Journal
CELL ADHESION & MIGRATION
Volume 3, Issue 1, Pages 129-137Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.3.1.7401
Keywords
atypical antipsychotics; neuroprotective effect; memory; anxiety-like behavior; neurotoxicity
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Funding
- Canadian Psychiatry Research Foundation
- Canadian Institutes of Health Research, NeuroScience Canada
- Saskatchewan Health Research Foundation
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Antipsychotic drugs are divided into two groups: typical and atypical. Recent clinical studies show atypical antipsychotics have advantages over typical antipsychotics in a wide variety of neuropsychiatric conditions, in terms of greater efficacy for positive and negative symptoms, beneficial effects on cognitive functioning, and fewer extra pyramidal side effects in treating schizophrenia. As such, atypical antipsychotics may be effective in the treatment of depressive symptoms associated with psychotic and mood disorders, posttraumatic stress disorder and psychosis in Alzheimer disease. In this paper, we describe the effects and potential neurochemical mechanisms of action of atypical antipsychotics in several animal models showing memory impairments and/or non-cognitive behavioral changes. The data provide new insights into the mechanisms of action of atypical antipsychotics that may broaden their clinical applications.
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