Review
Endocrinology & Metabolism
Kristy A. Brown, Philipp E. Scherer
Summary: Adipose tissue, as the largest endocrine organ, has been strongly linked to cancer development due to the metabolic dysfunction and insulin resistance caused by increased adiposity. Adipose tissue also directly impacts the development and progression of specific cancers, such as breast cancer. Changes in factor secretion and adipose tissue remodeling contribute to the obesity-cancer link. Additionally, adipose tissue provides essential nutrients for tumor cells through increased lipolysis and aerobic glycolysis. This article aims to provide an update on the role of adipose tissue in cancer initiation and progression.
Review
Medical Laboratory Technology
Xuan Xiao, Yi-Zhang Liu, Zhe-Bin Cheng, Jia-Xiang Sun, Yi-Duo Shao, Shun-Lin Qu, Liang Huang, Chi Zhang
Summary: Adipokines, as important endocrine factors, play crucial roles in regulating glycolipid metabolism and inflammatory response. They can connect obesity with cardiovascular diseases by promoting vascular calcification. Chronic hypoxia caused by adipocyte hypertrophy leads to imbalanced adipokine generation, contributing to the occurrence of vascular calcification.
CLINICA CHIMICA ACTA
(2021)
Review
Immunology
Jorge Correale, Mariano Marrodan
Summary: This paper explores the relationship between Multiple Sclerosis (MS) and obesity, as well as the potential underlying biological mechanisms shared by both conditions. The paper highlights the role of adipokines, a family of soluble factors produced by adipose tissue, in both obesity and MS, suggesting their involvement as immune response mediators. The findings of this study are significant for further understanding and treating MS and obesity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Mi Kyung Song, Ji Eun Kim, Jung Tae Kim, Yea Eun Kang, Sun Jong Han, Seok Hwan Kim, Hyun Jin Kim, Bon Jeong Ku, Ju Hee Lee
Summary: This study aimed to identify the adipokine potentially derived from subcutaneous adipose tissue (SAT) and its clinical significance. The results showed that GDF10 expression was higher in SAT than in VAT. Serum GDF10 concentration was high in patients with obesity, suggesting that GDF10 could be a SAT-derived protein related to obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Tamara Camino, Nerea Lago-Baameiro, Maria Pardo
Summary: Extracellular vesicles (EVs) are nanosized lipid bilayer spheres that have emerged as new metabolic players in energy homeostasis and intercellular communication. They carry bioactive molecules and serve as a source of biomarkers and drug-delivery vehicles. The research on the role of EVs in metabolism, obesity, and associated pathologies is rapidly increasing. This review focuses on adipose tissue shed EVs, their characterization, size profile, and molecular cargo content, and also discusses the deleterious effects of EVs released by obese adipose tissue at both local and distant levels.
Review
Biochemistry & Molecular Biology
Alina Kurylowicz
Summary: Menopausal decline in estrogen levels leads to changes in adipose tissue distribution and increased obesity prevalence in women. Hormone replacement therapy can partially restore these effects, indicating the significant role of estrogen in adipocyte regulation. Preclinical studies have shown involvement of estrogen in adipose tissue development, metabolism, and inflammation. However, the relationship between estrogen and obesity is bidirectional, as estrogen deficiency leads to fat accumulation and impairs adipocyte function, while obese individuals have altered expression of estrogen receptors and key enzymes involved in their synthesis. This narrative review provides an overview of estrogen's role in adipose tissue development, physiology, and obesity-related dysfunction, as well as discussing potential therapeutic applications in obesity treatment.
Article
Biochemistry & Molecular Biology
Ashleigh M. Philp, Sam Butterworth, Edward T. Davis, Simon W. Jones
Summary: Recent studies have shown that adipokine extracellular nicotinamide phosphoribosyltransferase (eNAMPT or visfatin) may promote articular cartilage degradation in obese patients with hip osteoarthritis. Elevated expression of visfatin in obese hip osteoarthritis joints and its co-localization with matrix metalloprotease-13 in areas of cartilage damage suggest its central role in loss of cartilage integrity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lukasz Pilarski, Marta Pelczynska, Anna Koperska, Agnieszka Seraszek-Jaros, Monika Szulinska, Pawel Bogdanski
Summary: This study aimed to determine the association between vaspin concentration and metabolic disorders in obese individuals. The results showed that serum vaspin concentrations were significantly higher in the obese group compared to the control group. The findings suggest that vaspin may be a useful diagnostic parameter for obesity-related complications.
Review
Endocrinology & Metabolism
Hong-Jin Chen, Ting Meng, Ping-Jin Gao, Cheng-Chao Ruan
Summary: BAT, primarily composed of brown adipocytes and stromal vascular fraction, plays a crucial role in regulating cardiovascular health and diseases. It enhances energy expenditure by promoting glucose and lipid metabolism and secreting adipokines in an autocrine and/or paracrine fashion to protect the cardiovascular system.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Ioannis G. Lempesis, Nicole Hoebers, Yvonne Essers, Johan W. E. Jocken, Rosemary Dineen, Ellen E. Blaak, Konstantinos N. Manolopoulos, Gijs H. Goossens
Summary: This study investigated the inflammatory signatures of abdominal and femoral subcutaneous adipose tissue in postmenopausal women with normal weight or obesity. The results showed that women with obesity had larger adipocytes and higher plasma concentrations of leptin and plasminogen activator inhibitor (PAI)-1. Both abdominal and femoral subcutaneous adipose tissue released leptin and monocyte chemoattractant protein (MCP)-1, but the release of MCP-1 was higher in abdominal adipose tissue. Additionally, gene expression of inflammatory factors differed between abdominal and femoral adipose tissue.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Oscar Osorio-Conles, Josep Vidal, Ana de Hollanda
Summary: Bariatric surgery is the most effective intervention for significant and sustained weight loss in severe obesity, as it can improve white adipose tissue function beyond reducing fat depot sizes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Monika Gawalko, Arnela Saljic, Na Li, Issam Abu-Taha, Thomas Jespersen, Dominik Linz, Stanley Nattel, Jordi Heijman, Anke Fender, Dobromir Dobrev
Summary: Obesity is a significant contributing factor to atrial fibrillation (AF) by causing systemic changes and affecting different adipose tissue depots. Adipose tissue secretes various mediators that promote AF and cardiac remodeling. This review discusses the role of obesity-related factors, specific adipose tissue depots, and molecular mechanisms in AF, highlighting gaps in current knowledge and implications for clinical management.
CARDIOVASCULAR RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Gabriela Reolon Passos, Ana Carolina Ghezzi, Edson Antunes, Mariana Goncalves de Oliveira, Fabiola Zakia Monica
Summary: Lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) are highly prevalent worldwide, especially in patients with vascular-related disorders or in the ageing population. Obesity is a significant risk factor for developing LUTS-BPH, with obese men being more likely to develop it. Adipose tissues surrounding the prostate gland release various mediators that can interfere with prostate growth.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Gema Fruehbeck, Victoria Catalan, Beatriz Ramirez, Victor Valenti, Sara Becerril, Amaia Rodriguez, Rafael Moncada, Jorge Baixauli, Camilo Silva, Javier Escalada, Javier Gomez-Ambrosi
Summary: The study compared IL-1RA levels in individuals with different weight statuses and analyzed its association with adipose tissue dysfunction. The results showed a significant increase in IL-1RA levels in individuals with obesity, particularly in the group associated with impaired glucose tolerance and type 2 diabetes. IL1RN mRNA expression in adipose tissue also increased, correlating with the expression of inflammation-related genes.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Cell Biology
Mauro Zamboni, Gloria Mazzali, Anna Brunelli, Tanaz Saatchi, Silvia Urbani, Anna Giani, Andrea P. Rossi, Elena Zoico, Francesco Fantin
Summary: Due to aging, there are changes in body composition, with a decrease in muscle mass and an increase in adipose tissue. This redistribution of adipose tissue to visceral areas and ectopic storage in organs contribute to the development of sarcopenic obesity. Understanding the crosstalk between dysfunctional adipose and muscle cells can help in developing prevention strategies and treatments for this condition.
Article
Biochemistry & Molecular Biology
Valentin Jargaud, Sandy Bour, Francois Terce, Xavier Collet, Philippe Valet, Anne Bouloumie, Jean-Claude Guillemot, Pascale Mauriege, Sirpa Jalkanen, Craig Stolen, Marko Salmi, David J. Smith, Christian Carpene
Summary: The study compared the endocrine-metabolic phenotypes of mice lacking the AOC3 gene and mice expressing a mutated VAP-1, finding that both types of mice exhibited obesity, glucose and lipid handling disorders, as well as certain common adipocyte changes. The results suggest that modulation of SSAO activity could be a potential target for treating cardiometabolic diseases, particularly obesity with low-grade inflammation.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Regine A. Jersin, Divya Sri Priyanka Tallapragada, Andre Madsen, Linn Skartveit, Even Fjaere, Adrian McCann, Laurence Dyer, Aron Willems, Jan-Inge Bjune, Mona S. Bjune, Villy Vage, Hans Jorgen Nielsen, Havard Luong Thorsen, Bjorn Gunnar Nedrebo, Christian Busch, Vidar M. Steen, Matthias Blueher, Peter Jacobson, Per-Arne Svensson, Johan Ferno, Mikael Ryden, Peter Arner, Ottar Nygard, Melina Claussnitzer, Stale Ellingsen, Lise Madsen, Jorn V. Sagen, Gunnar Mellgren, Simon N. Dankel
Summary: This study reveals that the small neutral amino acid transporter SLC7A10 plays a significant role in regulating adipocyte resilience to nutrient and oxidative stress, reducing reactive oxygen species generation and lipid accumulation, and improving mitochondrial respiration, ultimately leading to decreased adipocyte hypertrophy, insulin resistance, and type 2 diabetes.
Article
Biology
Carl Herdenberg, Pascal M. Mutie, Ola Billing, Ahmad Abdullah, Rona J. Strawbridge, Ingrid Dahlman, Simon Tuck, Camilla Holmlund, Peter Arner, Roger Henriksson, Paul W. Franks, Hakan Hedman
Summary: Herdenberg et al. demonstrate that adipogenesis and BMP signaling are disrupted in mouse cells lacking LRIG (Leucine-rich repeats and immunoglobulin-like domains) proteins. They also show that mutant LRIG/sma-10 variant worms exhibit defects in lipid storage and human LRIG1 variants are linked to higher body mass index while protecting against type 2 diabetes. This study suggests a conserved role of LRIG proteins in lipid metabolism and BMP signaling across different species.
COMMUNICATIONS BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Pauline Morigny, Jeremie Boucher, Peter Arner, Dominique Langin
Summary: White adipocyte metabolism plays a crucial role in systemic metabolism regulation and is often disrupted in conditions like cancer and type 2 diabetes mellitus. This review provides an overview of lipid metabolism in white adipocytes and discusses how these pathways can serve as therapeutic targets in metabolic disorders.
NATURE REVIEWS ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
P. Sofia Marsetti, Fermin Milagro, Maria Angeles Zulet, J. Alfredo Martinez, Silvia Lorente-Cebrian
Summary: The study analyzed the expression patterns of microRNAs in white blood cells in response to two different energy-restricted diets in patients with metabolic syndrome. Results showed specific changes in miRNA expression in white blood cells between the two different dietary strategies, suggesting the potential involvement of miRNAs in the regulation of metabolic diseases.
Review
Nutrition & Dietetics
Ester Diez-Sainz, Silvia Lorente-Cebrian, Paula Aranaz, Jose Riezu-Boj, J. Alfredo Martinez, Fermin Milagro
Summary: MiRNAs are small non-coding RNA molecules that play a crucial role in regulating gene expression. Dietary plant-derived miRNAs may be incorporated into humans through various mechanisms and have an impact on gut microbiota composition, intestinal barrier permeability, and overall health. The interaction between xenomiRs and gut microbiota could potentially explain the variation in research results regarding dietary miRNA uptake and function in humans.
FRONTIERS IN NUTRITION
(2021)
Article
Endocrinology & Metabolism
Enrichetta Mileti, Kelvin H. M. Kwok, Daniel P. Andersson, Anthony Mathelier, Amitha Raman, Jesper Backdahl, Jutta Jalkanen, Lucas Massier, Anders Thorell, Hui Gao, Peter Arner, Niklas Mejhert, Carsten O. Daub, Mikael Ryden
Summary: Selective hepatic insulin resistance is a feature of obesity and type 2 diabetes. This study showed that white adipose tissue in obese individuals also displays a selective insulin response, which is normalized by weight loss in most genes.
Article
Neurosciences
William V. Trim, Jean-Philippe Walhin, Francoise Koumanov, Anne Bouloumie, Mark A. Lindsay, Yung-Chih Chen, Rebecca L. Travers, James E. Turner, Dylan Thompson
Summary: The study reveals that adipose tissue shows significant pro-inflammatory changes with age in healthy and lean older adults, while skeletal muscle does not. These changes are tissue-specific and more profound than those observed in circulation or skeletal muscle. Adipose tissue's role in the biological ageing process in humans is highlighted, showing signs of immunometabolic dysfunction before systemic manifestation.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Food Science & Technology
Catherine A. M. Graham, Leta Pilic, Alexandra King, Jonathan E. Nixon, Julie Pipe, Juliet Holton, Krisztina Tamba, Gary Hearne, Charles R. Pedlar, Silvia Lorente-Cebrian, Pedro Gonzalez Muniesa, Yiannis Mavrommatis
Summary: This study suggests that different genotypes may influence fat taste sensitivity, with some genotypes being associated with differences in dietary intake. In a cohort of Caucasian females in the UK, individuals with certain genotypes showed variations in fat taste sensitivity and dietary intake. Further research on a larger, ethnically similar cohort is needed to validate these findings.
FOOD QUALITY AND PREFERENCE
(2021)
Article
Biochemistry & Molecular Biology
Marta Lopez-Yus, Rebeca Lopez-Perez, Maria Pilar Garcia-Sobreviela, Raquel Del Moral-Bergos, Silvia Lorente-Cebrian, Jose M. Arbones-Mainar
Summary: The overexpression of adiponectin in skeletal muscle can increase lipid oxidation and transition muscle fibers from glycolytic to oxidative type, potentially offering a way to alleviate muscle diseases caused by oxidative muscle fiber deficiency.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ester Diez-Sainz, Fermin Milagro, Jose Riezu-Boj, Silvia Lorente-Cebrian
Summary: The increasing rates of obesity and diabetes call for a better understanding of their underlying mechanisms. The dysbiosis of gut microbiota is closely linked to the progression of these metabolic disorders, and manipulation through diet is seen as a promising therapeutic approach. Extracellular vesicles secreted by gut microbiota and probiotic bacteria play a crucial role in mediating communication between microbiota and host, with potential impacts on the modulation of important biological functions and overall host health.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Oncology
Florent Morfoisse, Fabienne De Toni, Jeremy Nigri, Mohsen Hosseini, Audrey Zamora, Florence Tatin, Francoise Pujol, Jean-Emmanuel Sarry, Dominique Langin, Eric Lacazette, Anne-Catherine Prats, Richard Tomasini, Jean Galitzky, Anne Bouloumie, Barbara Garmy-Susini
Summary: This study found that lymphangiogenesis occurs in tumor lesions and surrounding adipose tissue, and the density of lymphatic vessels is correlated with an increase in circulating free fatty acids in the lymph of tumor-bearing mice. Adipocyte-released FFA can stimulate the sprouting of lymphatic endothelial cells, with monounsaturated oleic acid playing a key role in the promotion of lymphangiogenesis in the tumor microenvironment.
Article
Biochemistry & Molecular Biology
Marta Lopez-Yus, Silvia Lorente-Cebrian, Raquel Del Moral-Bergos, Carlos Horndler, Maria Pilar Garcia-Sobreviela, Carmen Casamayor, Alejandro Sanz-Paris, Vanesa Bernal-Monterde, Jose M. Arbones-Mainar
Summary: This study investigated the molecular mechanisms of subcutaneous white adipose tissue (scWAT) in the progression of nonalcoholic fatty liver disease (NAFLD). Through RNA sequencing analysis and in vitro experiments, potential key genes related to NAFLD progression were identified. These findings provide new potential targets for future therapies against liver steatosis.
Article
Medicine, General & Internal
Sara Nikolic, Patrick Maisonneuve, Ingrid Dahlman, J-Matthias Lohr, Miroslav Vujasinovic
Summary: The prevalence of endocrine and exocrine insufficiency is high in patients with autoimmune pancreatitis (AIP), and there is a risk of developing pancreatic exocrine insufficiency (PEI) and diabetes mellitus (DM) despite pharmacological treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Marta Lopez-Yus, Silvia Lorente-Cebrian, Carlos Horndler, Almudena Sobrino-Prados, Carmen Casamayor, Alejandro Sanz Paris, Vanesa Bernal Monterde, Jose M. Arbones Mainar
JOURNAL OF HEPATOLOGY
(2022)