Review
Oncology
Ali Amidi, Lisa M. Wu
Summary: Cancer patients often experience side effects such as fatigue, sleep difficulties, depressive symptoms, and cognitive impairment, which can persist long after treatment. These symptoms may have a shared underlying mechanism, with circadian rhythm disruption emerging as a potential pathophysiological mechanism. This review discusses the measurement of circadian rhythms, research findings on circadian disruption in cancer patients, and the associations between circadian rhythm disruption and cancer- and treatment-related symptoms.
FRONTIERS IN ONCOLOGY
(2022)
Article
Neurosciences
Joram Soch, Anni Richter, Hartmut Schuetze, Jasmin M. Kizilirmak, Anne Assmann, Gusalija Behnisch, Hannah Feldhoff, Larissa Fischer, Julius Heil, Lea Knopf, Christian Merkel, Matthias Raschick, Clara-Johanna Schietke, Annika Schult, Constanze Seidenbecher, Renat Yakupov, Gabriel Ziegler, Jens Wiltfang, Emrah Duezel, Bjoern H. Schott
Summary: As older adults, especially those at risk for dementia, show declines in memory performance, fMRI can be used to detect alterations in memory network activity. The FADE and FADE-SAME scores are developed as potential biomarkers for successful aging and are correlated with behavioral measures of cognitive aging.
HUMAN BRAIN MAPPING
(2021)
Article
Nutrition & Dietetics
Paulina Maria Przybycien-Gaweda, Tih Shih Lee, Wee Shiong Lim, Mei Sian Chong, Philip Yap, Chin Yee Cheong, Iris Rawtaer, Tau Ming Liew, Xinyi Gwee, Qi Gao, Keng Bee Yap, Tze Pin Ng
Summary: There is a lack of evidence supporting the association between folate and vitamin B12 exposure with cognitive outcomes. However, this study found that low vitamin B12 levels, high homocysteine levels, and a hypo-methylation one-carbon index are significantly associated with the progression to neurocognitive disorder among cognitively-normal adults.
Article
Psychiatry
Alexander Weigard, Katherine L. McCurry, Zvi Shapiro, Meghan E. Martz, Mike Angstadt, Mary M. Heitzeg, Ivo D. Dinov, Chandra Sripada
Summary: This study developed and tested machine learning models to predict ADHD symptoms in children using neurocognitive abilities, demographics, and child and family characteristics. The models explained 15-20% of the variance in 1-year ADHD symptoms and 12-13% of the variance in 2-year ADHD symptoms. The models showed high generalizability and minimal predictive power loss when applied to new data.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Pharmacology & Pharmacy
S. Alboni, C. Benatti, C. Colliva, G. Radighieri, J. M. C. Blom, N. Brunello, F. Tascedda
Summary: The study demonstrates that pretreatment with Vortioxetine prevents LPS-induced cognitive memory impairment without affecting acute sickness behavior and anhedonia. Vortioxetine may impact the immune response by affecting the microglia in the hippocampus.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Alexandra M. Gaynor, Anam Ahsan, Duane Jung, Elizabeth Schofield, Yuelin Li, Elizabeth Ryan, Tim A. Ahles, James C. Root
Summary: This study evaluated the ability of a novel computerized battery of cognitive neuroscience-based tests to distinguish cognitive performance between breast cancer survivors and controls. The results showed that survivors had lower performance in multiple cognitive domains compared to controls. The battery demonstrated sensitivity to cancer-related cognitive dysfunction and identified specific cognitive processes that may be affected in survivors. This has implications for the initial diagnosis and monitoring of cognitive function in cancer survivors.
JOURNAL OF CANCER SURVIVORSHIP
(2022)
Article
Immunology
Erika G. Marques de Menezes, Jocelyn S. Liu, Scott A. Bowler, Leila B. Giron, Michelle L. D'Antoni, Cecilia M. Shikuma, Mohamed Abdel-Mohsen, Lishomwa C. Ndhlovu, Philip J. Norris
Summary: The study found that EVs expressing markers of monocyte activation and neuronal injury were elevated in HIV-infected individuals with cognitive impairment, suggesting that specific EV subsets may serve as novel biomarkers of neuronal injury in HIV infection. Additionally, levels of circulating platelet EVs were linked to monocyte activation, indicating a potential novel interaction in the pathogenesis of HIV-related cognitive impairment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Psychiatry
Emily K. Lindsay, Tristen K. Inagaki, Catherine P. Walsh, Berhane Messay, Linda J. Ewing, Anna L. Marsland
Summary: This study examines the impact of chronic inflammation on social behavior and its relationship with stress and inflammation. The results demonstrate that higher levels of stress after cancer diagnosis are associated with higher inflammation levels. In turn, increased inflammation is related to a decrease in social roles and slower increases in stress and inflammation.
PSYCHOSOMATIC MEDICINE
(2022)
Article
Multidisciplinary Sciences
Mayssam Nehme, Olivia Braillard, Francois Chappuis, Idris Guessous
Summary: This study found that 10-35% of COVID-19 cases in outpatient settings develop post-COVID condition. The duration and severity of symptoms contribute to the complexity and heterogeneity of post-COVID condition. Patients with chronic symptoms experience increased healthcare utilization, treatment needs, functional impairment, and poorer quality of life. Having multiple symptoms and difficulty concentrating at 7 months after infection are associated with a chronicity of symptoms.
SCIENTIFIC REPORTS
(2022)
Article
Psychology, Developmental
Sharifah Shameem Agha, Lucy Riglin, Rhian Carbury, Rachel Blakey, Amy Shakeshaft, Ajay K. Thapar, Kate Tilling, Stephan Collishaw, Evie Stergiakouli, Anita Thapar, Kate Langley
Summary: This study found that adult ADHD symptoms in the general population are associated with neurocognitive impairments, which are similar to those seen in childhood ADHD symptoms and adult ADHD clinical samples.
JOURNAL OF ATTENTION DISORDERS
(2023)
Article
Endocrinology & Metabolism
Leonie J. T. Balter, Xueqi Li, Lilly Schwieler, Sophie Erhardt, John Axelsson, Mats J. Olsson, Julie Lasselin, Mats Lekander
Summary: This study shows that LPS-induced inflammation is associated with changes in kynurenine pathway metabolites, but these changes in blood levels do not directly correlate with symptoms of sickness behavior.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Immunology
Danxi Li, Di Hu, Yuta Ochi, Wakiko Arakaki, Aya Mawatari, Mika Shigeta, Yuping Wu, Emi Hayashinaka, Hiroyuki Neyama, Tsuyoshi Tahara, Yasuhiro Wada, Feng Li, Hisashi Doi, Yasuyoshi Watanabe, Yilong Cui
Summary: To investigate the mechanism of fatigue induced by peripheral infection, this study conducted a brain-wide investigation of neuroinflammation using PET imaging analysis in a peripheral pseudoinfection rat model.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Kristoffer N. T. Mansson, Julie Lasselin, Bianka Karshikoff, John Axelsson, Harald Engler, Manfred Schedlowski, Sven Benson, Predrag Petrovic, Mats Lekander
Summary: This study investigated the vulnerability factors to inflammation-induced sickness and anxiety responses in individuals, and found that the gray matter volume of the anterior insula plays a central role in the development of symptoms. The results suggest that anterior insula morphology may be a risk factor in inflammation-related psychopathologies.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Neurosciences
Anni Richter, Joram Soch, Jasmin M. Kizilirmak, Larissa Fischer, Hartmut Schutze, Anne Assmann, Gusalija Behnisch, Hannah Feldhoff, Lea Knopf, Matthias Raschick, Annika Schult, Constanze I. Seidenbecher, Renat Yakupov, Emrah Duezel, Bjorn H. Schott
Summary: In this study, we investigated the associations between two single-value scores and brain function and cognitive changes in middle-aged and older adults. The results showed that these scores were related to memory recall performance and one of the scores also correlated with brain gray matter and other neuropsychological measures. This suggests that single-value scores of memory-related fMRI provide valuable information about network dysfunction in individuals and age-related cognitive decline.
HUMAN BRAIN MAPPING
(2023)
Article
Multidisciplinary Sciences
Philip S. Amara, Zaeema Naveed, Christopher S. Wichman, Howard S. Fox, Lorena Baccaglini
Summary: The study found a negative association between HIV-associated neurocognitive impairment (NCI) and health-related quality of life (HRQoL), particularly in terms of mental health. Besides depression, employment status also influenced this association.
Article
Computer Science, Theory & Methods
Runze Yan, Whitney R. Ringwald, Julio Vega, Madeline Kehl, Sang Won Bae, Anind K. Dey, Carissa A. Low, Aidan G. C. Wright, Afsaneh Doryab
Summary: This paper presents novel analytic approaches to extract and understand behavioral patterns associated with adaptive and maladaptive personality traits through continuous passive sensing of daily behavior from mobile devices. The analysis shows that both adaptive and maladaptive traits are linked to passively sensed behavior, providing initial evidence for the utility of this data in studying personality and its pathology. The findings also suggest directions for future research into the underlying behavior patterns that connect adaptive and maladaptive variants.
FUTURE GENERATION COMPUTER SYSTEMS-THE INTERNATIONAL JOURNAL OF ESCIENCE
(2022)
Article
Chemistry, Analytical
Chen Qian, Patraporn Leelaprachakul, Matthew Landers, Carissa Low, Anind K. Dey, Afsaneh Doryab
Summary: Hospital readmissions pose challenges for healthcare systems and patients, accurate prediction is difficult, but this research shows promise in leveraging mobile data for daily risk prediction after discharge.
Article
Gastroenterology & Hepatology
Jason B. Liu, Vernissia Tam, Mazen S. Zenati, Danielle Schwartz, Areej Ali, Carissa A. Low, Lillian J. Smith, Herbert J. Zeh III, Amer H. Zureikat, Melissa E. Hogg
Summary: Robotic-assisted pancreatectomy may offer greater improvement in symptoms from the patient's perspective compared to open surgery by three months postoperatively. However, patients who underwent robotic surgery experienced worse FACT-Hep scores, while showing significant improvement in the HCS scores. There was no significant change in the FACT-G scores.
Article
Psychology, Multidisciplinary
Geralyn R. Ruissen, Mark R. Beauchamp, Eli Puterman, Bruno D. Zumbo, Ryan E. Rhodes, Benjamin A. Hives, Brinkley M. Sharpe, Julio Vega, Carissa A. Low, Aidan G. C. Wright
Summary: Using continuous-time analysis, this study examined the dynamic relationship between incidental affect and moderate-to-vigorous physical activity (MVPA). The results showed that positive and negative incidental affect predicted subsequent MVPA, and engaging in MVPA also predicted subsequent affect. The influence of incidental affect on MVPA was stronger than the reciprocal relationship. The effects were strongest at 7-9 hour time intervals.
ANNALS OF BEHAVIORAL MEDICINE
(2022)
Meeting Abstract
Psychiatry
Carissa A. Low, Meng Li, Krina C. Durica, Abhineeth Kunta, Aidan G. Wright
PSYCHOSOMATIC MEDICINE
(2022)
Meeting Abstract
Psychology, Multidisciplinary
Geralyn R. Ruissen, Mark R. Beauchamp, Eli Puterman, Bruno D. Zumbo, Ryan E. Rhodes, Benjamin A. Hives, Brinkley M. Sharpe, Julio Vega, Carissa A. Low, Aidan G. Wright
ANNALS OF BEHAVIORAL MEDICINE
(2022)
Meeting Abstract
Geriatrics & Gerontology
Eli Puterman, Benjamin Hives, A. Janet Tomiyama, Carissa Low, Geralyn Ruissen, Mark Beauchamp, Aidan Wright
INNOVATION IN AGING
(2021)
Article
Oncology
Carissa A. Low, Meng Li, Julio Vega, Krina C. Durica, Denzil Ferreira, Vernissia Tam, Melissa Hogg, Herbert Zeh, Afsaneh Doryab, Anind K. Dey
Summary: This study demonstrates the potential of using smartphone and Fitbit data to predict symptom burden in cancer patients before and after surgery, particularly for pain, fatigue, and diarrhea. Digital biomarkers show promise in informing symptom management interventions and monitoring patient symptoms passively.
Meeting Abstract
Psychiatry
Carissa A. Low, Krina C. Durica, Michaela Danko, Julio Vega, Abhineeth Kunta, Meng Li
PSYCHOSOMATIC MEDICINE
(2021)
Review
Health Care Sciences & Services
Benjamin W. Nelson, Carissa A. Low, Nicholas Jacobson, Patricia Arean, John Torous, Nicholas B. Allen
NPJ DIGITAL MEDICINE
(2020)
Review
Health Care Sciences & Services
Carissa A. Low
NPJ DIGITAL MEDICINE
(2020)
Meeting Abstract
Psychiatry
John F. Hunter, John Hunter, Adrian Aguilera, Charles R. Jonassaint, Betina Yanez, Carissa A. Low
PSYCHOSOMATIC MEDICINE
(2020)
Meeting Abstract
Psychology, Multidisciplinary
Carissa A. Low, Michaela Danko, Krina C. Durica, Raghu Mulukutla, Yiyi Ren, Elynna B. Youm, David L. Bartlett, Dana H. Bovbjerg, Anind K. Dey, John M. Jakicic
ANNALS OF BEHAVIORAL MEDICINE
(2020)
Meeting Abstract
Psychology, Multidisciplinary
Krina C. Durica, Michaela Danko, Raghu Mulukutla, Yiyi Ren, Elynna B. Youm, David L. Bartlett, Dana H. Bovbjerg, Anind K. Dey, John M. Jakicic, Carissa A. Low
ANNALS OF BEHAVIORAL MEDICINE
(2020)
Article
Psychology, Multidisciplinary
Carissa A. Low, Dana H. Bovbjerg, Steven Ahrendt, M. Haroon Choudry, Matthew Holtzman, Heather L. Jones, James F. Pingpank, Lekshmi Ramalingam, Herbert J. Zeh, Amer H. Zureikat, David L. Bartlett
ANNALS OF BEHAVIORAL MEDICINE
(2018)
