Article
Multidisciplinary Sciences
Keiko Azuma, Atsushi Okubo, Takafumi Suzuki, Nozomi Igarashi, Yoko Nomura, Hirotsugu Soga, Hiroshi Murata, Ryosuke Fujino, Asako Ogawa, Haruka Matsui, Takeshi Nagamatsu, Takayuki Iriyama, Ryo Asaoka, Tatsuya Inoue, Maiko Maruyama-Inoue, Kazuaki Kadonosono, Ryo Obata
Summary: Anatomical differences in choroidal structure between pregnant women in the first trimester and healthy nonpregnant women were investigated using EDI-OCT and choroidal binarization analysis. The study identified a significant correlation between a larger choroidal luminal area and higher systolic blood pressure, particularly in the first trimester of pregnancy.
SCIENTIFIC REPORTS
(2021)
Article
Rheumatology
Rugina Neuman, Hieronymus T. W. Smeele, A. H. Jan Danser, Radboud J. E. M. Dolhain, Willy Visser
Summary: This study shows that the sFlt-1/PlGF ratio is not altered due to disease activity in pregnant women with RA, and a cut-off of <= 38 can be used to exclude preeclampsia. Additionally, the use of SSZ does not affect the levels of sFlt-1 or PlGF in this population.
Article
Endocrinology & Metabolism
Maria Fernanda Garces, Haiver Antonio Rodriguez-Navarro, Julieth Daniela Buell-Acosta, Alvaro Javier Burgos-Cardenas, Roberto Franco-Vega, Luis Miguel Maldonado-Acosta, Javier Eslava-Schmalbach, Arturo Jose Parada-Banos, Andres Castro-Pinzon, Elizabeth Sanchez, Edith Angel-Muller, Ezequiel Lacunza, Justo P. Castano, Carlos Dieguez, Ruben Nogueiras, Ariel Ivan Ruiz-Parra, Jorge Eduardo Caminos
Summary: The study found that serum ANGPTL3 levels significantly decreased in healthy pregnant women during pregnancy, with no significant differences in levels between different trimesters and healthy states. Additionally, a significant positive correlation was observed between serum ANGPTL3 levels and triglyceride, very low-density lipoprotein cholesterol, and total cholesterol levels in healthy non-pregnant women.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jose Sergio Possomato-Vieira, Ana Carolina Palei, Caroline Cristina Pinto-Souza, Ricardo Cavalli, Carlos Alan Dias-Junior, Valeria Sandrim
Summary: This study measured plasma H2S levels in healthy pregnant women, gestational hypertensive patients, and preeclamptic patients. It found that H2S levels were elevated in preeclampsia and further increased in gestational hypertension, with a negative correlation with nitrite. This suggests that increased H2S may be a compensatory mechanism for reduced NO in hypertensive disorders of pregnancy.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Susana Vazquez, Julio Pascual, Xavier Duran-Jorda, Jose Luis Hernandez, Marta Crespo, Anna Oliveras
Summary: This study aimed to find the best predictor of preeclampsia (PE) and explore if it differs among women with and without hypertension. The study found that in the first trimester of pregnancy, mean blood pressure was the best predictor of PE in normotensive women, while renal parameters were the strongest predictors in women with chronic hypertension. Additionally, office blood pressure was non-inferior to 24-hour ambulatory blood pressure in predicting PE.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Piotr Tousty, Magda Fraszczyk-Tousty, Anna Golara, Adrianna Zahorowska, Michal Slawinski, Sylwia Dzidek, Hanna Jasiak-Jozwik, Magda Nawceniak-Balczerska, Agnieszka Kordek, Ewa Kwiatkowska, Aneta Cymbaluk-Ploska, Andrzej Torbe, Sebastian Kwiatkowski
Summary: This study aimed to evaluate the implementation of low-dose acetylsalicylic acid (ASA) for the prevention of pregnancy-induced hypertension (PE) and fetal growth restriction (FGR) in a Polish population. The results showed that patients in the high-risk group were more likely to experience complications during pregnancy, including pre-eclampsia, fetal growth restriction, gestational diabetes, and cesarean section. The conclusion is that the first-trimester screening is crucial in identifying high-risk pregnancies, and ASA prophylaxis may have the most beneficial effect on these high-risk patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Developmental Biology
S. Rowson, M. Reddy, D. L. De Guingand, A. Langston-Cox, S. A. Marshall, F. da Silva Costa, K. R. Palmer
Summary: This study found that using placental-specific sFLT-1 e15a performs comparably to total sFLT-1 in diagnosing preeclampsia, which is particularly helpful in diagnosing early-onset preeclampsia.
Article
Obstetrics & Gynecology
Montserrat Uriel, Ximena Carolina Romero Infante, Sara Rincon Franco, Edgar Antonio Ibanez Pinilla, Nydia Alexandra Rojas
Summary: This study aims to compare the levels of PAPP-A in different impaired placental diseases, such as PE, IUGR, and GH, to expand knowledge about the behavior of this protein in these conditions. The study measured PAPP-A levels in 422 patients and compared them between outcome groups. The results showed that PAPP-A levels were significantly lower in the IUGR and GH groups compared to the PE group, and pregnant women with early-onset PE had significantly higher PAPP-A levels than those with IUGR. The study highlights the need for further research in populations with a high prevalence of preeclampsia.
REPRODUCTIVE SCIENCES
(2023)
Article
Endocrinology & Metabolism
Xinxin Chen, Qingyao Wang, Huanhuan Zang, Xiangguo Cong, Qiong Shen, Lei Chen
Summary: This study aimed to observe adverse neonatal outcomes in euthyroid pregnant women with positive thyroid peroxidase antibodies (TPOAb) and investigate the underlying risk factors. Results showed that approximately one in four euthyroid women with positive TPOAb had adverse neonatal outcomes. Measurement of soluble CD40 ligand (sCD40L) in the first trimester may have predictive value for adverse neonatal outcomes in these women.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Julieth Daniela Buell-Acosta, Maria Fernanda Garces, Arturo Jose Parada-Banos, Edith Angel-Muller, Maria Carolina Paez, Javier Eslava-Schmalbach, Franklin Escobar-Cordoba, Sofia Alexandra Caminos-Cepeda, Ezequiel Lacunza, Justo P. Castano, Ruben Nogueiras, Carlos Dieguez, Ariel Ivan Ruiz-Parra, Jorge Eduardo Caminos
Summary: This study investigated the serum FGF-21 levels in healthy and mild preeclamptic pregnant women at different stages of pregnancy. The results showed that FGF-21 levels were highest in the third trimester of healthy pregnancy and higher throughout the entire pregnancy in preeclamptic women. FGF-21 may play a critical role in protecting against the negative effects of high concentrations of NEFA and hypertensive disorder, as well as in reproductive function during the menstrual cycle in healthy women.
Article
Obstetrics & Gynecology
Hiroaki Tanaka, Yuko Nagahashi, Kuniaki Toriyabe, Shintaro Maki, Sho Takakura, Naosuke Enomoto, Kayo Tanaka, Katsuragi Shinji, Tomoaki Ikeda
Summary: The aim of this study was to analyze the correlation between sFlt-1 and the severity of PE. By measuring sFlt-1 levels and analyzing the correlation with pregnancy prolongation periods, it was found that sFlt-1 was significantly negatively correlated with the duration of pregnancy after diagnosis. Therefore, sFlt-1 may serve as an indicator for evaluating the severity of PE.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Julia Binder, Pilar Palmrich, Erkan Kalafat, Petra Pateisky, Ebru Oeztuerk, Johanna Mittelberger, Asma Khalil
Summary: This study evaluated the predictive value of the sFlt-1/PlGF ratio in women with chronic hypertension for delivery due to superimposed preeclampsia, finding that angiogenic imbalance can predict delivery related to superimposed preeclampsia and is associated with a significantly shorter time to delivery interval.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Obstetrics & Gynecology
Hua Zou, Wei Zou, Qian Li, Zhen Chen, Yuanju Shi, Chunli Li
Summary: Recent studies have shown that gut fungi play a crucial role in many noninfectious inflammatory diseases, but their role in the pathogenesis of preeclampsia remains unclear. In this study, the gut mycobiota of preeclampsia, pregnancy with chronic hypertension, and normal pregnancy groups were compared using internal transcribed spacer sequencing. The results revealed changes in the gut mycobiota in the third trimester of pregnant women with preeclampsia. Additionally, the correlation analysis indicated a positive correlation between Candida spp. and glycerophosphocholine, which was significantly increased in preeclampsia.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Article
Medicine, General & Internal
Dandan Wang, Chenwei Xiao, Hongyu Li, Jing Fan
Summary: This study investigated the levels of serum ferritin and 25-hydroxyvitamin D in pregnant women with preeclampsia and analyzed their predictive value for premature birth. The results showed that these markers were abnormally expressed in pregnant women with preeclampsia and were associated with premature birth.
Article
Peripheral Vascular Disease
Akihide Ohkuchi, Shigeru Saito, Tatsuo Yamamoto, Hisanori Minakami, Hisashi Masuyama, Keiichi Kumasawa, Jun Yoshimatsu, Takeshi Nagamatsu, Angela Dietl, Sonja Grill, Martin Hund
Summary: The subanalysis of Japanese women with suspected preeclampsia showed a high predictive value of Elecsys sFlt-1/PlGF ratio cutoff of 38 for short-term prediction of preeclampsia. This ratio can effectively rule out or diagnose preeclampsia within 1 week, helping to accurately determine the condition of pregnant women.
HYPERTENSION RESEARCH
(2021)
Review
Obstetrics & Gynecology
Sarosh Rana, Suzanne D. Burke, S. Ananth Karumanchi
Summary: Preeclampsia is a serious complication of pregnancy that can lead to morbidity and mortality for both the mother and fetus. Abnormal levels of circulating angiogenic factors released from the placenta are believed to be responsible for the symptoms of preeclampsia. Measuring these angiogenic biomarkers in the blood can help clinicians diagnose and predict preeclampsia. Additionally, these biomarkers are useful in studying the mechanisms of related disorders of placental implantation.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Transplantation
Sahir Kalim, Anders H. Berg, Subbian Ananth Karumanchi, Ravi Thadhani, Andrew S. Allegretti, Sagar Nigwekar, Sophia Zhao, Anand Srivastava, Dominic Raj, Rajat Deo, Anne Frydrych, Jing Chen, James Sondheimer, Tariq Shafi, Matthew Weir, James P. Lash
Summary: The study suggests that protein carbamylation is a predictor of CKD progression beyond traditional risk factors like eGFR and proteinuria. However, the association of carbamylation with mortality was weaker in this limited sample size.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Obstetrics & Gynecology
Laura A. Magee, Mark A. Brown, David R. Hall, Sanjay Gupte, Annemarie Hennessy, S. Ananth Karumanchi, Louise C. Kenny, Fergus McCarthy, Jenny Myers, Liona C. Poon, Sarosh Rana, Shigeru Saito, Anne Cathrine Staff, Eleni Tsigas, Peter von Dadelszen
Summary: Uniform departmental management protocols should be maintained for managing hypertensive pregnant women, and regular audits of maternal and fetal outcomes should be conducted. The cause and optimal clinical management of pre-eclampsia and hypertensive disorders of pregnancy remain uncertain, therefore, it is recommended that every hypertensive pregnant woman be given the opportunity to participate in research, clinical trials, and follow-up studies.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2022)
Article
Cardiac & Cardiovascular Systems
Zolt Arany, Denise Hilfiker-Kleiner, S. Ananth Karumanchi
Summary: Cardiovascular complications during pregnancy, such as preeclampsia and peripartum cardiomyopathy, have become a major cause of maternal mortality and have long-term effects on maternal cardiovascular health. However, the causes and mechanisms underlying these complications are not well understood, and treatment options are limited. Preclinical models have played an important role in advancing our understanding of these diseases.
CIRCULATION RESEARCH
(2022)
Editorial Material
Medical Laboratory Technology
Kathryn J. Gray, Martin Hemberg, S. Ananth Karumanchi
CLINICAL CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Sarah M. Davis, Vignesh N. Hariharan, Agnes Lo, Anton A. Turanov, Dimas Echeverria, Jacquelyn Sousa, Nicholas McHugh, Annabelle Biscans, Julia F. Alterman, S. Ananth Karumanchi, Melissa J. Moore, Anastasia Khvorova
Summary: Preeclampsia is a potentially lethal pregnancy complication driven by overexpression of placental soluble fms-like tyrosine kinase 1 (sFLT1). Researchers have found that injecting specific siRNA can reduce placental sFLT1 and improve symptoms. They also discovered that modifying siRNA chemically can enhance its effectiveness and safety, providing a framework for further development of this therapeutic approach.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Endocrinology & Metabolism
Mengyao Tang, Anders Berg, Eugene P. Rhee, Andrew S. Allegretti, Sagar Nigwekar, S. Ananth Karumanchi, James P. Lash, Sahir Kalim
Summary: The impact of glycated hemoglobin (HbA(1c)) on renal outcomes in patients with diabetes and chronic kidney disease (CKD) is modified by carbamylation and anemia.
Review
Peripheral Vascular Disease
Takahiko Nakagawa, Ana Andres-Hernando, Tomoki G. Kosugi, Laura Sanchez-Lozada, Peter Stenvinkel, Karolina Kublickiene, S. Ananth Karumanchi, Duk-Hee Kang, Hideto Kojima, Bernardo R. Rodriguez-Iturbe, Dean A. Tolan, Miguel J. Lanaspa, Richard Johnson
Summary: Preeclampsia is a hypertensive disorder of pregnancy caused by abnormal placentation. Fructose, which plays a critical role in fetal growth, is produced in the placenta during early pregnancy to assist fetal survival in a hypoxic environment. Impaired placentation leads to excessive fructose production, which drives various pathological features of preeclampsia. In addition, dietary fructose intake has been identified as an independent risk factor for preeclampsia.
HYPERTENSION RESEARCH
(2023)
Article
Urology & Nephrology
Sahir Kalim, Sophia Zhao, Mengyao Tang, Eugene P. Rhee, Andrew S. Allegretti, Sagar Nigwekar, S. Ananth Karumanchi, James P. Lash, Anders H. Berg
Summary: Protein carbamylation, driven by elevated blood urea levels, is associated with adverse outcomes in ESKD. However, its relationship to clinical outcomes in earlier stages of CKD is not well understood.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Multidisciplinary Sciences
Gena Guidry, Nicklaus A. Sparrow, Hyyat S. Marshall, Roberta De Souza Santos, Suman P. Bharath, Michael M. Gezalian, Margareta D. Pisarska, Jean-Philippe Vit, Scott A. Kelly, S. Ananth Karumanchi, Shouri Lahiri
Summary: Urinary tract infections (UTIs) can lead to delirium-like states, and postmenopausal females are more susceptible to delirium following UTIs. It has been found that 17 beta-estradiol can reduce neuronal injury and improve delirium-like behaviors caused by UTIs, possibly by suppressing the expression of interleukin-6 (IL-6).
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Nicklaus A. A. Sparrow, Gena Guidry, Faizan Anwar, Sonja Darwish, Scott A. A. Kelly, S. Ananth Karumanchi, Shouri Lahiri
Summary: Prone positioning can alleviate neuronal injury and inflammation by reducing interleukin 6 (IL-6) in a model of mechanical ventilation-induced acute lung injury. Further studies are needed to investigate the relationship between prone positioning and delirium, and to develop novel diagnostic or therapeutic approaches to reduce systemic and cerebral IL-6 expression.
FRONTIERS IN MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Lauren A. Biwer, Qing Lu, Jaime Ibarrola, Alec Stepanian, Joshua J. Man, Brigett V. Carvajal, Nicholas D. Camarda, Zsuzsanna Zsengeller, Geraldine Skurnik, Ellen W. Seely, S. Ananth Karumanchi, Iris Z. Jaffe
Summary: Preeclampsia is associated with hypertension and end organ damage, and women exposed to preeclampsia have an increased risk of hypertension after pregnancy. This study found that exposure to sFlt1 during pregnancy leads to enhanced responsiveness of smooth muscle cell mineralocorticoid receptors (SMC-MR) to hypertensive stimuli, contributing to postpartum hypertension. These findings suggest that targeting SMC-MR could be a potential intervention to mitigate cardiovascular risk in women after preeclampsia.
CIRCULATION RESEARCH
(2023)
Article
Obstetrics & Gynecology
Eynav Accortt, James Mirocha, Dongsheng Zhang, Sarah J. Kilpatrick, Towia Libermann, S. Ananth Karumanchi
Summary: This study aimed to determine if a panel of novel third-trimester plasma protein biomarkers in pregnant women can be used to identify those who have a high predisposed risk for perinatal mood and anxiety disorders. The results showed that participants with perinatal mood and anxiety disorders had a unique and distinct plasma protein signature that regulated a variety of neuronal signaling and proinflammatory pathways. Further validation studies with larger sample sizes are needed to determine the potential use of these molecules for early detection of perinatal mood and anxiety disorders when combined with traditional risk factors.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Medicine, Research & Experimental
Vincent Dupont, Anders H. Berg, Michifumi Yamashita, Chengqun Huang, Ambart E. Covarrubias, Shafat Ali, Aleksandr Stotland, Jennifer E. Van Eyk, Belinda Jim, Ravi Thadhani, S. Ananth Karumanchi
Summary: Kidney donation increases the risk of preeclampsia by impairing renal reserve and preventing the upregulation of l-kynurenine, resulting in impaired placentation, placental hypoperfusion, and an antiangiogenic state.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Critical Care Medicine
Faizan Anwar, Nicklaus A. Sparrow, Mohammad Harun Rashid, Gena Guidry, Michael M. Gezalian, Eric J. Ley, Maya Koronyo-Hamaoui, Itai Danovitch, E. Wesley Ely, S. Ananth Karumanchi, Shouri Lahiri
Summary: This study demonstrates the pathogenic role of systemic IL-6 in mediating structural and functional acute neuropsychiatric symptoms in VILI. The researchers found that inhibiting IL-6 can reduce neural injury and improve acute neuropsychiatric behaviors in mice with VILI.
