PKR negatively regulates leukemia progression in association with PP2A activation, Bcl-2 inhibition and increased apoptosis

PKR regulates proliferation, differentiation, and survival of murine hematopoietic stem/progenitor cells

(2013) X. Liu et al.   BLOOD

Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer

(2013) Parthasarathy Seshacharyulu et al.   CANCER LETTERS

The RAX/PACT-PKR stress response pathway promotes p53 sumoylation and activation, leading to G1arrest

(2012) Richard Bennett et al.   CELL CYCLE

Disparate In Vivo Efficacy of FTY720 in Xenograft Models of Philadelphia Positive and Negative B-lineage Acute Lymphoblastic Leukemia

(2012) Craig T. Wallington-Beddoe et al.   PLoS One

Increased Expression of the dsRNA-Activated Protein Kinase PKR in Breast Cancer Promotes Sensitivity to Doxorubicin

(2012) Richard L. Bennett et al.   PLoS One

Reactivating PP2A by FTY720 as a Novel therapy for AML with C-KIT tyrosine kinase domain mutation

(2011) Yan Yang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Pharmacokinetics, pharmacodynamics, safety, and tolerability of single-dose fingolimod (FTY720) in adolescents with stable renal transplants

(2011) R. Ettenger et al.   PEDIATRIC TRANSPLANTATION

Prognostic Significance of RNA-Dependent Protein Kinase on Non-Small Cell Lung Cancer Patients

(2010) A. Pataer et al.   CLINICAL CANCER RESEARCH

Protein phosphatase 2A inactivates Bcl2's antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding

(2008) X. Deng et al.   BLOOD

Protein phosphatase 2A (PP2A), a drugable tumor suppressor in Ph1(+) leukemias

(2008) Danilo Perrotti et al.   CANCER AND METASTASIS REVIEWS

PKR Regulates B56α-mediated BCL2 Phosphatase Activity in Acute Lymphoblastic Leukemia-derived REH Cells

(2008) Vivian R. Ruvolo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bcl2 enhances induced hematopoietic differentiation of murine embryonic stem cells

(2007) Yan-Yi Wang et al.   EXPERIMENTAL HEMATOLOGY