Structural basis of transmembrane domain interactions in integrin signaling

The structure of a glycogen phosphorylase glucopyranose spirohydantoin complex at 1.8 Å resolution and 100 K: The role of the water structure and its contribution to binding

(2010) Mary Gregoriou et al.   PROTEIN SCIENCE

The Transmembrane Structure of Integrin αIIbβ3: Significance for Signal Transduction

(2009) Martin Hoefling et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Interactions of platelet integrin αΙΙband β3transmembrane domains in mammalian cell membranes and their role in integrin activation

(2009) Chungho Kim et al.   BLOOD

The structure of an integrin/talin complex reveals the basis of inside-out signal transduction

(2009) Nicholas J Anthis et al.   EMBO JOURNAL

The structure of the integrin αIIbβ3 transmembrane complex explains integrin transmembrane signalling

(2009) Tong-Lay Lau et al.   EMBO JOURNAL

Crystal structure of the complete integrin αVβ3 ectodomain plus an α/β transmembrane fragment

(2009) Jian-Ping Xiong et al.   JOURNAL OF CELL BIOLOGY

Integrin signalling at a glance

(2009) D. S. Harburger et al.   JOURNAL OF CELL SCIENCE

Linking integrin conformation to function

(2009) J. A. Askari et al.   JOURNAL OF CELL SCIENCE

Multiple Approaches Converge on the Structure of the Integrin αIIb/β3 Transmembrane Heterodimer

(2009) Douglas G. Metcalf et al.   JOURNAL OF MOLECULAR BIOLOGY

The structure and function of platelet integrins

(2009) J. S. BENNETT et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The Structure of a Receptor with Two Associating Transmembrane Domains on the Cell Surface: Integrin αIIbβ3

(2009) Jieqing Zhu et al.   MOLECULAR CELL

Structure of an integrin  IIb 3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activation

(2009) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Permissive transmembrane helix heterodimerization is required for the expression of a functional integrin

(2008) Ardcharaporn Vararattanavech et al.   BIOCHEMICAL JOURNAL

Computationally Designed Peptide Inhibitors of Protein−Protein Interactions in Membranes†

(2008) Gregory A. Caputo et al.   BIOCHEMISTRY

Structure of the Integrin β3 Transmembrane Segment in Phospholipid Bicelles and Detergent Micelles†

(2008) Tong-Lay Lau et al.   BIOCHEMISTRY

Structural Studies of the Transmembrane C-Terminal Domain of the Amyloid Precursor Protein (APP): Does APP Function as a Cholesterol Sensor?†‡

(2008) Andrew J. Beel et al.   BIOCHEMISTRY

Genetic perturbation of the putative cytoplasmic membrane-proximal salt bridge aberrantly activates  4 integrins

(2008) Y. Imai et al.   BLOOD

Disruption of the Integrin αLβ2 Transmembrane Domain Interface by β2 Thr-686 Mutation Activates αLβ2 and Promotes Micro-clustering of the αL Subunits

(2008) Ardcharaporn Vararattanavech et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spatial Structure and pH-dependent Conformational Diversity of Dimeric Transmembrane Domain of the Receptor Tyrosine Kinase EphA1

(2008) Eduard V. Bocharov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the Integrin αIIb Transmembrane Segment

(2008) Tong-Lay Lau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin αIIbβ3 in a Membrane Environment Remains the Same Height after Mn2+ Activation when Observed by Cryoelectron Tomography

(2008) Feng Ye et al.   JOURNAL OF MOLECULAR BIOLOGY

Bilayer in Small Bicelles Revealed by Lipid−Protein Interactions Using NMR Spectroscopy

(2008) Donghan Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces

(2008) Jianghai Zhu et al.   MOLECULAR CELL

A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the  IIb 3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia

(2007) C. Ghevaert et al.   BLOOD

Transmembrane signal transduction of the αIIbβ3 integrin

(2002) Kay E. Gottschalk et al.   PROTEIN SCIENCE