Article
Medicine, Research & Experimental
Matthew D. Cheung, Elise N. Erman, Kyle H. Moore, Jeremie M. P. Lever, Zhang Li, Jennifer R. LaFontaine, Gelare Ghajar-Rahimi, Shanrun Liu, Zhengqin Yang, Rafay Karim, Bradley K. Yoder, Anupam Agarwal, James F. George
Summary: A study has found that there are 7 subpopulations of resident macrophages in the kidney, which have different functions and spatial distributions. Using single-cell RNA sequencing and spatial transcriptomics, researchers have localized and characterized these subpopulations, and discovered that their locations and transcriptomic signatures change following acute kidney injury, taking at least 28 days to fully restore.
Article
Multidisciplinary Sciences
Xavier Arnan, Elena Angulo, Raphael Boulay, Roberto Molowny-Horas, Xim Cerda, Javier Retana
Summary: This study aimed to examine the climatic niche similarity in native and introduced ant species in Europe, and found a strong phylogenetic signal in the optimal climatic niches of the most common ant species in Europe. Introduced species occupied different climatic niches in Europe compared to their native ranges, and their European climatic niches did not resemble those of their closest relative species in Europe.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Silvia Pineda-Munoz, Yue Wang, S. Kathleen Lyons, Aniko B. Toth, Jenny L. McGuire
Summary: Human activities have significantly altered the climate environments of many mammal species, leading to extirpation of large-bodied dietary specialists from human-impacted areas and colonization of smaller, generalist mammals. This trend is likely to continue in the Anthropocene, resulting in a biodiversity dominated by small, generalist mammals.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Business
Dean Neu, Gregory D. Saxton, Abu S. Rahaman
Summary: This study analyzes the use of character and concept terms in English-language tweets during the 2011 Occupy Wall Street protests, demonstrating how individuals crafted a narrative of social accountability through ethical stances. The centrality of these terms in conversations shifted over time, amplifying the ethical attributes of different characters and contributing to an evolving understanding of demands for social accountability.
JOURNAL OF BUSINESS ETHICS
(2022)
Article
Multidisciplinary Sciences
Finn Box, Alexander Erlich, Jian H. Guan, Chris Thorogood
Summary: The giant Amazonian waterlily produces the largest floating leaves in the plant kingdom. The unique structure of these leaves has inspired artists, engineers, and architects. However, little is known about the mechanics of these leaves. This study reveals that the geometric form of the leaf is structurally more efficient, allowing for extensive coverage and optimal light capture.
Article
Chemistry, Physical
Longbing Shang, Mingzhe Liu, Chang-Kui Duan
Summary: By choosing hosts with appropriate sites, the Cr3+ activators can produce desired near-infrared broadband emission via ligand field engineering. First-principles calculations help to analyze the site, valence, and luminescent mechanism of the activators. It is found that the experimentally reported near-infrared emission is actually produced by Cr3+ at the octahedral site.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Ecology
Clara Qin, Peter T. Pellitier, Michael E. Van Nuland, Kabir G. Peay, Kai Zhu
Summary: This study predicts the climate sensitivity of North American soil fungal assemblage composition and reveals that soil fungal assemblages in North American climates are more likely to be limited by cold and dry conditions. The boreal forest is especially vulnerable to compositional changes triggered by small degrees of warming.
GLOBAL ECOLOGY AND BIOGEOGRAPHY
(2023)
Article
Biochemistry & Molecular Biology
Kamaludin Dingle, Fatme Ghaddar, Petr Sulc, Ard A. Louis
Summary: Developmental bias is the primary explanation for the occupation of the RNA secondary structure morphospace, with only the most frequent structures appearing in nature and a small number of random sequences needed to produce all observed RNA secondary structures. These patterns are accurately predicted by the likelihood of structures appearing upon a uniform random sampling of sequences.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)
Article
Oncology
Simona Corso, Filippo Pietrantonio, Maria Apicella, Cristina Migliore, Daniela Conticelli, Annalisa Petrelli, Laura D'Errico, Stefania Durando, Daniel Moya-Rull, Sara E. Bellomo, Stefano Ughetto, Maurizio Degiuli, Rossella Reddavid, Uberto Fumagalli, Stefano De Pascale, Giovanni Sgroi, Emanuele Rausa, Gian Luca Baiocchi, Sarah Molfino, Giovanni De Manzoni, Maria Bencivenga, Salvatore Siena, Andrea Sartore-Bianchi, Federica Morano, Salvatore Corallo, Michele Prisciandaro, Maria Di Bartolomeo, Annunziata Gloghini, Silvia Marsoni, Antonino Sottile, Anna Sapino, Caterina Marchio, Asa Dahle-Smith, Zosia Miedzybrodzka, Jessica Lee, Siraj M. Ali, Jeffrey S. Ross, Brian M. Alexander, Vincent A. Miller, Russell Petty, Alexa B. Schrock, Silvia Giordano
Summary: The study highlights EGFR amplification as a driving factor of aggressive behavior and poor prognosis in gastric cancer, with EGFR inhibitors showing activity in patients with EGFR copy number gain. Additionally, the combination of EGFR and mTOR inhibitors shows promise in overcoming primary resistance mechanisms.
CLINICAL CANCER RESEARCH
(2021)
Article
Development Studies
Deanne Bell
Summary: This paper discusses the issue of coloniality in westernized universities and classrooms, pointing out the challenges that teachers face in recognizing the harm caused by colonial knowledge and existence to students. It argues for the transformation of these effects through decolonized teaching and learning practices, emphasizing the importance of creating decolonial atmospheres in classrooms.
THIRD WORLD QUARTERLY
(2022)
Article
Multidisciplinary Sciences
Mengmeng Niu, Jing Xu, Yang Liu, Yuhuang Li, Tao He, Liangping Ding, Yajun He, Yong Yi, Fengtian Li, Rongtian Guo, Ya Gao, Rui Li, Luping Li, Mengyuan Fu, Qingyong Hu, Yangkun Luo, Chunyan Zhang, Kewei Qin, Jianqiao Yi, Shuhan Yu, Jian Yang, Hu Chen, Liang Wang, Zhonghan Li, Biao Dong, Shiqian Qi, Liang Ouyang, Yujun Zhang, Yang Cao, Zhi-Xiong Jim Xiao
Summary: The study shows that FBXL2 targets EGFR and TKI-resistant mutants for degradation, which inhibits EGFR-driven NSCLC growth and TKI resistance.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Mahmoud G. Abo G. Al-Hamd, Haytham O. Tawfik, Omeima Abdullah, Koki Yamaguchi, Masaharu Sugiura, Ahmed B. M. Mehany, Mervat H. El-Hamamsy, Tarek F. El-Moselhy
Summary: The Hexahydroquinoline (HHQ) scaffold was utilized to develop a new series of anticancer agents. Thirty-two new compounds were synthesized and enantiomerism was confirmed through X-ray crystallography. Thirteen compounds exhibited moderate to good activity against NCI 60 cancer cell lines, with compound 10c showing the highest activity. In comparison to the reference drug erlotinib, compound 10d demonstrated superior inhibitory activity against EGFR(WT), EGFR(T790M), and EGFR(L858R), with IC50 values of 0.097, 0.280, and 0.051 & mu;M, respectively. Safety profiling using normal human lung cells validated the safety of compounds 10c and 10d. Molecular docking analysis provided insights into the potential binding interactions and affinities of the compounds in the active sites of the three versions of EGFR.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Cell Biology
Carolien Eggermont, Philippe Giron, Maxim Noeparast, Hugo Vandenplas, Pedro Aza-Blanc, Gustavo J. Gutierrez, Jacques De Greve
Summary: In this study, a high-throughput siRNA kinome screen was performed to identify targets involved in functional drug tolerance against EGFR TKI in NSCLC. STYK1 was identified as a potential target that, when downregulated, enhances the effects of EGFR inhibition. The study also found that STYK1 selectively interacts with mutant EGFR and that its downregulation counteracts the upregulation of FGF1 induced by EGFR TKI. Co-targeting EGFR and STYK1 could lead to a better overall outcome for NSCLC patients.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Michael G. Sugiyama, Aidan I. Brown, Jesus Vega-Lugo, Jazlyn P. Borges, Andrew M. Scott, Khuloud Jaqaman, Gregory D. Fairn, Costin N. Antonescu
Summary: Using single particle tracking, the authors discovered that EGFR is more confined when bound to ligands, and this confinement is regulated by clathrin and tetraspanin nanodomains. Ligand binding to unliganded EGFR occurs mainly in tetraspanin nanodomains, and disrupting these nanodomains impairs ligand binding and alters the receptor's ectodomain conformation. This study reveals a mechanism by which EGFR confinement within tetraspanin nanodomains regulates ligand binding and signaling.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Sei-Yong Jun, Dae-Seong Kim, Yong-Sung Kim
Summary: Based on an anti-EGFR monobody, this study developed a new strategy for immunotoxins that can distinguish between cells with EGFR overexpression in tumors and normal tissues, providing a new approach for targeting antigens overexpressed in tumors in broad normal tissues with immunotoxins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Kelsey F. Speer, Anselm Sommer, Benjamin Tajer, Mary C. Mullins, Peter S. Klein, Mark A. Lemmon
Review
Biochemistry & Molecular Biology
E. Joseph Jordan, Keshav Patil, Krishna Suresh, Jin H. Park, Yael P. Mosse, Mark A. Lemmon, Ravi Radhakrishnan
CELLULAR AND MOLECULAR LIFE SCIENCES
(2019)
Article
Oncology
Marta Baro, Cecilia Lopez Sambrooks, Barbara A. Burtness, Mark A. Lemmon, Joseph N. Contessa
MOLECULAR CANCER THERAPEUTICS
(2019)
Article
Oncology
Jacqueline H. Starrett, Alexis A. Guernet, Maria Emanuela Cuomo, Kamrine E. Poels, Iris K. van Alderwerelt van Rosenburgh, Amy Nagelberg, Dylan Farnsworth, Kristin S. Price, Hina Khan, Kumar Dilip Ashtekar, Mmaserame Gaefele, Deborah Ayeni, Tyler F. Stewart, Alexandra Kuhlmann, Susan M. Kaech, Arun M. Unni, Robert Homer, William W. Lockwood, Franziska Michor, Sarah B. Goldberg, Mark A. Lemmon, Paul D. Smith, Darren A. E. Cross, Katerina Politi
Review
Biochemistry & Molecular Biology
Kathryn M. Ferguson, Chun Hu, Mark A. Lemmon
Article
Biochemistry & Molecular Biology
Joshua B. Sheetz, Sebastian Mathea, Hanna Karvonen, Ketan Malhotra, Deep Chatterjee, Wilhelmiina Niininen, Robert Perttila, Franziska Preuss, Krishna Suresh, Steven E. Stayrook, Yuko Tsutsui, Ravi Radhakrishnan, Daniela Ungureanu, Stefan Knapp, Mark A. Lemmon
Review
Biochemistry & Molecular Biology
Stephen C. Artim, Anatoly Kiyatkin, Mark A. Lemmon
BIOCHEMICAL JOURNAL
(2020)
Article
Biochemistry & Molecular Biology
Anatoly Kiyatkin, Iris K. van Alderwerelt van Rosenburgh, Daryl E. Klein, Mark A. Lemmon
Article
Multidisciplinary Sciences
Keshav Patil, Earl Joseph Jordan, Jin H. Park, Krishna Suresh, Courtney M. Smith, Abigail A. Lemmon, Yael P. Mosse, Mark A. Lemmon, Ravi Radhakrishnan
Summary: Kinases are crucial in various cellular processes and commonly mutated in cancer, their activation status can be effectively predicted through computational studies despite mutations occurring throughout the kinase domain. The results provide insights into convergent activation mechanisms in majority of studied mutations.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Courtney M. Smith, Alice Li, Nithya Krishnamurthy, Mark A. Lemmon
Summary: This study demonstrates that TIM-3 promotes NF-Kappa B signaling and IL-2 secretion in T cells through binding to phosphatidylserine (PS). The findings clarify the importance of PS as a functional ligand for TIM-3 and suggest that TIM-3 signaling can be regulated by mutating the PS-binding site or occluding it with an antibody.
BIOCHEMICAL JOURNAL
(2021)
Article
Multidisciplinary Sciences
Chun Hu, Carlos A. Leche, Anatoly Kiyatkin, Zhaolong Yu, Steven E. Stayrook, Kathryn M. Ferguson, Mark A. Lemmon
Summary: The epidermal growth factor receptor (EGFR) frequently mutates in human cancer, and is an important therapeutic target. However, EGFR inhibitors have limited effectiveness in glioblastoma multiforme (GBM) due to exclusive mutations in the extracellular region. This study reveals that GBM mutations impair EGFR's ability to distinguish between activating ligands, which may have implications for therapeutic targeting.
Article
Multidisciplinary Sciences
Tongqing Li, Steven E. Stayrook, Yuko Tsutsui, Jianan Zhang, Yueyue Wang, Hengyi Li, Andrew Proffitt, Stefan G. Krimmer, Mansoor Ahmed, Olivia Belliveau, Ian X. Walker, Krishna C. Mudumbi, Yoshihisa Suzuki, Irit Lax, Diego Alvarado, Mark A. Lemmon, Joseph Schlessinger, Daryl E. Klein
Summary: The proto-oncogene ALK encodes anaplastic lymphoma kinase, which is primarily expressed in the developing nervous system. Its activity is associated with learning and memory, energy expenditure, and obesity prevention. Aberrant ALK signaling causes various cancers, including being a driver in pediatric neuroblastoma. The study reveals the crystal structures of ALK's extracellular glycine-rich domain (GRD) and how it regulates receptor activity, providing insights into potential therapeutics for ALK-expressing cancers.
Article
Cell Biology
Fumin Shi, Jeannine M. Mendrola, Joshua B. Sheetz, Neo Wu, Anselm Sommer, Kelsey F. Speer, Jasprina N. Noordermeer, Zhong-Yuan Kan, Kay Perry, S. Walter Englander, Steven E. Stayrook, Lee G. Fradkin, Mark A. Lemmon
Summary: WNTs play crucial roles in development and disease by signaling through various receptors, including Frizzled (FZD) and co-receptors like ROR and RYK. Crystal structures of Drosophila ROR and RYK orthologs Nrk and Derailed-2 reveal their binding characteristics with WNTs through specific domains, providing insight into how WNTs recruit co-receptors into signaling complexes.
Review
Biochemistry & Molecular Biology
Joshua B. Sheetz, Mark A. Lemmon
Summary: Progress has been made in understanding the role of pseudokinases in biology and disease over the past decade. Despite lacking key catalytic residues, pseudokinases show striking similarity to their kinase relatives. Recent structural data suggest that both pseudokinases and bona fide kinases maintain distinct conformational states, which play a crucial role in their function. Understanding and targeting the conformational toggle in pseudokinases could have implications for disease treatment.
TRENDS IN BIOCHEMICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Iris K. van Alderwerelt van Rosenburgh, David M. Lu, Michael J. Grant, Steven E. Stayrook, Manali Phadke, Zenta Walther, Sarah B. Goldberg, Katerina Politi, Mark A. Lemmon, Kumar D. Ashtekar, Yuko Tsutsui
Summary: This study investigates the molecular basis for the varying response of non-small cell lung cancers driven by EGFR mutations to tyrosine kinase inhibitors. The researchers identify structural features that contribute to inhibitor sensitivity and propose a classification system for predicting clinical outcomes.
NATURE COMMUNICATIONS
(2022)
