Article
Physics, Multidisciplinary
Andrey Baydin, Felix G. G. Hernandez, Martin Rodriguez-Vega, Anderson K. Okazaki, Fuyang Tay, G. Timothy Noe, Ikufumi Katayama, Jun Takeda, Hiroyuki Nojiri, Paulo H. O. Rappl, Eduardo Abramof, Gregory A. Fiete, Junichiro Kono
Summary: PbTe crystals possess a soft transverse optical phonon mode in the terahertz range, which softens with decreasing temperature and indicates incipient ferroelectricity. In the presence of a magnetic field, the phonon mode splits into two modes with opposite handedness, exhibiting circular dichroism. These observations are the result of magnetic field-induced morphic changes in crystal symmetries.
PHYSICAL REVIEW LETTERS
(2022)
Article
Biochemical Research Methods
Almog Taieb, Garry Berkovic, Miki Haifler, Ori Cheshnovsky, Natan T. Shaked
Summary: We propose a multimodal label-free optical measurement approach for analyzing sliced tissue biopsies using quantitative phase imaging and localized Raman spectroscopy. The approach involves performing label-free quantitative phase imaging of the tissue slice and then using kernelled structural support vector machine to segment the tissue layers. The segmented areas are used to guide localized Raman spectroscopy measurements for classification of tissue types. The results show that the prior segmentation using quantitative phase imaging improves the classification accuracy of Raman spectra.
JOURNAL OF BIOPHOTONICS
(2022)
Article
Optics
Ignacio Iglesias
Summary: This non-interferometric technique offers a simple way to achieve quantitative phase microscopy by rotating a mask to detect wavefront gradient. The method also includes calibrating the sensor and processing signals for phase extraction. Three-dimensional images of polystyrene microspheres immersed in index-matching liquid were successfully obtained using this technique.
OPTICS AND LASER TECHNOLOGY
(2021)
Article
Chemistry, Analytical
Coralie Elmaleh, Fabien Simon, Jean Decker, Julien Dumont, Fabrice Cazier, Marc Fourmentin, Robin Bocquet, Arnaud Cuisset, Gael Mouret, Francis Hindle
Summary: The development of cavity based infrared spectroscopy techniques, particularly cavity ring-down spectroscopy, has been successful for sensitive measurements. However, the construction difficulty of high finesse cavities has limited its application for THz frequencies. By using a corrugated waveguide and photonic mirrors, we have achieved finesse values of 3500. This has allowed us to measure the absorption of various gases and samples, demonstrating good agreement with a certified gas analyser for industrial samples.
Article
Materials Science, Multidisciplinary
Alexander Yu. Germov, Dmitriy A. Prokopyev, Konstantin N. Mikhalev, Boris Yu. Goloborodskiy, Mikhail A. Uimin, Anatoliy E. Yermakov, Alexander S. Konev, Artem S. Minin, Sergey I. Novikov, Vasiliy S. Gaviko, Aidar M. Murzakaev
Summary: This paper focuses on the quantitative analysis of the phase composition of ferromagnetic nanoparticles and the transition to the single domain magnetic state. Fe@C nanoparticles were studied comprehensively, revealing the presence of multiple phases in their cores. Annealing leads to redistribution of phase composition and increased magnetization, while also observing a nanoscale effect in the NMR spectra.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Rikizo Yano, Shota Nagasaka, Naoki Matsubara, Kazushige Saigusa, Tsuyoshi Tanda, Seiichiro Ito, Ai Yamakage, Yoshihiko Okamoto, Koshi Takenaka, Satoshi Kashiwaya
Summary: In CaAg1-xPdxP, Pd doping raises the Fermi level, increasing the critical temperature and resulting in unconventional superconductivity in the surface states. Ultrahigh mobility carriers derived from the surface generate a new class of unconventional superconductivity.
NATURE COMMUNICATIONS
(2023)
Article
Optics
Chen Fan, Junxiang Li, Yijun Du, Zirui Hu, Huan Chen, Gaopeng Zhang, Lu Zhang, Zixin Zhao, Hong Zhao
Summary: We propose a novel, accurate, full-field, dynamic quantitative phase imaging (QPI) technique using multi-wavelength multiplexing and multi-plane iterative phase retrieval algorithm. Our method utilizes a liquid crystal spatial light modulator to generate multiple defocus intensity images simultaneously with different wavelengths. These images are captured by two color cameras for accurate dynamic phase reconstruction using a multi-plane iterative algorithm based on the transport of intensity equation (TIE). Experimental results on various samples demonstrate the accuracy, dynamic measurement ability, and flexibility of our method, which also effectively compensates for errors caused by color coupling and chromatic aberration in the optical system.
OPTICS AND LASERS IN ENGINEERING
(2023)
Article
Engineering, Electrical & Electronic
Miguel Moscoso, Alexei Novikov, George Papanicolaou, Chrysoula Tsogka
Summary: We present an algorithm for coherent diffractive imaging with phaseless measurements, which can reconstruct the absorption and phase contrast of the object. The computational cost of the algorithm is linear in the number of pixels, making it efficient for high-resolution imaging. Numerical experiments validate the efficiency and precision of the suggested algorithm.
IEEE TRANSACTIONS ON COMPUTATIONAL IMAGING
(2022)
Article
Optics
D. Peller, C. Roelcke, L. Z. Kastner, T. Buchner, A. Neef, J. Hayes, F. Bonafe, D. Sidler, M. Ruggenthaler, A. Rubio, R. Huber, J. Repp
Summary: The article introduces a new method for sampling waveforms at the atomic scale to determine tip-confined near-field transients, with measurements and calibrations using a quantum-level atomic waveform sampler to understand and validate the effectiveness of this method. The study reveals the impact of local quantum dynamics on femtosecond atomic near fields, accessing an uncharted domain of nano-opto-electronics.
Article
Spectroscopy
Karlis Berzins, Samuel D. L. Harrison, Claudia Leong, Sara J. Fraser-Miller, Michelle J. Harper, Aly Diana, Rosalind S. Gibson, Lisa A. Houghton, Keith C. Gordon
Summary: Raman and ATR-FTIR spectroscopy were used to analyze 208 breast milk samples as part of a larger research study. Comprehensive qualitative and quantitative analysis was carried out using chemometric methods, revealing the relationship between macronutrients and sample metadata. The study location and primary food sources were found to have a stronger impact on fat composition than its absolute content, highlighting the limitations and challenges of using spectroscopic techniques for this type of analysis.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Physics, Multidisciplinary
JuHyeon Lee, Johannes Bischoff, A. O. Hernandez-Castillo, Boris Sartakov, Gerard Meijer, Sandra Eibenberger-Arias
Summary: In this study, we quantitatively investigated enantiomer-specific state transfer using a pulsed supersonic molecular beam. By using optical pumping and microwave pulses, we were able to improve enantiomer enrichment and create a molecular beam with an enantiomer-pure rotational level, which holds great potential for future spectroscopic and scattering studies.
PHYSICAL REVIEW LETTERS
(2022)
Article
Chemistry, Analytical
Naoki Saito
Summary: A fresh dual pre-SAT method was developed to accurately quantify analytes near the suppressed water signal in 1H NMR spectra from H2O-rich samples. The method includes an extra dummy pre-SAT with a suitable offset for each analyte signal, in addition to the water pre-SAT. The proposed method achieved accurate quantification of glycine and maleic acid in D2O/H2O solutions.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Thang L. Nguyen, Soorya Pradeep, Robert L. Judson-Torres, Jason Reed, Michael A. Teitell, Thomas A. Zangle
Summary: Quantitative phase imaging (QPI) is a label-free, wide-field microscopy technique with significant applications in biomedical research. It quantifies biomass distribution and changes by measuring the natural phase shift of light passing through a transparent object. QPI has been used to study cell size, morphology, behavior, drug efficacy, and more, supporting research in development, physiology, neural activity, cancer, and other fields.
Article
Optics
J. Pupeikis, B. Willenberg, S. L. Camenzind, A. Benayad, P. Camy, C. R. Phillips, U. Keller
Summary: Single-cavity dual-comb lasers are a new type of ultrafast lasers with wide application potential. The researchers propose a method for multiplexing a single laser cavity to support noise-correlated modes, achieving high-energy, short-pulse, and low-timing-noise laser output.
Article
Optics
Zhang Xu, Xin Xie, Run Li, Kangyuan Yu, Samantha R. Lish, Min Xu
Summary: Quantitative chemometric widefield endogenous fluorescence microscopy (CFM) can reveal cellular and tissue structure information by measuring the concentration and spatial distribution of endogenous chromophores. The information entropy of chromophores can improve the diagnosis of photonic lung cancer and eliminate dependence on measurement details for accurate diagnosis.
Review
Engineering, Biomedical
Jina Kim, William Brown, Jason R. Maher, Howard Levinson, Adam Wax
PHYSICS IN MEDICINE AND BIOLOGY
(2015)
Article
Biochemical Research Methods
Jason R. Maher, Thomas E. Matthews, Ashley K. Reid, David F. Katz, Adam Wax
JOURNAL OF BIOMEDICAL OPTICS
(2014)
Article
Optics
William J. Brown, Sanghoon Kim, Adam Wax
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION
(2014)
Article
Optics
Jason R. Maher, Volker Jaedicke, Manuel Medina, Howard Levinson, Maria Angelica Selim, William J. Brown, Adam Wax
Article
Optics
Matthew T. Rinehart, Volker Jaedicke, Adam Wax
Article
Multidisciplinary Sciences
Tyler K. Drake, Tejen Shah, Jennifer J. Peters, Adam Wax, David F. Katz
Article
Multidisciplinary Sciences
Matthew Rinehart, Sheila Grab, Lisa Rohan, David Katz, Adam Wax
Article
Biochemical Research Methods
Derek Ho, Sanghoon Kim, Tyler K. Drake, Will J. Eldridge, Adam Wax
BIOMEDICAL OPTICS EXPRESS
(2014)
Article
Biochemical Research Methods
Will J. Eldridge, Amihai Meiri, Adi Sheinfeld, Matthew T. Rinehart, Adam Wax
BIOMEDICAL OPTICS EXPRESS
(2014)
Article
Biochemical Research Methods
Yang Zhao, Kengyeh K. Chu, Evan T. Jelly, Adam Wax
JOURNAL OF BIOPHOTONICS
(2019)
Article
Cell Biology
Han-Sang Park, Hillel Price, Silvia Ceballos, Jen-Tsan Chi, Adam Wax
Summary: Holographic cytometry was used for high-throughput phase imaging to characterize individual red blood cells stored under blood bank conditions. Physical traits of the cells were observed to change over time. The large volume of cell imaging data could be utilized for training machine-learning algorithms.
Biographical-Item
Optics
Natan T. Shaked, YongKeun Park, Stephen A. Boppart, Adam Wax, Peter T. C. So
Summary: Gabriel Popescu will be remembered as a creative leader in biophotonics, making pioneering contributions to quantitative phase imaging and spectroscopy. He was also known as an engaging collaborator and a dear friend.
Article
Biophysics
Albert Rancu, Cindy X. Chen, Hillel Price, Adam Wax
Summary: Optical methods based on endogenous contrast can be used to examine cellular structure by analyzing refractive index changes. These changes can be visualized using different techniques and quantified using disorder strength and fractal dimension. By linking these two measurements, we can better understand cellular restructuring during different pathways.
BIOPHYSICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Cindy X. X. Chen, George T. Funkenbusch, Adam Wax
Summary: Sickle cell disease (SCD) is a hereditary blood disorder with high mortality rates, especially in sub-Saharan Africa. Using holographic cytometry (HC), a label-free imaging modality, for morphological profiling of red blood cells (RBCs) can be an effective method to detect SCD. In this study, a deep learning classifier was developed using training data from over 2.5 million single-cell holographic images, and it demonstrated highly accurate classification even on unknown patient samples.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Engineering, Biomedical
Ge Song, Evan T. Jelly, Kengyeh K. Chu, Wesley Y. Kendall, Adam Wax
Summary: OCT is a powerful optical imaging technique with applications in ophthalmology, but its high cost has limited accessibility, leading to the development of low-cost systems for widespread use. Low-cost OCT systems offer potential for clinical detection and enable application in fields outside ophthalmology.
PROGRESS IN BIOMEDICAL ENGINEERING
(2021)