetic peripheral neuropathy and other peripheral nerve lesions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Paulina M. Getsy, Gregory A. Coffee, Yee-Hsee Hsieh, Stephen J. Lewis
Summary: This study aimed to determine the effects of bilateral transection of the cervical sympathetic chain (CSC) on ventilatory responses during hypoxic gas challenge in C57BL6 mice, suggesting that the CSC may provide inhibitory input to structures involved in ventilatory responses.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Lijun Cheng, Lin Yu, Xiaoping Zhan, Gary Tse, Tong Liu, Huaying Fu, Guangping Li
Summary: The aim of this study was to investigate the changes in ion channel characteristics of the superior cervical ganglion (SCG) following myocardial infarction (MI), and the role of pretreatment with the P2Y12 receptor antagonist ticagrelor (TIC). The results showed that MI led to alterations in the activation and inactivation characteristics of SCG neuron ion channels accompanied by increased expression of P2Y12, which were attenuated by TIC pretreatment. This may be the mechanism underlying the cardiac protective effects of TIC.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Pharmacology & Pharmacy
Lifang Zou, Shuangmei Liu, Lin Li, Runan Yang, Xiumei Xu, Guilin Li, Chunping Zhang, Guodong Li, Shangdong Liang
Summary: The upregulation of P2Y(12) receptor in the SCGs during MI is accompanied by increased expression of lncRNA uc.48+. Inhibiting the upregulation of P2Y(12) receptor with uc.48+ shRNA can improve cardiac dysfunction caused by MI.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Xizhong Yang, Cuijie Ji, Xinyue Liu, Chaoqun Zheng, Yanxin Zhang, Ruowu Shen, Zanggong Zhou
Summary: The study aimed to explore the significance of the neuregulin-1/ErbB signaling pathway in the differentiation of mouse bone marrow mesenchymal stem cells into Schwann-like cells. Results showed that the pathway plays an important role in promoting the differentiation and maintaining the expression of Sox10, with decreased differentiation observed in groups where the pathway was blocked.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Laura Rodriguez Doblado, Cristina Martinez-Ramos, Manuel Monleon Pradas
Summary: This study investigated the use of a multimodular preseeded conduit to promote axon growth in the nervous system, showing potential clinical applications.
Article
Biology
Stephan Heermann, Lucas Schuetz, Steffen Lemke, Kerstin Krieglstein, Joachim Wittbrodt
Article
Ophthalmology
Stephan Heermann
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2017)
Article
Ophthalmology
Stephan Heermann
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2017)
Article
Biochemistry & Molecular Biology
Max D. Knickmeyer, Juan L. Mateo, Priska Eckert, Eleni Roussa, Belal Rahhal, Aimee Zuniga, Kerstin Krieglstein, Joachim Wittbrodt, Stephan Heermann
Article
Neurosciences
Stephan Heermann, Kert Matlik, Ursula Hinz, Jutta Fey, Urmas Arumae, Kerstin Krieglstein
JOURNAL OF NEUROSCIENCE RESEARCH
(2013)
Article
Developmental Biology
Rebecca Sinn, Ravindra Peravali, Stephan Heermann, Joachim Wittbrodt
MECHANISMS OF DEVELOPMENT
(2014)
Article
Neurosciences
Katalin Zajzon, Felicitas Proels, Stephan Heermann
Article
Biochemistry & Molecular Biology
Priska Eckert, Max D. Knickmeyer, Lucas Schuetz, Joachim Wittbrodt, Stephan Heermann
Article
Neurosciences
Shokoufeh Khakipoor, Marina Giannaki, Shefeeq M. Theparambil, Jana Zecha, Bernhard Kuester, Stephan Heermann, Joachim W. Deitmer, Eleni Roussa
Article
Anatomy & Morphology
Carlos Gonzalez Blum, Robert Richter, Reinhard Fuchs, Florian Sandeck, Stephan Heermann
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2020)
Article
Anatomy & Morphology
Carlos Gonzalez Blum, Robert Richter, Reinhard Fuchs, Florian Sandeck, Kevin Kunz, Stephan Heermann
Summary: This study conducted interprofessional education workshops to effectively improve medical and physiotherapy students' perceptions and attitudes towards interprofessionalism and skills. Students who had obtained a professional qualification prior to their current studies rated themselves higher on certain items, which is beneficial for the development of future interprofessional collaboration.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2022)
Article
Cell Biology
Marina Giannaki, Christina Ludwig, Stephan Heermann, Eleni Roussa
Summary: Astrocytes play a crucial role in responding to extracellular pH changes through the regulation of NBCe1, an acid-base transporter. The study found that mTOR-dependent and NBCe1-mediated astrocytic response to extracellular acidosis involves multiple molecular mechanisms, including serine residue phosphorylation at Ser(245) as a novel regulator of NBCe1 functional expression. The results suggest that context-dependent and mTOR-mediated multisite phosphorylation of serine residues of NBCe1 may be a potent mechanism contributing to astrocytes' response to acid/base challenges in pathophysiological conditions.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Education, Scientific Disciplines
Alexander Michael Kerner, Uta Biedermann, Lars Braeuer, Svenja Caspers, Sara Doll, Maren Engelhardt, Timm J. Filler, Estifanos Ghebremedhin, Stefanie Gundlach, Gregor U. Hayn-Leichsenring, Stephan Heermann, Ingrid Hettwer-Steeger, Laura Hiepe, Bernhard Hirt, Lena Hirtler, Romed Hoermann, Christoph Kulisch, Tobias Lange, Rudolf Leube, Annika Hela Meuser, Magdalena Mueller-Gerbl, Christina Nassenstein, Peter H. Neckel, Ute Nimtschke, Friedrich Paulsen, Andreas Prescher, Michael Pretterklieber, Stefanie Schliwa, Katja Schmidt, Andreas Schmiedl, Christof Schomerus, Gundula Schulze-Tanzil, Udo Schumacher, Sven Schumann, Volker Spindler, Johannes Streicher, Thomas Tschernig, Axel Unverzagt, Ursula Valentiner, Christoph Viebahn, Thilo Wedel, Janet Weigner, Wolfgang W. Weninger, Juergen Westermann, Imke Weyers, Jens Waschke, Niels Hammer
Summary: Hands-on courses that use preserved human tissues for educational training are important for acquiring basic anatomical knowledge. A survey was conducted among anatomies in German-speaking Europe to identify commonalities in embalming protocols and infrastructure. The results showed significant variations in the use of chemicals, volumes of chemicals, and infrastructure between different embalming procedures. This study provides decision support for altering embalming protocols or establishing joint protocols between institutions.
ANATOMICAL SCIENCES EDUCATION
(2023)
Article
Biochemistry & Molecular Biology
Johannes Bulk, Valentyn Kyrychenko, Philipp M. Rensinghoff, Zahra Ghaderi Ardekani, Stephan Heermann
Summary: Vision is dependent on the correct development of the eye, which is tightly connected to the development of the forebrain. Holoprosencephaly (HPE) is a developmental disorder where the eye field and the forebrain fail to separate, leading to ocular abnormalities such as cyclopia, anophthalmia, and coloboma. This study identifies the importance of a balance between Bone morphogenetic proteins (BMPs) and their antagonists in eye and forebrain cleavage, and demonstrates that dysregulation of BMP signaling results in severe forms of HPE with anophthalmia. Additionally, the study suggests that BMP signaling also affects the development of hypothalamic cells during neurulation and neural keel formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)