4.7 Editorial Material

A Systems Biology Approach to Personalizing Therapeutic Combinations

Journal

CANCER DISCOVERY
Volume 3, Issue 12, Pages 1339-1344

Publisher

AMER ASSOC CANCER RESEARCH
DOI: 10.1158/2159-8290.CD-13-0394

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Funding

  1. NCI NIH HHS [U01 CA141508-05, R01 CA93947-10, U01 CA141508, R01 CA093947] Funding Source: Medline

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The identification of evidence-based, efficacious drug combinations for each cancer, among thousands of potential permutations, is a daunting task. In this perspective, we propose a systematic approach to defining such combinations by molecularly benchmarking a drug against a desired state of efficacy using model systems. (C) 2013 AACR.

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