Review
Pathology
Wen Bi, Jingjing Li, Mengqiu Xiong, Bei Pan, Zhongqiu Zhang, Lubanga Nasifu, Bangshun He, Ping Wang
Summary: MicroRNA-27a (miR-27a) is abnormally expressed in cancer patients and can serve as a potential diagnostic and prognostic biomarker. It is a valuable diagnostic biomarker in serum/plasma and can predict poor prognosis in cancer patients. However, its diagnostic value is slightly reduced in tumor tissue samples.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Microbiology
Min Xiao, Song Yang, An Zhou, Tongxin Li, Jingjing Liu, Yang Chen, Ya Luo, Chunfang Qian, Fuping Yang, Bo Tang, Chunhua Li, Na Su, Jing Li, Mingying Jiang, Shiming Yang, Hui Lin
Summary: This study found that miR-27a-3p and miR-30b-5p affect the progression of TB by targeting VDR, and regulate the secretion of proinflammatory cytokines and macrophage differentiation through the NF-kB inflammatory cytokine signaling pathway.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Yunxia Liu, Xia Liu, Yanhua Zhou, Tingting Liu, Jie Li
Summary: The study revealed that high expression of miR-27a in cholangiocarcinoma patients is associated with lymph node metastasis, TNM stages, and poorer overall survival. Overexpression of miR-27a promotes cell proliferation, migration, and invasion in CCA, while knockdown suppresses these processes. These findings suggest the potential utility of miR-27a in prognosis and progression of CCA.
CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
Esra Duman, Ozge Ozmen, Selim Kul
Summary: The study aimed to determine the expression pattern of important miRNAs associated with lactation in sheep milk between high and low lactating-yield ewe groups. Significant differences in miRNA expression levels were found between the groups, with certain miRNAs showing negative correlations with milk protein, lactose contents, and milk yield. Additionally, hub genes for the target genes of these miRNAs were identified. This study provides new insights into the relationship between miRNA expression profiles in sheep milk and milk yield and composition in different lactating yield groups.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haifei Chen, Weiling Cao, Jiao Chen, Danbo Liu, Lingyun Zhou, Fang Du, Feiqi Zhu
Summary: This study investigated the role and molecular mechanism of miRNAs in multiple myeloma, revealing that aberrant expression of miR-218 contributes to drug resistance in MM by targeting LRRC28, suggesting LRRC28 as a potential therapeutic target for MM.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Pelin Telkoparan-Akillilar, Dilek Cevik
Summary: The study aimed to investigate the expression levels of miR-17, miR-21, miR-27a, miR-106b, miR-222, and CHOP in patients with atherosclerosis compared to healthy controls. It was found that miR-17 and miR-106b were significantly increased in patients, while miR-21, miR-27a, and miR-222 were significantly decreased. Additionally, CHOP gene was significantly induced in patient samples.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Jun You, Jiayi Li, Chunlin Ke, Yanru Xiao, Chuanhui Lu, Fakun Huang, Yanjun Mi, Rongmu Xia, Qiyuan Li
Summary: This study demonstrates that Linc00284 is upregulated in CRC tissues and cell lines, associated with tumor metastasis and poor clinical outcome in CRC patients. Serum expression levels of Linc00284 and miR-27a may serve as potential clinical biomarkers for CRC diagnosis.
Article
Biochemistry & Molecular Biology
Emanuele Fosso, Manuela Leo, Livio Muccillo, Vittorio Maria Mandrone, Maria Chiara Di Meo, Annamaria Molinario, Ettore Varricchio, Lina Sabatino
Summary: Quercetin (Qc) inhibits cell proliferation and induces apoptosis in colon cancer cells by upregulating negative modulators of proliferation pathways, such as Sprouty2, PTEN, and SFRP1, and reducing the expression of miR-27a, which is an onco-miRNA. Qc also induces the degradation of Sp1, a transcription factor that regulates the expression of miR-27a and other components of the gene cluster.
Article
Medicine, Research & Experimental
Ana C. Andrade, Tulio R. Freitas, Geovana G. Dornelas, Lorena C. Gomes, Barbara L. F. Barbosa, Sergio S. S. Araujo, Karina B. Gomes, Adriano P. Sabino
Summary: This study evaluated the potential of miR-197, miR-26a, and miR-27a as biomarkers for CLL. The results showed a significant reduction of these microRNAs in CLL patients compared to controls, and a correlation with clinical staging.
BIOMARKERS IN MEDICINE
(2022)
Article
Oncology
Mauro Scaravilli, Sonja Koivukoski, Andrew Gillen, Aya Bouazza, Pekka Ruusuvuori, Tapio Visakorpi, Leena Latonen
Summary: The study demonstrates that miR-32 promotes MYC-induced prostate adenocarcinoma and identifies PDK4 as a PC-relevant metabolic target of miR-32-3p. Elevated expression of miR-32 influences prostate tumor growth and phenotype, and regulates the expression of prostate secretome and several PC-related target genes.
Article
Oncology
Xiaolan Lai, Chuanqian Huang, Xuekun Nie, Qi Chen, Yirong Tang, Xianguo Fu, Ying Lin, Chengjun Nie, Xinyu Xu, Xiukang Wang, Renli Chen, Zichun Chen
Summary: This study found that ATF3 increased and regulated cell apoptosis in the process of bortezomib treatment, while being negatively regulated by miR-135a-5p. These results reveal the combinatorial regulatory patterns of ATF3 and miR-135a-5p in the regulatory protein interactome, indicating the clinical significance of the miR-135a-5p-ATF3 protein interaction network in bortezomib therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Ariana N. Renrick, Menaka C. Thounaojam, Maria Teresa P. de Aquino, Evan Chaudhuri, Jui Pandhare, Chandravanu Dash, Anil Shanker
Summary: The study demonstrates that bortezomib can enhance the function of anti-tumor CD8(+) T cells by inducing the downregulation of negative regulatory proteins SOCS1 and SHIP1 through the miR-155 pathway, thus overcoming T cell exhaustion in the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Andrology
Ahmet Tektemur, Ebru Etem Onalan, Nalan Kaya Tektemur, Serap Dayan Cinkara, Ayten Kilincli cetin, Ibrahim Tekedereli, Tuncay Kuloglu, Gaffari Turk
Summary: The study revealed a significant relationship between carbamazepine usage and male infertility, with decreased sperm motility and hormonal balance, as well as increased abnormal sperm morphology. Alterations in the expressions of KCNJ11, CFTR, and miRNAs were found to be associated with impaired sperm parameters, indicating potential mechanisms underlying male infertility caused by carbamazepine.
Article
Oncology
Daniele Caracciolo, Caterina Riillo, Giada Juli, Francesca Scionti, Katia Todoerti, Nicoletta Polera, Katia Grillone, Lucia Fiorillo, Mariamena Arbitrio, Maria Teresa Di Martino, Antonino Neri, Pierosandro Tagliaferri, Pierfrancesco Tassone
Summary: The MYC-driven deregulation of microRNAs, particularly the repression of miR-22, plays a critical role in multiple myeloma (MM) and resistance to immunomodulatory imide drugs (IMiDs). Lenalidomide treatment enhances miR-22 activity by reducing MYC inhibition, which restores drug sensitivity and leads to synergistic anti-MM activity.
Article
Cell Biology
Aneta Szudy-Szczyrek, Radoslaw Mlak, Michal Mielnik, Marcin Mazurek, Sylwia Chocholska, Martyna Podgajna, Michal Szczyrek, Iwona Homa-Mlak, Teresa Malecka-Massalska, Marek Hus
Summary: High expression of miRNA-8074 is significantly associated with poor prognosis in multiple myeloma patients.
Article
Oncology
Delphine Casabonne, Yolanda Benavente, Julia Seifert, Laura Costas, Maria Armesto, Maria Arestin, Caroline Besson, Fatemeh S. Hosnijeh, Eric J. Duell, Elisabete Weiderpass, Giovanna Masala, Rudolf Kaaks, Federico Canzian, Maria-Dolores Chirlaque, Vittorio Perduca, Francesca R. Mancini, Valeria Pala, Antonia Trichopoulou, Anna Karakatsani, Carlo La Vecchia, Maria-Jose Sanchez, Rosario Tumino, Marc J. Gunter, Pilar Amiano, Salvatore Panico, Carlotta Sacerdote, Julie A. Schmidt, Heiner Boeing, Matthias B. Schulze, Aurelio Barricarte, Elio Riboli, Anja Olsen, Anne Tjonneland, Roel Vermeulen, Alexandra Nieters, Charles H. Lawrie, Silvia de Sanjose
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Oncology
Carla Sole, Ibai Goicoechea, Alai Goni, Maike Schramm, Maria Armesto, Maria Arestin, Lorea Manterola, Maitena Tellaetxe, Aitor Alberdi, Leonor Nogueira, Mathieu Roumiguie, Jose Ignacio Lopez, Juan Pablo Sanz Jaka, Ander Urruticoechea, Itziar Vergara, Ana Loizaga-Iriarte, Miguel Unda, Arkaitz Carracedo, Bernard Malavaud, Charles H. Lawrie
Article
Oncology
Daniela Gerovska, Gorka Larrinaga, Jon Danel Solano-Iturri, Joana Marquez, Patricia Garcia Gallastegi, Abdel-Majid Khatib, Gereon Poschmann, Kai Stuehler, Maria Armesto, Charles H. Lawrie, Iker Badiola, Marcos J. Arauzo-Bravo
Article
Biochemistry & Molecular Biology
Erika Larrea, Marta Fernandez-Mercado, Jose Afonso Guerra-Assuncao, Jun Wang, Ibai Goicoechea, Ayman Gaafar, Izaskun Ceberio, Carmen Lobo, Jessica Okosun, Anton J. Enright, Jude Fitzgibbon, Charles H. Lawrie
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Carla Sole, Charles Henderson Lawrie
Summary: Metastasis, the spread of cancer cells from the primary tumor to other parts of the body, is a primary cause of cancer-related mortality. Understanding the role of microRNAs in cancer development and progression, particularly in the interaction between tumor cells and the tumor microenvironment, is crucial for developing new strategies to combat metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Maria Armesto, Maitane Marquez, Maria Arestin, Peio Errarte, Ane Rubio, Lorea Manterola, Jose Lopez, Charles H. Lawrie
Summary: Clear cell renal cell carcinoma (ccRCC) is a common cancer with a high mortality rate. While treatment with targeted drugs like sunitinib has improved patient outcomes, drug resistance remains a major challenge. By studying sunitinib-resistant cell lines, researchers have identified various pathways and mechanisms by which tumor cells develop resistance to sunitinib. The discovery of common miRNAs across multiple resistance mechanisms suggests potential therapeutic targets for overcoming sunitinib resistance in ccRCC.
Article
Virology
Sarah Keep, Phoebe Stevenson-Leggett, Giulia Dowgier, Holly Everest, Graham Freimanis, Michael Oade, John A. Hammond, Maria Armesto, Rut Vila, Tura Bru, Harm Geerligs, Paul Britton, Erica Bickerton
Summary: The Gammacoronavirus infectious bronchitis virus (IBV) is a highly contagious and economically important disease in poultry. Vaccination with live attenuated and inactivated vaccines is used to control the virus. Researchers have identified specific amino acid changes that can attenuate IBV and have the potential for vaccine development.
JOURNAL OF VIROLOGY
(2022)
Article
Oncology
Estefania Carrasco-Garcia, Lidia Lopez, Veronica Moncho-Amor, Fernando Carazo, Paula Aldaz, Manuel Collado, Donald Bell, Ayman Gaafar, Eva Karamitopoulou, Alexandar Tzankov, Manuel Hidalgo, Angel Rubio, Manuel Serrano, Charles H. Lawrie, Robin Lovell-Badge, Ander Matheu
Summary: The study shows that SOX9 plays a crucial role in the progression and metastasis of pancreatic cancer by regulating stemness and EMT processes. High levels of SOX9 are associated with metastases in clinical samples.
Article
Biochemistry & Molecular Biology
Paula Aldaz, Natalia Martin-Martin, Ander Saenz-Antonanzas, Estefania Carrasco-Garcia, Maria Alvarez-Satta, Alejandro Elua-Pinin, Steven M. Pollard, Charles H. Lawrie, Manuel Moreno-Valladares, Nicolas Sampron, Juergen Hench, Robin Lovell-Badge, Arkaitz Carracedo, Ander Matheu
Summary: SOX9 is a critical transcription factor associated with poor survival in glioma patients. Knockdown of SOX9 impairs glioma stem cell proliferation, suggesting its potential as a therapeutic target. This study reveals a regulatory loop involving SOX9, STAT3, and PML that is essential for glioma stem cell activity and self-renewal. Inhibition of STAT3 or PML reduces the expression of SOX9, STAT3, and PML proteins, leading to decreased tumorigenicity in glioma stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Maria Armesto, Mathias Charconnet, Jose M. Marimon, Cristina Lia Fernandez Regueiro, Jia Jia, Tingdong Yan, Ane Sorarrain, Marek Grzelczak, Maria Sanroman, Monica Vicente, Boris Klempa, Javier Zubiria, Yuan Peng, Lei Zhang, Jianhua Zhang, Charles H. Lawrie
Summary: Despite widespread vaccination, the COVID-19 pandemic caused by SARS-CoV-2 continues to burden healthcare systems globally. To address this, researchers have developed an instrument-free molecular diagnostic test called Repvit. This test uses gold nanoparticles to detect SARS-CoV-2 RNA directly from nasal swab or saliva samples, providing results in less than 20 minutes with high sensitivity and specificity. This technology has the potential to be used in resource-limited settings or for individual self-testing.
