Review
Pharmacology & Pharmacy
Maya Ezzo, Boris Hinz
Summary: The ability of cells to sense and respond to mechanical changes is crucial in tissue injury and fibrosis. Fibroblasts play a central role in tissue repair by regulating extracellular matrix secretion and organization. Dysregulated mechanotransduction can lead to fibrosis, and targeting the elements involved in fibroblast mechanotransduction may be a potential therapeutic approach.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Lenka Koudelkova, Jan Brabek, Daniel Rosel
Summary: Cells have developed a unique set of molecular mechanisms to probe the mechanical properties of their surrounding environment and transform mechanical stimuli into versatile biochemical information. Src kinase plays a central role in the mechanotransduction network, working in cooperation with primary sensors and the cytoskeleton to execute cellular responses and adaptations to mechanical cues.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Yujie Zhao, Yao Liu, Jianjun Deng, Chenhui Zhu, Xiaoxuan Ma, Min Jiang, Daidi Fan
Summary: This study found that ginsenoside F4 can inhibit skeletal muscle insulin resistance and improve the state of T2DM, and its mechanism is related to the inhibition of PTP1B activity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Cell Biology
Yu Zhu, Jianbo Yu, Jiangbiao Gong, Jie Shen, Di Ye, Dexin Cheng, Zhikai Xie, Jianping Zeng, Kangli Xu, Jian Shen, Hengjun Zhou, Yuxiang Weng, Jianwei Ran, Renya Zhan
Summary: The study found that microglial PTP1B expression significantly increased after ischemia/reperfusion injury. The PTP1B inhibitor sc-222227 attenuated IR-induced microglial activation, ER stress, and autophagy, promoting M2 polarization. Targeting microglial PTP1B could be a potential therapeutic strategy for ischemic stroke treatment.
Article
Biochemical Research Methods
Samuel Campbell, Michelle C. Mendoza, Aravind Rammohan, Matthew E. McKenzie, Tamara C. Bidone
Summary: Cells create physical connections with the extracellular environment through adhesions. Nascent adhesions form at the leading edge of migrating cells and either undergo cycles of disassembly and reassembly, or elongate and stabilize at the end of actin fibers. The exact role of actin fibers in the elongation and stabilization of nascent adhesions remains largely elusive.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jinfeng Wang, Junyao Li, Juan Liu, Manping Lin, Shilong Mao, Yuanliang Wang, Yanfeng Luo
Summary: The protein-material interfacial force (F-ad) plays a crucial role in regulating cell traction force (CTF) and fluid shear stress (FSS) transmission, influencing the structure and function of the actin cytoskeleton and focal adhesions (FAs) within cells, and thereby affecting the mechanical balance between cells and materials.
Review
Cell Biology
Kouminin Kanwore, Piniel Alphayo Kambey, Xiao-Xiao Guo, Ayanlaja Abdulrahman Abiola, Ying Xia, Dianshuai Gao
Summary: The external and internal factors of the cell play a critical role in glioma initiation, with multiple factors and molecules implicated in brain cancer progression. Glioma stem cells have been identified as the origin, and oncogene overexpression is involved in tumorigenesis, maintenance, and progression. Additionally, defects in cell organelles contribute to cancer cell resistance to drugs, apoptosis, and immune cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Ulises Diaz, Wallace Marshall, Blake Riggs
Summary: Modern quantitative live cell imaging techniques are important for exploring cell biology, but current cell culture model systems have limitations. There is a need for a scalable high-throughput imaging system. This study describes a method for simultaneously acquiring multiple videos of Drosophila melanogaster embryos using a high-content image analyzer.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Immunology
Irving Ulises Martinez-Vargas, Maria Elena Sanchez-Bello, Carlos Emilio Miguel-Rodriguez, Felipe Hernandez-Cazares, Leopoldo Santos-Argumedo, Patricia Talamas-Rohana
Summary: Gamma delta T intraepithelial lymphocytes account for up to 60% of the small intestine intraepithelial compartment. The adhesion and migration of these cells are dependent on the protein Myo1f. Myo1f deficiency leads to reduced surface expression of CCR9 and alpha 4 beta 7, affecting the homing of intraepithelial lymphocytes. In vitro experiments confirm that Myo1f is required for adhesion to integrin ligands and for CCL25-dependent and independent migration.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Plant Sciences
Jingze Zang, Verena Kriechbaumer, Pengwei Wang
Summary: Plant endoplasmic reticulum (ER) remodelling is important for targeted protein secretion, organelle interaction, and signal exchange, regulated by actin cytoskeleton and microtubule-based machinery. The dependence on cell type and developmental stages for ER dynamics in plants is highlighted in recent discoveries. The ER membrane also plays a role in organizing the cytoskeletal network, impacting cytoskeleton structure.
JOURNAL OF PLANT PHYSIOLOGY
(2021)
Article
Cell Biology
Claudia Brito, Joana M. Pereira, Francisco S. Mesquita, Didier Cabanes, Sandra Sousa
Summary: Non-muscle myosin 2A (NM2A) is a cytoskeletal enzyme involved in cell adhesion and motility. Its phosphorylation at residue 158 regulates cytoskeletal organization, focal adhesion assembly/disassembly, and cell migration. This phosphorylation is promoted by Listeria monocytogenes infection and is dependent on Src kinase. We propose NM2A pTyr(158) as a novel regulatory mechanism for actomyosin cytoskeleton organization.
Review
Cell Biology
Satish Bodakuntla, Hana Nedozralova, Nirakar Basnet, Naoko Mizuno
Summary: Axon branching is a critical process for neural network formation, requiring a local system to dynamically control and regulate axonal growth. Regulation of axon branching involves coordination of cellular functions such as cytoskeleton and membrane remodeling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Sangyoon J. Han, Evgenia Azarova, Austin J. Whitewood, Alexia Bachir, Edgar Guttierrez, Alex Groisman, Alan R. Horwitz, Benjamin T. Goult, Kevin M. Dean, Gaudenz Danuser
Summary: The study reveals the crucial role of concurrent recruitment of talin and vinculin in early integrin-based nascent adhesions, which is essential for the maturation of NAs. Specifically, the function of the R8 domain in talin is identified as important for NA maturation, affecting vinculin binding and recruitment rates.
Article
Orthopedics
Jianxin Wu, Lei Yu, Yi Liu, Bing Xiao, Xiaojian Ye, Hong Zhao, Yanhai Xi, Zhicai Shi, Weiheng Wang
Summary: This study investigates the impact of hypoxia on adipose mesenchymal stem cells (ADSCs) proliferation, migration, and NPC-like differentiation through the regulation of HIF-1a and ER stress. The results show that hypoxia and HIF-1a overexpression increase ADSCs proliferation and migration, while HIF-1a inhibition reduces these processes. Additionally, hypoxia regulates ER stress in ADSCs through the HIF-1a pathway.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Oncology
Yilong Zhu, Yiquan Li, Bing Bai, Chao Shang, Jinbo Fang, Jianan Cong, Wenjie Li, Shanzhi Li, Gaojie Song, Zirui Liu, Jin Zhao, Xiao Li, Guangze Zhu, Ningyi Jin
Summary: The study investigated the effects of Apoptin-induced endoplasmic reticulum stress on HepG-2 cells' lipid metabolism, migration, and invasion, and found that it can cause lasting ER stress response, alter lipid metabolism related enzymes expression levels, and reduce migration and invasion abilities of HepG-2 cells. Apoptin can also affect lipid metabolism through ER stress, potentially reducing tumor cells' migration and invasion abilities.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biology
Ana E. Gonzalez Wusener, Angela Gonzalez, Fumihiko Nakamura, Carlos O. Arregui
Article
Cell Biology
Juan E. Burdisso, Angela Gonzalez, Carlos O. Arregui
JOURNAL OF CELL SCIENCE
(2013)
Article
Cell Biology
Federico Fuentes, Carlos O. Arregui
MOLECULAR BIOLOGY OF THE CELL
(2009)
Article
Cell Biology
Mariana V. Hernandez, Diana P. Wehrendt, Carlos O. Arregui
MOLECULAR BIOLOGY OF THE CELL
(2010)
Article
Multidisciplinary Sciences
Melisa C. Monteleone, Ana E. Gonzalez Wusener, Juan E. Burdisso, Cecilia Conde, Alfredo Caceres, Carlos O. Arregui
Article
Multidisciplinary Sciences
Federico Fuentes, Derek Zimmer, Marybless Atienza, Jamie Schottenfeld, Ian Penkala, Tracy Bale, Kendra K. Bence, Carlos O. Arregui
Article
Multidisciplinary Sciences
Diana P. Wehrendt, Fernando Carmona, Ana E. Gonzalez Wusener, Angela Gonzalez, Juan M. Lazaro Martinez, Carlos O. Arregui
Editorial Material
Cell Biology
Ana E. Gonzalez Wusener, Angela Gonzalez, Maria E. Perez Collado, Melina R. Maza, Ignacio J. General, Carlos O. Arregui
JOURNAL OF CELL SCIENCE
(2021)
Article
Neurosciences
Glen S. Marrs, Takashi Honda, Leah Fuller, Ramasamy Thangavel, Janne Balsamo, Jack Lilien, Michael E. Dailey, Carlos Arregui
MOLECULAR AND CELLULAR NEUROSCIENCE
(2006)
Article
Cell Biology
MV Hernández, MGD Sala, J Balsamo, J Lilien, CO Arregui
JOURNAL OF CELL SCIENCE
(2006)
Article
Biochemistry & Molecular Biology
G Xu, C Arregui, J Lilien, J Balsamo
JOURNAL OF BIOLOGICAL CHEMISTRY
(2002)
Article
Biochemistry & Molecular Biology
CR Mas, CO Arregui, A Filiberti, CE Argaraña, HS Barra
NEUROCHEMICAL RESEARCH
(2002)
Article
Cell Biology
J Rhee, NS Mahfooz, C Arregui, J Lilien, J Balsamo, MFA VanBerkum
NATURE CELL BIOLOGY
(2002)
Review
Anatomy & Morphology
J Lilien, J Balsamo, C Arregui, G Xu
DEVELOPMENTAL DYNAMICS
(2002)
