Journal
CELL ADHESION & MIGRATION
Volume 2, Issue 3, Pages 153-160Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.2.3.6484
Keywords
boron; boric acid; DU-145; PC-3; ZR-75-1; RWPE-1; MCF-10A; adhesion; fibronectin
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Funding
- NIH from the INBRE of the National Center for Research Resources [2P20RR016464]
- Department of Defense [W81XWH-06-2-0015]
- NIGMS Biomolecular Science and Engineering Training [1 T32 GM067545-01A1]
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We compared the in vitro effect of boric acid (BA) versus phenylboronic acid (PBA) on the migration of prostate and breast cancer cell lines and non-tumorigenic cells from the same tissues. Treatment at 24 hours with BA (<= 500 mu M) did not inhibit chemotaxis on fibronectin in any cell line. However, treatment over the same time course with concentrations of PBA as low as 1 mu M significantly inhibited cancer cell migration without effecting non-tumorigenic cell lines. The compounds did not affect cell adhesion or viability at 24 hours but did alter morphology; both decreased cancer cell viability at eight days. These results suggest that PBA is more potent than BA in targeting the metastatic and proliferative properties of cancer cells.
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