Journal
CELL ADHESION & MIGRATION
Volume 3, Issue 3, Pages 305-310Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.3.3.8399
Keywords
stem cells; cardiomyocytes; N-cadherin; connexin 43; gap junctions
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Funding
- NIH
- American Heart Association
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Constitutive overexpression of N-cadherin in mouse embryonic stem cells led to marked changes in the phenotype and adhesion properties of these cells. The changes included the formation of smaller embryonic bodies, elevated mRNA and total protein levels of N-cadherin, and increased amounts of p 120 catenin and connexin-43. N-cadherin cells exhibited decreased attachment to non-cell surfaces, while their adhesiveness to each other and to rat neonatal cardiomyocytes was significantly elevated. The findings suggest that N-cadherin overexpression can facilitate electromechanical integration of stem cells into excitable tissues with endogenously high levels of N-cadherin, such as the heart and brain.
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