Journal
CELL ADHESION & MIGRATION
Volume 3, Issue 1, Pages 3-6Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.3.1.7275
Keywords
decorin; angiogenesis; motility; alpha 2 beta 1 integrin; insulin-like growth factor I receptor; Rac GTPase
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Funding
- Cardiff University, Deutsche Forschungsgemeinschaft [SFB 293, SFB 492, SPP1086, Eb177/5-1]
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Interactions between endothelial cells and the surrounding extracellular matrix are continuously adapted during angiogenesis, from early sprouting through to lumen formation and vessel maturation. Regulated control of these interactions is crucial to sustain normal responses in this rapidly changing environment, and dysfunctional endothelial cell behaviour results in angiogenic disorders. The proteoglycan decorin, an extracellular matrix component, is upregulated during angiogenesis. While it was shown previously that the absence of decorin leads to dysregulated angiogenesis in vivo, the molecular mechanisms were not clear. These abnormal endothelial cell responses have been attributed to indirect effects of decorin; however, our recent data provides evidence that decorin directly regulates endothelial cell-matrix interactions. This data will be discussed in conjunction with findings from previous studies, to better understand the role of this proteoglycan in angiogenesis.
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