Article
Oncology
Ngoc-Lan Thi Nguyen, Ngoc-Dzung Thi Dang, Quang-Huy Dang, Van-Chuc Tran, Hoang-Long Vo, Masamitsu Yamaguchi, Thanh-Van Ta
Summary: The study found that the polymorphisms of Mucin 1 gene, specifically rs4072037 and rs2070803, are associated with gastric cancer risk, with the AA genotype potentially increasing risk while the AG genotype may lower it. Combining factors such as age, gender, alcoholism, and personal history of gastric disease significantly elevate the risk of gastric cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Michele Rouleau, Flora Nguyen Van Long, Veronique Turcotte, Patrick Caron, Louis Lacombe, Armen Aprikian, Fred Saad, Michel Carmel, Simone Chevalier, Eric Levesque, Chantal Guillemette
Summary: Naturally occurring germline gene deletions (KO) of UGT2B17 and UGT2B28 genes lead to metabolic rewiring, promoting prostate cancer growth and metastasis.
BRITISH JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Muhammad T. Abdel Ghafar, Ola A. Elshora, Alzahraa A. Allam, Raghda Gabr Mashaal, Shereen Awny Abdelsalam Hamous, Sarah Ragab Abd El-Khalik, Rania Nagi Abd-Ellatif, Reham A. Mariah, Radwa Eissa, Mai Mwafy, Rasha E. Shalaby, Elham Nasif, Rasha A. Elkholy
Summary: This study aimed to assess the possible association between two single nucleotide polymorphisms (SNPs) of the autoimmune regulator (AIRE) gene (rs2075876 G/A and rs760426 A/G) with the risk of primary immune thrombocytopenia (ITP) and AIRE serum levels in the Egyptian population. The results showed that AIRE rs2075876 AA genotype and A allele were associated with increased ITP risk, while AIRE rs760426 A/G different genetic models showed no significant association with ITP risk. Furthermore, lower serum AIRE levels were found in the ITP group, especially in carriers of AIRE rs2075876 AA genotype and A allele, as well as A-G and A-A haplotypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Zhenlian Zhang, Dilihumaier Duolikun, Tingting Dang, Yuanyuan Wang, Lijuan Ma, Xueyun Ma, Qiaoling Yao
Summary: This meta-analysis suggests that the TNF-α-308A allele may be a risk factor for the development of obstructive sleep apnea (OSA). However, large scale, multi-center, and well-designed case-control studies are needed in the future to validate these findings.
Article
Genetics & Heredity
Byung Woo Yoon, Hyun-Tae Shin, Je Hyun Seo
Summary: This study provides insights into the genetic differences in prostate cancer incidence among different ethnicities, using data on single-nucleotide polymorphisms associated with prostate cancer. The study reveals that the polygenic risk score, as well as certain genes such as AR, CDKN1B, and MAD1L1, are associated with ethnic differences in prostate cancer.
Article
Environmental Sciences
Alice Hinchliffe, Juan Alguacil, Wendy Bijoux, Manolis Kogevinas, Florence Menegaux, Marie-Elise Parent, Beatriz Perez Gomez, Sanni Uuksulainen, Michelle C. Turner
Summary: This study found no clear evidence for an association between occupational heat exposure and prostate cancer risk.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biology
Pouria Pourzand, Farhad Tabasi, Fariba Fayazbakhsh, Shamim Sarhadi, Gholamreza Bahari, Mohsen Mohammadi, Sahar Jomepour, Mohammad Nafeli, Fatemeh Mosayebi, Mehrdad Heravi, Mohsen Taheri, Mohammad Hashemi, Saeid Ghavami
Summary: Breast cancer is a complex disease and novel biomarkers are needed for better understanding and treatment. This study investigates the association between the rs34917480 variant in the RTN4 gene and breast cancer risk in an Iranian population. The study finds that the variant is associated with a decreased risk of breast cancer and may modify the mRNA structure of RTN4. Additionally, it reveals that RTN4 is involved in apoptosis regulation and key signaling pathways related to breast cancer.
Article
Medical Laboratory Technology
Dongdong Liu, Bangwei Che, Pan Chen, Jun He, Yi Mu, Kehang Chen, Wenjun Zhang, Shenghan Xu, Kaifa Tang
Summary: This study found that GSTs gene polymorphism may be a risk factor for PCa and can predict the susceptibility and malignancy of PCa. In Mets patients, GSTT1 null genotype significantly increased the risk of PCa, while GSTM1 null genotype and the effect of GSTP1 (AG + GG) on PCa were not significantly related to Mets.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Oncology
Vishwajeet Singh, Amit Kumar Madeshiya, Nasreen Ghazi Ansari, Mukul Kumar Singh, Amar Abhishek
Summary: This study found an association between heavy metal toxicity (lead and cadmium) and an increased risk of benign prostatic hyperplasia (BPH) and prostate cancer (CaP). Additionally, individuals with heavy metal toxicity in BPH have a high-risk genetic susceptibility to the CYP1A1 gene in the north Indian population.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Article
Medical Laboratory Technology
Leila Jamali, Hossein Sadeghi, Mohammad-Reza Ghasemi, Roohollah Mohseni, Ehsan Nazemalhosseini-Mojarad, Vahid Reza Yassaee, Pegah Larki, Mohammad Reza Zali, Reza Mirfakhraie
Summary: This study evaluated the association between ATG16L1 rs2241880 and ATG5 rs1475270 variants with CRC risk in an Iranian population. The T allele of ATG16L1 rs2241880 was significantly associated with increased CRC risk, while no significant differences were found in ATG5 rs1475270 alleles and genotypes between cases and controls. Further investigations among different populations and ethnicities are needed to refine these conclusions.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Medicine, Research & Experimental
Hanjiang Xu, Meng Zhang, Zongyao Hao, Chaozhao Liang
Summary: This case-control study and meta-analysis suggest that the hOGG1 rs1052133 polymorphism is associated with prostate cancer risk, but further verification is needed in the Chinese population.
MEDICAL SCIENCE MONITOR
(2022)
Article
Oncology
Malene Outzen, Anne Tjonneland, David J. Hughes, Mazda Jenab, Kirsten Frederiksen, Lutz Schomburg, Steve Morris, Kim Overvad, Anja Olsen
Summary: The study did not find any association between toenail selenium or plasma SELENOP concentrations with advanced, high-grade or advanced-stage prostate cancer. Additionally, variations in selenoprotein genes were not found to be associated with PC risk.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Medicine, General & Internal
Shilin Xue, Wenya Shen, Jianning Cai, Jinhai Jia, Dan Zhao, Shan Zhang, Xiujun Zhao, Ning Ma, Wenjuan Wang, Bingshuang Wang, Xiaolin Zhang, Xuehui Liu
Summary: This meta-analysis aimed to examine the association between rs735482 polymorphism and cancer risk. The results showed that there is no significant association between rs735482 polymorphism and susceptibility to various cancers overall. However, stratified analysis by ethnicity indicated that rs735482 is associated with an increased risk of cancer in the Chinese population and a decreased risk in the Italian population.
Article
Multidisciplinary Sciences
Heng-Jui Chang, Yuan-Hung Pong, Chen-Yen Chiang, Po-Chien Huang, Ming-Hua Wang, Yu-Jiun Chan, Tzuo-Yun Lan
Summary: The rising incidence rate of prostate cancer (PCa) worldwide is a concern. The association between human papillomavirus (HPV) and PCa has been widely investigated. This case-control study in Taiwan found a slightly significant association between HPV infection and PCa, but the focus should be on other risk factors such as dietary habits, personal lifestyle, and family history.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Yueh Jia Lee, Wei Qi Loh, Trung Kien Dang, Cecilia Woon Chien Teng, Wen-Chi Pan, Chih-Da Wu, Sin Eng Chia, Wei Jie Seow
Summary: Living in green environments may increase the risk of prostate cancer. This Singapore study found that individuals with a BMI in the second quartile had higher levels of NDVI compared to those in the lowest quartile. Additionally, being widowed or separated was associated with lower levels of NDVI compared to being married. The study also found that an increase in NDVI was positively associated with prostate cancer risk.
ENVIRONMENTAL RESEARCH
(2023)
