Journal
CANCER GENETICS
Volume 204, Issue 2, Pages 108-110Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cancergencyto.2010.10.006
Keywords
Xp11.2; renal cell carcinoma; secondary tumor
Categories
Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, FAPESP [06/04827-3, 07/54236-4]
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Xp11.2 translocation-associated renal cell carcinoma (RCC) is a rare tumor that accounts for at least one-third of childhood RCC. Different reports have emphasized that previous radio/chemotherapy might be involved in its pathogenesis. We describe a child who developed a t(X;1) (p11.2;p34) associated RCC after previous treatment for genitourinary rhabdomyosarcoma in infancy. The presence of the PSF-TFE3 fusion has only been described in a very limited number of cases. Our report expands the spectrum of tumors in which RCC can arise in the pediatric age group after chemotherapy.
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