Article
Medicine, General & Internal
Alexandra Oltea Dan, Alin Stefanescu-Dima, Andrei Teodor Balasoiu, Ileana Puiu, Carmen Luminita Mocanu, Mihaela Ionescu, Andreea Cornelia Tanasie, Anca Elena Tartea, Veronica Sfredel
Summary: The purpose of this study is to identify and quantify preclinical changes in the retinal microcirculation of young type 1 diabetes patients. The results show significant differences in various retinal parameters between the T1D group and the control group. OCTA has the potential to be a valuable tool for early diagnosis in these patients.
Article
Ophthalmology
Kosha Y. Dholakia, Andres Guevara-Torres, Guanping Feng, Derek Power, Jesse Schallek
Summary: This study characterized the early structural and functional changes in the retinal microvasculature in response to hyperglycemia in Ins2(Akita) mice. The results showed that, despite 3 months of chronically elevated blood glucose, the structure and function of retinal microvasculature were not impaired.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Medicine, General & Internal
Magdalena Kupis, Zbigniew M. Wawrzyniak, Jacek P. Szaflik, Anna Zaleska-Zmijewska
Summary: This study used Rtx1 (TM) technology to analyze the cones and retinal microvascular changes in 50 diabetic individuals and 18 healthy volunteers. The results showed significant differences in cone density, mosaic arrangement, and vascular morphology between healthy and diabetic patients. The study also found statistically significant morphological changes in both groups' Rtx1 (TM)-acquired images over the 2-year follow-up period.
Article
Biology
Qinrong Zhang, Yuhan Yang, Kevin J. Cao, Wei Chen, Santosh Paidi, Chun-hong Xia, Richard H. Kramer, Xiaohua Gong, Na Ji
Summary: Optimizing the design of a two-photon fluorescence microscope (2PFM) and using adaptive optics (AO) for measuring and correcting ocular aberrations, researchers have successfully achieved high-resolution imaging of retinal structure and function in live mice. This technique has been further applied to study retinal pathology in transgenic models, enabling detailed characterization of microvascular lesions and finding effective treatments for retinal degeneration. The ability of AO-2PFM to track structural and functional changes longitudinally provides valuable insights for disease diagnosis and treatment in vivo.
Article
Biochemistry & Molecular Biology
Yeon-Ju Lee, Hye-Yoon Jeon, Ah-Jun Lee, Minsoo Kim, Kwon-Soo Ha
Summary: The role of dopamine in retinal vascular dysfunction in diabetic retinopathy (DR) remains unclear. This study found that dopamine can alleviate retinal microvascular leakage and abnormalities caused by hyperglycemic memory by inhibiting persistent oxidative stress and mitochondrial dysfunction.
Article
Ophthalmology
Feng Zhang, Zijing Du, Xiayin Zhang, Yaxin Wang, Yesheng Chen, Guanrong Wu, Yingying Liang, Dan Cao, Jun Zhao, Ying Fang, Jianhua Ma, Honghua Yu, Yijun Hu
Summary: This study investigated alterations in outer retinal reflectivity in diabetic patients without clinically detectable retinopathy. The results showed that the reflectivity was significantly lower in most retinal locations in these patients compared to controls. The reduction in outer retinal reflectivity was correlated with diabetes duration, HbA1c, and visual acuity. These findings suggest that the measurement of outer retinal reflectivity could potentially serve as a biomarker for early retinal alterations in diabetic patients.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Review
Medicine, Research & Experimental
Randhir Singh, Shah Asma Farooq, Ashi Mannan, Thakur Gurjeet Singh, Agnieszka Najda, Zawislak Grazyna, Ghadeer M. Albadrani, Amany A. Sayed, Mohamed M. Abdel-Daim
Summary: Diabetes is becoming more common worldwide, with the primary concern being the development of complications. Appropriate screening models are required to study pathogenesis and potential therapeutic agents for the disease. Various animal models are used to assess pharmacological potentials and investigate disease progression.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Instruments & Instrumentation
Kopal Agarawal, Yogesh Anant Kulkarni, Sarika Wairkar
Summary: This review article focuses on the application of flavonoid nanoformulations in the treatment of diabetes, overcoming limitations by enhancing solubility, absorption, and therapeutic efficacy. These nanoformulations have the potential to be effective interventions for diabetes and its complications.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Ophthalmology
Serena Fragiotta, Eliana Costanzo, Fabiana Picconi, Paola Giorno, Daniele De Geronimo, Daniela Giannini, Simona Frontoni, Monica Varano, Mariacristina Parravano
Summary: This study assessed the predictors of microvasculature and photoreceptor changes in type 1 diabetes mellitus patients over a 4-year follow-up. The study found that the perfusion density in the superficial capillary plexus and deep capillary plexus changed over time, with different influencing factors. Additionally, the study revealed the relationship between microvascular changes and photoreceptor integrity in diabetic patients.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Review
Medicine, General & Internal
Mengting Xue, Xiying Mao, Mingkang Chen, Wenjie Yin, Songtao Yuan, Qinghuai Liu
Summary: This review summarizes the current understanding of the activation mechanism of adaptive immunity in DR microenvironments and discusses the relationship between adaptive immunity and local vascular units or innate immunity, which opens new avenues for clinical applications in DR treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Yongqing Han, Xiaogang Wang, Gang Sun, Jing Luo, Xing Cao, Pengyi Yin, Renhe Yu, Simin He, Fang Yang, Frank L. Myers, Liang Zhou
Summary: Optical coherence tomography angiography (OCTA) can be used to quantitatively evaluate microvascular abnormalities in the macula and peripapillary area of diabetic patients. The study found that FD-300 was an important parameter for distinguishing diabetic eyes without clinical signs of DR from healthy normal eyes.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wojciech Matuszewski, Katarzyna Gontarz-Nowak, Joanna M. Harazny, Elzbieta Bandurska-Stankiewicz
Summary: The study aims to evaluate the morphological parameters of retinal arterioles in patients with type 1 diabetes mellitus (DM1). The results showed significant morphological changes in retinal vessels in DM1 patients without previously diagnosed diabetic retinopathy. These changes may be early indicators of cardiovascular risk.
Article
Endocrinology & Metabolism
Hongyan Yao, Zijing Li
Summary: This study analyzed retinal vessel density and thickness characteristics in patients with diabetic nephropathy (DN) and preclinical diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA). The findings suggest that DN individuals have more severe microvascular and microstructural impairment compared to individuals without DN. Additionally, estimated glomerular filtration rate (eGFR) may serve as an indicator for retinal microvascular impairment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Ahmed Ismail, Hesham A. El-Mahdy, Mahmoud Gomaa Eldeib, Ahmed S. Doghish
Summary: Diabetes mellitus is often accompanied by microvascular complications such as nephropathy, retinopathy, and neuropathy. MicroRNAs (miRNAs) play a crucial role in the pathogenesis of these complications by affecting the kidney, retina, and peripheral neurons through various molecular pathways. This review provides an updated understanding of the involvement of miRNAs in diabetic microvascular complications, with a focus on the key molecular pathways mediating the adverse effects of hyperglycemia on vascular tissues. The review highlights specific miRNAs (miR-126, miR-29b, miR-125a, and miR-146a) and their impact on vascular endothelial growth factors.
MOLECULAR GENETICS AND METABOLISM
(2023)
Article
Endocrinology & Metabolism
Yaru Bi, Yanjing Liu, Heyuan Wang, Suyan Tian, Chenglin Sun
Summary: The study aimed to investigate the causal effect of genetically determined ALT on diabetic nephropathy and diabetic retinopathy. The results showed a positive association between genetically determined ALT level and both diabetic nephropathy and diabetic retinopathy in observational studies, but no causal association was found in other methods. Therefore, it was concluded that ALT does not play a linear causal role in developing these complications.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Optics
Ting Luo, Raymond L. Warner, Kaitlyn A. Sapoznik, Brittany R. Walker, Stephen A. Burns
Summary: This letter introduces a dual raster scanning approach to correct image warping caused by target motion in scanning imaging systems, without the need for prior knowledge of the undistorted image. By simultaneously imaging two different regions of the target, accurate spatial information is provided, which accurately measures target motion. The technique is demonstrated using data from adaptive optics scanning laser ophthalmoscope imaging of the human retina.
Article
Multidisciplinary Sciences
Clara Benedi-Garcia, Maria Vinas, Carlos Dorronsoro, Stephen A. Burns, Eli Peli, Susana Marcos
Summary: The research demonstrates that both chromatic and monochromatic aberrations in the eye affect the optical quality of images projected on the retina, but their combination is not always simply additive, and the eye has a high degree of adaptability to blur.
SCIENTIFIC REPORTS
(2021)
Review
Ophthalmology
Frank Brodie, Michael Repka, Stephen Allan Burns, S. Grace Prakalapakorn, Christie Morse, Joel S. Schuman, Michael R. Duenas, Natalie Afshari, John S. Pollack, Jennifer E. Thorne, Albert Vitale, H. Nida Sen, David Myung, Mark S. Blumenkranz, Elmer Tu, Daniel X. Hammer, Michelle Tarver, Bradley Cunningham, Larry Kagemann, SriniVas Sadda, David Sarraf, Glenn J. Jaffe, Malvina Eydelman
Summary: The forum brought together professionals from various fields to discuss the innovative applications and related issues of laser imaging technology in ophthalmology, with a focus on the emerging role of artificial intelligence in ocular imaging.
JAMA OPHTHALMOLOGY
(2021)
Article
Ophthalmology
William H. Swanson, Brett J. King, Stephen A. Burns
Summary: Diagnosing the severity of perimetric damage in glaucoma patients by analyzing the presence of nerve fiber bundles in AOSLO images of RNFL reflectance defects could potentially provide valuable insights for predicting and managing the condition.
OPTOMETRY AND VISION SCIENCE
(2021)
Article
Biochemical Research Methods
Justin Migacz, Oscar Otero-Marquez, Rebecca Zhou, Kara Rickford, Brian Murillo, Davis B. Zhou, Maria Castanos, Nripun Sredar, Alfredo Dubra, Richard B. Rosen, Toco Y. P. Chui
Summary: This study demonstrates the non-invasive visualization of the movement and morphological changes of vitreous cortex hyalocytes using advanced imaging technology. The findings suggest that these cells move in quick bursts and may have potential applications in the treatment of eye diseases.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Ophthalmology
Oscar Otero-Marquez, Mona Fayad, Alexander Pinhas, Toco Y. P. Chui, Richard B. B. Rosen, Harsha S. S. Reddy
Summary: This study investigated the variation of parafoveal surface macrophages in a thyroid eye disease patient before and after treatment with teprotumumab. The results showed that the macrophage density decreased and their morphology changed from activated to quiescent state after treatment.
CASE REPORTS IN OPHTHALMOLOGICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Ann E. Elsner, Brittany R. Walker, Robert N. Gilbert, Vamsi Parimi, Joel A. Papay, Thomas J. Gast, Stephen A. Burns
Summary: AOSLO imaging revealed widespread retinal vascular remodeling in all diabetic eyes, while SDOCT showed no increased retinal thickness. Cone reflectivity changes were found in all diabetic patients, but significantly low cone density was only present in some patients.
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Alexander Pinhas, Jorge S. Andrade Romo, Giselle Lynch, Davis B. Zhou, Maria V. Castanos Toral, Phillip A. Tenzel, Oscar Otero-Marquez, Shoshana Yakubova, Alexander Barash, David Della Rocca, Robert Della Rocca, Toco Y. P. Chui, Richard B. Rosen, Harsha S. Reddy
Summary: This pilot study used OCT-A to investigate the perfusion changes around the optic nerve head in TRO eyes without DON. The results showed a significant decrease in non-capillary peripapillary perfusion density in TRO eyes, which may represent decreased blood flow and subclinical ischemia to the optic nerve.
CLINICAL OPHTHALMOLOGY
(2022)
Article
Biochemical Research Methods
Alessandra Carmichael-Martins, Thomas J. Gast, Stephen A. Burns, Rittany R. Walker, Brett J. King
Summary: Intraocular pressure is the only modifiable risk factor for glaucoma progression, and many treatments aim to target the trabecular meshwork. However, imaging this region in vivo is challenging due to optical limitations. This study proposes a gonioscopic OCT approach using a custom goniolens and a commercially available OCT device to improve imaging of the trabecular meshwork and adjacent structures.
BIOMEDICAL OPTICS EXPRESS
(2022)
Review
Biochemical Research Methods
David R. Williams, Stephen A. Burns, Donald T. Miller, Austin Roorda
Summary: This review discusses the advancements that have been made in the field of ophthalmoscopes with adaptive optics (AO) technology over the past 25 years. The integration of AO has revolutionized our ability to image the retina at a cellular level inside the living eye. The review highlights the technological progress achieved through the combination of AO with other imaging modalities and the potential future developments in this field.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Biochemical Research Methods
Alessandra Carmichael-Martins, Thomas J. Gast, Brett J. King, Brittany R. Walker, Marcelina Sobczak, Stephen A. Burns
Summary: The trabecular meshwork is a target for glaucoma treatments, with a newly designed gonioscopic lens optimized for high-resolution imaging to capture fine structures in vivo. This design improves imaging quality and reveals details not visible with previous designs.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Biochemical Research Methods
Ann Elsner, Joel Papay, Vamsi Parimi, Hae Won Jung, Christopher Clark, Stephen Burns, Thomas Gast
Summary: This article introduces a free-space, trolley-mounted potential vision tester, which is designed to study and improve the accuracy of visual acuity measurements in the aging eye. The device includes features such as a high-resolution visual display, a 3 mm pupil to limit wavefront aberrations, and a moderate cost deformable mirror. The results demonstrate that the device can accurately measure visual acuity and the induced aberrations are repeatable and stable.
BIOMEDICAL OPTICS EXPRESS
(2023)
Meeting Abstract
Ophthalmology
Vamsi Parimi, Ann E. Elsner, Joel A. Papay, Robert N. Gilbert, Thomas J. Gast, Christopher Anderson Clark, Stephen A. Burns
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
Alessandra Carmichael-Martins, Brett King, Thomas J. Gast, Brittany Walker, Stephen A. Burns
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
Ann E. Elsner, Thomas J. Gast, Brittany Walker, Robert N. Gilbert, Vamsi Parimi, Stephen A. Burns
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)