Par6 is phosphorylated by aPKC to facilitate EMT

Atypical Protein Kinase C Phosphorylates Par6 and Facilitates Transforming Growth Factor  -Induced Epithelial-to-Mesenchymal Transition

(2012) A. Gunaratne et al.   MOLECULAR AND CELLULAR BIOLOGY

Loss of Par3 promotes breast cancer metastasis by compromising cell–cell cohesion

(2012) Bin Xue et al.   NATURE CELL BIOLOGY

Regulation of TGFβ receptor trafficking and signaling by atypical protein kinase C

(2011) Adrian Gunaratne et al.   CELLULAR SIGNALLING

TGFβ and BMP-2 regulate epicardial cell invasion via TGFβR3 activation of the Par6/Smurf1/RhoA pathway

(2011) Nora S. Sánchez et al.   CELLULAR SIGNALLING

TGF-β Signaling Specifies Axons during Brain Development

(2010) Jason J. Yi et al.   CELL

Involvement of PKC-ι in glioma proliferation

(2010) R. Patel et al.   CELL PROLIFERATION

Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators

(2010) Ling Huang et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Protein kinase Cι expression and oncogenic signaling mechanisms in cancer

(2010) Nicole R. Murray et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Coordination of glioblastoma cell motility by PKCι

(2010) R Mitchell Baldwin et al.   Molecular Cancer

Numb

(2010) Zezhou Wang et al.   Cell Adhesion & Migration

Expression of P-aPKC-ι, E-Cadherin, and β-Catenin Related to Invasion and Metastasis in Hepatocellular Carcinoma

(2009) Guang-Sheng Du et al.   ANNALS OF SURGICAL ONCOLOGY

Numb regulates cell–cell adhesion and polarity in response to tyrosine kinase signalling

(2009) Zezhou Wang et al.   EMBO JOURNAL

A role for the TGF -Par6 polarity pathway in breast cancer progression

(2009) A. M. Viloria-Petit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Polarity Protein Par6 Induces Cell Proliferation and Is Overexpressed in Breast Cancer

(2008) M. E. Nolan et al.   CANCER RESEARCH

Atypical Protein Kinase C  Expression and Aurothiomalate Sensitivity in Human Lung Cancer Cells

(2008) R. P. Regala et al.   CANCER RESEARCH

The overexpression and altered localization of the atypical protein kinase C λ/ι in breast cancer correlates with the pathologic type of these tumors

(2008) Yasuyuki Kojima et al.   HUMAN PATHOLOGY

Cell polarity and cancer - cell and tissue polarity as a non-canonical tumor suppressor

(2008) M. Lee et al.   JOURNAL OF CELL SCIENCE

Crosstalk between small GTPases and polarity proteins in cell polarization

(2008) Sandra Iden et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of glioblastoma cell invasion by PKCι and RhoB

(2008) R M Baldwin et al.   ONCOGENE

Matrix metalloproteinase-10 is a critical effector of protein kinase Cι-Par6α-mediated lung cancer

(2008) L A Frederick et al.   ONCOGENE