Article
Oncology
E. Tagkalos, P. C. van der Sluis, F. Berlth, A. Poplawski, E. Hadzijusufovic, H. Lang, M. I. van Berge Henegouwen, S. S. Gisbertz, B. P. Mueller-Stich, J. P. Ruurda, M. Schiesser, P. M. Schneider, R. van Hillegersberg, P. P. Grimminger
Summary: This study is a randomized controlled trial comparing RAMIE and MIE as surgical treatments for resectable esophageal adenocarcinoma or adenocarcinoma of the gastroesophageal junction in the Western World. The primary outcome is the total number of resected lymph nodes in the abdomen and mediastinum per lymph node station.
Article
Surgery
Benjamin Babic, Dolores T. Muller, Jin-On Jung, Lars M. Schiffmann, Paula Grisar, Thomas Schmidt, Seung-Hun Chon, Wolfgang Schroeder, Christiane J. Bruns, Hans F. Fuchs
Summary: This study compares the short-term outcomes of standardized RAMIE and HE and confirms the safety and feasibility of both procedures in a high-risk European population. RAMIE patients had a shorter ICU stay and a lower rate of postoperative complications. Both procedures showed excellent results in terms of lymph node harvest and R0 resection rates.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Yaxing Shen, Xiaosang Chen, Junyi Hou, Youwen Chen, Yong Fang, Zhanggang Xue, Xavier Benoit D'Journo, Robert J. Cerfolio, Hiran C. Fernando, Alfonso Fiorelli, Alessandro Brunelli, Jing Cang, Lijie Tan, Hao Wang
Summary: Implementation of an enhanced recovery after surgery (ERAS) protocol for three-stage minimally invasive esophagectomy (MIE) resulted in earlier ambulation and lower pulmonary complications, without a change in anastomotic leakage or length of hospital stay. Further studies on minimizing leakage should be addressed in ERAS for MIE.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Frans van Workum, Moniek H. P. Verstegen, Bastiaan R. Klarenbeek, Stefan A. W. Bouwense, Mark I. van Berge Henegouwen, Freek Daams, Suzanne S. Gisbertz, Gerjon Hannink, Jan Willem Haveman, Joos Heisterkamp, Walther Jansen, Ewout A. Kouwenhoven, Jan J. B. van Lanschot, Grard A. P. Nieuwenhuijzen, Donald L. van der Peet, Fatih Polat, Sander Ubels, Bas P. L. Wijnhoven, Maroeska M. Rovers, Camiel Rosman
Summary: In this randomized clinical trial, intrathoracic anastomosis resulted in better outcomes for patients undergoing transthoracic MIE for midesophageal to distal esophageal or gastroesophageal junction cancer.
Article
Oncology
Fan Yu, Yaozhong Zhang, Haidi Xu, Kuankuan Li, Jingge Gheng, Chenxi Lin, Lei Li, Na Wang, Lei Wang
Summary: This study evaluated and compared the therapeutic effects of Sweet esophagectomy and McKeown Minimally Invasive esophagectomy (McKeown MIE) for middle and lower third esophageal cancer patients receiving neoadjuvant chemotherapy combined with immunotherapy (NACI). The results showed that both Sweet esophagectomy and McKeown MIE were safe and effective for resectable esophageal squamous cell carcinoma (ESCC) patients after NACI therapy, with low operative mortality and morbidity rate. Sweet esophagectomy had a lower incidence of severe complications and shorter hospital stay for patients over 70 years old compared to McKeown MIE.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Boshi Fan, Zengfeng Sun, Jing Lu, JunQiang Liu, Jiahua Zhao, Shaohua Zhou, Shouyin Di, Weian Song, Taiqian Gong
Summary: This study compared the 3-year survival and recurrence outcomes between three-field lymphadenectomy (3-FL) and two-field lymphadenectomy (2-FL) in minimally invasive esophagectomy (MIE) for esophageal cancer. The results showed similar survival and disease-free survival rates between the two groups, but the 3-FL group had a higher incidence of cervical lymphatic recurrence compared to the 2-FL group.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Paul L. Feingold, Darren S. Bryan, John Kuckelman, Lee Kennedy-Shaffer, Vivian Wang, Ashley Deeb, Jon Wee, Michael Jaklitsch, Margaret Blair Marshall
Summary: Despite improved outcomes, anastomotic strictures are still associated with minimally invasive esophagectomy (MIE), especially in North America where there is limited research on this topic.
ANNALS OF THORACIC SURGERY
(2023)
Article
Surgery
Christopher P. Wang, Michael P. Rogers, Gregory Bach, Joseph Sujka, Rahul Mhaskar, Christopher DuCoin
Summary: The study found that a minimally invasive abdomen-only approach for esophageal resection in specific patient populations is as safe as a minimally invasive Ivor Lewis approach, with the added benefit of shorter operative duration.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Laura F. C. Fransen, Thijs H. J. B. Janssen, Martijn Aarnoudse, Grard A. P. Nieuwenhuijzen, Misha D. P. Luyer
Summary: This study aimed to compare the effects of direct oral feeding (DOF) to standard of care in patients who underwent minimally invasive esophagectomy (MIE). The results showed that DOF resulted in faster functional recovery and lower 30-day postoperative complication rate compared to conventional fasting.
Article
Oncology
Miao Lin, Mengjiang He, Qiaomeng Yu, Yiqun Zhang, Yaxing Shen, Hong Fan, Pinghong Zhou, Lijie Tan
Summary: This study aims to compare the outcomes of two different surgical approaches (transcervical and transthoracic) for esophageal cancer resection through a randomized controlled trial (RCT). The study will enroll patients over a 2-year period and collect perioperative and long-term outcome data, with a focus on perioperative morbidity as the primary endpoint.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Review
Surgery
Himam Murad, Biying Huang, Nelson Ndegwa, Ioannis Rouvelas, Fredrik Klevebro
Summary: The risk of post-esophagectomy hiatal hernia is significantly higher after minimally invasive esophagectomy compared to the open technique. Future studies should focus on exploring preventive measures to reduce PEHH after minimally invasive esophagectomy.
INTERNATIONAL JOURNAL OF SURGERY
(2021)
Article
Oncology
Tessa C. M. Geraedts, Teus J. Weijs, Gijs H. K. Berkelmans, Laura F. C. Fransen, Ewout A. Kouwenhoven, Marc J. van Det, Magnus Nilsson, Sjoerd M. Lagarde, Richard van Hillegersberg, Sheraz R. Markar, Grard A. P. Nieuwenhuijzen, Misha D. P. Luyer
Summary: The direct start of oral intake after minimally invasive esophagectomy can improve short-term and long-term outcomes. Patients in the direct oral feeding group had higher 3-year overall survival and 5-year disease-free survival.
Article
Medicine, General & Internal
Jacqueline Kruse, Miriam Silaschi, Markus Velten, Maria Wittmann, Eissa Alaj, Ali El-Sayed Ahmad, Sebastian Zimmer, Michael A. Borger, Farhad Bakhtiary
Summary: In this multicenter randomized trial, the study aimed to compare the efficacy of femoral and axillary cannulation in minimally invasive heart valve surgery and determine the risk of postoperative stroke. The results showed that axillary cannulation had a lower risk of stroke within 7 days postoperatively, suggesting it may be a better alternative.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Wen-Quan Yu, Li-Xue Zhai, Guo-Dong Shi, Jia-Yu Tang, Hui-Jiang Gao, Yu-Cheng Wei
Summary: This study retrospectively analyzed the clinical outcomes of TMIE and HMIE in Ivor-Lewis esophagectomy. The results showed that TMIE had better short-term outcomes in terms of blood loss and postoperative complications compared to HMIE. Additionally, the HMIE group had higher pain scores and more patients requiring additional analgesia after surgery.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Surgery
Yang Yang, Bin Li, Jun Yi, Rong Hua, Hezhong Chen, Lijie Tan, Hecheng Li, Yi He, Xufeng Guo, Yifeng Sun, Bentong Yu, Zhigang Li
Summary: This study compared the outcomes of robot-assisted minimally invasive esophagectomy (RAMIE) and conventional minimally invasive esophagectomy (MIE) in the treatment of esophageal squamous cell carcinoma (ESCC). The results showed that RAMIE had shorter operation time and better lymph node dissection in patients who received neoadjuvant therapy. RAMIE and MIE had similar rates of complications and postoperative complications.
Letter
Gastroenterology & Hepatology
Marco Sozzi, Stefano Siboni, Luigi Bonavina
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Swathikan Chidambaram, Nikhil M. Patel, Viknesh Sounderajah, Rita Alfieri, Luigi Bonavina, Edward Cheong, Andy Cockbain, Xavier Benoit D'Journo, Lorenzo Ferri, Ewen A. Griffiths, Peter Grimminger, Caroline Gronnier, Christian Gutschow, Jakob Hedberg, Joonas H. Kauppila, Sjoerd Lagarde, Donald Low, Philippe Nafteux, Grard Nieuwenhuijzen, Magnus Nilsson, Riccardo Rosati, Wolfgang Schroeder, B. Mark Smithers, Mark I. van Berge Henegouwen, Richard van Hillegesberg, David Watson, Ravinder Vohra, Nick Maynard, Sheraz R. Markar
Summary: Currently, there is a lack of evidence-based guidelines for surveillance of recurrence after esophageal and gastric (OG) cancer surgical resection. This study used a modified Delphi consensus process to identify eight symptoms that should prompt further investigations for suspected recurrent malignancy.
DISEASES OF THE ESOPHAGUS
(2023)
Article
Oncology
Sofie P. G. Henckens, Eliza R. C. Hagens, Mark I. van Berge Henegouwen, Sybren L. Meijer, Wietse J. Eshuis, Suzanne S. Gisbertz
Summary: This study investigates the impact of lymph node yield after transthoracic esophagectomy on lymph node metastasis, complications, and survival in patients with esophageal adenocarcinoma. The results demonstrate that a lymph node yield of 31 or higher is associated with an increased number of positive lymph nodes, improved disease-free survival, and overall survival, without increasing morbidity.
Editorial Material
Gastroenterology & Hepatology
Pamela Milito, Stefano Siboni, Emanuele Asti, Luigi Bonavina
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Gastroenterology & Hepatology
J. C. H. B. M. Luijten, M. H. P. Verstegen, F. van Workum, G. A. P. Nieuwenhuijzen, M. I. van Berge Henegouwen, S. S. Gisbertz, B. P. L. Wijnhoven, R. H. A. Verhoeven, C. Rosman
Summary: It is unclear whether Ivor Lewis (IL) or McKeown (McK) esophagectomy is preferred in patients with potentially curable esophageal or gastro-esophageal junction (GEJ) cancer. A study in the Netherlands found similar survival rates and complication rates between patients who underwent IL or McK esophagectomy. Therefore, both IL and McK esophagectomy can be considered for patients with mid to distal esophageal and GEJ cancer.
DISEASES OF THE ESOPHAGUS
(2023)
Article
Gastroenterology & Hepatology
Sander Ubels, Bastiaan Klarenbeek, Moniek Verstegen, Stefan Bouwense, Ewen A. Griffiths, Frans van Workum, Camiel Rosman, Gerjon Hannink
Summary: This study aimed to develop a prediction model for postoperative mortality in patients with Anastomotic leak (AL) after esophagectomy. The developed model combines patient-related and leak-related factors to accurately predict postoperative mortality and can be useful for clinicians during counselling of patients and their families.
DISEASES OF THE ESOPHAGUS
(2023)
Article
Oncology
Sander Ubels, Eric Matthee, Moniek Verstegen, Bastiaan Klarenbeek, Stefan Bouwense, Mark I. van Berge Henegouwen, Freek Daams, Jan Willem T. Dekker, Marc J. van Det, Stijn van Esser, Ewen A. Griffiths, Jan Willem Haveman, Grard Nieuwenhuijzen, Peter D. Siersema, Bas Wijnhoven, Gerjon Hannink, Frans van Workum, Camiel Rosman, Joos Heisterkamp, Fatih Polat, Jeroen Schouten, Pritam Singh
Summary: This study aimed to assess the differences in failure to rescue (FTR) after anastomotic leak (AL) between different centers. The results showed that high-volume centers had lower FTR, which could be explained by lower leak severity, lower secondary ICU readmission rate, and higher availability of therapeutic modalities.
Review
Surgery
Caterina Froiio, Ahmad Tareq, Valentina Riggio, Stefano Siboni, Luigi Bonavina
Summary: Magnetic sphincter augmentation (MSA) is an effective and safe procedure for reducing GERD symptoms and improving patients' quality of life. It can be removed laparoscopically if needed, and the use of high-resolution manometry and functional lumen imaging probes can help predict procedural outcomes.
EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA
(2023)
Review
Surgery
Alessia Kersik, Luca Galassi, Giulia Colombo, Luigi Bonavina
Summary: This article reports the surgical treatment of a giant liver cyst in a symptomatic patient and reviews the current evidence regarding the procedural details of laparoscopic deroofing. The results show that wide laparoscopic deroofing is an effective and relatively simple procedure.
EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA
(2023)
Article
Pathology
Maria J. Valkema, Anne-Marie Vos, Rachel S. van der Post, Ariadne H. A. G. Ooms, Lindsey Oudijk, Ben M. Eyck, Sjoerd M. Lagarde, Bas P. L. Wijnhoven, Bastiaan R. Klarenbeek, Camiel Rosman, J. Jan B. van Lanschot, Michail Doukas
Summary: Oesophageal adenocarcinomas may exhibit different histopathological patterns, such as excessive acellular mucin pools, signet-ring cells, and poorly cohesive cells. These components have been suggested to correlate with poor outcomes after neoadjuvant chemoradiotherapy. However, their independent effects and potential confounders have not been thoroughly studied. In this study, we evaluated the presence of extracellular mucin, signet-ring cells, and poorly cohesive cells before and after treatment, and their association with pathological response and prognosis. The findings suggest that the presence of these factors is not related to pathological response, but a pre-treatment presence of ≥10% poorly cohesive cells and a post-treatment presence of ≥1% signet-ring cells may indicate inferior prognosis.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2023)
Letter
Surgery
Alberto Aiolfi, Gianluca Bonitta, Davide Tosi, Emanuele Rausa, Mario Nosotti, Davide Bona, Luigi Bonavina
BRITISH JOURNAL OF SURGERY
(2023)
Article
Gastroenterology & Hepatology
Kammy Keywani, Alexander B. J. Borgstein, Djamila Boerma, Stijn van Esser, Wietse J. Eshuis, Mark van Berge I. Henegouwen, Johanna van Sandick, Suzanne S. Gisbertz
Summary: Curative therapy for gastric cancer usually includes perioperative chemotherapy and radical gastrectomy. The role of omentectomy in improving survival remains uncertain. This study presents the follow-up data of the OMEGA study.
Article
Surgery
Sander Ubels, Moniek H. P. Verstegen, Bastiaan R. Klarenbeek, Stefan Bouwense, Mark I. van Berge Henegouwen, Freek Daams, Marc J. van Det, Ewen A. Griffiths, Jan Willem Haveman, Joos Heisterkamp, Grard Nieuwenhuijzen, Fatih Polat, Jeroen Schouten, Peter D. Siersema, Pritam Singh, Bas Wijnhoven, Gerjon Hannink, Frans van Workum, Camiel Rosman
Summary: This retrospective cohort study aimed to assess the effectiveness of different treatment strategies for anastomotic leak after oesophagectomy. The study found that less invasive primary treatment resulted in fewer complications. Therefore, less invasive primary treatment may lead to better clinical outcomes, but further studies are needed to confirm these findings.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Gastroenterology & Hepatology
B. Feike Kingma, Eliza R. C. Hagens, Mark. I. Van Berge I. Henegouwen, Alicia. S. S. Borggreve, Jelle. P. P. Ruurda, Suzanne. S. S. Gisbertz, R. Richard van Hillegersberg
Summary: This study investigated the impact of paratracheal lymphadenectomy on lymph node yield and short-term outcomes in patients undergoing esophagectomy for cancer in the Netherlands. The results showed that paratracheal lymphadenectomy increased lymph node yield, but also led to longer hospital stay and more re-interventions.